ATE423788T1 - Neues tgf-beta-ahnliches cytokin - Google Patents

Neues tgf-beta-ahnliches cytokin

Info

Publication number: ATE423788T1
Authority: AT; Austria
Prior art keywords: cytokine; beta; new tgf; pcl13; tgf
Prior art date: 1995-06-22

Application number

AT96918521T

Other languages

English (en)

Inventor

Samuel Breit

Michelle Bootcov

Original Assignee

St Vincents Hosp Sydney

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-22

Filing date

1996-06-24

Publication date

2009-03-15

1995-06-22 Priority claimed from AUPN3706A external-priority patent/AUPN370695A0/en

1995-08-23 Priority claimed from AUPN4990A external-priority patent/AUPN499095A0/en

1996-02-09 Priority claimed from AUPN7983A external-priority patent/AUPN798396A0/en

1996-06-24 Application filed by St Vincents Hosp Sydney filed Critical St Vincents Hosp Sydney

2009-03-15 Application granted granted Critical

2009-03-15 Publication of ATE423788T1 publication Critical patent/ATE423788T1/de

Links

102000004127 Cytokines Human genes 0.000 title abstract 2
108090000695 Cytokines Proteins 0.000 title abstract 2
239000012634 fragment Substances 0.000 abstract 2
102000040430 polynucleotide Human genes 0.000 abstract 2
108091033319 polynucleotide Proteins 0.000 abstract 2
239000002157 polynucleotide Substances 0.000 abstract 2
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Orthopedic Medicine & Surgery (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT96918521T 1995-06-22 1996-06-24 Neues tgf-beta-ahnliches cytokin ATE423788T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
AUPN3706A AUPN370695A0 (en)	1995-06-22	1995-06-22	Novel cytokine
AUPN4990A AUPN499095A0 (en)	1995-08-23	1995-08-23	Novel cytokine
AUPN7983A AUPN798396A0 (en)	1996-02-09	1996-02-09	Novel cytokine

Publications (1)

Publication Number	Publication Date
ATE423788T1 true ATE423788T1 (de)	2009-03-15

Family

ID=27157870

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96918521T ATE423788T1 (de)	1995-06-22	1996-06-24	Neues tgf-beta-ahnliches cytokin

Country Status (7)

Country	Link
EP (1)	EP0833912B1 (de)
AT (1)	ATE423788T1 (de)
CA (1)	CA2225377C (de)
DE (1)	DE69637844D1 (de)
ES (1)	ES2324433T3 (de)
NZ (1)	NZ310370A (de)
WO (1)	WO1997000958A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6180602B1 (en)	1992-08-04	2001-01-30	Sagami Chemical Research Center	Human novel cDNA, TGF-beta superfamily protein encoded thereby and the use of immunosuppressive agent
US5994102A (en) *	1994-12-15	1999-11-30	Human Genome Sciences, Inc.	Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides
US6521227B1 (en)	1999-11-18	2003-02-18	Peter L. Hudson	Polynucleotides encoding prostatic growth factor and process for producing prostatic growth factor polypeptides
US6524802B1 (en)	1996-03-29	2003-02-25	The Johns Hopkins University School Of Medicine	Methods of detecting growth differentiation factor-14
NZ334592A (en) *	1996-09-11	2000-10-27	Ortho Mcneil Pharm Inc	Protein growth factor related to TNF-beta and coupled with a toxic moiety for use in treating prostate cancer
US6465181B2 (en) *	1999-03-25	2002-10-15	Abbott Laboratories	Reagents and methods useful for detecting diseases of the prostate
WO2000070051A1 (en) *	1999-05-17	2000-11-23	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Und Zum Vertrieb Von Pharmaka Mbh	NEUROPROTECTIVE PROPERTIES OF GDF-15, A NOVEL MEMBER OF THE TGF-β SUPERFAMILY
ES2300325T3 (es) *	2000-04-20	2008-06-16	St Vincent's Hospital Sydney Limited	Ensayo diagnostico que implica la citoquina 1 inhibitoria de macrofagos (mc1).
SE0002364D0 (sv) *	2000-06-22	2000-06-22	Pharmacia & Upjohn Ab	Growth Factors
US7141661B2 (en)	2000-09-08	2006-11-28	The United States Of America As Represented By The Department Of Health And Human Services	Non-steroidal anti-inflammatory drug activated gene with anti-tumorigenic properties
US7919084B2 (en)	2002-06-17	2011-04-05	St. Vincent's Hospital Sydney Limited	Methods of diagnosis, prognosis and treatment of cardiovascular disease
CA2390820A1 (en)	2002-06-17	2003-12-17	St. Vincent's Hospital Sydney Limited	Methods of diagnosis, prognosis and treatment of cardiovascular disease
WO2005068663A2 (en) *	2004-01-14	2005-07-28	Janssen Pharmaceutica Nv	Methods of using peroxisome proliferator-activated receptor alpha target genes
PT2441466E (pt)	2004-04-13	2014-09-09	St Vincents Hosp Sydney	Agente de inibição de mic-1
EP1740609A2 (de)	2004-04-27	2007-01-10	Research Development Foundation	Antagonismus des tgf-beta superfamily signal rezeptors
US20070237713A1 (en)	2006-04-04	2007-10-11	Fan Rong A	PCan065 Antibody Compositions and Methods of Use
CN102203619B (zh)	2008-10-31	2015-12-16	圣文森特医院悉尼有限公司	慢性肾病中的预测方法
WO2010144696A1 (en)	2009-06-11	2010-12-16	Burnham Institute For Medical Research	Directed differentiation of stem cells
JP6254146B2 (ja)	2012-03-27	2017-12-27	エヌジーエムバイオファーマシューティカルス，インコーポレーテッド	代謝障害を治療するための組成物および方法
MX370720B (es)	2012-12-21	2019-12-20	Aveo Pharmaceuticals Inc	Anticuerpos anti-gdf15.
US9161966B2 (en)	2013-01-30	2015-10-20	Ngm Biopharmaceuticals, Inc.	GDF15 mutein polypeptides
KR101993714B1 (ko)	2013-01-30	2019-06-28	엔지엠 바이오파마슈티컬스, 아이엔씨.	대사 장애를 치료하는데 이용하기 위한 조성물과 방법
US10588980B2 (en)	2014-06-23	2020-03-17	Novartis Ag	Fatty acids and their use in conjugation to biomolecules
UA123432C2 (uk)	2014-07-30	2021-04-07	Нджм Біофармасьютікалз, Інк.	Димер та спосіб його застосування для лікування метаболічних розладів
MD20170035A2 (ro)	2014-10-31	2017-09-30	Ngm Biopharmaceuticals Inc	Compoziţii şi metode de utilizare pentru tratamentul tulburărilor metabolice
WO2017109706A1 (en)	2015-12-22	2017-06-29	Novartis Ag	Methods of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)
CN117986363A (zh)	2016-03-31	2024-05-07	恩格姆生物制药公司	结合蛋白及其使用方法
US20200069774A1 (en)	2016-12-06	2020-03-05	St Vincent's Hospital Sydney Limited	Treatment of obesity and eating disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994003599A1 (fr) *	1992-08-04	1994-02-17	Sagami Chemical Research Center	ADNc HUMAIN ET PROTEINE POUR LAQUELLE CODE CET ADNc
AU8116494A (en) *	1993-11-12	1995-06-13	Kenichi Matsubara	Gene signature
JPH07250688A (ja) *	1994-01-28	1995-10-03	Sagami Chem Res Center	ＴＧＦ−βスーパーファミリー蛋白質をコードするヒト新規ｃＤＮＡ
JPH07258293A (ja) *	1994-03-23	1995-10-09	Asahi Chem Ind Co Ltd	新規な蛋白質ならびにその製造方法
AU1830195A (en) *	1994-12-15	1996-07-03	Human Genome Sciences, Inc.	Prostatic growth factor
US6524802B1 (en) *	1996-03-29	2003-02-25	The Johns Hopkins University School Of Medicine	Methods of detecting growth differentiation factor-14

1996
- 1996-06-24 DE DE69637844T patent/DE69637844D1/de not_active Expired - Lifetime
- 1996-06-24 NZ NZ310370A patent/NZ310370A/en not_active IP Right Cessation
- 1996-06-24 WO PCT/AU1996/000386 patent/WO1997000958A1/en not_active Ceased
- 1996-06-24 ES ES96918521T patent/ES2324433T3/es not_active Expired - Lifetime
- 1996-06-24 EP EP96918521A patent/EP0833912B1/de not_active Expired - Lifetime
- 1996-06-24 CA CA2225377A patent/CA2225377C/en not_active Expired - Lifetime
- 1996-06-24 AT AT96918521T patent/ATE423788T1/de active

Also Published As

Publication number	Publication date
CA2225377C (en)	2013-08-13
EP0833912A1 (de)	1998-04-08
ES2324433T3 (es)	2009-08-06
EP0833912B1 (de)	2009-02-25
WO1997000958A1 (en)	1997-01-09
CA2225377A1 (en)	1997-01-09
DE69637844D1 (de)	2009-04-09
NZ310370A (en)	2001-04-27
EP0833912A4 (de)	2002-10-02

Legal Events

Date

Code

Title

Description

2009-11-15

UEP

Publication of translation of european patent specification

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Publication	Publication Date	Title
ATE423788T1 (de)	2009-03-15	Neues tgf-beta-ahnliches cytokin
DK1009832T3 (da)	2007-02-12	Cytokin betegnet LERK-6
EP1019365A4 (de)	2001-01-17	Zubereitungen zur abgabe von negativ geladenen molekülen
ATE271058T1 (de)	2004-07-15	Mycophenol bisphosponatverbindungen
BR9306683A (pt)	1998-12-08	Adesivo proteináceo curado com aldeído
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ATE114169T1 (de)	1994-12-15	Morphogenetisches knochenprotein.
ES2101499T3 (es)	1997-07-01	Fibras.
MXPA02004666A (es)	2003-06-24	Gelatinas recombinantes.
DE69731285D1 (de)	2004-11-25	Langwellig fluorezierende proteine
EA199801031A1 (ru)	1999-06-24	Ингибиторы протеинфарнезилтрансферазы
NO960767L (no)	1996-04-26	Protocadherinproteiner og deres anvendelse
HUT77049A (hu)	1998-03-02	Katepszin-02-fehérjék, -nukleinsavak és -ellenanyagok
FI962247A7 (fi)	1996-07-22	Uudet apoptoosia muuntavat proteiinit, niitä koodaava DNA ja näiden kä yttömenetelmät
DE59410132D1 (de)	2002-07-11	Humanes zirkulierendes cytokin cc-1
PT1290160E (pt)	2006-07-31	Polipeptideos pellino humanos
DK0785716T3 (da)	2007-04-02	Cytokin betegnet LERK-6
ATE291586T1 (de)	2005-04-15	Humanes antibiotisches protein
DK0939769T3 (da)	2006-03-13	Vertebrat-Smoothened-proteiner
EP0957936A4 (de)	2001-09-12	Zusammensetzungen von rekombinanten papillomavirus vakzinen
KR950700988A (ko)	1995-02-20	미생물, 이들의 제조방법 및 이들의 사용(Micro-organisms, preparation method therefor and uses thereof)
AU5163598A (en)	1998-05-22	Novel hepatitis b inhibitors
WO2001064840A8 (en)	2002-03-21	Novel bone marrow nucleic acids and polypeptides
ITMI931034A1 (it)	1994-11-21	Processo per la preparazione di proteine inibenti i ribosomi