ATE419347T1 - Verfahren zur rna-spaltung - Google Patents

Verfahren zur rna-spaltung

Info

Publication number
ATE419347T1
ATE419347T1 AT01940942T AT01940942T ATE419347T1 AT E419347 T1 ATE419347 T1 AT E419347T1 AT 01940942 T AT01940942 T AT 01940942T AT 01940942 T AT01940942 T AT 01940942T AT E419347 T1 ATE419347 T1 AT E419347T1
Authority
AT
Austria
Prior art keywords
bulge
target molecule
rna cleaving
helix
molecule
Prior art date
Application number
AT01940942T
Other languages
English (en)
Inventor
Glauco Tocchini-Valentini
Giancarlo Deidda
Nicoletta Rossi
Maria Baldi
Paolo Fruscoloni
Original Assignee
Istituto Di Biolog Cellulare C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Di Biolog Cellulare C filed Critical Istituto Di Biolog Cellulare C
Application granted granted Critical
Publication of ATE419347T1 publication Critical patent/ATE419347T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes

Landscapes

  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01940942T 2000-05-31 2001-05-30 Verfahren zur rna-spaltung ATE419347T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20843200P 2000-05-31 2000-05-31

Publications (1)

Publication Number Publication Date
ATE419347T1 true ATE419347T1 (de) 2009-01-15

Family

ID=22774580

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01940942T ATE419347T1 (de) 2000-05-31 2001-05-30 Verfahren zur rna-spaltung

Country Status (7)

Country Link
US (1) US20040023239A1 (de)
EP (1) EP1303597B1 (de)
JP (1) JP2003534789A (de)
AT (1) ATE419347T1 (de)
AU (1) AU2001274428A1 (de)
DE (1) DE60137226D1 (de)
WO (1) WO2001092463A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8512945B2 (en) * 2000-05-31 2013-08-20 Glauco P. Tocchini-Valentini Method of RNA cleavage and recombination
CA2520510A1 (en) * 2003-03-27 2004-10-14 Ptc Therapeutics, Inc. Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-fungal agents
EP2319318A3 (de) * 2003-03-27 2011-08-17 PTC Therapeutics, Inc. Verfahren zur Identifizierung von Verbindungen mit tRNA-Splicing Endonuklease als Aufhänger, und Verwendungen für diese Verbindungen als anti-Proliferationsmittel
DE04777457T1 (de) * 2003-07-02 2008-08-14 Ptc Therapeutics, Inc. Rna prozessierende proteinkomplexe und verwendungen davon

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869248A (en) * 1994-03-07 1999-02-09 Yale University Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences
AU2601495A (en) * 1994-05-23 1995-12-18 Indiana University Foundation Sequence-specific endonucleases, and preparation and use of same

Also Published As

Publication number Publication date
EP1303597B1 (de) 2008-12-31
WO2001092463A2 (en) 2001-12-06
EP1303597A2 (de) 2003-04-23
DE60137226D1 (de) 2009-02-12
JP2003534789A (ja) 2003-11-25
WO2001092463A3 (en) 2003-01-09
AU2001274428A1 (en) 2001-12-11
US20040023239A1 (en) 2004-02-05

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties