ATE420889T1 - Betulinsäurederivate zur inhibierung des krebswachstums und ein verfahren zu ihrer herstellung - Google Patents

Betulinsäurederivate zur inhibierung des krebswachstums und ein verfahren zu ihrer herstellung

Info

Publication number
ATE420889T1
ATE420889T1 AT99964769T AT99964769T ATE420889T1 AT E420889 T1 ATE420889 T1 AT E420889T1 AT 99964769 T AT99964769 T AT 99964769T AT 99964769 T AT99964769 T AT 99964769T AT E420889 T1 ATE420889 T1 AT E420889T1
Authority
AT
Austria
Prior art keywords
derivatives
betulinic acid
acid derivatives
production
cancer growth
Prior art date
Application number
AT99964769T
Other languages
English (en)
Inventor
Sunder Ramadoss
Mannu Jaggi
Mohammad Siddiqui
Achla Khanna
Original Assignee
Dabur Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dabur Pharma Ltd filed Critical Dabur Pharma Ltd
Application granted granted Critical
Publication of ATE420889T1 publication Critical patent/ATE420889T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Plant Substances (AREA)
AT99964769T 1998-11-18 1999-11-17 Betulinsäurederivate zur inhibierung des krebswachstums und ein verfahren zu ihrer herstellung ATE420889T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN3458DE1998 1998-11-18

Publications (1)

Publication Number Publication Date
ATE420889T1 true ATE420889T1 (de) 2009-01-15

Family

ID=11092803

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99964769T ATE420889T1 (de) 1998-11-18 1999-11-17 Betulinsäurederivate zur inhibierung des krebswachstums und ein verfahren zu ihrer herstellung

Country Status (11)

Country Link
EP (1) EP1131337B1 (de)
JP (1) JP2002536382A (de)
KR (1) KR20010080507A (de)
CN (1) CN1326462A (de)
AT (1) ATE420889T1 (de)
AU (1) AU766599B2 (de)
BR (1) BR9915448A (de)
CA (1) CA2350786C (de)
DE (1) DE69940320D1 (de)
WO (1) WO2000046235A1 (de)
ZA (1) ZA200103616B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869535A (en) 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
EP1309605A1 (de) 2000-08-18 2003-05-14 The Board Of Trustees Of The University Of Illinois Prodrogen von beulinsauer derivate zur behandlung von krebs und hiv
EP1322661A1 (de) 2000-09-29 2003-07-02 Regents Of The University Of Minnesota Triterpene mit fungicider wirkung gegen hefe
US6951847B2 (en) 2000-09-29 2005-10-04 Regents Of The University Of Minnesota Methods of treating fungal infections using lupeol
US6979470B2 (en) * 2001-07-17 2005-12-27 Metaproteomics, Llc Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2
JP4722031B2 (ja) 2003-02-11 2011-07-13 ノベリックス・ファーマシューティカルズ・インコーポレイテッド 腫瘍増殖を阻害するための医薬
EP1869063A2 (de) * 2005-03-29 2007-12-26 Regents Of The University Of Minnesota Verfahren zur herstellung biologisch aktiver 3-ester von betulinaldehyd und betulinsäure
GB0604535D0 (en) * 2006-03-07 2006-04-12 Sndv Sprl Betulonic acid derivatives
CZ300722B6 (cs) * 2006-09-27 2009-07-22 Univerzita Karlova v Praze, Prírodovedecká fakulta Zpusob prípravy inkluzního komplexu pentacyklických a tetracyklických terpenoidu a farmaceutického prostredku obsahujícího tento inkluzní komplex, inkluzní komplex pentacyklického nebo tetracyklického terpenoidu a farmaceutický prostredek obsahující
EP2227233B1 (de) * 2007-11-30 2013-02-13 Newlink Genetics Ido-inhibitoren
KR101027217B1 (ko) * 2009-03-11 2011-04-06 주식회사 바이오폴리메드 신규한 수용성 베툴린 유도체, 이의 제조방법 및 이를 포함하는 주름 개선용 화장료 조성물
US8802727B2 (en) 2009-07-14 2014-08-12 Hetero Research Foundation, Hetero Drugs Limited Pharmaceutically acceptable salts of betulinic acid derivatives
US9067966B2 (en) * 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
WO2014105926A1 (en) 2012-12-31 2014-07-03 Hetero Research Foundation Novel betulinic acid proline derivatives as hiv inhibitors
KR101531821B1 (ko) * 2013-11-27 2015-06-24 주식회사 휴메딕스 페길레이션된 베튤린 유도체를 포함하는 경구 투여용 항암제 조성물
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
US10370405B2 (en) 2015-03-16 2019-08-06 Hetero Labs Limited C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
KR101909885B1 (ko) * 2018-05-25 2018-10-19 김예원 살리드로사이드 또는 베툴린을 이용한 뇌수막종 개선용 조성물
WO2020006510A1 (en) 2018-06-29 2020-01-02 Dfh Therapeutics Triterpene amine derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1415601A (en) * 1973-03-14 1975-11-26 Biorex Laboratories Ltd Dihydrobetulinic acid derivatives
US5869535A (en) * 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
US5962527A (en) * 1995-03-21 1999-10-05 The Board Of Trustees Of The University Of Illinois Method and composition for treating cancers
EP0943620B1 (de) * 1998-03-18 2005-11-16 Dabur Pharma Ltd. Betulinsauer Derivate zur Hemmung von Krebswachstum

Also Published As

Publication number Publication date
EP1131337A1 (de) 2001-09-12
AU3073100A (en) 2000-08-25
WO2000046235A1 (en) 2000-08-10
JP2002536382A (ja) 2002-10-29
CA2350786C (en) 2008-08-12
CN1326462A (zh) 2001-12-12
DE69940320D1 (de) 2009-03-05
BR9915448A (pt) 2002-01-15
ZA200103616B (en) 2002-02-19
AU766599B2 (en) 2003-10-16
KR20010080507A (ko) 2001-08-22
EP1131337B1 (de) 2009-01-14
CA2350786A1 (en) 2000-08-10
WO2000046235B1 (en) 2000-11-02

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