ATE425164T1 - Tetrazyklische immunmodulierende verbindungen - Google Patents
Tetrazyklische immunmodulierende verbindungenInfo
- Publication number
- ATE425164T1 ATE425164T1 AT03781198T AT03781198T ATE425164T1 AT E425164 T1 ATE425164 T1 AT E425164T1 AT 03781198 T AT03781198 T AT 03781198T AT 03781198 T AT03781198 T AT 03781198T AT E425164 T1 ATE425164 T1 AT E425164T1
- Authority
- AT
- Austria
- Prior art keywords
- tetracyclic
- methods
- heterocyclic compounds
- relates
- present
- Prior art date
Links
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 abstract 2
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43358002P | 2002-12-16 | 2002-12-16 | |
| SE0203722A SE0203722D0 (sv) | 2002-12-16 | 2002-12-16 | Tetracyclic Immunomodulatory Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE425164T1 true ATE425164T1 (de) | 2009-03-15 |
Family
ID=32599440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03781198T ATE425164T1 (de) | 2002-12-16 | 2003-12-12 | Tetrazyklische immunmodulierende verbindungen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7674906B2 (de) |
| EP (1) | EP1572689B1 (de) |
| AT (1) | ATE425164T1 (de) |
| AU (1) | AU2003287129A1 (de) |
| DE (1) | DE60326639D1 (de) |
| WO (1) | WO2004055014A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0408365B8 (pt) | 2003-03-14 | 2021-05-25 | Avidex Ltd | compostos heterocíclicos de imunomodulação |
| GB0325644D0 (en) | 2003-11-04 | 2003-12-10 | Avidex Ltd | Immuno ihibitory pyrazolone compounds |
| CN1997645B (zh) | 2004-08-09 | 2012-05-23 | 麦迪金股份公司 | 免疫调节作为cd80抑制剂的氧代吡唑并噌啉类 |
| US7872002B2 (en) * | 2007-06-08 | 2011-01-18 | Helicon Therapeutics, Inc. | Therapeutic pyrazoloquinoline derivatives |
| WO2008154447A1 (en) * | 2007-06-08 | 2008-12-18 | Helicon Therapeutics, Inc. | Therapeutic pyrazolonaphthyridine derivatives |
| WO2008154442A1 (en) * | 2007-06-08 | 2008-12-18 | Helicon Therapeutics, Inc. | Therapeutic pyrazoloquinoline urea derivatives |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA895646B (en) * | 1988-08-09 | 1990-04-25 | Boots Co Plc | Therapeutic agents |
| EP0539372A1 (de) * | 1990-02-02 | 1993-05-05 | The Boots Company PLC | Therapeutische mittel |
| AR006520A1 (es) | 1996-03-20 | 1999-09-08 | Astra Pharma Prod | Derivados de 2-arilpirazolisoquinolina y cinolinona y procedimiento para su preparacion. |
| SE0102404D0 (sv) | 2001-07-04 | 2001-07-04 | Active Biotech Ab | Novel immunomodulating compounds |
| US6642249B2 (en) * | 2001-07-04 | 2003-11-04 | Active Biotech Ab | Immunomodulating compounds |
| WO2004048378A1 (en) * | 2002-11-22 | 2004-06-10 | Active Biotech Ab | Pyrazoloquinolines with immunomodulating activity |
-
2003
- 2003-12-12 EP EP03781198A patent/EP1572689B1/de not_active Expired - Lifetime
- 2003-12-12 WO PCT/SE2003/001941 patent/WO2004055014A1/en not_active Ceased
- 2003-12-12 DE DE60326639T patent/DE60326639D1/de not_active Expired - Lifetime
- 2003-12-12 AU AU2003287129A patent/AU2003287129A1/en not_active Abandoned
- 2003-12-12 AT AT03781198T patent/ATE425164T1/de not_active IP Right Cessation
- 2003-12-12 US US10/537,538 patent/US7674906B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1572689A1 (de) | 2005-09-14 |
| US7674906B2 (en) | 2010-03-09 |
| EP1572689B1 (de) | 2009-03-11 |
| AU2003287129A1 (en) | 2004-07-09 |
| US20060035919A1 (en) | 2006-02-16 |
| DE60326639D1 (de) | 2009-04-23 |
| WO2004055014A1 (en) | 2004-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |