ATE132504T1 - Immunotestreagenzien und verfahren zur bestimmung von cyclosporin - Google Patents

Immunotestreagenzien und verfahren zur bestimmung von cyclosporin

Info

Publication number: ATE132504T1
Authority: AT; Austria
Prior art keywords: cyclosporine; cyclosporin; determining; test reagents; amino acid
Prior art date: 1990-08-15

Application number

AT91113328T

Other languages

English (en)

Inventor

Marjorie A Morrison

Victoria P Meucci

Steven E Lunetta

Mariola B Zajac

Elizabeth A Simpson

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-15

Filing date

1991-08-08

Publication date

1996-01-15

1991-08-08 Application filed by Abbott Lab filed Critical Abbott Lab

1996-01-15 Application granted granted Critical

1996-01-15 Publication of ATE132504T1 publication Critical patent/ATE132504T1/de

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 12
108010036949 Cyclosporine Proteins 0.000 title abstract 9
229960001265 ciclosporin Drugs 0.000 title abstract 9
229930182912 cyclosporin Natural products 0.000 title abstract 9
229930105110 Cyclosporin A Natural products 0.000 title 1
239000003153 chemical reaction reagent Substances 0.000 title 1
238000003018 immunoassay Methods 0.000 abstract 4
150000001413 amino acids Chemical class 0.000 abstract 2
230000010287 polarization Effects 0.000 abstract 2
XJODGRWDFZVTKW-LURJTMIESA-N (2s)-4-methyl-2-(methylamino)pentanoic acid Chemical compound CN[C@H](C(O)=O)CC(C)C XJODGRWDFZVTKW-LURJTMIESA-N 0.000 abstract 1
AHQFCPOIMVMDEZ-UNISNWAASA-N (e,2s,3r,4r)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoic acid Chemical compound CN[C@H](C(O)=O)[C@H](O)[C@H](C)C\C=C\C AHQFCPOIMVMDEZ-UNISNWAASA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000700 radioactive tracer Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT91113328T 1990-08-15 1991-08-08 Immunotestreagenzien und verfahren zur bestimmung von cyclosporin ATE132504T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US56784290A	1990-08-15	1990-08-15

Publications (1)

Publication Number	Publication Date
ATE132504T1 true ATE132504T1 (de)	1996-01-15

Family

ID=24268868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91113328T ATE132504T1 (de)	1990-08-15	1991-08-08	Immunotestreagenzien und verfahren zur bestimmung von cyclosporin

Country Status (10)

Country	Link
US (2)	US5489668A (de)
EP (1)	EP0473961B1 (de)
JP (1)	JP3171460B2 (de)
AT (1)	ATE132504T1 (de)
AU (1)	AU642035B2 (de)
CA (1)	CA2049089C (de)
DE (1)	DE69116034T2 (de)
DK (1)	DK0473961T3 (de)
ES (1)	ES2084069T3 (de)
GR (1)	GR3019512T3 (de)

Families Citing this family (34)

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ATE142344T1 (de) *	1990-11-20	1996-09-15	Behringwerke Ag	Immunotest für cyclosporin
US5352803A (en) *	1992-03-30	1994-10-04	Abbott Laboratories	5(6)-methyl substituted fluorescein derivatives
WO1993020442A1 (en) *	1992-03-30	1993-10-14	Abbott Laboratories	Reagents and methods for the detection and quantification of thyroxine in fluid samples
GB9307491D0 (en) *	1993-04-08	1993-06-02	Sandoz Ltd	Organic compounds
USRE40596E1 (en) *	1993-04-08	2008-12-02	Novartis Ag	Rapamycin assay
US5504091A (en) *	1993-04-23	1996-04-02	American Home Products Corporation	Biotin esters of rapamycin
US7279561B1 (en)	1993-04-23	2007-10-09	Wyeth	Anti-rapamycin monoclonal antibodies
AU686629B2 (en)	1993-04-23	1998-02-12	Wyeth	Rapamycin Conjugates and Antibodies
US5393891A (en) *	1993-06-08	1995-02-28	The Du Pont Merck Pharmaceutical Company	Immunoassay reagents and methods for detecting brequinar and analogs
US5650288A (en) *	1995-07-14	1997-07-22	Macfarlane; Gordon D.	Immunophilin-bound immunosuppressant assay
US20030220234A1 (en)	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
ATE314388T1 (de)	1997-10-08	2006-01-15	Isotechnika Inc	Deuterierte und undeuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agentien
US5990274A (en) *	1997-11-25	1999-11-23	Dade Behring Inc.	Cyclosporine derivatives and uses thereof
US8569516B2 (en)	2001-09-07	2013-10-29	Elitech Holding B.V.	Compounds and methods for fluorescent labeling
US6972339B2 (en)	2001-09-07	2005-12-06	Epoch Biosciences, Inc.	Compounds and methods for fluorescent labeling
BRPI0213658A8 (pt)	2001-10-19	2016-12-06	F Hoffmann La Roche Ltd	Método para preparar uma mistura isomérica predeterminada ou não dos análogos de ciclosporina a modificados no resíduo de 1-aminoácido, métodopara produzir uma mistura enriquecida com e-isômero ou com z-isômero de análogos de ciclosporina a modificados no resíduo de 1-aminoácido, mistura de (e) e (z)-isômeros, composição, método para a síntese estereoseletiva do z-isômero de isatx247, método para a preparação de aldeído do ciclosporina a
KR100444698B1 (ko) *	2001-11-08	2004-08-21	한국과학기술연구원	면역복합체 단일검출시약, 그의 제조방법 및 그를 이용한농약의 검출방법
EP1603512A2 (de)	2003-03-17	2005-12-14	Albany Molecular Research, Inc.	Neue cyclosporine
US7511013B2 (en)	2004-09-29	2009-03-31	Amr Technology, Inc.	Cyclosporin analogues and their pharmaceutical uses
JP2008514701A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキン類似体およびそれらの薬学的使用
US7361636B2 (en)	2004-10-06	2008-04-22	Amr Technology, Inc.	Cyclosporin alkynes and their utility as pharmaceutical agents
US8022188B2 (en) *	2006-04-24	2011-09-20	Abbott Laboratories	Immunosuppressant binding antibodies and methods of obtaining and using same
US7883855B2 (en) *	2006-07-21	2011-02-08	Abbott Laboratories	Immunosuppressant drug extraction reagent for immunoassays
WO2008069917A2 (en)	2006-11-20	2008-06-12	Scynexis, Inc.	Novel cyclic peptides
WO2008082982A1 (en) *	2006-12-29	2008-07-10	Abbott Laboratories	Improved assay for immunosuppressant drugs
CA2672972C (en) *	2006-12-29	2015-06-23	Abbott Laboratories	Diagnostic test for the detection of a molecule or drug in whole blood
EP2118657B1 (de) *	2006-12-29	2014-05-21	Abbott Laboratories	Nichtdenaturierendes lysereagens zur verwendung mit einem capture-in-solution-immunoassay
US7914999B2 (en) *	2006-12-29	2011-03-29	Abbott Laboratories	Non-denaturing lysis reagent
JP5174898B2 (ja)	2007-05-24	2013-04-03	アボット・ラボラトリーズ	疎水性薬物検体代謝産物との交差反応性が低下している免疫アッセイ
JP5134692B2 (ja) *	2007-12-19	2013-01-30	アボット・ラボラトリーズ	免疫アッセイのための免疫抑制剤薬剤抽出試薬
US20090170218A1 (en) *	2008-01-02	2009-07-02	Dade Behring Inc.	Methods for detection of cyclosporin a
CN110320364B (zh) *	2018-03-30	2023-03-31	洛阳普泰生物技术有限公司	一种双抗夹心胶体金检测试剂盒、及其制备方法与应用
KR20230009394A (ko)	2020-04-17	2023-01-17	아이덱스 래보러토리즈, 인코포레이티드	형광 소광 면역검정
JP7755932B2 (ja)	2021-01-08	2025-10-17	ＴｉａｎｍａＪａｐａｎ株式会社	蛍光偏光免疫分析用支持体、蛍光偏光免疫分析用キットおよび蛍光偏光免疫分析法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1023287A (en) *	1972-12-08	1977-12-27	Boehringer Mannheim G.M.B.H.	Process for the preparation of carrier-bound proteins
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds
DE2819094A1 (de) *	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
US5169773A (en) *	1984-10-04	1992-12-08	Sandoz Ltd.	Monoclonal antibodies to cyclosporins
EP0314862A1 (de) *	1984-10-04	1989-05-10	Sandoz Ag	Immunogenische Konjugate, die Cyclosporine enthalten
US4727035A (en) *	1984-11-14	1988-02-23	Mahoney Walter C	Immunoassay for cyclosporin
US5124457A (en) *	1986-05-21	1992-06-23	Abbott Laboratories	Phencyclidine and phencyclidine metabolites assay, tracers, immunogens and antibodies
US4939264A (en) *	1986-07-14	1990-07-03	Abbott Laboratories	Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies
US5239057A (en) *	1987-03-27	1993-08-24	Abbott Laboratories	Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
EP0283801A3 (de) *	1987-03-27	1990-05-30	Abbott Laboratories	Fluoreszenz-Polarisations-Test für Cyclosporin A und Metaboliten und verwandte Immunogene und Antikörper
US5427960A (en) *	1987-03-27	1995-06-27	Abbott Laboratories	Fluorescence polarization assay for cyclosporin A and metabolites and related immunogens and antibodies
EP0329184A3 (de) *	1988-02-19	1990-05-23	Neorx Corporation	Antimere und antimere Konjugation

1991
- 1991-08-08 AT AT91113328T patent/ATE132504T1/de not_active IP Right Cessation
- 1991-08-08 EP EP91113328A patent/EP0473961B1/de not_active Expired - Lifetime
- 1991-08-08 DE DE69116034T patent/DE69116034T2/de not_active Expired - Fee Related
- 1991-08-08 DK DK91113328.8T patent/DK0473961T3/da active
- 1991-08-08 ES ES91113328T patent/ES2084069T3/es not_active Expired - Lifetime
- 1991-08-13 CA CA002049089A patent/CA2049089C/en not_active Expired - Fee Related
- 1991-08-14 AU AU82471/91A patent/AU642035B2/en not_active Ceased
- 1991-08-15 JP JP20523391A patent/JP3171460B2/ja not_active Expired - Fee Related
1993
- 1993-11-04 US US08/148,164 patent/US5489668A/en not_active Expired - Lifetime
1995
- 1995-05-04 US US08/433,104 patent/US5750413A/en not_active Expired - Lifetime
1996
- 1996-04-02 GR GR960400900T patent/GR3019512T3/el unknown

Also Published As

Publication number	Publication date
AU642035B2 (en)	1993-10-07
DK0473961T3 (da)	1996-07-01
CA2049089A1 (en)	1992-02-16
EP0473961A3 (en)	1993-04-14
EP0473961B1 (de)	1996-01-03
US5750413A (en)	1998-05-12
GR3019512T3 (en)	1996-07-31
JP3171460B2 (ja)	2001-05-28
DE69116034T2 (de)	1996-06-20
AU8247191A (en)	1992-02-20
EP0473961A2 (de)	1992-03-11
DE69116034D1 (de)	1996-02-15
US5489668A (en)	1996-02-06
CA2049089C (en)	2002-09-03
ES2084069T3 (es)	1996-05-01
JPH04253999A (ja)	1992-09-09

Legal Events

Date	Code	Title	Description
1996-08-15	UEP	Publication of translation of european patent specification
2006-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE132504T1 (de)	1996-01-15	Immunotestreagenzien und verfahren zur bestimmung von cyclosporin
DK261386A (da)	1986-06-03	Monoklonale antistoffer
ES2091301T3 (es)	1996-11-01	Inmunoensayo de ciclosporina.
DE68907372D1 (de)	1993-08-05	Diagnostischer satz und verfahren zur schnellen bestimmung von antikoerpern.
EP0284587A3 (de)	1990-11-22	Synthetische Peptid-Antigene für den Nachweis von HIV-1-Infektionen
NO901899L (no)	1990-04-27	Hiv-peptider, syntetiske hiv-antigener og immunoanalysekit
Elphick et al.	1991	Isolation of the neuropeptide SALMFamide-1 from starfish using a new antiserum
EP0869177A3 (de)	1999-10-20	Menschliche Typ-A und Typ-B Blutplättchen abstammenden Wachstumfaktor Rezeptoren
DE4430973A1 (de)	1996-02-01	Hapten-markierte Peptide
CA2001206A1 (en)	1990-05-18	Substrate composition for alkaline phosphatase and method for assay using same
KR880014376A (ko)	1988-12-23	Hiv 특이 항원 영역의 모노클로날 항체 및 그 용법
ATE116660T1 (de)	1995-01-15	Künstliche peptid-zusammensetzungen mit immunoreaktiven antikörpern von htlv-1.
CA2100586A1 (en)	1992-08-09	Htlv-i and htlv-ii peptide antigens and methods
EP0009147B1 (de)	1982-10-06	Verfahren zur enzym-immunologischen Bestimmung von Pankreas-Glucagon und dafür verwendbares Peptid-Enzym-Konjugat
EP0832689A3 (de)	1998-10-14	Kit zur Sammlung von Proben
FI891872A0 (fi)	1989-04-19	Nya peptider och anvaendning daerav.
BR9508748A (pt)	1997-08-12	Peptídeo uso do mesmo anticorpos linhagens de células linhagem de célula de hibridoma composição farmacêutica vacina contraceptiva processo para detectar anticorpos auto-imunes no soro de um paciente estojo de teste e reagente diagnóstico
ES2256862T3 (es)	2006-07-16	Conjugados hapteno-peptido mejorados para detectar anticuerpos anti-vih-1 o anti-vih-2.
Brann	1988	Response: Expression of Transducin in Retinal Rod Photoreceptor Outer Segments
EP0642023A4 (de)	1997-05-14	Reagens und verfahren zur testung auf hepatitis c.
NO924226L (no)	1992-12-08	Proteinnukleinsyreprober og immunoanalyser som anvender disse