ATE420670T1 - Arzneimittel freisetzende matrizen zur förderung der wundheilung - Google Patents

Arzneimittel freisetzende matrizen zur förderung der wundheilung

Info

Publication number: ATE420670T1
Authority: AT; Austria
Prior art keywords: matrix; wound healing; bioactive; promote wound; bioactive molecule
Prior art date: 2001-04-25

Application number

AT02737999T

Other languages

English (en)

Inventor

Hugo Schmoekel

Franz Weber

Jason Schense

Jeffrey Hubbell

Original Assignee

Eidgenoess Tech Hochschule

Univ Zuerich

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-25

Filing date

2002-04-25

Publication date

2009-01-15

2002-04-25 Application filed by Eidgenoess Tech Hochschule, Univ Zuerich filed Critical Eidgenoess Tech Hochschule

2009-01-15 Application granted granted Critical

2009-01-15 Publication of ATE420670T1 publication Critical patent/ATE420670T1/de

Links

239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
230000029663 wound healing Effects 0.000 title 1
239000011159 matrix material Substances 0.000 abstract 6
230000000975 bioactive effect Effects 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 2
LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 abstract 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 1
108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 1
229960003067 cystine Drugs 0.000 abstract 1
230000022811 deglycosylation Effects 0.000 abstract 1
238000001879 gelation Methods 0.000 abstract 1
239000003102 growth factor Substances 0.000 abstract 1
230000035876 healing Effects 0.000 abstract 1
229960002897 heparin Drugs 0.000 abstract 1
229920000669 heparin Polymers 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/046—Fibrin; Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/225—Fibrin; Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Oral & Maxillofacial Surgery (AREA)
Surgery (AREA)
Transplantation (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Materials Engineering (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT02737999T 2001-04-25 2002-04-25 Arzneimittel freisetzende matrizen zur förderung der wundheilung ATE420670T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US28630701P	2001-04-25	2001-04-25

Publications (1)

Publication Number	Publication Date
ATE420670T1 true ATE420670T1 (de)	2009-01-15

Family

ID=23098000

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02737999T ATE420670T1 (de)	2001-04-25	2002-04-25	Arzneimittel freisetzende matrizen zur förderung der wundheilung

Country Status (9)

Country	Link
US (3)	US20030012818A1 (de)
EP (1)	EP1406678B1 (de)
JP (1)	JP4566515B2 (de)
AT (1)	ATE420670T1 (de)
CA (2)	CA2445239C (de)
DE (1)	DE60230873D1 (de)
ES (1)	ES2321068T3 (de)
MX (1)	MXPA03009760A (de)
WO (1)	WO2002085422A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6992066B2 (en) *	1998-10-16	2006-01-31	Zimmer Orthobiologics, Inc.	Povidone-containing carriers for polypeptide growth factors
US7687462B2 (en)	1999-10-05	2010-03-30	The Regents Of The University Of California	Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
EP1564220A4 (de) *	2002-11-21	2010-03-17	Chugai Pharmaceutical Co Ltd	Retard-arzneistoffträger
AU2003300076C1 (en) *	2002-12-30	2010-03-04	Angiotech International Ag	Drug delivery from rapid gelling polymer composition
JP4745826B2 (ja) *	2003-11-14	2011-08-10	中外製薬株式会社	架橋多糖微粒子およびその製造方法
WO2005072764A2 (en) *	2004-01-16	2005-08-11	Novocell, Inc.	Fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells
US7351423B2 (en)	2004-09-01	2008-04-01	Depuy Spine, Inc.	Musculo-skeletal implant having a bioactive gradient
WO2008133918A1 (en) *	2007-04-24	2008-11-06	Rutgers, The State University Of New Jersey	Dressing compositions and methods
US8575101B2 (en)	2005-01-06	2013-11-05	Kuros Biosurgery Ag	Supplemented matrices for the repair of bone fractures
WO2006073711A2 (en)	2005-01-06	2006-07-13	Kuros Biosurgery Ag	Use of a matrix comprising a contrast agent in soft tissues
MX2007008319A (es) *	2005-01-06	2007-10-04	Kuros Biosurgery Ag	Matrices suplementadas para la reparacion de fracturas oseas.
CN100436477C (zh) *	2005-03-25	2008-11-26	复旦大学附属中山医院	含精-甘-天冬氨酸序列环肽及其主动靶向脂质体
US20070149916A1 (en) *	2005-12-22	2007-06-28	Alza Corporation	Dry matrices as drug reservoirs in electrotransport applications
EP2046361A4 (de)	2006-07-26	2011-06-29	Univ California	Osteogene verstärkerzusammensetzung
US20080183124A1 (en) *	2006-07-31	2008-07-31	Gerut Zachary E	Method and device for treating breast implant encapsulation
US20080027541A1 (en) *	2006-07-31	2008-01-31	Gerut Zachary E	Method and device for treating breast implant encapsulation
BRPI0718328A2 (pt)	2006-12-15	2011-10-11	Lifebond Ltd	composição, curativo hemostático e dispositivo médico para a inserção em um corpo de um ser humano ou de um mamìfero inferior
MX2009007688A (es) *	2007-01-18	2009-09-28	Baxter Int	Gel de fibrina para liberacion controlada de tgp-beta y usos del mismo.
DK2136850T3 (da)	2007-04-13	2012-04-10	Kuros Biosurgery Ag	Polymervævforsegling
US8377864B2 (en)	2007-06-19	2013-02-19	Baxter International Inc.	Fibrin gel for controlled release of PDGF and uses thereof
WO2009083544A2 (en) *	2007-12-28	2009-07-09	Kuros Biosurgery Ag	Pdgf fusion proteins incorporated into fibrin foams
JP5437236B2 (ja) *	2008-04-16	2014-03-12	一般財団法人化学及血清療法研究所	トロンビン固定化生体吸収性シート製剤の製造方法
KR100971271B1 (ko) *	2008-04-28	2010-07-20	한양대학교 산학협력단	헤파린이 결합된 피브린젤, 그 제조방법 및 키트
EP2487206A3 (de) *	2008-06-18	2012-11-28	Lifebond Ltd	Vernetzbare Gelatine-Zusammensetzungen
CA2763466C (en)	2009-05-26	2019-02-26	B. Chia Soo	Fibromodulin peptide
WO2011031476A2 (en) *	2009-08-25	2011-03-17	Emory University	Compositions and methods for treatment or prevention of post-operative organ or tissue inflammation
WO2011077388A1 (en)	2009-12-22	2011-06-30	Lifebond Ltd	Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
CN103080301B (zh)	2010-08-19	2016-10-19	加州大学董事会	包含血管周干细胞和nell-1蛋白的组合物
EP2686027B1 (de)	2011-03-16	2021-05-05	Kuros Biosurgery AG	Pharmazeutische formulierung zur verwendung für die wirbelsäulenfusion
US9879062B2 (en)	2012-07-03	2018-01-30	Ecole Polytechnique Federale De Lausanne	Protein-binding peptide isolated from placenta growth factor
US9540428B2 (en)	2012-07-03	2017-01-10	Ecole Polytechnique Federale De Lausanne (Epfl)	Extracellular matrix heparin-binding domains
US9550012B2 (en)	2013-08-05	2017-01-24	University Of Notre Dame Du Lac	Tissue scaffolds having bone growth factors
US11732029B2 (en)	2017-11-13	2023-08-22	The University Chicago	Methods and compositions for the treatment of wounds
US10675330B2 (en) *	2018-03-21	2020-06-09	Warsaw Orthopedic, Inc.	Injectable bone morphogenetic protein
US11998654B2 (en)	2018-07-12	2024-06-04	Bard Shannon Limited	Securing implants and medical devices
CN109248333B (zh) *	2018-11-08	2021-06-18	广州润虹医药科技股份有限公司	一种抗菌促进创面愈合的医用敷料及其制备方法和应用
EP4159227A1 (de) *	2021-10-03	2023-04-05	Herbert Jennissen	Pharmazeutische zusammensetzung zur förderung der osteoinduktion und angiogenese

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6150328A (en) *	1986-07-01	2000-11-21	Genetics Institute, Inc.	BMP products
WO1989009787A2 (en) *	1988-04-08	1989-10-19	Creative Biomolecules, Inc.	Osteogenic devices
WO1990009783A1 (en) *	1989-02-22	1990-09-07	Massachusetts Institute Of Technology	Delivery system for controlled release of bioactive factors
US5606031A (en) *	1990-04-06	1997-02-25	Lile; Jack	Production and purification of biologically active recombinant neurotrophic protein in bacteria
US6197325B1 (en) *	1990-11-27	2001-03-06	The American National Red Cross	Supplemented and unsupplemented tissue sealants, methods of their production and use
US6117425A (en) *	1990-11-27	2000-09-12	The American National Red Cross	Supplemented and unsupplemented tissue sealants, method of their production and use
US5206023A (en) *	1991-01-31	1993-04-27	Robert F. Shaw	Method and compositions for the treatment and repair of defects or lesions in cartilage
US5270300A (en) *	1991-09-06	1993-12-14	Robert Francis Shaw	Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
CN1091315A (zh) *	1992-10-08	1994-08-31	E·R·斯奎布父子公司	血纤维蛋白封闭剂组合物及其使用方法
JPH0788174A (ja) *	1993-09-28	1995-04-04	Yamanouchi Pharmaceut Co Ltd	骨形成用移植体
JPH07101874A (ja) *	1993-10-04	1995-04-18	Suntory Ltd	骨修復治療剤
US6221854B1 (en) *	1996-03-05	2001-04-24	Orquest, Inc.	Method of promoting bone growth with hyaluronic acid and growth factors
AU6245898A (en)	1997-01-21	1998-08-07	Genetics Institute Inc.	Injectable formulations for treatment of osteoporotic bone
DE19882746T1 (de)	1997-04-03	2001-10-18	California Inst Of Techn	Enzymvermittelte Modifikation von Fibrin für das Gewebs-Engineering
CA2253647A1 (en) *	1998-07-20	2000-01-20	Jeffrey L. Wrana	Smad binding proteins
DK1181323T3 (da) *	1999-02-01	2011-10-17	Eidgenoess Tech Hochschule	Biomaterialer dannet med nukleofil additionsreaktion med konjugerede uimættede grupper
US6958212B1 (en) *	1999-02-01	2005-10-25	Eidgenossische Technische Hochschule Zurich	Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
ES2255257T3 (es)	1999-04-22	2006-06-16	Eidgenossische Technische Hochschule (Eth)	Liberacion controlada de factores de crecimiento a partir de matrices que contienen heparina.
MXPA01010692A (es) *	1999-04-22	2004-09-06	Univ Zuerich	Matrices de proteina modificadas para ingenieria de tejidos o liberacion controlada.
US7358056B1 (en) *	1999-08-30	2008-04-15	Signal Pharmaceuticals	Methods for modulating signal transduction mediated by TGF-β and related proteins

2002
- 2002-04-25 WO PCT/EP2002/004592 patent/WO2002085422A1/en not_active Ceased
- 2002-04-25 EP EP02737999A patent/EP1406678B1/de not_active Expired - Lifetime
- 2002-04-25 MX MXPA03009760A patent/MXPA03009760A/es active IP Right Grant
- 2002-04-25 DE DE60230873T patent/DE60230873D1/de not_active Expired - Lifetime
- 2002-04-25 JP JP2002582995A patent/JP4566515B2/ja not_active Expired - Lifetime
- 2002-04-25 AT AT02737999T patent/ATE420670T1/de not_active IP Right Cessation
- 2002-04-25 CA CA2445239A patent/CA2445239C/en not_active Expired - Lifetime
- 2002-04-25 US US10/132,619 patent/US20030012818A1/en not_active Abandoned
- 2002-04-25 CA CA002681952A patent/CA2681952A1/en not_active Abandoned
- 2002-04-25 ES ES02737999T patent/ES2321068T3/es not_active Expired - Lifetime
2007
- 2007-04-24 US US11/739,607 patent/US20070202178A1/en not_active Abandoned
2010
- 2010-07-28 US US12/845,354 patent/US8309518B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2002085422A1 (en)	2002-10-31
US20100291215A1 (en)	2010-11-18
JP2004531534A (ja)	2004-10-14
CA2445239C (en)	2012-08-21
CA2681952A1 (en)	2002-10-31
US20030012818A1 (en)	2003-01-16
CA2445239A1 (en)	2002-10-31
ES2321068T3 (es)	2009-06-02
EP1406678B1 (de)	2009-01-14
DE60230873D1 (de)	2009-03-05
US8309518B2 (en)	2012-11-13
EP1406678A1 (de)	2004-04-14
JP4566515B2 (ja)	2010-10-20
US20070202178A1 (en)	2007-08-30
MXPA03009760A (es)	2005-10-05

Legal Events

Date	Code	Title	Description
2009-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE420670T1 (de)	2009-01-15	Arzneimittel freisetzende matrizen zur förderung der wundheilung
Zhao et al.	2023	Self-healing and shape-adaptive nanocomposite hydrogels with anti-inflammatory, antioxidant, antibacterial activities and hemostasis for real-time visual regeneration of diabetic wounds
Dai et al.	2009	Chitosan‐alginate sponge: preparation and application in curcumin delivery for dermal wound healing in rat
ATE316786T1 (de)	2006-02-15	Behandlung von mukositis
DE60023520D1 (de)	2005-12-01	Flüssiges hochvisköses system mit gesteuerter freisetzung und medizinische oder chirurgische vorrichtung
Albu et al.	2009	Spectral characteristics and antioxidant properties of tannic acid immobilized on collagen drug-delivery systems
Nam et al.	2019	Synergistic effects of laminin-1 peptides, VEGF and FGF9 on salivary gland regeneration
IS4083A (is)	1994-04-15	Samsetning lyfjaefna, aðferð til framleiðslu hennar, og notkunar sem lyfja
DE60316291D1 (de)	2007-10-25	Esterderivate von hyaluronsäure zur herstellung von hydrogelmaterialien durch photohärtung
DE60103453D1 (de)	2004-07-01	Verwendung von albuminstabilisiertem Paclitaxel zur Herstellung eines Arzneimittels zum Behandeln von festen Tumoren und das so erhaltene Arzneimittel
CA2224253A1 (en)	1996-12-27	Chitin hydrogels, methods of their production and use
ATE552864T1 (de)	2012-04-15	Therapeutisch aktive wundauflagen, deren herstellung und deren verwendung
ATE256186T1 (de)	2003-12-15	Verwendungen von angiogenischer factor vegf145 in der behandlung von kardiovaskulaeren krankheiten
BRPI0507680A (pt)	2007-07-17	partìculas de fosfato de cálcio terapêuticas e métodos de fabricação e uso das mesmas
ATE140388T1 (de)	1996-08-15	Zusammensetzungen enthaltend omega conotoxin peptide derivate und deren verwendung zur behandlung von ischämie-artigen neuronalen schädigungen
WO2005012492A3 (en)	2007-07-19	Human skin equivalents expressing exogenous polypeptides
Yin et al.	2023	Regulatable and reversible native paramyosin hydrogels promote the wound healing of the skin in mice
ATE439833T1 (de)	2009-09-15	Pharmazeutische zubereitung enthaltend ein catechin, ascorbinsäure, prolin und lysin zur behandlung von neoplastischen krankheiten
Zhou et al.	2025	Bioinspired adhesive hydrogel platform with photothermal antimicrobial, antioxidant, and angiogenic properties for whole-process management of diabetic wounds
Ioan et al.	2019	Piroxicam‐Collagen‐Based Sponges for Medical Applications
ATE400277T1 (de)	2008-07-15	Pharmazeutische zusammenstellung zur vorbeugung und behandlung von mit zellkrankheiten des augenhintergrundes zusammenhängenden krankheiten
DE60218636D1 (de)	2007-04-19	Antikörper zur vorbeugung und behandlung von e. coli aeec krankheiten
RU96124444A (ru)	1998-09-10	Биологическая композиция для лечения ран "коллахит"
Ramineni et al.	2015	Effects of epidermal growth factor-loaded mucoadhesive films on wounded oral tissue rafts
Pita‐Vilar et al.	2026	Growth Hormone‐Loaded 3D Printed Silk Fibroin‐Cellulose Dressings for Ischemic Wounds