ATE534748T1 - Direkter snp-nachweis mit nichtamplifizierter dna - Google Patents

Direkter snp-nachweis mit nichtamplifizierter dna

Info

Publication number
ATE534748T1
ATE534748T1 AT03810070T AT03810070T ATE534748T1 AT E534748 T1 ATE534748 T1 AT E534748T1 AT 03810070 T AT03810070 T AT 03810070T AT 03810070 T AT03810070 T AT 03810070T AT E534748 T1 ATE534748 T1 AT E534748T1
Authority
AT
Austria
Prior art keywords
nucleic acid
amplified dna
acid molecules
snp detection
direct snp
Prior art date
Application number
AT03810070T
Other languages
English (en)
Inventor
Yijia Bao
Sudhakar Marla
Uwe Muller
James Storhoff
Susan Hetzel
Original Assignee
Nanosphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanosphere Inc filed Critical Nanosphere Inc
Application granted granted Critical
Publication of ATE534748T1 publication Critical patent/ATE534748T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Nanotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
AT03810070T 2002-12-12 2003-12-12 Direkter snp-nachweis mit nichtamplifizierter dna ATE534748T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43344202P 2002-12-12 2002-12-12
US43277202P 2002-12-12 2002-12-12
PCT/US2003/039836 WO2004053105A2 (en) 2002-12-12 2003-12-12 Direct snp detection with unamplified dna

Publications (1)

Publication Number Publication Date
ATE534748T1 true ATE534748T1 (de) 2011-12-15

Family

ID=32511667

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03810070T ATE534748T1 (de) 2002-12-12 2003-12-12 Direkter snp-nachweis mit nichtamplifizierter dna

Country Status (7)

Country Link
US (1) US20050059030A1 (de)
EP (1) EP1578952B1 (de)
JP (1) JP2006517786A (de)
AT (1) ATE534748T1 (de)
AU (1) AU2003302253B2 (de)
CA (1) CA2508359A1 (de)
WO (1) WO2004053105A2 (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
EP2000803A1 (de) 1998-11-30 2008-12-10 Nanosphere, Inc. Nanoteilchen mit Polymerschalen
JP2004501340A (ja) 2000-01-13 2004-01-15 ナノスフェアー インコーポレイテッド オリゴヌクレオチドを付着させたナノ粒子とその使用方法
US7147687B2 (en) 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7238472B2 (en) 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
ATE403751T1 (de) 2001-11-09 2008-08-15 Nanosphere Inc Biokonjugat-nanopartikelsonden
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
ATE420357T1 (de) 2002-07-02 2009-01-15 Nanosphere Inc Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten
US20060183132A1 (en) * 2005-02-14 2006-08-17 Perlegen Sciences, Inc. Selection probe amplification
WO2005001113A2 (en) * 2003-06-27 2005-01-06 Thomas Jefferson University Methods for detecting nucleic acid variations
EP1709198B1 (de) * 2003-11-26 2013-08-14 AdvanDx, Inc. Peptid-nukleinsäure-sonden zur analyse bestimmter staphylococcus spezies
AU2004312893B2 (en) 2003-12-31 2010-06-17 President And Fellows Of Harvard College Assay device and method
JP2005227154A (ja) * 2004-02-13 2005-08-25 Eiichi Tamiya 特定遺伝子検出方法及びこれに用いる塩基修飾ナノ粒子、1塩基変異型遺伝子識別用試薬
US20060057613A1 (en) * 2004-07-26 2006-03-16 Nanosphere, Inc. Method for distinguishing methicillin resistant S. aureus from methicillin sensitive S. aureus in a mixed culture
JP4742544B2 (ja) * 2004-09-08 2011-08-10 凸版印刷株式会社 遺伝子チェック装置及び方法
WO2007044025A2 (en) * 2004-11-22 2007-04-19 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nonoparticle probe complexes
US7611908B2 (en) 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7749445B2 (en) 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
EP1888779A4 (de) 2005-05-20 2009-06-10 Synergenz Bioscience Ltd Verfahren zur analyse von polymorphismen sowie verwendungen davon
WO2007002567A2 (en) * 2005-06-23 2007-01-04 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
US20070003938A1 (en) * 2005-06-30 2007-01-04 Perlegen Sciences, Inc. Hybridization of genomic nucleic acid without complexity reduction
JP4822753B2 (ja) * 2005-07-11 2011-11-24 一般社団法人オンチップ・セロミクス・コンソーシアム 細胞構成物質分取チップならびに細胞構成物質解析システム及びこれらを用いる細胞構成物質解析法
ATE489482T1 (de) * 2005-08-19 2010-12-15 Nanosphere Inc Verfahren zur herstellung von hybridsubstraten mit dna und antikörpern sowie verwendungen davon
US20070174128A1 (en) * 2005-11-30 2007-07-26 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Computational and/or control systems related to individualized pharmaceutical and nutraceutical selection and packaging
JP2009520209A (ja) * 2005-12-19 2009-05-21 バイオスケール, インコーポレイテッド バイオプロセス液を分析するための方法および装置
EP2284539B1 (de) * 2005-12-19 2014-04-09 Bioscale, Inc. Verfahren und Gerät zur Untersuchung von Bioprozess-Flüssigkeiten
RU2487169C2 (ru) * 2006-01-19 2013-07-10 Зе Рисерч Фаундейшн Оф Стейт Юниверсити Оф Нью Йорк Способы и приборы для обнаружения и идентификации закодированных гранул и биологических молекул
AU2007268369A1 (en) * 2006-05-30 2007-12-06 Synergenz Bioscience Limited Methods and compositions for assessment of pulmonary function and disorders
WO2008020090A1 (es) * 2006-08-18 2008-02-21 Laboratorios Indas, S.A. Método y kit para diagnosticar el riesgo de desarrollar una enfermedad trombótica venosa
AU2007313551A1 (en) * 2006-10-17 2008-04-24 Synergenz Bioscience Limited Methods and compositions for assessment of pulmonary function and disorders
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
EP2129795A4 (de) * 2006-12-19 2010-10-20 Synergenz Bioscience Ltd Verfahren und zusammensetzungen zur beurteilung von herz-kreislauf-funktion und -erkrankungen
US8360321B2 (en) 2007-04-02 2013-01-29 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
JP2010530912A (ja) 2007-06-22 2010-09-16 フィオ コーポレイション 量子ドットをドープしたポリマーマイクロビーズの製造システム及び方法
WO2009006739A1 (en) * 2007-07-09 2009-01-15 Fio Corporation Systems and methods for enhancing fluorescent detection of target molecules in a test sample
WO2009012585A1 (en) * 2007-07-23 2009-01-29 Fio Corporation A method and system for collating, storing, analyzing and enabling access to collected and analyzed data associated with biological and environmental test subjects
WO2009033056A1 (en) 2007-09-06 2009-03-12 Bioscale, Inc. Reusable detection surfaces and methods of using same
CN101861203B (zh) * 2007-10-12 2014-01-22 Fio公司 用于形成浓缩体积的微珠的流动聚焦方法和系统以及形成的微珠
NZ600235A (en) 2008-01-25 2013-11-29 Theranostics Lab Methods and compositions for the assessment of drug response
US9792809B2 (en) 2008-06-25 2017-10-17 Fio Corporation Bio-threat alert system
BRPI0917839A2 (pt) 2008-08-29 2015-11-24 Fio Corp dispositivo de teste de diagnóstico portátil de uso único, e um sistema associado e método para teste de amostras de teste ambientais e biológicas
CN104374932A (zh) 2009-01-13 2015-02-25 Fio公司 与电子设备和快速诊断测试中的测试盒结合使用的手持诊断测试设备
GB0904934D0 (en) 2009-03-23 2009-05-06 Geneseqe As Method and apparatus for detecting molecules
HUE038539T2 (hu) 2010-08-27 2018-10-29 Sienna Biopharmaceuticals Inc Készítmények eljárások célzott hõmodulációhoz
US9572880B2 (en) 2010-08-27 2017-02-21 Sienna Biopharmaceuticals, Inc. Ultrasound delivery of nanoparticles
GB201016484D0 (en) 2010-09-30 2010-11-17 Geneseque As Method
JP2015508655A (ja) 2012-02-14 2015-03-23 コーネル ユニバーシティー 組み合わせたヌクレアーゼ反応、連結反応、およびポリメラーゼ反応を用いて核酸配列、発現、またはコピー変化を相対的に定量するための方法
JP6325552B2 (ja) 2012-10-11 2018-05-16 ナノコンポジックス,インコーポレイテッド 銀ナノプレート組成物および方法
US20180258473A1 (en) * 2015-11-10 2018-09-13 Administracion General De La Comunidad Autonoma De Euskadi Diagnostic methods and devices
US20180057881A1 (en) * 2016-08-24 2018-03-01 William Beaumont Hospital Methods of detecting snps related to mrsa and ssi
US11331019B2 (en) 2017-08-07 2022-05-17 The Research Foundation For The State University Of New York Nanoparticle sensor having a nanofibrous membrane scaffold
JP2021534804A (ja) 2018-09-03 2021-12-16 ビスビュー メディカル,インコーポレイテッド 抗生物質感受性検査のための装置および方法
WO2021138544A1 (en) * 2020-01-03 2021-07-08 Visby Medical, Inc. Devices and methods for antibiotic susceptibility testing
CN111733215A (zh) * 2020-06-24 2020-10-02 深圳市光与生物科技有限公司 一种基于上转换荧光探针的核酸快速检测方法
KR102880002B1 (ko) * 2022-04-21 2025-11-11 주식회사 이지다이아텍 단일 염기 다형성 분석을 위한 미세입자 프로브
CN118658530B (zh) * 2024-06-19 2024-12-17 中国科学院水生生物研究所 生成淡水经济鱼snp探针的方法、装置、电子设备及介质

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200313A (en) * 1983-08-05 1993-04-06 Miles Inc. Nucleic acid hybridization assay employing detectable anti-hybrid antibodies
US5288609A (en) * 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US5137827A (en) * 1986-03-25 1992-08-11 Midwest Research Technologies, Inc. Diagnostic element for electrical detection of a binding reaction
US5360895A (en) * 1987-04-22 1994-11-01 Associated Universities, Inc. Derivatized gold clusters and antibody-gold cluster conjugates
US5151510A (en) * 1990-04-20 1992-09-29 Applied Biosystems, Inc. Method of synethesizing sulfurized oligonucleotide analogs
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
WO1993010564A1 (en) * 1991-11-22 1993-05-27 The Regents Of The University Of California Semiconductor nanocrystals covalently bound to solid inorganic surfaces using self-assembled monolayers
US5472881A (en) * 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
US5384265A (en) * 1993-03-26 1995-01-24 Geo-Centers, Inc. Biomolecules bound to catalytic inorganic particles, immunoassays using the same
US5637508A (en) * 1993-03-26 1997-06-10 Geo-Centers, Inc. Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits containing the same
DE69531542T2 (de) * 1994-02-07 2004-06-24 Beckman Coulter, Inc., Fullerton Ligase/polymerase-vermittelte analyse genetischer elemente von einzelnukleotid-polymorphismen und ihre verwendung in der genetischen analyse
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
CA2255774C (en) * 1996-05-29 2008-03-18 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US6506564B1 (en) * 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) * 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US5830986A (en) * 1996-10-28 1998-11-03 Massachusetts Institute Of Technology Methods for the synthesis of functionalizable poly(ethylene oxide) star macromolecules
US5858671A (en) * 1996-11-01 1999-01-12 The University Of Iowa Research Foundation Iterative and regenerative DNA sequencing method
US5900481A (en) * 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US5939021A (en) * 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
EP1009802B1 (de) * 1997-02-12 2004-08-11 Eugene Y. Chan Verfahren zur analyse von polymeren
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6251303B1 (en) * 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6306610B1 (en) * 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
US6203989B1 (en) * 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
US6277489B1 (en) * 1998-12-04 2001-08-21 The Regents Of The University Of California Support for high performance affinity chromatography and other uses
US6410231B1 (en) * 1999-02-26 2002-06-25 Incyte Genomics, Inc. SNP detection
EP1246935B1 (de) * 1999-09-28 2013-08-14 Geneohm Sciences Canada Inc. Konservierte gene und dessen benutzung für die herstellung von sonden und primern für mikroorganismen nachweis
US20020090649A1 (en) * 1999-12-15 2002-07-11 Tony Chan High density column and row addressable electrode arrays
US7163790B2 (en) * 2001-11-28 2007-01-16 Bio-Rad Laboratories, Inc. Parallel polymorphism scoring by amplification and error correction
US20030211488A1 (en) * 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
DE60229890D1 (de) * 2002-09-30 2008-12-24 Hoffmann La Roche Oligonukleotide zur genotypisierung des thymidylat-synthase gens
US7354706B2 (en) * 2003-09-09 2008-04-08 The Regents Of The University Of Colorado, A Body Corporate Use of photopolymerization for amplification and detection of a molecular recognition event
EP1694869A2 (de) * 2003-11-10 2006-08-30 Investigen, Inc. Verfahren zur herstellung von nukleinsäure für einen nachweis

Also Published As

Publication number Publication date
EP1578952B1 (de) 2011-11-23
AU2003302253B2 (en) 2007-06-28
EP1578952A4 (de) 2008-05-07
CA2508359A1 (en) 2004-06-24
AU2003302253A1 (en) 2004-06-30
EP1578952A2 (de) 2005-09-28
US20050059030A1 (en) 2005-03-17
WO2004053105A9 (en) 2004-10-07
JP2006517786A (ja) 2006-08-03
WO2004053105A2 (en) 2004-06-24
WO2004053105A3 (en) 2006-04-06

Similar Documents

Publication Publication Date Title
EP1578952A4 (de) Direkter snp-nachweis mit nichtamplifizierter dna
ES2868328T3 (es) Cuantificación precisa y masivamente paralela de ácido nucleico
Kurdyukov et al. DNA methylation analysis: choosing the right method
WO2007002567A3 (en) Selective isolation and concentration of nucleic acids from complex samples
WO2000077260A8 (en) Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms
ATE461292T1 (de) Erstellung von expressionsprofilen unter verwendung von mikroarrays
WO2001075166A3 (en) Compositions and methods for detecting and quantifying gene expression
DE50015854D1 (de) Oligonukleotide zur schnellen Bestimmung von mikrobieller DNS/RNS
ATE368125T1 (de) Verfahren zur erkennung von einzel-nukleotid- polymorphismen
DE60322880D1 (de) Einfache katalytische dna-biosensoren für ionen auf grundlage von farbveränderungen
EP1580269A4 (de) Verfahren zum genmutationsnachweis
ATE431433T1 (de) Ligation und amplifikationsreaktionen zur bestimmung von zielmolekülen
ATE358733T1 (de) Schnell-verfahren zur detektion von mikroorganismen in lebensmittelproben
WO2007115242A3 (en) Binary probes for fluorescent analysis of nucleic acids
ATE431854T1 (de) Auf bio-barcodes beruhender nachweis von zielanalyten
TW200720441A (en) New labelling strategies for the sensitive detection of analytes
ATE420209T1 (de) Dna-sequenzanalyse
SE0301951D0 (sv) New method
WO2002044416A3 (en) Sulfonated diarylrhodamine dyes as fluorescent labels
DK1436420T3 (da) Teststripassaysystem og fremgangsmåde til detektering af specifikke nucleinsyresekvenser
DE602004031022D1 (de) Nukleinsäuresequenzidentifikation
ATE546550T1 (de) Verfahren zum nachweis von hpv sowie sonden, primer und kits
WO2008066730A3 (en) Pna-dna oligomers and methods of use thereof
PT1907588E (pt) Ensaios para determinação da resistência aos medicamentos da classe das equinocandinas
BR0014518A (pt) Método e ácidos nucléicos para a detecção de microorganismos pertinentes à fermentação