DK497476A - Fremgangsmade til fremstilling af et antibiotisk stof - Google Patents

Fremgangsmade til fremstilling af et antibiotisk stof

Info

Publication number
DK497476A
DK497476A DK497476A DK497476A DK497476A DK 497476 A DK497476 A DK 497476A DK 497476 A DK497476 A DK 497476A DK 497476 A DK497476 A DK 497476A DK 497476 A DK497476 A DK 497476A
Authority
DK
Denmark
Prior art keywords
procedure
preparation
antibiotic substance
antibiotic
substance
Prior art date
Application number
DK497476A
Other languages
English (en)
Inventor
J S Kahan
F M Kahan
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK497476A publication Critical patent/DK497476A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK497476A 1975-11-24 1976-11-03 Fremgangsmade til fremstilling af et antibiotisk stof DK497476A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63456075A 1975-11-24 1975-11-24

Publications (1)

Publication Number Publication Date
DK497476A true DK497476A (da) 1977-05-25

Family

ID=24544292

Family Applications (1)

Application Number Title Priority Date Filing Date
DK497476A DK497476A (da) 1975-11-24 1976-11-03 Fremgangsmade til fremstilling af et antibiotisk stof

Country Status (16)

Country Link
JP (1) JPS5265295A (da)
AR (1) AR224224A1 (da)
AU (1) AU510252B2 (da)
BE (1) BE848349A (da)
CH (1) CH625803A5 (da)
DE (1) DE2652678A1 (da)
DK (1) DK497476A (da)
ES (1) ES453508A1 (da)
FR (1) FR2351979A1 (da)
GB (1) GB1561108A (da)
GR (1) GR61407B (da)
HU (1) HU175266B (da)
NL (1) NL7612932A (da)
PT (1) PT65845B (da)
SE (1) SE7612295L (da)
ZA (1) ZA766986B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7800979L (sv) * 1977-02-11 1978-08-12 Merck & Co Inc Antibiotikum
NL7800957A (nl) * 1977-02-11 1978-08-15 Merck & Co Inc Antibioticum desacetyl 890 a10, werkwijze ter bereiding daarvan en farmaceutische preparaten die dit antibioticum bevatten.
US4162193A (en) * 1977-08-19 1979-07-24 Merck & Co., Inc. Enzymatic cleavage of N-acyl-thienamycins
NZ190994A (en) 1978-07-24 1981-10-19 Merck & Co Inc Z-2-acylamino-3-monosubstituted propenoates
DE2965923D1 (en) * 1979-08-28 1983-08-25 Merck & Co Inc Process for purifying thienamycin
DE3146190A1 (de) * 1981-11-21 1983-06-16 Hoechst Ag, 6230 Frankfurt Isolierung von chemisch instabilen antibiotika aus fermentationsloesungen
US10695322B2 (en) 2016-01-29 2020-06-30 The Johns Hopkins University Inhibitors of bacterial growth

Also Published As

Publication number Publication date
NL7612932A (nl) 1977-05-26
PT65845A (en) 1976-12-01
FR2351979B1 (da) 1982-08-13
JPS5265295A (en) 1977-05-30
BE848349A (fr) 1977-05-16
DE2652678A1 (de) 1977-06-02
PT65845B (en) 1978-10-10
AR224224A1 (es) 1981-11-13
SE7612295L (sv) 1977-05-25
ZA766986B (en) 1978-06-28
AU1964576A (en) 1978-05-25
AU510252B2 (en) 1980-06-19
FR2351979A1 (fr) 1977-12-16
HU175266B (hu) 1980-06-28
ES453508A1 (es) 1978-03-01
GR61407B (en) 1978-11-11
GB1561108A (en) 1980-02-13
CH625803A5 (en) 1981-10-15

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Legal Events

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ATS Application withdrawn