ATE420636T1 - Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen - Google Patents

Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen

Info

Publication number
ATE420636T1
ATE420636T1 AT00931031T AT00931031T ATE420636T1 AT E420636 T1 ATE420636 T1 AT E420636T1 AT 00931031 T AT00931031 T AT 00931031T AT 00931031 T AT00931031 T AT 00931031T AT E420636 T1 ATE420636 T1 AT E420636T1
Authority
AT
Austria
Prior art keywords
treatment
ischemia
cation channel
related diseases
channel inhibitors
Prior art date
Application number
AT00931031T
Other languages
English (en)
Inventor
Thomas Varming
Frank Waetjen
Original Assignee
Painceptor Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Painceptor Pharma Corp filed Critical Painceptor Pharma Corp
Application granted granted Critical
Publication of ATE420636T1 publication Critical patent/ATE420636T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00931031T 1999-05-19 2000-05-12 Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen ATE420636T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA199900695 1999-05-19

Publications (1)

Publication Number Publication Date
ATE420636T1 true ATE420636T1 (de) 2009-01-15

Family

ID=8096483

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00931031T ATE420636T1 (de) 1999-05-19 2000-05-12 Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen

Country Status (8)

Country Link
US (4) US6727260B2 (de)
EP (1) EP1183025B1 (de)
AT (1) ATE420636T1 (de)
AU (1) AU4910500A (de)
CA (1) CA2369746A1 (de)
DE (1) DE60041399D1 (de)
DK (1) DK1183025T3 (de)
WO (1) WO2000071102A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE420636T1 (de) * 1999-05-19 2009-01-15 Painceptor Pharma Corp Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen
JP2003520851A (ja) 2000-01-24 2003-07-08 ニューロサーチ、アクティーゼルスカブ 神経栄養活性を有するイサチン誘導体
US20040077634A1 (en) * 2001-02-15 2004-04-22 Ulrik Lademann Treatment of diseases characterized by excessive or insufficient cell death
DE10238723A1 (de) 2002-08-23 2004-03-11 Bayer Ag Phenyl-substituierte Pyrazolyprimidine
RU2271738C1 (ru) * 2004-08-26 2006-03-20 Государственное учреждение Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского (МОНИКИ им. М.Ф. Владимирского) Способ диагностики ишемического поражения ствола головного мозга при вестибулярной шванноме
CN101346375B (zh) * 2005-11-23 2013-04-10 阿罗斯药物有限责任公司 调节门离子通道用组合物和方法
CA2652307A1 (en) * 2006-04-10 2007-10-18 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
US7598039B2 (en) * 2007-01-30 2009-10-06 Academia Sinica Treatment of insulin resistance
US20090246134A1 (en) * 2007-05-30 2009-10-01 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
WO2009042797A1 (en) * 2007-09-27 2009-04-02 Honeywell International Inc. Method and system for repairing potholes in roads
US9051311B2 (en) * 2012-03-09 2015-06-09 Amgen Inc. Sulfamide sodium channel inhibitors

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Publication number Priority date Publication date Assignee Title
DE3333994A1 (de) 1983-09-21 1985-04-04 Troponwerke GmbH & Co KG, 5000 Köln Neue pyridoindolderivate, verfahren zu ihrer herstellung und ihre verwendung
IE69677B1 (en) * 1989-12-11 1996-10-02 Neurosearch As Isatine derivatives their preparation and use
AU639301B2 (en) 1990-01-11 1993-07-22 Pharmacia & Upjohn Company New centrally acting 6,7,8,9-tetrahydro-3h-benz(e)indole heterocyclics
AU655643B2 (en) * 1991-07-09 1995-01-05 Neurosearch A/S Novel isatineoxime derivatives, their preparation and use
US5436250A (en) * 1991-08-28 1995-07-25 Neurosearch A/S Isatineoxime derivatives, their preparation and use
MX9204914A (es) * 1991-08-28 1993-07-01 Frank Watjen Nuevos derivados de isatinoxima, metodo para su preparacion y composicion farmaceutica que los comprende.
US5242918A (en) 1991-08-28 1993-09-07 Neurosearch A/S Isatinoxime derivatives, their preparation and use
CA2161783C (en) * 1993-05-13 2006-08-15 Frank Watjen Ampa antagonists and a method of treatment therewith
US5843945A (en) 1993-05-13 1998-12-01 Neurosearch A/S AMPA antagonists and a method of treatment
DK81593D0 (da) * 1993-07-07 1993-07-07 Neurosearch As Nye isatinoximderivater, deres fremstilling og anvendelse
NZ293266A (en) * 1994-09-14 1998-01-26 Neurosearch As Fused indole and quinoxaline dione and dione oxime derivatives, preparation and pharmaceutical compositions
US5917053A (en) 1994-09-14 1999-06-29 Neurosearch A/S Indole-2,3-dione-3-oxime derivatives, their preparation and use
UA54403C2 (uk) 1996-10-01 2003-03-17 Н'Юросерч А/С Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
FR2759373B1 (fr) * 1997-02-11 2001-05-04 Centre Nat Rech Scient Nouveau canal cationique neuronal de mammifere sensible a l'acidite, son clonage et ses applications
GB9718365D0 (en) * 1997-08-29 1997-11-05 Univ London Ion channel proteins
ES2279583T3 (es) 1997-10-29 2007-08-16 Mcgill University Adn que codifica para un canal ionico regulado por protones humano y usos del mismo.
JP2002509885A (ja) 1998-03-31 2002-04-02 ニューロサーチ、アクティーゼルスカブ 治療に使用するためのインドール−２，３−ジオン−３−オキシム誘導体
US6287859B1 (en) 1998-08-05 2001-09-11 Centre National De La Recherche Identification, functional expression and chromosal localization of a sustained human proton-gated cation channel
WO2000043514A2 (en) 1999-01-22 2000-07-27 Millennium Pharmaceuticals, Inc. Human acid sensing ion channel and uses thereof
US6789252B1 (en) * 1999-04-15 2004-09-07 Miles D. Burke Building business objects and business software applications using dynamic object definitions of ingrediential objects
ATE420636T1 (de) 1999-05-19 2009-01-15 Painceptor Pharma Corp Hemmer der protonenabhängigen kationenkanäle und deren verwendung in der behandlung von ischemiebedingten erkrankungen
US6941323B1 (en) * 1999-08-09 2005-09-06 Almen Laboratories, Inc. System and method for image comparison and retrieval by enhancing, defining, and parameterizing objects in images
US6591377B1 (en) * 1999-11-24 2003-07-08 Unisys Corporation Method for comparing system states at different points in time
TWI271406B (en) 1999-12-13 2007-01-21 Eisai Co Ltd Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
JP2003520851A (ja) 2000-01-24 2003-07-08 ニューロサーチ、アクティーゼルスカブ 神経栄養活性を有するイサチン誘導体
CA2415532C (en) 2000-07-11 2010-05-11 Albany Molecular Research, Inc. Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
ES2230337T3 (es) 2000-09-01 2005-05-01 Glaxo Group Limited Derivados de oxindol.
JP2004523543A (ja) 2001-02-15 2004-08-05 ニューロサーチ、アクティーゼルスカブ 神経栄養活性を有する化合物とドパミン活性を増加させる化合物の組み合わせ作用によるパーキンソン病の治療法
ATE424194T1 (de) 2001-04-09 2009-03-15 Neurosearch As Adenosin-a2a-rezeptor-antagonisten in kombination mit verbindungen mit neurotrophischer aktivität bei der behandlung von morbus parkinson
US7632948B2 (en) 2002-08-22 2009-12-15 Neurosearch A/S Method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives
AU2003301439A1 (en) 2002-10-16 2004-05-04 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
US7232842B2 (en) 2003-01-10 2007-06-19 Board Of Trustees Of The Leland Stanford Junior University Kinase inhibitors and associated pharmaceutical compositions and methods of use
CN101346375B (zh) * 2005-11-23 2013-04-10 阿罗斯药物有限责任公司 调节门离子通道用组合物和方法

Also Published As

Publication number Publication date
AU4910500A (en) 2000-12-12
US20040142936A1 (en) 2004-07-22
WO2000071102A3 (en) 2001-03-15
US6727260B2 (en) 2004-04-27
DE60041399D1 (de) 2009-03-05
DK1183025T3 (da) 2009-05-04
US7288653B2 (en) 2007-10-30
US20020058663A1 (en) 2002-05-16
CA2369746A1 (en) 2000-11-30
EP1183025B1 (de) 2009-01-14
US20060079529A1 (en) 2006-04-13
WO2000071102A2 (en) 2000-11-30
US20080269230A1 (en) 2008-10-30
EP1183025A2 (de) 2002-03-06

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