ATE433966T1 - Methylendipiperidinderivate - Google Patents

Methylendipiperidinderivate

Info

Publication number
ATE433966T1
ATE433966T1 AT05789636T AT05789636T ATE433966T1 AT E433966 T1 ATE433966 T1 AT E433966T1 AT 05789636 T AT05789636 T AT 05789636T AT 05789636 T AT05789636 T AT 05789636T AT E433966 T1 ATE433966 T1 AT E433966T1
Authority
AT
Austria
Prior art keywords
derivatives
dipperidine
methylene
neurological
processes
Prior art date
Application number
AT05789636T
Other languages
English (en)
Inventor
Gordon Bruton
Vicky Johnstone
Barry Sidney Orlek
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE433966T1 publication Critical patent/ATE433966T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Indole Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT05789636T 2004-09-17 2005-09-16 Methylendipiperidinderivate ATE433966T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0420831A GB0420831D0 (en) 2004-09-17 2004-09-17 Novel compounds
PCT/EP2005/010169 WO2006029906A1 (en) 2004-09-17 2005-09-16 Methylene dipiperidine derivatives

Publications (1)

Publication Number Publication Date
ATE433966T1 true ATE433966T1 (de) 2009-07-15

Family

ID=33306857

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05789636T ATE433966T1 (de) 2004-09-17 2005-09-16 Methylendipiperidinderivate

Country Status (8)

Country Link
US (1) US7638631B2 (de)
EP (1) EP1789410B1 (de)
JP (1) JP2008513405A (de)
AT (1) ATE433966T1 (de)
DE (1) DE602005015002D1 (de)
ES (1) ES2326182T3 (de)
GB (1) GB0420831D0 (de)
WO (1) WO2006029906A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
CN103382174A (zh) 2006-06-23 2013-11-06 雅培制药有限公司 作为组胺h3受体调节物的环丙胺衍生物
CA2687931C (en) * 2007-05-31 2016-05-24 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists and uses thereof
HUE025547T2 (en) 2008-12-19 2016-02-29 Boehringer Ingelheim Int Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD
US9186353B2 (en) * 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
US20120028931A1 (en) * 2009-09-14 2012-02-02 Recordati Ireland Limited Heterocyclic m-glu5 antagonists
ES2674275T3 (es) 2009-12-17 2018-06-28 Centrexion Therapeutics Corporation Antagonistas del receptor CCR2 y usos de los mismos
AU2011212951A1 (en) * 2010-02-04 2012-08-23 Flsmidth A/S Method for treating tailings
EP2569298B1 (de) 2010-05-12 2015-11-25 Boehringer Ingelheim International GmbH Neuartige ccr2-rezeptorantagnonisten, herstellungsverfahren dafür und verwendung davon als medikamente
WO2011141477A1 (en) 2010-05-12 2011-11-17 Boehringer Ingelheim International Gmbh New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
WO2011144501A1 (en) 2010-05-17 2011-11-24 Boehringer Ingelheim International Gmbh Ccr2 antagonists and uses thereof
EP2576542B1 (de) 2010-05-25 2015-04-22 Boehringer Ingelheim International GmbH Zur Behandlung von Atemwegs-, Schmerz,- Immun- und cardoivaskulären Erkrankungen geeignete cyclische Amidderivate von Pyridazin-3-carbonsäuren
EP2576538B1 (de) 2010-06-01 2015-10-28 Boehringer Ingelheim International GmbH Neue CCR2-Antagonisten
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives
EP2731941B1 (de) 2011-07-15 2019-05-08 Boehringer Ingelheim International GmbH Neuartige und selektive ccr2-antagonisten
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
EP2647377A1 (de) 2012-04-06 2013-10-09 Sanofi Verwendung eines H3-Rezeptorantagonisten zur Behandlung von Morbus Alzheimer
MX383744B (es) 2015-07-02 2025-03-14 Centrexion Therapeutics Corp Citrato de (4-((3r,4r)-3-metoxitetrahidro-piran-4-ilamino)piperidin-1-il) (5-metil-6-(((2r, 6s)-6-(p-tolil)tetrahidro-2h-piran-2-il) metilamino) pirimidin-4-il) metanona.
EP3383853B1 (de) 2015-12-01 2020-11-04 Merck Sharp & Dohme Corp. Homobispiperidinylderivate als leber x rezeptor (lxr) beta agonisten zur behandlung von z.b. alzheimer
WO2025256550A1 (zh) * 2024-06-12 2025-12-18 杭州中美华东制药有限公司 靶向降解剂配体及连接基的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0418071A (ja) 1990-05-11 1992-01-22 Sumitomo Pharmaceut Co Ltd ビスピペリジン誘導体
TR200002182T2 (tr) 1998-01-27 2000-12-21 Aventis Pharmaceuticals Products Inc. İkame edilmiş aksozaherosayklil faktör xa inhibitörleri
AP2005003199A0 (en) 1999-04-01 2005-03-31 Pfizer Prod Inc Aminopyrimidines as sorbitol dehydrogenase inhibitors
SK1182002A3 (en) 1999-07-28 2002-11-06 Aventis Pharm Prod Inc Substituted oxoazaheterocyclyl compounds
PE20020507A1 (es) * 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3
BR0115783A (pt) 2000-11-30 2003-09-16 Pfizer Prod Inc Combinação de agonistas de gaba e inibidores de sorbitol desidrogenase
AU2002253929A1 (en) 2001-02-08 2002-09-24 Schering Corporation Use of dual h3/m2 antagonists with a bipiperidinic structure in the treatment of cognition deficit disorders
US6660858B2 (en) 2001-03-28 2003-12-09 Lion Bioscience Ag 2-aminobenzoxazole derivatives and combinatorial libraries thereof
US6956040B2 (en) * 2001-07-16 2005-10-18 Ranbaxy Laboratories Limited Oxazolidinone piperazinyl derivatives as potential antimicrobials
EP2243776A1 (de) 2001-10-12 2010-10-27 High Point Pharmaceuticals, LLC Substituierte Piperidine und ihre Verwendung zur Behandlung von Histamine H3 Rezeptor bedingten Erkrankungen

Also Published As

Publication number Publication date
ES2326182T3 (es) 2009-10-02
GB0420831D0 (en) 2004-10-20
WO2006029906A1 (en) 2006-03-23
EP1789410B1 (de) 2009-06-17
US20080108624A1 (en) 2008-05-08
EP1789410A1 (de) 2007-05-30
DE602005015002D1 (de) 2009-07-30
JP2008513405A (ja) 2008-05-01
US7638631B2 (en) 2009-12-29

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Legal Events

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