ATE419845T1 - Il-8-rezeptor-antagonisten - Google Patents

Il-8-rezeptor-antagonisten

Info

Publication number: ATE419845T1
Authority: AT; Austria
Prior art keywords: receptor antagonists; squaramides; chemokine; interleukin; amide
Prior art date: 2001-01-16

Application number

AT02726557T

Other languages

English (en)

Inventor

Michael R Palovich

Katherine L Widdowson

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-16

Filing date

2002-01-16

Publication date

2009-01-15

2002-01-16 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2009-01-15 Application granted granted Critical

2009-01-15 Publication of ATE419845T1 publication Critical patent/ATE419845T1/de

Links

108090001007 Interleukin-8 Proteins 0.000 title abstract 3
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
102000004890 Interleukin-8 Human genes 0.000 abstract 2
XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 abstract 2
229940096397 interleukin-8 Drugs 0.000 abstract 2
102000019034 Chemokines Human genes 0.000 abstract 1
108010012236 Chemokines Proteins 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P11/06—Antiasthmatics
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- A61P11/10—Expectorants
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Cardiology (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Pregnancy & Childbirth (AREA)
Hospice & Palliative Care (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Vascular Medicine (AREA)

AT02726557T 2001-01-16 2002-01-16 Il-8-rezeptor-antagonisten ATE419845T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US26191401P	2001-01-16	2001-01-16

Publications (1)

Publication Number	Publication Date
ATE419845T1 true ATE419845T1 (de)	2009-01-15

Family

ID=22995428

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02726557T ATE419845T1 (de)	2001-01-16	2002-01-16	Il-8-rezeptor-antagonisten

Country Status (7)

Country	Link
US (2)	US20040132694A1 (de)
EP (1)	EP1357909B1 (de)
JP (1)	JP2004520412A (de)
AT (1)	ATE419845T1 (de)
DE (1)	DE60230722D1 (de)
ES (1)	ES2318003T3 (de)
WO (1)	WO2002067919A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1355875A1 (de) *	2001-02-02	2003-10-29	Schering Corporation	3,4-disubstituierte cyclobuten-1,2-dione als cxc chemokin-rezeptor-antagonisten
US20040106794A1 (en)	2001-04-16	2004-06-03	Schering Corporation	3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US7132445B2 (en)	2001-04-16	2006-11-07	Schering Corporation	3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
JP2005505595A (ja)	2001-10-12	2005-02-24	シェーリング　コーポレイション	Ｃｘｃ−ケモカインレセプターアンタゴニストとしての３，４−二置換マレイミド化合物
US6878709B2 (en)	2002-01-04	2005-04-12	Schering Corporation	3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
NZ535314A (en)	2002-03-18	2007-08-31	Schering Corp	Combination treatments for chemokine-mediated diseases
US7626042B2 (en)	2002-06-06	2009-12-01	Institute Of Medicinal Molecular Design, Inc.	O-substituted hydroxyaryl derivatives
EP1551818B1 (de) *	2002-10-09	2009-02-04	Schering Corporation	Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden
AR041834A1 (es) *	2002-10-29	2005-06-01	Smithkline Beecham Corp	Compuesto de difenilurea sustituido con sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion
US20070042997A1 (en) *	2003-07-16	2007-02-22	Akiko Itai	Medicament for treatment of dermal pigmentation
GB0323793D0 (en) *	2003-10-10	2003-11-12	Imp College Innovations Ltd	Methods
US7338968B2 (en)	2003-12-19	2008-03-04	Schering Corporation	Thiadiazoles AS CXC- and CC- chemokine receptor ligands
WO2005068460A1 (en)	2003-12-22	2005-07-28	Schering Corporation	Isothiazole dioxides as cxc- and cc- chemokine receptor ligands
WO2006043950A1 (en) *	2004-10-20	2006-04-27	Smithkline Beecham Corporation	Il-8 receptor antagonists
WO2007002764A2 (en)	2005-06-29	2007-01-04	Schering Corporation	Di-substituted oxadiazoles as cxc-chemokine receptor ligands
ATE486078T1 (de)	2005-06-29	2010-11-15	Schering Corp	5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc- chemokinrezeptors
MX2008013600A (es) *	2006-04-21	2008-10-31	Smithkline Beechman Corp	Antagonistas del receptor de interleuquina-8.
CA2650007A1 (en) *	2006-04-21	2007-11-01	Smithkline Beecham Corporation	Il-8 receptor antagonists
US7671058B2 (en)	2006-06-21	2010-03-02	Institute Of Medicinal Molecular Design, Inc.	N-(3,4-disubstituted phenyl) salicylamide derivatives
CL2007001829A1 (es) *	2006-06-23	2008-01-25	Smithkline Beecham Corp	P-toluensulfonato de n-[4-cloro-2-hidroxi-3-(piperazina-1-sulfonil)fenil]-n-(2-cloro-3-fluorofenil)urea;procedimiento de preparacion;composicion farmaceutica;combinacion farmaceutica;y uso en el tratamiento de una enfermedad mediada por la quiimioquina il-8, tales como asma y epoc.
WO2013030803A1 (en)	2011-09-02	2013-03-07	Novartis Ag	Choline salt of an anti - inflammatory substituted cyclobutenedione compound
TWI734715B (zh)	2015-11-19	2021-08-01	美商卡默森屈有限公司	趨化因子受體調節劑
TWI724056B (zh)	2015-11-19	2021-04-11	美商卡默森屈有限公司	Ｃｘｃｒ２抑制劑
ES3067325T3 (en)	2018-01-08	2026-05-21	Chemocentryx Inc	Methods of treating generalized pustular psoriasis with an antagonist of ccr6 or cxcr2

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH11503110A (ja) *	1995-02-17	1999-03-23	スミスクライン・ビーチャム・コーポレイション	Ｉｌ−８受容体拮抗剤
AR033803A1 (es) *	2000-03-01	2004-01-07	Smithkline Beecham Corp	Compuestos de dianilino escuarano, composiciones farmaceuticas que los comprenden, y el uso de los mismos en la fabricacion de medicamentos para tratar enfermedades mediadas por quimioquinas
US6432960B2 (en) *	2000-05-10	2002-08-13	Bristol-Myers Squibb Company	Squarate derivatives of dihydropyridine NPY antagonists
WO2001092202A1 (en) *	2000-05-30	2001-12-06	Smithkline Beecham Corporation	Il-8 receptor antagonists

2002
- 2002-01-16 DE DE60230722T patent/DE60230722D1/de not_active Expired - Fee Related
- 2002-01-16 ES ES02726557T patent/ES2318003T3/es not_active Expired - Lifetime
- 2002-01-16 AT AT02726557T patent/ATE419845T1/de not_active IP Right Cessation
- 2002-01-16 US US10/466,383 patent/US20040132694A1/en not_active Abandoned
- 2002-01-16 EP EP02726557A patent/EP1357909B1/de not_active Expired - Lifetime
- 2002-01-16 JP JP2002567287A patent/JP2004520412A/ja active Pending
- 2002-01-16 WO PCT/US2002/001412 patent/WO2002067919A1/en not_active Ceased
2005
- 2005-12-05 US US11/294,660 patent/US20060084661A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1357909A4 (de)	2006-01-04
JP2004520412A (ja)	2004-07-08
US20060084661A1 (en)	2006-04-20
WO2002067919A1 (en)	2002-09-06
US20040132694A1 (en)	2004-07-08
ES2318003T3 (es)	2009-05-01
EP1357909B1 (de)	2009-01-07
EP1357909A1 (de)	2003-11-05
DE60230722D1 (de)	2009-02-26

Legal Events

Date	Code	Title	Description
2009-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60230722D1 (de)	2009-02-26	Il-8-rezeptor-antagonisten
CY1106514T1 (el)	2012-01-25	Ανταγωνιστες υποδοχεων il-8
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