ATE420351T1 - Sonden mit affinitätsverschiebung zur quantifizierung von analytenpolynukleotiden - Google Patents
Sonden mit affinitätsverschiebung zur quantifizierung von analytenpolynukleotidenInfo
- Publication number
- ATE420351T1 ATE420351T1 AT02757500T AT02757500T ATE420351T1 AT E420351 T1 ATE420351 T1 AT E420351T1 AT 02757500 T AT02757500 T AT 02757500T AT 02757500 T AT02757500 T AT 02757500T AT E420351 T1 ATE420351 T1 AT E420351T1
- Authority
- AT
- Austria
- Prior art keywords
- probes
- quantification
- probe
- analyte
- immobilized
- Prior art date
Links
- 239000000523 sample Substances 0.000 title abstract 4
- 239000012491 analyte Substances 0.000 title abstract 3
- 108091033319 polynucleotide Proteins 0.000 title abstract 3
- 102000040430 polynucleotide Human genes 0.000 title abstract 3
- 239000002157 polynucleotide Substances 0.000 title abstract 3
- 238000011002 quantification Methods 0.000 title 1
- 230000003321 amplification Effects 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 2
- 108091093088 Amplicon Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000003366 endpoint assay Methods 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6832—Enhancement of hybridisation reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31677001P | 2001-08-31 | 2001-08-31 | |
| US36807202P | 2002-03-26 | 2002-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE420351T1 true ATE420351T1 (de) | 2009-01-15 |
Family
ID=26980589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02757500T ATE420351T1 (de) | 2001-08-31 | 2002-08-30 | Sonden mit affinitätsverschiebung zur quantifizierung von analytenpolynukleotiden |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20030105320A1 (de) |
| EP (1) | EP1440311B1 (de) |
| JP (1) | JP4291143B2 (de) |
| AT (1) | ATE420351T1 (de) |
| CA (1) | CA2457527A1 (de) |
| DE (1) | DE60230787D1 (de) |
| WO (1) | WO2003020952A2 (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003038046A2 (en) * | 2001-10-27 | 2003-05-08 | Sigma Genosys, Inc. | Multiple oligonucleotides per gene for use in gene arrays |
| EP1426448A1 (de) * | 2002-12-03 | 2004-06-09 | bioMérieux BV | Methode zur Reduktion des Effektes von Sequenzvariationen in einem diagnostischen Hybridisierungsverfahren, Sonde zur Verwendung in einem solchen Verfahren, sowie das Verfahren selbst |
| US7198900B2 (en) * | 2003-08-29 | 2007-04-03 | Applera Corporation | Multiplex detection compositions, methods, and kits |
| US20050048498A1 (en) * | 2003-08-29 | 2005-03-03 | Applera Corporation | Compositions, methods, and kits for assembling probes |
| US20050069895A1 (en) * | 2003-08-29 | 2005-03-31 | Applera Corporation | Compositions, methods, and kits for fabricating coded molecular tags |
| US8173785B2 (en) * | 2003-11-26 | 2012-05-08 | Advandx, Inc. | Peptide nucleic acid probes for analysis of certain Staphylococcus species |
| US7662562B2 (en) * | 2004-08-10 | 2010-02-16 | Becton, Dickinson And Company | Method for rapid identification of microorganisms |
| WO2007005305A1 (en) * | 2005-06-30 | 2007-01-11 | Syngenta Participations Ag | METHODS FOR SCREENING FOR GENE SPECIFIC HYBRIDIZATION POLYMORPHISMS (GSHPs) AND THEIR USE IN GENETIC MAPPING AND MARKER DEVELOPMENT |
| FR2894596B1 (fr) * | 2005-12-13 | 2012-08-10 | Centre Nat Rech Scient | Procede d'autocalibration de biopuces |
| AU2007233270B2 (en) * | 2006-04-04 | 2013-06-20 | Fluidigm Corporation | Cooperative probes and methods of using them |
| US20100216657A1 (en) * | 2006-05-16 | 2010-08-26 | Arcxis Biotechnologies, Inc. | Pcr-free sample preparation and detection systems for high speed biologic analysis and identification |
| JP5627886B2 (ja) * | 2006-05-16 | 2014-11-19 | フルイディウム コーポレーション | 生物学的な高速解析および高速識別のための、ｐｃｒを使用しない試料調製および検出システム |
| US8338109B2 (en) | 2006-11-02 | 2012-12-25 | Mayo Foundation For Medical Education And Research | Predicting cancer outcome |
| US9938641B2 (en) * | 2006-12-18 | 2018-04-10 | Fluidigm Corporation | Selection of aptamers based on geometry |
| WO2008140620A2 (en) * | 2006-12-21 | 2008-11-20 | Nanosphere, Inc. | Ultra sensitive biomolecule detection using double stranded dna co-loaded gold nanoparticles and co-immobilized capture molecules |
| JP2009034052A (ja) * | 2007-08-02 | 2009-02-19 | Canon Inc | ハイブリダイゼーション方法および装置 |
| US20090215050A1 (en) * | 2008-02-22 | 2009-08-27 | Robert Delmar Jenison | Systems and methods for point-of-care amplification and detection of polynucleotides |
| JP4580996B2 (ja) * | 2008-02-27 | 2010-11-17 | 株式会社東芝 | 標的核酸の検出方法および標的核酸検出用基体 |
| EP2806054A1 (de) | 2008-05-28 | 2014-11-26 | Genomedx Biosciences Inc. | Systeme und Verfahren zur expressionsbasierten Unterscheidung verschiedener klinischer Krankheitszustände bei Prostatakrebs |
| US10407731B2 (en) | 2008-05-30 | 2019-09-10 | Mayo Foundation For Medical Education And Research | Biomarker panels for predicting prostate cancer outcomes |
| US9495515B1 (en) | 2009-12-09 | 2016-11-15 | Veracyte, Inc. | Algorithms for disease diagnostics |
| US8541170B2 (en) | 2008-11-17 | 2013-09-24 | Veracyte, Inc. | Methods and compositions of molecular profiling for disease diagnostics |
| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
| US9074258B2 (en) | 2009-03-04 | 2015-07-07 | Genomedx Biosciences Inc. | Compositions and methods for classifying thyroid nodule disease |
| EP3360978A3 (de) | 2009-05-07 | 2018-09-26 | Veracyte, Inc. | Verfahren zur diagnose von schilddrüsenerkrankungen |
| US8628924B2 (en) | 2009-07-21 | 2014-01-14 | Gen-Probe Incorporated | Methods and compositions for quantitative amplification and detection over a wide dynamic range |
| US10446272B2 (en) | 2009-12-09 | 2019-10-15 | Veracyte, Inc. | Methods and compositions for classification of samples |
| US8648016B2 (en) * | 2010-02-08 | 2014-02-11 | Robert Bosch Gmbh | Array with extended dynamic range and associated method |
| US20110312520A1 (en) | 2010-05-11 | 2011-12-22 | Veracyte, Inc. | Methods and compositions for diagnosing conditions |
| CN102985566B (zh) | 2010-06-30 | 2015-06-17 | 简.探针公司 | 使用分析物和过程控制信号的单次读取确定而鉴定含分析物的样品的方法和设备 |
| EP2627781B1 (de) | 2010-10-15 | 2017-02-22 | Olink Bioscience AB | Dynamikbereich verfahren |
| US20130267443A1 (en) | 2010-11-19 | 2013-10-10 | The Regents Of The University Of Michigan | ncRNA AND USES THEREOF |
| US20130040859A1 (en) * | 2011-08-08 | 2013-02-14 | Gen-Probe Incorporated | Spectrally-resolved chemiluminescent probes for sensitive multiplex molecular quantification |
| WO2013090620A1 (en) | 2011-12-13 | 2013-06-20 | Genomedx Biosciences, Inc. | Cancer diagnostics using non-coding transcripts |
| ES2945036T3 (es) | 2012-08-16 | 2023-06-28 | Veracyte Sd Inc | Pronóstico del cáncer de próstata mediante biomarcadores |
| BR112015022490A2 (pt) | 2013-03-15 | 2017-07-18 | Veracyte Inc | métodos e composições para classificação de amostras |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| US12297505B2 (en) | 2014-07-14 | 2025-05-13 | Veracyte, Inc. | Algorithms for disease diagnostics |
| EP3194620A1 (de) | 2014-09-17 | 2017-07-26 | Vito NV | Sondensets und verfahren zur analyse von hybridisierung |
| US20170335396A1 (en) | 2014-11-05 | 2017-11-23 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
| AU2017315425B2 (en) | 2016-08-24 | 2023-11-09 | The Regents Of The University Of Michigan | Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy |
| EP3571322B9 (de) | 2017-01-20 | 2023-10-04 | VERACYTE SD, Inc. | Molekulare untertypisierung, prognose und behandlung von blasenkrebs |
| CA3055925A1 (en) | 2017-03-09 | 2018-09-13 | Decipher Biosciences, Inc. | Subtyping prostate cancer to predict response to hormone therapy |
| US11078542B2 (en) | 2017-05-12 | 2021-08-03 | Decipher Biosciences, Inc. | Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness |
| US11217329B1 (en) | 2017-06-23 | 2022-01-04 | Veracyte, Inc. | Methods and systems for determining biological sample integrity |
| US12497660B2 (en) | 2017-08-04 | 2025-12-16 | Veracyte SD, Inc. | Use of immune cell-specific gene expression for prognosis of prostate cancer and prediction of responsiveness to radiation therapy |
| RU2020105929A (ru) | 2017-08-04 | 2021-09-06 | Скайхоук Терапьютикс, Инк. | Способы и композиции для модулирования сплайсинга |
| EP3920926A4 (de) | 2019-02-05 | 2022-10-19 | Skyhawk Therapeutics, Inc. | Verfahren und zusammensetzungen zur modulierung der spleissung |
| JP7603592B2 (ja) | 2019-02-05 | 2024-12-20 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
| CN119638696A (zh) | 2019-02-06 | 2025-03-18 | 斯基霍克疗法公司 | 用于调节剪接的方法和组合物 |
| WO2020163544A1 (en) | 2019-02-06 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
| US11129829B2 (en) | 2019-06-17 | 2021-09-28 | Skyhawk Therapeutics, Inc. | Methods for modulating splicing |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4766062A (en) * | 1984-05-07 | 1988-08-23 | Allied Corporation | Displacement polynucleotide assay method and polynucleotide complex reagent therefor |
| US6004745A (en) * | 1987-09-21 | 1999-12-21 | Gen-Probe Incorporated | Hybridization protection assay |
| US6040138A (en) * | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US5219727A (en) * | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| US5200314A (en) * | 1990-03-23 | 1993-04-06 | Chiron Corporation | Polynucleotide capture assay employing in vitro amplification |
| US6156501A (en) * | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| US5514551A (en) * | 1994-10-14 | 1996-05-07 | Gen-Probe Incorporated | Compositions for the detection of Chlamydia trachomatis |
| JPH11505126A (ja) * | 1995-05-19 | 1999-05-18 | アボツト・ラボラトリーズ | プライマーシリーズ集団を使用する広い動的範囲の核酸検出 |
| US5710029A (en) * | 1995-06-07 | 1998-01-20 | Gen-Probe Incorporated | Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product |
| US5741650A (en) * | 1996-01-30 | 1998-04-21 | Exact Laboratories, Inc. | Methods for detecting colon cancer from stool samples |
| US6143496A (en) * | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| US6566101B1 (en) * | 1997-06-16 | 2003-05-20 | Anthony P. Shuber | Primer extension methods for detecting nucleic acids |
| EP1025120B1 (de) * | 1997-10-27 | 2010-08-18 | Boston Probes, Inc. | Sich auf "pna molecular beacons" beziehende verfahren, testsätze und zusammensetzungen |
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| US6238869B1 (en) * | 1997-12-19 | 2001-05-29 | High Throughput Genomics, Inc. | High throughput assay system |
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| US6066458A (en) * | 1998-05-18 | 2000-05-23 | Becton, Dickinson And Company | Methods, apparatus and computer program products for determining quantities of nucleic acid sequences in samples using standard curves and amplification ratio estimates |
| US6037130A (en) * | 1998-07-28 | 2000-03-14 | The Public Health Institute Of The City Of New York, Inc. | Wavelength-shifting probes and primers and their use in assays and kits |
| US20020001800A1 (en) * | 1998-08-14 | 2002-01-03 | Stanley N. Lapidus | Diagnostic methods using serial testing of polymorphic loci |
| US6245517B1 (en) * | 1998-09-29 | 2001-06-12 | The United States Of America As Represented By The Department Of Health And Human Services | Ratio-based decisions and the quantitative analysis of cDNA micro-array images |
| US6238927B1 (en) * | 1998-10-05 | 2001-05-29 | Mosaic Technologies, Incorporated | Reverse displacement assay for detection of nucleic acid sequences |
| US6245511B1 (en) * | 1999-02-22 | 2001-06-12 | Vialogy Corp | Method and apparatus for exponentially convergent therapy effectiveness monitoring using DNA microarray based viral load measurements |
| CA2644688C (en) * | 1999-04-20 | 2012-11-13 | Kankyo Engineering Co., Ltd. | Method for determining a concentration of target nucleic acid molecules, nucleic acid probes for the method, and method for analysing data obtained by the method |
| DE60030145T2 (de) * | 1999-10-22 | 2008-01-10 | PHRI Properties, Inc., Newark | Nachweisverfahren für kurze sequenzvarianten |
| US20020197630A1 (en) * | 2001-04-12 | 2002-12-26 | Knapp Michael R. | Systems and methods for high throughput genetic analysis |
-
2002
- 2002-08-30 CA CA002457527A patent/CA2457527A1/en not_active Abandoned
- 2002-08-30 US US10/233,223 patent/US20030105320A1/en not_active Abandoned
- 2002-08-30 JP JP2003525653A patent/JP4291143B2/ja not_active Expired - Lifetime
- 2002-08-30 AT AT02757500T patent/ATE420351T1/de not_active IP Right Cessation
- 2002-08-30 WO PCT/US2002/027710 patent/WO2003020952A2/en not_active Ceased
- 2002-08-30 DE DE60230787T patent/DE60230787D1/de not_active Expired - Lifetime
- 2002-08-30 EP EP02757500A patent/EP1440311B1/de not_active Expired - Lifetime
-
2007
- 2007-08-30 US US11/847,950 patent/US20080131892A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003020952A2 (en) | 2003-03-13 |
| JP4291143B2 (ja) | 2009-07-08 |
| EP1440311B1 (de) | 2009-01-07 |
| US20030105320A1 (en) | 2003-06-05 |
| WO2003020952A3 (en) | 2003-06-05 |
| DE60230787D1 (de) | 2009-02-26 |
| JP2005502349A (ja) | 2005-01-27 |
| EP1440311A4 (de) | 2005-03-30 |
| EP1440311A2 (de) | 2004-07-28 |
| CA2457527A1 (en) | 2003-03-13 |
| US20080131892A1 (en) | 2008-06-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |