ATE4224T1 - Verfahren zur reinigung von thienamycin. - Google Patents
Verfahren zur reinigung von thienamycin.Info
- Publication number
- ATE4224T1 ATE4224T1 AT79103173T AT79103173T ATE4224T1 AT E4224 T1 ATE4224 T1 AT E4224T1 AT 79103173 T AT79103173 T AT 79103173T AT 79103173 T AT79103173 T AT 79103173T AT E4224 T1 ATE4224 T1 AT E4224T1
- Authority
- AT
- Austria
- Prior art keywords
- thienamycin
- polystyrene
- gram
- purification
- procedure
- Prior art date
Links
- WKDDRNSBRWANNC-ATRFCDNQSA-N Thienamycin Chemical compound C1C(SCCN)=C(C(O)=O)N2C(=O)[C@H]([C@H](O)C)[C@H]21 WKDDRNSBRWANNC-ATRFCDNQSA-N 0.000 title abstract 2
- WKDDRNSBRWANNC-UHFFFAOYSA-N Thienamycin Natural products C1C(SCCN)=C(C(O)=O)N2C(=O)C(C(O)C)C21 WKDDRNSBRWANNC-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 239000011347 resin Substances 0.000 abstract 2
- 229920005989 resin Polymers 0.000 abstract 2
- 239000003463 adsorbent Substances 0.000 abstract 1
- 239000003957 anion exchange resin Substances 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 235000010633 broth Nutrition 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 239000003456 ion exchange resin Substances 0.000 abstract 1
- 229920003303 ion-exchange polymer Polymers 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
- C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP79103173A EP0024447B1 (de) | 1979-08-28 | 1979-08-28 | Verfahren zur Reinigung von Thienamycin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE4224T1 true ATE4224T1 (de) | 1983-08-15 |
Family
ID=8186184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT79103173T ATE4224T1 (de) | 1979-08-28 | 1979-08-28 | Verfahren zur reinigung von thienamycin. |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0024447B1 (de) |
| AT (1) | ATE4224T1 (de) |
| DE (1) | DE2965923D1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3146190A1 (de) * | 1981-11-21 | 1983-06-16 | Hoechst Ag, 6230 Frankfurt | Isolierung von chemisch instabilen antibiotika aus fermentationsloesungen |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2528622A1 (de) * | 1975-06-26 | 1977-01-13 | Bayer Ag | Verfahren zur reinigung der bei der enzymatischen spaltung von beta-lactam- antibiotika anfallenden produkte |
| DK497476A (da) * | 1975-11-24 | 1977-05-25 | Merck & Co Inc | Fremgangsmade til fremstilling af et antibiotisk stof |
| SE7801695L (sv) * | 1977-03-01 | 1978-09-02 | Merck & Co Inc | Tienamycin |
-
1979
- 1979-08-28 AT AT79103173T patent/ATE4224T1/de not_active IP Right Cessation
- 1979-08-28 DE DE7979103173T patent/DE2965923D1/de not_active Expired
- 1979-08-28 EP EP79103173A patent/EP0024447B1/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0024447B1 (de) | 1983-07-20 |
| EP0024447A1 (de) | 1981-03-11 |
| DE2965923D1 (en) | 1983-08-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |