ATE420654T1 - Behandlung von muskeldystrophien und verwandter erkrankungen - Google Patents

Behandlung von muskeldystrophien und verwandter erkrankungen

Info

Publication number
ATE420654T1
ATE420654T1 AT02757182T AT02757182T ATE420654T1 AT E420654 T1 ATE420654 T1 AT E420654T1 AT 02757182 T AT02757182 T AT 02757182T AT 02757182 T AT02757182 T AT 02757182T AT E420654 T1 ATE420654 T1 AT E420654T1
Authority
AT
Austria
Prior art keywords
abnormal
treatment
related diseases
activity
diseases
Prior art date
Application number
AT02757182T
Other languages
English (en)
Inventor
Justin Fallon
Michael Rafii
Beth Mckechnie
Mark Bowe
Mary Lynn Mercado
Hiroki Hagiwara
Alison Amenta
Original Assignee
Univ Brown Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Brown Res Found filed Critical Univ Brown Res Found
Application granted granted Critical
Publication of ATE420654T1 publication Critical patent/ATE420654T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT02757182T 2001-08-15 2002-08-15 Behandlung von muskeldystrophien und verwandter erkrankungen ATE420654T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31255101P 2001-08-15 2001-08-15

Publications (1)

Publication Number Publication Date
ATE420654T1 true ATE420654T1 (de) 2009-01-15

Family

ID=23211978

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02757182T ATE420654T1 (de) 2001-08-15 2002-08-15 Behandlung von muskeldystrophien und verwandter erkrankungen

Country Status (7)

Country Link
US (3) US7759314B2 (de)
EP (1) EP1423133B1 (de)
AT (1) ATE420654T1 (de)
AU (1) AU2002323217B2 (de)
CA (1) CA2455884C (de)
DE (1) DE60230877D1 (de)
WO (1) WO2003015615A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7612038B2 (en) 1999-11-18 2009-11-03 Brown University Biglycan and related therapeutics and methods of use
US6864236B1 (en) 1999-11-18 2005-03-08 Brown University Research Foundation Biglycan and related therapeutics and methods of use
ATE420654T1 (de) 2001-08-15 2009-01-15 Univ Brown Res Found Behandlung von muskeldystrophien und verwandter erkrankungen
DK2280720T3 (en) * 2008-03-27 2019-06-11 Purdue Research Foundation COLLAGEN BINDING SYNTHETIC PEPTIDOGLYCANES, MANUFACTURING AND PROCEDURE FOR USE
US20110224128A1 (en) * 2009-04-13 2011-09-15 Anne Whalen Methods and compositions for treatment of muscular dystrophy
KR100983182B1 (ko) * 2009-08-14 2010-09-20 (주)엔솔테크 신규 펩타이드 및 그 용도
CN102869775A (zh) 2009-09-30 2013-01-09 哈佛大学校长及研究员协会 通过调节自噬抑制基因产物调节自噬的方法
ES2691443T3 (es) * 2010-05-17 2018-11-27 Brown University Mutantes de biglicano y agentes terapéuticos relacionados y métodos de uso
CA2823194A1 (en) 2010-12-27 2012-07-05 Brown University Therapeutic and diagnostic methods involving biglycan and utrophin
HUE031596T2 (en) 2011-05-24 2017-07-28 Symic Ip Llc Synthetic peptidoglycans that bind hyaluronic acid, their production and use
EP2717902B1 (de) 2011-06-06 2018-01-24 Phasebio Pharmaceuticals, Inc. Verwendung modifizierter vasoaktiver darmpeptide bei der behandlung von bluthochdruck
BR112015022917A2 (pt) 2013-03-15 2017-07-18 Symic Biomedical Inc peptidoglicanos sintéticos componentes da matriz extracelular
US10772931B2 (en) 2014-04-25 2020-09-15 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
US11052132B2 (en) 2014-05-08 2021-07-06 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating cystic fibrosis
CA2976038A1 (en) 2015-02-09 2016-08-18 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating muscle disease and disorders
US11617783B2 (en) 2015-11-16 2023-04-04 Research Institute At Nationwide Children's Hospital Repairing a mutant human titin gene using CRISPR technology
WO2018067449A1 (en) * 2016-10-05 2018-04-12 Bio-Techne Corporation Methods and kits for assaying endoglycosidase activity
EP3648774A4 (de) 2017-07-07 2021-04-21 Symic IP, LLC Synthetische biokonjugate
US12391928B2 (en) 2018-06-29 2025-08-19 Research Institute At Nationwide Children's Hospital Recombinant adeno-associated virus products and methods for treating limb girdle muscular dystrophy 2A
JP2022500387A (ja) * 2018-09-10 2022-01-04 アカデミシュ・ジークンホイス・ライデン・ハー・オー・デー・エン・ライドス・ユニヴェルシタイル・メディシュ・セントルム Ｍｕｓｋ阻害
CN113766935A (zh) 2019-02-26 2021-12-07 全国儿童医院研究所 β-肌聚糖的腺相关病毒载体递送和肌营养不良症的治疗
US12458657B2 (en) 2019-04-18 2025-11-04 Brown University Neurogenesis
EP4045031A4 (de) * 2019-10-16 2023-11-29 Brown University Muskelregeneration und -wachstum
CN118290567A (zh) * 2023-08-28 2024-07-05 科兴生物制药股份有限公司 重组人源化iii型三螺旋胶原蛋白及其制备方法和应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654270A (en) * 1988-06-28 1997-08-05 La Jolla Cancer Research Foundation Use of fibromodulin to prevent or reduce dermal scarring
US5705609A (en) * 1988-06-28 1998-01-06 La Jolla Cancer Research Foundation Decorin fragments inhibiting cell regulatory factors
ATE240401T1 (de) 1989-03-21 2003-05-15 Vical Inc Expression von exogenen polynukleotidsequenzen in wirbeltieren
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5340934A (en) * 1989-11-03 1994-08-23 The United States Of Americas As Represented By The Secretary Of Health & Human Services CDNA sequences of human bone matrix proteins
DK0616536T3 (da) 1991-12-04 1999-10-11 Jolla Cancer Res Found Anvendelse af decorin eller biglycan til fremstilling af et lægemiddel til behandling af diabetesbetingede tilstande
US5955265A (en) 1992-02-06 1999-09-21 Massachusetts Institute Of Technology DNA sequence encoding the myotonic dystrophy gene and uses thereof
DE69433970T2 (de) 1993-08-10 2005-08-11 W.L. Gore & Associates, Inc., Newark Zelleinkapselungsvorrichtung
US5679647A (en) 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
AU7200694A (en) 1993-11-10 1995-05-29 Worcester Foundation For Experimental Biology Agrin receptor
AU6926194A (en) 1994-05-09 1995-11-29 Boehringer Mannheim Gmbh Use of chondroitin sulphate proteoglycans for protection of neurons
US5882868A (en) 1997-04-14 1999-03-16 The Nemours Foundation Method of diagnosing spinal muscular atrophy
WO2000054801A1 (en) * 1999-03-17 2000-09-21 Entremed, Inc. Compositions and methods of use of ldl-like receptor ligands for the treatment of cancer and angiogenic-based disease
US7612038B2 (en) 1999-11-18 2009-11-03 Brown University Biglycan and related therapeutics and methods of use
US6864236B1 (en) * 1999-11-18 2005-03-08 Brown University Research Foundation Biglycan and related therapeutics and methods of use
EP1230262B1 (de) * 1999-11-18 2017-11-01 Brown University Research Foundation Biglycan und verwandte therapeutika sowie methoden zu deren verwendung
ATE420654T1 (de) 2001-08-15 2009-01-15 Univ Brown Res Found Behandlung von muskeldystrophien und verwandter erkrankungen
WO2007123848A2 (en) 2006-04-19 2007-11-01 Brown University Therapeutic compositions containing modified class i slrp proteins
US8367619B2 (en) 2007-02-16 2013-02-05 Benaroya Research Institute At Virginia Mason Methods for promoting elastogenesis and elastin fiber formation by increasing tropoelastin expression
ES2691443T3 (es) 2010-05-17 2018-11-27 Brown University Mutantes de biglicano y agentes terapéuticos relacionados y métodos de uso

Also Published As

Publication number Publication date
EP1423133B1 (de) 2009-01-14
EP1423133A2 (de) 2004-06-02
WO2003015615A2 (en) 2003-02-27
CA2455884C (en) 2015-09-22
US20150182589A1 (en) 2015-07-02
EP1423133A4 (de) 2006-03-01
US20110053854A1 (en) 2011-03-03
DE60230877D1 (de) 2009-03-05
CA2455884A1 (en) 2003-02-27
AU2002323217B2 (en) 2008-04-10
WO2003015615A9 (en) 2003-08-07
US7759314B2 (en) 2010-07-20
WO2003015615A3 (en) 2003-11-13
US20050043221A1 (en) 2005-02-24
US8822418B2 (en) 2014-09-02

Similar Documents

Publication Publication Date Title
ATE420654T1 (de) Behandlung von muskeldystrophien und verwandter erkrankungen
ATE325343T1 (de) Diagnose und behandlung von arthritischen erkrankungen
ATE460402T1 (de) Für die behandlung von thrombotischen leiden geeignete harnstoffantagonisten des p2y1- rezeptors
DE60236206D1 (de) Spiroazacyclische verbindungen als monoaminrezeptormodulatoren
NO20010446L (no) Substituert anilidforbindelser og metoder
ES2178668T3 (es) Naftilamidas como agentes del sistema nervioso central.
TR200103104T2 (tr) Glukortikoid alıcı modülatörleri
ATE443699T1 (de) Pyridine zur behandlung von verletztemsäugetiernervengewebe
DE69738613D1 (de) Prävention und behandlung von skeletterkrankungen mit ep2 subtyp selektiven prostaglandin e2 agonisten
ATE260653T1 (de) Verwendung von naaladase inhibitoren zur behandlung von angstzuständen und gedächtnisstörungen
ATE381533T1 (de) Pharmazeutisch wirksame verbindungen und methoden zu ihrer anwendung
DE602004023762D1 (de) Für die behandlung von alzheimer-krankheit und ähnlichen leiden geeignete 1-alkyl-3-thiosubstituierte indol-2-alkinsäuren
ATE355054T1 (de) Verfahren und verbindungen zur behandlung der depression
Monemi et al. Adverse changes in fibre type and myosin heavy chain compositions of human jaw muscle vs. limb muscle during ageing
ATE352311T1 (de) Verwendung von brustkrebs membranproteine für behandlung, prophylaxe und diagnose von brustkrebs
ATE338142T1 (de) Methoden zur diagnose und behandlung von herzkrankheiten
ATE290857T1 (de) Bretyliumhaltige zusammensetzungen und kits und deren verwendung zur vorbeugung und behandlung cardiovaskulärer erkrankungen
WO2003070195A3 (en) Biglycan and related therapeutics and methods of use
ATE313561T1 (de) Vgf polypeptide und verfahren zur behandlung von vgf-erkrankungen
ATE494903T1 (de) Verwendung von slurp-1 zur behandlung von krankheiten, die durch störungen der acetylcholinerezeptoren ausgelöst werden
WO2004047727A3 (en) Compositions and methods for diagnosing and treating mood disorders
WO2001036475A3 (en) Biglycan and related therapeutics and methods of use
DE69905489D1 (de) Protein c zur behandlung von sichelzellanämie und thalassämie
DE602004022423D1 (de) Hemmung der s6-kinase-aktivität zur behandlung von insulinresistenz
ATE260111T1 (de) Mittel zur behandlung von autoimmunkrankheiten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties