ATE423130T1 - Deuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agenzien - Google Patents

Deuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agenzien

Info

Publication number: ATE423130T1
Authority: AT; Austria
Prior art keywords: cyclosporine; substitution; disclosed; derivatives; cyclosporine derivatives
Prior art date: 1997-10-08

Application number

AT05024216T

Other languages

English (en)

Inventor

S Selveraj Naicker

Robert T Foster

Randall W Yatscoff

Original Assignee

Isotechnika Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-08

Filing date

1998-10-08

Publication date

2009-03-15

1998-10-08 Application filed by Isotechnika Inc filed Critical Isotechnika Inc

2009-03-15 Application granted granted Critical

2009-03-15 Publication of ATE423130T1 publication Critical patent/ATE423130T1/de

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 9
239000002955 immunomodulating agent Substances 0.000 title 1
238000006467 substitution reaction Methods 0.000 abstract 4
229930105110 Cyclosporin A Natural products 0.000 abstract 3
108010036949 Cyclosporine Proteins 0.000 abstract 3
YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 2
229910052805 deuterium Inorganic materials 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000000126 substance Substances 0.000 abstract 2
230000001988 toxicity Effects 0.000 abstract 2
231100000419 toxicity Toxicity 0.000 abstract 2
108010036941 Cyclosporins Proteins 0.000 abstract 1
206010062016 Immunosuppression Diseases 0.000 abstract 1
125000003275 alpha amino acid group Chemical class 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
229930182912 cyclosporin Natural products 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
230000000155 isotopic effect Effects 0.000 abstract 1
230000004060 metabolic process Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/807—Hapten conjugated with peptide or protein

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Neurology (AREA)
Analytical Chemistry (AREA)
Surgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Transplantation (AREA)
Hematology (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT05024216T 1997-10-08 1998-10-08 Deuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agenzien ATE423130T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US6136097P	1997-10-08	1997-10-08

Publications (1)

Publication Number	Publication Date
ATE423130T1 true ATE423130T1 (de)	2009-03-15

Family

ID=22035297

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT98947718T ATE314388T1 (de)	1997-10-08	1998-10-08	Deuterierte und undeuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agentien
AT05024216T ATE423130T1 (de)	1997-10-08	1998-10-08	Deuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agenzien

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT98947718T ATE314388T1 (de)	1997-10-08	1998-10-08	Deuterierte und undeuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agentien

Country Status (14)

Country	Link
US (3)	US6613739B1 (de)
EP (1)	EP0991660B8 (de)
JP (6)	JP4261049B2 (de)
KR (1)	KR100585348B1 (de)
AT (2)	ATE314388T1 (de)
AU (1)	AU750245B2 (de)
BR (1)	BR9811716A (de)
CA (1)	CA2298572C (de)
DE (2)	DE69840586D1 (de)
DK (1)	DK0991660T3 (de)
ES (1)	ES2256959T3 (de)
NO (1)	NO324042B1 (de)
NZ (1)	NZ502362A (de)
WO (1)	WO1999018120A1 (de)

Families Citing this family (100)

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1998
- 1998-10-08 AT AT98947718T patent/ATE314388T1/de active
- 1998-10-08 AU AU94542/98A patent/AU750245B2/en not_active Expired
- 1998-10-08 AT AT05024216T patent/ATE423130T1/de not_active IP Right Cessation
- 1998-10-08 BR BR9811716-5A patent/BR9811716A/pt not_active Application Discontinuation
- 1998-10-08 DK DK98947718T patent/DK0991660T3/da active
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- 1998-10-08 KR KR1020007003743A patent/KR100585348B1/ko not_active Expired - Fee Related
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- 1998-10-08 WO PCT/IB1998/001693 patent/WO1999018120A1/en not_active Ceased
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2000
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- 2000-08-07 US US09/634,945 patent/US6613739B1/en not_active Expired - Lifetime
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2001
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DE69832984T2 (de)	2006-09-21
DE69832984D1 (de)	2006-02-02
US20020132763A1 (en)	2002-09-19
US6613739B1 (en)	2003-09-02
AU9454298A (en)	1999-04-27
JP2005343904A (ja)	2005-12-15
NZ502362A (en)	2001-05-25
EP0991660B1 (de)	2005-12-28
JP2008222724A (ja)	2008-09-25
HK1026432A1 (en)	2000-12-15
JP2004143168A (ja)	2004-05-20
EP0991660A1 (de)	2000-04-12
KR100585348B1 (ko)	2006-06-01
BR9811716A (pt)	2000-07-18
WO1999018120A1 (en)	1999-04-15
DK0991660T3 (da)	2006-02-13
JP2007119489A (ja)	2007-05-17
NO20001020D0 (no)	2000-02-29
NO324042B1 (no)	2007-07-30
US6605593B1 (en)	2003-08-12
DE69840586D1 (de)	2009-04-02
JP2001519355A (ja)	2001-10-23
NO20001020L (no)	2000-02-29
ES2256959T3 (es)	2006-07-16
ATE314388T1 (de)	2006-01-15
KR20010030978A (ko)	2001-04-16
EP0991660B8 (de)	2006-04-05
JP4261049B2 (ja)	2009-04-30
JP2008222725A (ja)	2008-09-25
CA2298572A1 (en)	1999-04-15
AU750245B2 (en)	2002-07-11
CA2298572C (en)	2002-04-09

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