ATE421521T1 - Prozess zur herstellung von antikonvulsiven derivaten von topiramat - Google Patents
Prozess zur herstellung von antikonvulsiven derivaten von topiramatInfo
- Publication number
- ATE421521T1 ATE421521T1 AT04716438T AT04716438T ATE421521T1 AT E421521 T1 ATE421521 T1 AT E421521T1 AT 04716438 T AT04716438 T AT 04716438T AT 04716438 T AT04716438 T AT 04716438T AT E421521 T1 ATE421521 T1 AT E421521T1
- Authority
- AT
- Austria
- Prior art keywords
- topiramate
- producing
- anticonvulsive
- derivatives
- anticonvulsive derivatives
- Prior art date
Links
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical class C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 title 1
- 230000002082 anti-convulsion Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/02—Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
- C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
- C07H9/04—Cyclic acetals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45186303P | 2003-03-04 | 2003-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE421521T1 true ATE421521T1 (de) | 2009-02-15 |
Family
ID=32962650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04716438T ATE421521T1 (de) | 2003-03-04 | 2004-03-02 | Prozess zur herstellung von antikonvulsiven derivaten von topiramat |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7157589B2 (de) |
| EP (1) | EP1599490B8 (de) |
| JP (1) | JP4725976B2 (de) |
| KR (1) | KR20050119111A (de) |
| CN (1) | CN100376591C (de) |
| AR (1) | AR043466A1 (de) |
| AT (1) | ATE421521T1 (de) |
| AU (1) | AU2004217974A1 (de) |
| BR (1) | BRPI0407967A (de) |
| CA (1) | CA2517964A1 (de) |
| CL (1) | CL2004000438A1 (de) |
| DE (1) | DE602004019191D1 (de) |
| DK (1) | DK1599490T3 (de) |
| ES (1) | ES2254047T3 (de) |
| HR (1) | HRP20050756A2 (de) |
| MX (1) | MXPA05009384A (de) |
| MY (1) | MY139235A (de) |
| NO (1) | NO20054538L (de) |
| NZ (1) | NZ541811A (de) |
| PT (1) | PT1599490E (de) |
| RU (1) | RU2333216C2 (de) |
| SI (1) | SI1599490T1 (de) |
| TW (1) | TW200504089A (de) |
| UA (1) | UA81657C2 (de) |
| WO (1) | WO2004078769A1 (de) |
| ZA (1) | ZA200507995B (de) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7638291B2 (en) | 2004-10-25 | 2009-12-29 | Seradyn, Inc. | Immunoassays for topiramate |
| US20060088886A1 (en) * | 2004-10-25 | 2006-04-27 | Anlong Ouyang | Topiramate analogs |
| WO2007099388A1 (en) * | 2006-03-01 | 2007-09-07 | Glade Organics Private Limited | An improved process for the manufacture of topiramate |
| WO2008010231A2 (en) * | 2006-05-26 | 2008-01-24 | Alembic Limited | A process for the purification of topiramate |
| US20090076128A1 (en) * | 2007-09-15 | 2009-03-19 | Protia Llc | Deuterium-enriched topiramate |
| WO2014037832A2 (en) * | 2012-09-06 | 2014-03-13 | Mahesh Kandula | Compositions and methods for the treatment of epilepsy and neurological diseases |
| WO2013167985A1 (en) | 2012-05-07 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of neurological disorders |
| US9399634B2 (en) | 2012-05-07 | 2016-07-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of depression |
| WO2013168021A1 (en) | 2012-05-07 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders |
| WO2013167992A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of inflammatory disorders |
| US9434704B2 (en) | 2012-05-08 | 2016-09-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological degenerative disorders |
| US9522884B2 (en) | 2012-05-08 | 2016-12-20 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic disorders |
| WO2013168025A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of blood clotting disorders |
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| WO2013167999A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of neurologic diseases |
| WO2013168004A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of fibromyalgia pain |
| WO2013168002A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of neurological conditions |
| US9321775B2 (en) | 2012-05-10 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of moderate to severe pain |
| WO2013168015A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of asthma and allergy |
| US9273061B2 (en) | 2012-05-10 | 2016-03-01 | Cellix Bio Private Limited | Compositions and methods for the treatment of chronic pain |
| WO2013168000A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of severe pain |
| WO2013167997A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of metabolic syndrome |
| WO2013168005A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of restless leg syndrome and fibromyalgia |
| WO2013168033A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of neurologic diseases |
| US9499527B2 (en) | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of familial amyloid polyneuropathy |
| WO2013168016A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of metabolic syndrome |
| WO2013168012A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of respiratory disorders |
| US9492409B2 (en) | 2012-05-23 | 2016-11-15 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
| AU2013264820A1 (en) | 2012-05-23 | 2014-11-27 | Cellixbio Private Limited | Compositions and methods for treatment of mucositis |
| JP2015518854A (ja) | 2012-05-23 | 2015-07-06 | セリックスビオ プライヴェート リミテッド | 多発性硬化症の治療のための組成物および方法 |
| WO2013175347A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of respiratory disorders |
| WO2013175344A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of periodontitis and rheumatoid arthritis |
| NZ701832A (en) | 2012-05-23 | 2016-08-26 | Cellix Bio Private Ltd | Compositions and methods for treatment of inflammatory bowel disease |
| US9108942B1 (en) | 2014-11-05 | 2015-08-18 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
| WO2014020480A2 (en) | 2012-08-03 | 2014-02-06 | Mahesh Kandula | Compositions and methods for the treatment migraine and neurologic diseases |
| WO2014037833A2 (en) | 2012-09-06 | 2014-03-13 | Mahesh Kandula | Compositions and methods for the treatment inflammation and lipid disorders |
| SG11201407325YA (en) | 2012-09-08 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for treatment of inflammation and lipid disorders |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| US9333187B1 (en) | 2013-05-15 | 2016-05-10 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
| SG11201509782TA (en) | 2013-06-04 | 2015-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of diabetes and pre-diabetes |
| US9096537B1 (en) | 2014-12-31 | 2015-08-04 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
| NZ736131A (en) | 2014-09-26 | 2019-04-26 | Cellix Bio Private Ltd | Compositions and methods for the treatment of epilepsy and neurological disorders |
| ES2799309T3 (es) | 2014-09-29 | 2020-12-16 | Cellix Bio Private Ltd | Compuestos y composiciones para el tratamiento de esclerosis múltiple |
| JP6564868B2 (ja) | 2014-10-27 | 2019-08-21 | セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ | 多発性硬化症の治療のための、フマル酸モノメチルエステルとピペラジン又はエチレンジアミンとの３つの成分の塩 |
| US9290486B1 (en) | 2014-11-05 | 2016-03-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy |
| US9150557B1 (en) | 2014-11-05 | 2015-10-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of hyperglycemia |
| US9284287B1 (en) | 2014-11-05 | 2016-03-15 | Cellix Bio Private Limited | Compositions and methods for the suppression of carbonic anhydrase activity |
| US10208014B2 (en) | 2014-11-05 | 2019-02-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological disorders |
| US9173877B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
| US9321716B1 (en) | 2014-11-05 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
| US9175008B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Prodrugs of anti-platelet agents |
| WO2016088132A1 (en) | 2014-12-01 | 2016-06-09 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
| US9206111B1 (en) | 2014-12-17 | 2015-12-08 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
| SG11201705524SA (en) | 2015-01-06 | 2017-08-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of inflammation and pain |
| CN106632530A (zh) * | 2016-12-08 | 2017-05-10 | 陕西大生制药科技有限公司 | 高纯度托吡酯的制备方法 |
| CN108341844A (zh) * | 2018-04-25 | 2018-07-31 | 广州小桔生物科技有限公司 | 一种高纯度托吡酯的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4513006A (en) | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| US4582916A (en) | 1983-09-26 | 1986-04-15 | Mcneilab, Inc. | Chlorosulfate and azidosulfate esters of tetrahydro-2H-pyran-2-yl-methanol |
| IL103172A (en) * | 1991-09-19 | 1997-01-10 | Mcneilab Inc | Preparation of chlorosulfate and sulfamate derivatives of 2, 3:4, 5-bis-o-(1-methylethylidene)-beta-d-fructopyranose and (1-methylcyclohexyl) methanol |
| FR2704226B1 (fr) * | 1993-04-22 | 1995-07-21 | Sanofi Elf | 3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2751334B1 (fr) * | 1996-07-19 | 1998-10-16 | Sanofi Sa | Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant |
-
2004
- 2004-02-03 UA UAA200508358A patent/UA81657C2/ru unknown
- 2004-03-01 US US10/790,274 patent/US7157589B2/en not_active Expired - Lifetime
- 2004-03-02 KR KR1020057016420A patent/KR20050119111A/ko not_active Ceased
- 2004-03-02 BR BRPI0407967-1A patent/BRPI0407967A/pt not_active IP Right Cessation
- 2004-03-02 RU RU2005127626/04A patent/RU2333216C2/ru active
- 2004-03-02 SI SI200431098T patent/SI1599490T1/sl unknown
- 2004-03-02 ES ES04716438T patent/ES2254047T3/es not_active Expired - Lifetime
- 2004-03-02 CN CNB2004800057108A patent/CN100376591C/zh not_active Expired - Fee Related
- 2004-03-02 DE DE602004019191T patent/DE602004019191D1/de not_active Expired - Lifetime
- 2004-03-02 CA CA002517964A patent/CA2517964A1/en not_active Abandoned
- 2004-03-02 AU AU2004217974A patent/AU2004217974A1/en not_active Abandoned
- 2004-03-02 DK DK04716438T patent/DK1599490T3/da active
- 2004-03-02 PT PT04716438T patent/PT1599490E/pt unknown
- 2004-03-02 MX MXPA05009384A patent/MXPA05009384A/es active IP Right Grant
- 2004-03-02 AT AT04716438T patent/ATE421521T1/de not_active IP Right Cessation
- 2004-03-02 NZ NZ541811A patent/NZ541811A/en unknown
- 2004-03-02 EP EP04716438A patent/EP1599490B8/de not_active Expired - Lifetime
- 2004-03-02 WO PCT/US2004/006263 patent/WO2004078769A1/en not_active Ceased
- 2004-03-02 HR HR20050756A patent/HRP20050756A2/xx not_active Application Discontinuation
- 2004-03-02 JP JP2006508970A patent/JP4725976B2/ja not_active Expired - Fee Related
- 2004-03-03 MY MYPI20040728A patent/MY139235A/en unknown
- 2004-03-03 TW TW093105458A patent/TW200504089A/zh unknown
- 2004-03-04 AR ARP040100680A patent/AR043466A1/es not_active Application Discontinuation
- 2004-03-04 CL CL200400438A patent/CL2004000438A1/es unknown
-
2005
- 2005-10-03 ZA ZA200507995A patent/ZA200507995B/en unknown
- 2005-10-03 NO NO20054538A patent/NO20054538L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20054538L (no) | 2005-10-03 |
| BRPI0407967A (pt) | 2006-03-07 |
| ES2254047T3 (es) | 2009-05-14 |
| PT1599490E (pt) | 2009-04-03 |
| CN100376591C (zh) | 2008-03-26 |
| MXPA05009384A (es) | 2006-02-28 |
| TW200504089A (en) | 2005-02-01 |
| RU2005127626A (ru) | 2006-01-27 |
| US7157589B2 (en) | 2007-01-02 |
| EP1599490B1 (de) | 2009-01-21 |
| HK1088336A1 (zh) | 2006-11-03 |
| AR043466A1 (es) | 2005-07-27 |
| ES2254047T1 (es) | 2006-06-16 |
| WO2004078769A1 (en) | 2004-09-16 |
| UA81657C2 (ru) | 2008-01-25 |
| CL2004000438A1 (es) | 2005-01-21 |
| NZ541811A (en) | 2008-07-31 |
| JP4725976B2 (ja) | 2011-07-13 |
| CA2517964A1 (en) | 2004-09-16 |
| CN1756760A (zh) | 2006-04-05 |
| AU2004217974A1 (en) | 2004-09-16 |
| JP2006519860A (ja) | 2006-08-31 |
| EP1599490B8 (de) | 2009-04-08 |
| DK1599490T3 (da) | 2009-04-27 |
| US20040215004A1 (en) | 2004-10-28 |
| SI1599490T1 (sl) | 2009-06-30 |
| MY139235A (en) | 2009-09-30 |
| HRP20050756A2 (en) | 2006-07-31 |
| EP1599490A1 (de) | 2005-11-30 |
| DE602004019191D1 (de) | 2009-03-12 |
| KR20050119111A (ko) | 2005-12-20 |
| ZA200507995B (en) | 2007-01-31 |
| RU2333216C2 (ru) | 2008-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1599490 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |