ATE420636T1 - Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen - Google Patents

Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen

Info

Publication number
ATE420636T1
ATE420636T1 AT00931031T AT00931031T ATE420636T1 AT E420636 T1 ATE420636 T1 AT E420636T1 AT 00931031 T AT00931031 T AT 00931031T AT 00931031 T AT00931031 T AT 00931031T AT E420636 T1 ATE420636 T1 AT E420636T1
Authority
AT
Austria
Prior art keywords
treatment
ischemia
cation channel
related diseases
channel inhibitors
Prior art date
Application number
AT00931031T
Other languages
English (en)
Inventor
Thomas Varming
Frank Waetjen
Original Assignee
Painceptor Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Painceptor Pharma Corp filed Critical Painceptor Pharma Corp
Application granted granted Critical
Publication of ATE420636T1 publication Critical patent/ATE420636T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00931031T 1999-05-19 2000-05-12 Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen ATE420636T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA199900695 1999-05-19

Publications (1)

Publication Number Publication Date
ATE420636T1 true ATE420636T1 (de) 2009-01-15

Family

ID=8096483

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00931031T ATE420636T1 (de) 1999-05-19 2000-05-12 Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen

Country Status (8)

Country Link
US (4) US6727260B2 (de)
EP (1) EP1183025B1 (de)
AT (1) ATE420636T1 (de)
AU (1) AU4910500A (de)
CA (1) CA2369746A1 (de)
DE (1) DE60041399D1 (de)
DK (1) DK1183025T3 (de)
WO (1) WO2000071102A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000071102A2 (en) * 1999-05-19 2000-11-30 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
EP1736468A3 (de) * 2000-01-24 2007-01-03 NeuroSearch A/S Isatinderivate mit neurotropischer Aktivität geeignet zur Behandlung von NGF-bedingten Krankheiten
JP2004520396A (ja) * 2001-02-15 2004-07-08 ニューロサーチ、アクティーゼルスカブ 過剰な又は不十分な細胞死によって特徴づけられる疾患の治療
DE10238723A1 (de) 2002-08-23 2004-03-11 Bayer Ag Phenyl-substituierte Pyrazolyprimidine
RU2271738C1 (ru) * 2004-08-26 2006-03-20 Государственное учреждение Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского (МОНИКИ им. М.Ф. Владимирского) Способ диагностики ишемического поражения ствола головного мозга при вестибулярной шванноме
KR20080070749A (ko) * 2005-11-23 2008-07-30 페인셉터 파마 코포레이션 개폐 이온 통로를 조절하기 위한 조성물 및 방법
CA2652307A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
US7598039B2 (en) * 2007-01-30 2009-10-06 Academia Sinica Treatment of insulin resistance
WO2008144931A1 (en) * 2007-05-30 2008-12-04 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
WO2009042797A1 (en) * 2007-09-27 2009-04-02 Honeywell International Inc. Method and system for repairing potholes in roads
US9051311B2 (en) * 2012-03-09 2015-06-09 Amgen Inc. Sulfamide sodium channel inhibitors

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3333994A1 (de) 1983-09-21 1985-04-04 Troponwerke GmbH & Co KG, 5000 Köln Neue pyridoindolderivate, verfahren zu ihrer herstellung und ihre verwendung
IE69677B1 (en) * 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use
ATE178893T1 (de) 1990-01-11 1999-04-15 Upjohn Co 6,7,8,9-tetrahydro-3h-benz(e)indolheterocyclen mit wirkung auf das zentrale nervensystem
AU655643B2 (en) * 1991-07-09 1995-01-05 Neurosearch A/S Novel isatineoxime derivatives, their preparation and use
CA2076948C (en) * 1991-08-28 2002-04-16 Frank Watjen Isatineoxime derivatives, their preparation and use
US5242918A (en) 1991-08-28 1993-09-07 Neurosearch A/S Isatinoxime derivatives, their preparation and use
US5436250A (en) * 1991-08-28 1995-07-25 Neurosearch A/S Isatineoxime derivatives, their preparation and use
US5843945A (en) 1993-05-13 1998-12-01 Neurosearch A/S AMPA antagonists and a method of treatment
NZ267081A (en) * 1993-05-13 1997-11-24 Neurosearch As Hetero-fused indole and quinoxaline compounds and medicaments thereof
DK81593D0 (da) * 1993-07-07 1993-07-07 Neurosearch As Nye isatinoximderivater, deres fremstilling og anvendelse
JP3164372B2 (ja) 1994-09-14 2001-05-08 ノイロサーチ アクティーゼルスカブ 融合インドール及びキノキサリン誘導体、その製造および使用
AU687255B2 (en) * 1994-09-14 1998-02-19 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives, their preparation and use
UA54403C2 (uk) 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
FR2759373B1 (fr) * 1997-02-11 2001-05-04 Centre Nat Rech Scient Nouveau canal cationique neuronal de mammifere sensible a l'acidite, son clonage et ses applications
GB9718365D0 (en) * 1997-08-29 1997-11-05 Univ London Ion channel proteins
EP1025226B1 (de) 1997-10-29 2006-12-06 McGill University Dna kodierend für einen humanen protonenabhängigen ionenkanal und deren verwendungen
AU751414B2 (en) 1998-03-31 2002-08-15 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives for therapeutic use
US6287859B1 (en) 1998-08-05 2001-09-11 Centre National De La Recherche Identification, functional expression and chromosal localization of a sustained human proton-gated cation channel
WO2000043514A2 (en) 1999-01-22 2000-07-27 Millennium Pharmaceuticals, Inc. Human acid sensing ion channel and uses thereof
US6789252B1 (en) * 1999-04-15 2004-09-07 Miles D. Burke Building business objects and business software applications using dynamic object definitions of ingrediential objects
WO2000071102A2 (en) 1999-05-19 2000-11-30 Neurosearch A/S Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
US6941323B1 (en) * 1999-08-09 2005-09-06 Almen Laboratories, Inc. System and method for image comparison and retrieval by enhancing, defining, and parameterizing objects in images
US6591377B1 (en) * 1999-11-24 2003-07-08 Unisys Corporation Method for comparing system states at different points in time
TWI271406B (en) 1999-12-13 2007-01-21 Eisai Co Ltd Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
EP1736468A3 (de) 2000-01-24 2007-01-03 NeuroSearch A/S Isatinderivate mit neurotropischer Aktivität geeignet zur Behandlung von NGF-bedingten Krankheiten
MXPA03000275A (es) 2000-07-11 2004-12-13 Albany Molecular Res Inc Nuevas tetrahidroisoquinolinas substituidas con 4-fenilo y su uso terapeutico.
ES2230337T3 (es) 2000-09-01 2005-05-01 Glaxo Group Limited Derivados de oxindol.
US20040063742A1 (en) 2001-02-15 2004-04-01 Dan Peters Treatment of parkinson's disease by the combined action of a compound with neurotrophic activity and a compound enhancing the dopamine activity
ATE424194T1 (de) 2001-04-09 2009-03-15 Neurosearch As Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson
DK1532146T3 (da) 2002-08-22 2006-07-03 Neurosearch As Fremgangsmåde til fremstilling af enantiomerer af indol-2,3-dion-3-oximderivater
AU2003301439A1 (en) 2002-10-16 2004-05-04 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
US7232842B2 (en) 2003-01-10 2007-06-19 Board Of Trustees Of The Leland Stanford Junior University Kinase inhibitors and associated pharmaceutical compositions and methods of use
KR20080070749A (ko) * 2005-11-23 2008-07-30 페인셉터 파마 코포레이션 개폐 이온 통로를 조절하기 위한 조성물 및 방법

Also Published As

Publication number Publication date
US6727260B2 (en) 2004-04-27
DE60041399D1 (de) 2009-03-05
US7288653B2 (en) 2007-10-30
US20060079529A1 (en) 2006-04-13
US20020058663A1 (en) 2002-05-16
EP1183025B1 (de) 2009-01-14
WO2000071102A2 (en) 2000-11-30
US20040142936A1 (en) 2004-07-22
DK1183025T3 (da) 2009-05-04
EP1183025A2 (de) 2002-03-06
CA2369746A1 (en) 2000-11-30
US20080269230A1 (en) 2008-10-30
AU4910500A (en) 2000-12-12
WO2000071102A3 (en) 2001-03-15

Similar Documents

Publication Publication Date Title
PT1543011E (pt) Composto de tienopirrolilo e furanopirrolilo e sua utilizacao como ligandos do receptor h4 da histamina
BRPI0414544A (pt) 2,4-di-(fenilamino) pirimidinas úteis no tratamento de transtornos proliferativos
DE60315146D1 (de) Heteroarylsubstituierte biphenylderivate als inhibitoren von p38-kinase
ATE316785T1 (de) Jak-3 hemmer zur behandlung von allergischen störungen
DE50010931D1 (de) Substituierte benzimidazole
MY133667A (en) Quinazoline ditosylate salt compounds
PT1153024E (pt) 2-amino-6-anilino-purinas e sua utilizacao como medicamentos
BR0314059A (pt) Compostos heterocìclicos
DE602004015269D1 (de) Piperazin derivate und ihre verwendung für die behandlung von neurologischen und psychiatrischen krankheiten.
DE60027768D1 (de) Behandlung von metastatischer krankheit
ATE438404T1 (de) Verwendung von k-252a und kinasehemmern zur vorbeugung und behandlung von hmgb1-assoziierten pathologien
ATE415962T1 (de) Verwendung von asiatsäure oder asiaticosid zur behandlung von krebs
DE60112766D1 (de) Verwendung von derivaten der valproinsäureamide und 2-valproinsäureamid zur behandlung und prävention von schmerzen und/oder kopfschmerzen
ATE288747T1 (de) Methoden und zusammensetzungen zur modulierung der aktivität von alpha-adrenergen rezeptoren
ATE433966T1 (de) Methylendipiperidinderivate
ATE271865T1 (de) Verwendung von cholinesterasehemmern zur behandlung von aufmerksamkeitsmangel-störungen
DE60041399D1 (de) Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen
ATE413392T1 (de) Kondensierte heteroyralderivate und deren verwendung als p38-kinase-inhibitoren
UY26426A1 (es) Nuevos compuestos
ATE402694T1 (de) Verwendung von 1-phenyl-3-dimethylamino-propan- verbindungen zur therapie der harninkontinenz
ATE206052T1 (de) Verwendung von sphingosin-1-phosphat, sphingosin- 1-phosphat-derivaten und/oder deren gemische zur behandlung von entzündlichen hautkrankheiten
DE60010934D1 (de) Medikamente geeignet zur Behandlung von proliferativen Erkrankungen
DK1368023T3 (da) Anvendelse af buprenoprphin til behandling af urininkontinens
ATE373658T1 (de) Pyrazoloisoquinolinenderivaten zur inhibierung von nfkappab-induzierende kinase
ATE360438T1 (de) Verwendung von inaktives cln2 proenzym zur behandlung von lincl

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties