ATE423115T1 - Herstellungsverfahren für aztreonam - Google Patents

Herstellungsverfahren für aztreonam

Info

Publication number: ATE423115T1
Authority: AT; Austria
Prior art keywords: aztreonam; production process; taem; azetidine; butyl
Prior art date: 2005-05-09

Application number

AT06759579T

Other languages

English (en)

Inventor

Domenico Fimognari

Original Assignee

Sicor Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-05-09

Filing date

2006-05-09

Publication date

2009-03-15

2006-05-09 Application filed by Sicor Inc filed Critical Sicor Inc

2009-03-15 Application granted granted Critical

2009-03-15 Publication of ATE423115T1 publication Critical patent/ATE423115T1/de

Links

229960003644 aztreonam Drugs 0.000 title abstract 3
WZPBZJONDBGPKJ-UHFFFAOYSA-N Antibiotic SQ 26917 Natural products O=C1N(S(O)(=O)=O)C(C)C1NC(=O)C(=NOC(C)(C)C(O)=O)C1=CSC(N)=N1 WZPBZJONDBGPKJ-UHFFFAOYSA-N 0.000 title abstract 2
WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000005580 one pot reaction Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
RCZJVHXVCSKDKB-OYKKKHCWSA-N tert-butyl 2-[(z)-[1-(2-amino-1,3-thiazol-4-yl)-2-(1,3-benzothiazol-2-ylsulfanyl)-2-oxoethylidene]amino]oxy-2-methylpropanoate Chemical compound N=1C2=CC=CC=C2SC=1SC(=O)\C(=N/OC(C)(C)C(=O)OC(C)(C)C)C1=CSC(N)=N1 RCZJVHXVCSKDKB-OYKKKHCWSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Optical Integrated Circuits (AREA)
Saccharide Compounds (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Materials For Medical Uses (AREA)
Bridges Or Land Bridges (AREA)

AT06759579T 2005-05-09 2006-05-09 Herstellungsverfahren für aztreonam ATE423115T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US67931305P	2005-05-09	2005-05-09
US68180805P	2005-05-17	2005-05-17

Publications (1)

Publication Number	Publication Date
ATE423115T1 true ATE423115T1 (de)	2009-03-15

Family

ID=37012142

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06759579T ATE423115T1 (de)	2005-05-09	2006-05-09	Herstellungsverfahren für aztreonam

Country Status (11)

Country	Link
US (1)	US7601832B2 (de)
EP (1)	EP1888576B1 (de)
JP (1)	JP2008505189A (de)
AT (1)	ATE423115T1 (de)
CA (1)	CA2606901A1 (de)
DE (1)	DE602006005240D1 (de)
ES (1)	ES2321336T3 (de)
IL (1)	IL185030A0 (de)
MX (1)	MX2007000526A (de)
PT (1)	PT1888576E (de)
WO (1)	WO2006122253A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2004103999A1 (en) *	2003-05-15	2004-12-02	TEVA Gyógyszergyár Részvénytársaság	AZTREONAM β POLYMORPH WITH VERY LOW RESIDUAL SOLVENT CONTENT
US20090069286A1 (en) *	2007-09-12	2009-03-12	Protia, Llc	Deuterium-enriched aztreonam
CN102086196B (zh)	2011-01-28	2012-06-13	海南灵康制药有限公司	一种氨曲南的方法
CN102382026A (zh) *	2011-10-17	2012-03-21	重庆南松医药科技股份有限公司	氨曲南主环(3s-反式)-3-氨基-4-甲基-2-氧代-1-氮杂环丁烷基磺酸的环保合成工艺
CN103570707B (zh) *	2012-07-21	2016-03-09	重庆圣华曦药业股份有限公司	一种改进的氨曲南的合成方法
CN114437059A (zh) *	2020-11-04	2022-05-06	重庆圣华曦药业股份有限公司	一种氨曲南二聚体杂质的制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4923998A (en) *	1977-03-14	1990-05-08	Fujisawa Pharmaceutical Company, Ltd.	Cephem and cepham compounds and processes for preparation thereof
NZ205240A (en) *	1980-02-07	1984-07-31	Squibb & Sons Inc	Sulphonamide derivatives,being starting materials for producing beta-lactams
US4775670A (en) *	1980-09-29	1988-10-04	E. R. Squibb & Sons, Inc.	2-oxo-1-azetidinesulfonic acid salts
US4529698A (en) *	1981-01-19	1985-07-16	E. R. Squibb & Sons, Inc.	Process for preparing a 2-oxo-1-azetidinesulfonic acid salt
US4946838A (en) *	1981-07-13	1990-08-07	E. R. Squibb & Sons, Inc.	Crystalline anhydrous aztreonam
CA1181075A (en)	1981-07-13	1985-01-15	David M. Floyd	CRYSTALLINE ANHYDROUS FORM OF [3-S-[3.alpha.(Z),4 .beta.]]-3-[[(2-AMINO-4-THIAZOLYL) [(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL] AMINO]-4-METHYL-2-OXO-1-AZETIDINESULFONIC ACID
US4443374A (en) *	1982-02-01	1984-04-17	E. R. Squibb & Sons, Inc.	Process for preparing (3S)-3-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]-acetyl]amino]-2-oxo-1-azetidinesulfonic acid, and 4-substituted derivatives
DE3372768D1 (de) *	1982-06-03	1987-09-03	Hoffmann La Roche	1-sulfo-2-oxoazetidine derivatives
US4652651A (en) *	1983-05-31	1987-03-24	Hoffmann-La Roche Inc.	Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
US4826973A (en) *	1984-07-20	1989-05-02	E. R. Squibb & Sons, Inc.	Delta form of aztreonam and preparation thereof
CA1339136C (en)	1987-07-01	1997-07-29	Sailesh Amilal Varia	Amorphous form of aztreonam
IT1231770B (it) *	1989-08-02	1991-12-21	Consiglio Nazionale Ricerche	Processo per la preparazione di monobattami ed intermedio di preparazione.
US5254681A (en) *	1989-08-02	1993-10-19	Consiglio Nazionale Delle Ricerche	Process for preparing monobactames and their intermediate product
US5194604A (en) *	1990-06-29	1993-03-16	E. R. Squibb & Sons, Inc.	Process and intermediates for beta-lactams having aminothiazole(iminooxyacetic acid)acetic acid sidechains
PL165700B1 (pl)	1991-10-15	1995-01-31	Pan	Sposób wytwarzania kwasu 32/2-amtnotiazoiilo-4/-2/1 -t-butoksykarbonylo- 1 -metyloetoksylmino/octowego
DE122011100043I1 (de)	2000-12-27	2011-12-15	Gilead Sciences Inc	Inhalierbares aztreonam zur behandlung und vorbeugung von bakteriellen lungeninfektionen.
US7214364B2 (en) *	2000-12-27	2007-05-08	Corus Pharma, Inc.	Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections
WO2003018578A1 (en)	2001-08-27	2003-03-06	Aurobindo Pharma Ltd.	Method for producing beta form of crystalline anhydrous aztreonam
KR100687001B1 (ko)	2002-08-05	2007-02-27	테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그	아즈트레오남의 제법
WO2004052333A1 (en)	2002-12-11	2004-06-24	Pari Gmbh	Pharmaceutical compositions for the pulmonary delivery of aztreonam
AU2004256124B2 (en) *	2003-07-02	2011-04-28	Corus Pharma, Inc.	Aztreonam L-lysine and methods for the preparation thereof
WO2007083187A2 (en)	2006-01-16	2007-07-26	Orchid Chemicals & Pharmaceuticals Limited	An improved process for the preparation of monobactam antibiotic

2006
- 2006-05-09 ES ES06759579T patent/ES2321336T3/es not_active Expired - Lifetime
- 2006-05-09 WO PCT/US2006/018261 patent/WO2006122253A1/en not_active Ceased
- 2006-05-09 MX MX2007000526A patent/MX2007000526A/es active IP Right Grant
- 2006-05-09 CA CA002606901A patent/CA2606901A1/en not_active Abandoned
- 2006-05-09 JP JP2007520595A patent/JP2008505189A/ja active Pending
- 2006-05-09 AT AT06759579T patent/ATE423115T1/de not_active IP Right Cessation
- 2006-05-09 DE DE602006005240T patent/DE602006005240D1/de active Active
- 2006-05-09 PT PT06759579T patent/PT1888576E/pt unknown
- 2006-05-09 US US11/431,178 patent/US7601832B2/en not_active Expired - Fee Related
- 2006-05-09 EP EP06759579A patent/EP1888576B1/de not_active Expired - Lifetime
2007
- 2007-08-02 IL IL185030A patent/IL185030A0/en unknown

Also Published As

Publication number	Publication date
JP2008505189A (ja)	2008-02-21
CA2606901A1 (en)	2006-11-16
WO2006122253A1 (en)	2006-11-16
DE602006005240D1 (de)	2009-04-02
MX2007000526A (es)	2007-03-28
IL185030A0 (en)	2007-12-03
EP1888576A1 (de)	2008-02-20
US20060276640A1 (en)	2006-12-07
PT1888576E (pt)	2009-04-03
US7601832B2 (en)	2009-10-13
ES2321336T3 (es)	2009-06-04
EP1888576B1 (de)	2009-02-18

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Legal Events

Date	Code	Title	Description
2009-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties