ATE423123T1 - Verfahren zur hestellung von cefixim - Google Patents
Verfahren zur hestellung von cefiximInfo
- Publication number
- ATE423123T1 ATE423123T1 AT05849882T AT05849882T ATE423123T1 AT E423123 T1 ATE423123 T1 AT E423123T1 AT 05849882 T AT05849882 T AT 05849882T AT 05849882 T AT05849882 T AT 05849882T AT E423123 T1 ATE423123 T1 AT E423123T1
- Authority
- AT
- Austria
- Prior art keywords
- cefixime
- acidification
- followed
- formula
- acid
- Prior art date
Links
- 229960002129 cefixime Drugs 0.000 title abstract 5
- OKBVVJOGVLARMR-QSWIMTSFSA-N cefixime Chemical compound S1C(N)=NC(C(=N\OCC(O)=O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 OKBVVJOGVLARMR-QSWIMTSFSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 cefixime ester Chemical class 0.000 abstract 3
- 230000020477 pH reduction Effects 0.000 abstract 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- HOKIDJSKDBPKTQ-UHFFFAOYSA-N 3-(acetyloxymethyl)-7-[(5-amino-5-carboxypentanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)C(NC(=O)CCCC(N)C(O)=O)C12 HOKIDJSKDBPKTQ-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1384MU2004 | 2004-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE423123T1 true ATE423123T1 (de) | 2009-03-15 |
Family
ID=36178376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05849882T ATE423123T1 (de) | 2004-12-21 | 2005-12-19 | Verfahren zur hestellung von cefixim |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8008478B2 (de) |
| EP (1) | EP1828206B1 (de) |
| AT (1) | ATE423123T1 (de) |
| DE (1) | DE602005012866D1 (de) |
| MX (1) | MX2007007476A (de) |
| WO (1) | WO2006067806A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103193798B (zh) * | 2013-04-18 | 2014-04-02 | 四川省惠达药业有限公司 | 一种头孢克肟化合物及其药物组合物 |
| CN103265562A (zh) * | 2013-05-29 | 2013-08-28 | 四川方向药业有限责任公司 | 头孢克肟的制备方法 |
| CN104693217B (zh) * | 2015-02-28 | 2017-01-11 | 浙江华方药业股份有限公司 | 一种头孢克肟的制备方法 |
| WO2016142902A1 (en) * | 2015-03-11 | 2016-09-15 | Lupin Limited | Cefixime with reduced surface area and high stability |
| CN107312019B (zh) * | 2017-06-16 | 2019-06-25 | 成都倍特药业有限公司 | 一种头孢克肟及其结晶方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4409214A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
| US4731443A (en) * | 1979-11-19 | 1988-03-15 | Fujisawa Pharmaceutical Co., Ltd. | 7-acylamino-3-vinylcephalosporanic acid derivatives |
| GB8323034D0 (en) * | 1983-08-26 | 1983-09-28 | Fujisawo Pharmaceutical Co Ltd | 7-substituted-3-vinyl-3-cephem compounds |
| CH688319A5 (fr) * | 1994-06-03 | 1997-07-31 | Marcham Trading & Investment L | Procédé pour la préparation du céfixime trihydraté. |
| PT102062B (pt) | 1997-10-08 | 2000-08-31 | J K Ind Ltd | Processo de preparacao de um antibiotico cefalosporina oralmente activo-cefixime |
| PT102061B (pt) | 1997-10-08 | 2000-06-30 | J K Ind Ltd | Processo de preparacao de um antibiotico cefalosporina geralmente activo-cefixime |
| AT406773B (de) * | 1998-04-02 | 2000-08-25 | Biochemie Gmbh | Neues salz von 7-(2-(aminothiazol-4yl)-2- |
| WO1999052913A1 (en) | 1998-04-14 | 1999-10-21 | Otsuka Kagaku Kabushiki Kaisha | Process for producing cephem compounds |
| KR100392409B1 (ko) * | 2000-03-20 | 2003-07-22 | 한미정밀화학주식회사 | 신규한 티아졸 화합물을 이용한 세팔로스포린계항생물질의 제조 방법 |
| ITMI20012364A1 (it) * | 2001-11-09 | 2003-05-09 | Antibioticos Spa | Processo di sintesi della cefixima via alchil-o arilsolfonati |
| US6800755B2 (en) | 2002-10-24 | 2004-10-05 | Orchid Chemicals And Pharmaceuticals Limited | Process for the preparation of cefixime |
| ES2334685T3 (es) * | 2005-03-29 | 2010-03-15 | Hetero Drugs Limited | Procedimiento mejorado de preparacion de cefixima. |
-
2005
- 2005-12-19 DE DE602005012866T patent/DE602005012866D1/de not_active Expired - Fee Related
- 2005-12-19 AT AT05849882T patent/ATE423123T1/de not_active IP Right Cessation
- 2005-12-19 US US11/722,422 patent/US8008478B2/en not_active Expired - Fee Related
- 2005-12-19 MX MX2007007476A patent/MX2007007476A/es unknown
- 2005-12-19 WO PCT/IN2005/000421 patent/WO2006067806A1/en not_active Ceased
- 2005-12-19 EP EP05849882A patent/EP1828206B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US8008478B2 (en) | 2011-08-30 |
| MX2007007476A (es) | 2007-08-15 |
| WO2006067806A1 (en) | 2006-06-29 |
| EP1828206B1 (de) | 2009-02-18 |
| US20090227787A1 (en) | 2009-09-10 |
| DE602005012866D1 (de) | 2009-04-02 |
| EP1828206A1 (de) | 2007-09-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |