ATE423788T1 - Neues tgf-beta-ahnliches cytokin - Google Patents

Neues tgf-beta-ahnliches cytokin

Info

Publication number: ATE423788T1
Authority: AT; Austria
Prior art keywords: cytokine; beta; new tgf; pcl13; tgf
Prior art date: 1995-06-22

Application number

AT96918521T

Other languages

English (en)

Inventor

Samuel Breit

Michelle Bootcov

Original Assignee

St Vincents Hosp Sydney

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-22

Filing date

1996-06-24

Publication date

2009-03-15

1995-06-22 Priority claimed from AUPN3706A external-priority patent/AUPN370695A0/en

1995-08-23 Priority claimed from AUPN4990A external-priority patent/AUPN499095A0/en

1996-02-09 Priority claimed from AUPN7983A external-priority patent/AUPN798396A0/en

1996-06-24 Application filed by St Vincents Hosp Sydney filed Critical St Vincents Hosp Sydney

2009-03-15 Application granted granted Critical

2009-03-15 Publication of ATE423788T1 publication Critical patent/ATE423788T1/de

Links

102000004127 Cytokines Human genes 0.000 title abstract 2
108090000695 Cytokines Proteins 0.000 title abstract 2
239000012634 fragment Substances 0.000 abstract 2
102000040430 polynucleotide Human genes 0.000 abstract 2
108091033319 polynucleotide Proteins 0.000 abstract 2
239000002157 polynucleotide Substances 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Orthopedic Medicine & Surgery (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT96918521T 1995-06-22 1996-06-24 Neues tgf-beta-ahnliches cytokin ATE423788T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
AUPN3706A AUPN370695A0 (en)	1995-06-22	1995-06-22	Novel cytokine
AUPN4990A AUPN499095A0 (en)	1995-08-23	1995-08-23	Novel cytokine
AUPN7983A AUPN798396A0 (en)	1996-02-09	1996-02-09	Novel cytokine

Publications (1)

Publication Number	Publication Date
ATE423788T1 true ATE423788T1 (de)	2009-03-15

Family

ID=27157870

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96918521T ATE423788T1 (de)	1995-06-22	1996-06-24	Neues tgf-beta-ahnliches cytokin

Country Status (7)

Country	Link
EP (1)	EP0833912B1 (de)
AT (1)	ATE423788T1 (de)
CA (1)	CA2225377C (de)
DE (1)	DE69637844D1 (de)
ES (1)	ES2324433T3 (de)
NZ (1)	NZ310370A (de)
WO (1)	WO1997000958A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6180602B1 (en)	1992-08-04	2001-01-30	Sagami Chemical Research Center	Human novel cDNA, TGF-beta superfamily protein encoded thereby and the use of immunosuppressive agent
US5994102A (en) *	1994-12-15	1999-11-30	Human Genome Sciences, Inc.	Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides
US6521227B1 (en)	1999-11-18	2003-02-18	Peter L. Hudson	Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides
US6524802B1 (en)	1996-03-29	2003-02-25	The Johns Hopkins University School Of Medicine	Methods of detecting growth differentiation factor-14
CA2265444C (en) *	1996-09-11	2008-11-18	Ortho-Mcneil Pharmaceutical, Inc.	Tnf-beta-like protein for treating prostate cancer, and related nucleic acid molecules, pharmaceutical compositions and methods
US6465181B2 (en) *	1999-03-25	2002-10-15	Abbott Laboratories	Reagents and methods useful for detecting diseases of the prostate
CA2372119A1 (en) *	1999-05-17	2000-11-23	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Und Zum Vertrie B Von Pharmaka Mbh	Neuroprotective properties of gdf-15, a novel member of the tgf-.beta. superfamily
CA2405680C (en)	2000-04-20	2018-02-13	St. Vincent's Hospital Sydney Limited	Diagnostic assay and method of treatment involving macrophage inhibitory cytokine -1 (mic-1)
SE0002364D0 (sv) *	2000-06-22	2000-06-22	Pharmacia & Upjohn Ab	Growth Factors
US7141661B2 (en)	2000-09-08	2006-11-28	The United States Of America As Represented By The Department Of Health And Human Services	Non-steroidal anti-inflammatory drug activated gene with anti-tumorigenic properties
US7919084B2 (en)	2002-06-17	2011-04-05	St. Vincent's Hospital Sydney Limited	Methods of diagnosis, prognosis and treatment of cardiovascular disease
CA2390820A1 (en)	2002-06-17	2003-12-17	St. Vincent's Hospital Sydney Limited	Methods of diagnosis, prognosis and treatment of cardiovascular disease
AU2005205595A1 (en) *	2004-01-14	2005-07-28	Janssen Pharmaceutica N.V.	Methods of using peroxisome proliferator-activated receptor alpha target genes
DK2441466T3 (da)	2004-04-13	2014-10-27	St Vincents Hosp Sydney	MIC-1-inhiberende middel
WO2005116052A2 (en)	2004-04-27	2005-12-08	Research Development Foundation	ANTAGONISM OF TGF-β SUPERFAMILY RECEPTOR SIGNALING
US20070237713A1 (en)	2006-04-04	2007-10-11	Fan Rong A	PCan065 Antibody Compositions and Methods of Use
CA2740632A1 (en)	2008-10-31	2010-05-06	St. Vincent's Hospital Sydney Limited	Methods of prognosis in chronic kidney disease
US20110002897A1 (en)	2009-06-11	2011-01-06	Burnham Institute For Medical Research	Directed differentiation of stem cells
JP6254146B2 (ja)	2012-03-27	2017-12-27	エヌジーエムバイオファーマシューティカルス，インコーポレーテッド	代謝障害を治療するための組成物および方法
ES3066738T3 (en)	2012-12-21	2026-05-14	Aveo Pharmaceuticals Inc	Anti-gdf15 antibodies
US9161966B2 (en)	2013-01-30	2015-10-20	Ngm Biopharmaceuticals, Inc.	GDF15 mutein polypeptides
CA2899170C (en)	2013-01-30	2022-08-02	Ngm Biopharmaceuticals, Inc.	Compositions and methods of use in treating metabolic disorders
JP6910800B2 (ja)	2014-06-20	2021-07-28	アベオファーマシューティカルズ，インコーポレイテッド	Ｇｄｆ１５調節剤を用いたうっ血性心不全及びその他の心機能不全の治療
US10588980B2 (en)	2014-06-23	2020-03-17	Novartis Ag	Fatty acids and their use in conjugation to biomolecules
JP6704358B2 (ja)	2014-07-30	2020-06-03	エヌジーエムバイオファーマシューティカルズインコーポレイテッド	代謝障害を治療するための組成物および使用方法
CN106687128B (zh)	2014-10-31	2022-05-10	Ngm生物制药有限公司	用于治疗代谢病症的组合物和方法
US20190000923A1 (en)	2015-12-22	2019-01-03	Novartis Ag	Methods of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)
CN117986363A (zh)	2016-03-31	2024-05-07	恩格姆生物制药公司	结合蛋白及其使用方法
EP3551214B1 (de)	2016-12-06	2024-03-13	St Vincent's Hospital Sydney Limited	Behandlung von fettleibigkeit und essstörungen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994003599A1 (fr) *	1992-08-04	1994-02-17	Sagami Chemical Research Center	ADNc HUMAIN ET PROTEINE POUR LAQUELLE CODE CET ADNc
EP0679716A4 (de) *	1993-11-12	1999-06-09	Kenichi Matsubara	Genetische Signaturen.
JPH07250688A (ja) *	1994-01-28	1995-10-03	Sagami Chem Res Center	ＴＧＦ−βスーパーファミリー蛋白質をコードするヒト新規ｃＤＮＡ
JPH07258293A (ja) *	1994-03-23	1995-10-09	Asahi Chem Ind Co Ltd	新規な蛋白質ならびにその製造方法
AU1830195A (en) *	1994-12-15	1996-07-03	Human Genome Sciences, Inc.	Prostatic growth factor
US6524802B1 (en) *	1996-03-29	2003-02-25	The Johns Hopkins University School Of Medicine	Methods of detecting growth differentiation factor-14

1996
- 1996-06-24 AT AT96918521T patent/ATE423788T1/de active
- 1996-06-24 NZ NZ310370A patent/NZ310370A/en not_active IP Right Cessation
- 1996-06-24 DE DE69637844T patent/DE69637844D1/de not_active Expired - Lifetime
- 1996-06-24 WO PCT/AU1996/000386 patent/WO1997000958A1/en not_active Ceased
- 1996-06-24 ES ES96918521T patent/ES2324433T3/es not_active Expired - Lifetime
- 1996-06-24 EP EP96918521A patent/EP0833912B1/de not_active Expired - Lifetime
- 1996-06-24 CA CA2225377A patent/CA2225377C/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0833912A1 (de)	1998-04-08
EP0833912B1 (de)	2009-02-25
WO1997000958A1 (en)	1997-01-09
DE69637844D1 (de)	2009-04-09
NZ310370A (en)	2001-04-27
CA2225377C (en)	2013-08-13
EP0833912A4 (de)	2002-10-02
CA2225377A1 (en)	1997-01-09
ES2324433T3 (es)	2009-08-06

Legal Events

Date

Code

Title

Description

2009-11-15

UEP

Publication of translation of european patent specification

Ref document number: 0833912

Country of ref document: EP

Publication	Publication Date	Title
DE69637844D1 (de)	2009-04-09	Neues tgf-beta-ahnliches cytokin
ATE341627T1 (de)	2006-10-15	Als lerk6 bezeichnetes cytokin
EP1019365A4 (de)	2001-01-17	Zubereitungen zur abgabe von negativ geladenen molekülen
DE69729877D1 (de)	2004-08-19	Mycophenol bisphosponatverbindungen
BR9306683A (pt)	1998-12-08	Adesivo proteináceo curado com aldeído
ATE140968T1 (de)	1996-08-15	Kultur des wachstumsfaktors der vaskularen endothelialzellen und dns, die dafür kodiert
DK0409472T3 (da)	1995-01-16	Knoglemorfogenetisk protein
ATE481480T1 (de)	2010-10-15	Methoden und zusammensetzungen zur herstellung von polypeptiden
MXPA02004666A (es)	2003-06-24	Gelatinas recombinantes.
DE69731285D1 (de)	2004-11-25	Langwellig fluorezierende proteine
NO960767L (no)	1996-04-26	Protocadherinproteiner og deres anvendelse
GR890100846A (el)	1991-03-15	Μεθοδος μετατροπης κυτταρικης διαφοροποιησης και λειτουργιας καισυνθεσεις της.
HUT77049A (hu)	1998-03-02	Katepszin-02-fehérjék, -nukleinsavak és -ellenanyagok
EA200000196A1 (ru)	2000-10-30	Универсальная плазма крови
FI962247L (fi)	1996-07-22	Uudet apoptoosia muuntavat proteiinit, niitä koodaava DNA ja näiden käyttömenetelmät
ATE288480T1 (de)	2005-02-15	Chondrogene in vitro induktion von menschlichen mensenchymalen stammzellen
DE59410132D1 (de)	2002-07-11	Humanes zirkulierendes cytokin cc-1
PT1290160E (pt)	2006-07-31	Polipeptideos pellino humanos
DK0785716T3 (da)	2007-04-02	Cytokin betegnet LERK-6
DE50009838D1 (de)	2005-04-28	Humanes antibiotisches protein
ATE341339T1 (de)	2006-10-15	Zusammensetzungen von rekombinanten papillomavirus vakzinen
DK0939769T3 (da)	2006-03-13	Vertebrat-Smoothened-proteiner
KR950700988A (ko)	1995-02-20	미생물, 이들의 제조방법 및 이들의 사용(Micro-organisms, preparation method therefor and uses thereof)
DK0952982T3 (da)	2004-03-29	Hidtil ukendte hepatitis B inhibitorer
WO2001064840A8 (en)	2002-03-21	Novel bone marrow nucleic acids and polypeptides