ATE419845T1 - Il-8-rezeptor-antagonisten - Google Patents

Il-8-rezeptor-antagonisten

Info

Publication number: ATE419845T1
Authority: AT; Austria
Prior art keywords: receptor antagonists; squaramides; chemokine; interleukin; amide
Prior art date: 2001-01-16

Application number

AT02726557T

Other languages

English (en)

Inventor

Michael R Palovich

Katherine L Widdowson

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-16

Filing date

2002-01-16

Publication date

2009-01-15

2002-01-16 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2009-01-15 Application granted granted Critical

2009-01-15 Publication of ATE419845T1 publication Critical patent/ATE419845T1/de

Links

108090001007 Interleukin-8 Proteins 0.000 title abstract 3
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
102000004890 Interleukin-8 Human genes 0.000 abstract 2
XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 abstract 2
229940096397 interleukin-8 Drugs 0.000 abstract 2
102000019034 Chemokines Human genes 0.000 abstract 1
108010012236 Chemokines Proteins 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P11/06—Antiasthmatics
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- A61P11/10—Expectorants
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Cardiology (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Rheumatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Tropical Medicine & Parasitology (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Pregnancy & Childbirth (AREA)
Hospice & Palliative Care (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Vascular Medicine (AREA)

AT02726557T 2001-01-16 2002-01-16 Il-8-rezeptor-antagonisten ATE419845T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US26191401P	2001-01-16	2001-01-16

Publications (1)

Publication Number	Publication Date
ATE419845T1 true ATE419845T1 (de)	2009-01-15

Family

ID=22995428

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02726557T ATE419845T1 (de)	2001-01-16	2002-01-16	Il-8-rezeptor-antagonisten

Country Status (7)

Country	Link
US (2)	US20040132694A1 (de)
EP (1)	EP1357909B1 (de)
JP (1)	JP2004520412A (de)
AT (1)	ATE419845T1 (de)
DE (1)	DE60230722D1 (de)
ES (1)	ES2318003T3 (de)
WO (1)	WO2002067919A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002076926A1 (en) *	2001-02-02	2002-10-03	Schering Corporation	3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists
US20040106794A1 (en)	2001-04-16	2004-06-03	Schering Corporation	3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US7132445B2 (en)	2001-04-16	2006-11-07	Schering Corporation	3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
JP2005505595A (ja)	2001-10-12	2005-02-24	シェーリング　コーポレイション	Ｃｘｃ−ケモカインレセプターアンタゴニストとしての３，４−二置換マレイミド化合物
US6878709B2 (en)	2002-01-04	2005-04-12	Schering Corporation	3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
WO2003080053A1 (en) *	2002-03-18	2003-10-02	Schering Corporation	Combination treatments for chemokine-mediated diseases
CA2488363C (en)	2002-06-06	2011-01-04	Institute Of Medicinal Molecular Design, Inc.	O-substituted hydroxyaryl derivatives
PE20040570A1 (es) *	2002-10-09	2004-08-30	Pharmacopeia Drug Discovery	Tiadiazoldioxidos y tiadiazoloxidos como ligandos del receptor de cxc- y cc-quimiocina
TW200418812A (en) *	2002-10-29	2004-10-01	Smithkline Beecham Corp	IL-8 receptor antagonists
JPWO2005007151A1 (ja) *	2003-07-16	2006-08-31	株式会社医薬分子設計研究所	皮膚色素沈着の治療剤
GB0323793D0 (en) *	2003-10-10	2003-11-12	Imp College Innovations Ltd	Methods
ES2308299T3 (es)	2003-12-19	2008-12-01	Schering Corp	Tiadiazoles como ligandos de receptores de cxc-y cc-quimioquinas.
TW200530231A (en)	2003-12-22	2005-09-16	Schering Corp	Isothiazole dioxides as CXC-and CC-chemokine receptor ligands
EP1812008A4 (de) *	2004-10-20	2008-10-29	Smithkline Beecham Corp	Il-8-rezeptorantagonisten
EP1912971A2 (de)	2005-06-29	2008-04-23	Shering Corporation	Disubstituierte oxadiazole als liganden des cxc-chemokinrezeptors
MX2008000367A (es)	2005-06-29	2008-03-07	Schering Corp	Oxidiazolopirazinas y tiadiazolopirazinas 5,6-di-sustituidas como ligandos de receptor de quimiocina en la que dos cisternas son separadas por un solo aminoacido.
US8097626B2 (en) *	2006-04-21	2012-01-17	Glaxosmithkline Llc	IL-8 receptor antagonists
PL2009992T3 (pl) *	2006-04-21	2012-11-30	Glaxosmithkline Llc	Antagoniści receptora IL-8
US7671058B2 (en)	2006-06-21	2010-03-02	Institute Of Medicinal Molecular Design, Inc.	N-(3,4-disubstituted phenyl) salicylamide derivatives
CL2007001829A1 (es) *	2006-06-23	2008-01-25	Smithkline Beecham Corp	P-toluensulfonato de n-[4-cloro-2-hidroxi-3-(piperazina-1-sulfonil)fenil]-n-(2-cloro-3-fluorofenil)urea;procedimiento de preparacion;composicion farmaceutica;combinacion farmaceutica;y uso en el tratamiento de una enfermedad mediada por la quiimioquina il-8, tales como asma y epoc.
ES2655942T3 (es)	2011-09-02	2018-02-22	Novartis Ag	Sal de colina de un compuesto anti-inflamatorio de ciclobutenodiona sustituida
TWI734715B (zh)	2015-11-19	2021-08-01	美商卡默森屈有限公司	趨化因子受體調節劑
TWI724056B (zh)	2015-11-19	2021-04-11	美商卡默森屈有限公司	Ｃｘｃｒ２抑制劑
EP3737366B1 (de)	2018-01-08	2026-02-25	ChemoCentryx, Inc.	Verfahren zur behandlung von generalisierter pustulöser psoriasis mit einem antagonisten von ccr6 oder cxcr2

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH11503110A (ja) *	1995-02-17	1999-03-23	スミスクライン・ビーチャム・コーポレイション	Ｉｌ−８受容体拮抗剤
AR033803A1 (es) *	2000-03-01	2004-01-07	Smithkline Beecham Corp	Compuestos de dianilino escuarano, composiciones farmaceuticas que los comprenden, y el uso de los mismos en la fabricacion de medicamentos para tratar enfermedades mediadas por quimioquinas
US6432960B2 (en) *	2000-05-10	2002-08-13	Bristol-Myers Squibb Company	Squarate derivatives of dihydropyridine NPY antagonists
CN1454204A (zh) *	2000-05-30	2003-11-05	史密丝克莱恩比彻姆公司	Il－8受体拮抗剂

2002
- 2002-01-16 JP JP2002567287A patent/JP2004520412A/ja active Pending
- 2002-01-16 US US10/466,383 patent/US20040132694A1/en not_active Abandoned
- 2002-01-16 AT AT02726557T patent/ATE419845T1/de not_active IP Right Cessation
- 2002-01-16 EP EP02726557A patent/EP1357909B1/de not_active Expired - Lifetime
- 2002-01-16 WO PCT/US2002/001412 patent/WO2002067919A1/en not_active Ceased
- 2002-01-16 ES ES02726557T patent/ES2318003T3/es not_active Expired - Lifetime
- 2002-01-16 DE DE60230722T patent/DE60230722D1/de not_active Expired - Fee Related
2005
- 2005-12-05 US US11/294,660 patent/US20060084661A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP2004520412A (ja)	2004-07-08
DE60230722D1 (de)	2009-02-26
WO2002067919A1 (en)	2002-09-06
ES2318003T3 (es)	2009-05-01
US20060084661A1 (en)	2006-04-20
EP1357909A1 (de)	2003-11-05
EP1357909B1 (de)	2009-01-07
US20040132694A1 (en)	2004-07-08
EP1357909A4 (de)	2006-01-04

Legal Events

Date	Code	Title	Description
2009-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
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JO2796B1 (en)	2014-03-15	Antiallergic drugs IL-8
BR9916159A (pt)	2001-12-04	Sulfonamidas de hidróxi-difenil-uréia comoantagonistas dos receptores de il-8
NO20090203L (no)	2009-03-20	IL-8 receptorantagonist
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AP1548A (en)	2006-01-16	Il-8 Receptor Antagonists.
EA200400399A1 (ru)	2004-08-26	Способы лечения легочных заболеваний
NZ514696A (en)	2004-03-26	IL-8 receptor antagonists
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MY143477A (en)	2011-05-31	Il-8 receptor antagonists
WO2001064165A3 (en)	2002-03-21	Il-8 receptor antagonists
AP2002002606A0 (en)	2002-09-30	INTERLEUKIN 8 RECEPTOR ANTAGONISTS
HK1045256A1 (zh)	2002-11-22	Il-8受体拮抗剂
WO2000072800A3 (en)	2001-03-08	Il-8 receptor antagonists
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WO2001068033A3 (en)	2002-03-07	Il-8 receptor antagonists
HK1044475A1 (zh)	2002-10-25	Il-8受体拮抗剂
WO2001068570A3 (en)	2002-04-18	Il-8 receptor antagonists
NZ515232A (en)	2004-02-27	IL-8 receptor antagonists
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