ATE425259T1 - Nachweis von amplifizierten nukleinsäuresequenzen durch bifunktionelle haptenisierung und farbige mikropartikel - Google Patents
Nachweis von amplifizierten nukleinsäuresequenzen durch bifunktionelle haptenisierung und farbige mikropartikelInfo
- Publication number
- ATE425259T1 ATE425259T1 AT96924465T AT96924465T ATE425259T1 AT E425259 T1 ATE425259 T1 AT E425259T1 AT 96924465 T AT96924465 T AT 96924465T AT 96924465 T AT96924465 T AT 96924465T AT E425259 T1 ATE425259 T1 AT E425259T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- bifunctional
- acid sequences
- detection
- haptenization
- Prior art date
Links
- 150000007523 nucleic acids Chemical group 0.000 title abstract 4
- 230000001588 bifunctional effect Effects 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title abstract 2
- 239000011859 microparticle Substances 0.000 title 1
- 230000003321 amplification Effects 0.000 abstract 2
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 2
- 238000012216 screening Methods 0.000 abstract 2
- 108091093088 Amplicon Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000009395 genetic defect Effects 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 230000000007 visual effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US224595P | 1995-07-13 | 1995-07-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE425259T1 true ATE425259T1 (de) | 2009-03-15 |
Family
ID=21699886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96924465T ATE425259T1 (de) | 1995-07-13 | 1996-07-12 | Nachweis von amplifizierten nukleinsäuresequenzen durch bifunktionelle haptenisierung und farbige mikropartikel |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5989813A (de) |
| EP (1) | EP0837946B1 (de) |
| AT (1) | ATE425259T1 (de) |
| AU (1) | AU715857B2 (de) |
| CA (1) | CA2226721C (de) |
| DE (1) | DE69637864D1 (de) |
| WO (1) | WO1997003207A1 (de) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6153425A (en) * | 1995-07-13 | 2000-11-28 | Xtrana, Inc. | Self-contained device integrating nucleic acid extraction, amplification and detection |
| US5667994A (en) * | 1996-02-28 | 1997-09-16 | Becton, Dickinson And Company | Amplification and detection of mycobacterium avium complex species |
| US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| US6399334B1 (en) * | 1997-09-24 | 2002-06-04 | Invitrogen Corporation | Normalized nucleic acid libraries and methods of production thereof |
| JP2002509443A (ja) * | 1997-10-31 | 2002-03-26 | ジェン−プローブ・インコーポレーテッド | 核酸検出法 |
| FR2786786A1 (fr) * | 1998-12-07 | 2000-06-09 | Microdiag | Procede et kit pour l'amplification, la detection et/ou la quantification de populations de genomes |
| DK1218542T3 (da) * | 1999-09-13 | 2004-08-02 | Nugen Technologies Inc | Fremgangsmåder og sammensætninger til lineær isotermisk amplifikation af polynukleotidsekvenser |
| EP2351853A1 (de) | 2000-06-06 | 2011-08-03 | Life Technologies Corporation | Methode und Vorrichtungen für multiplex Amplifizierungsreaktionen |
| US6605451B1 (en) | 2000-06-06 | 2003-08-12 | Xtrana, Inc. | Methods and devices for multiplexing amplification reactions |
| US7846733B2 (en) | 2000-06-26 | 2010-12-07 | Nugen Technologies, Inc. | Methods and compositions for transcription-based nucleic acid amplification |
| US6706474B1 (en) * | 2000-06-27 | 2004-03-16 | Board Of Trustees Of The University Of Illinois | Nucleic acid enzyme biosensors for ions |
| US6803196B1 (en) | 2000-10-13 | 2004-10-12 | Affymetrix, Inc. | Methods and compositions for detecting signals in binding assays using microparticles |
| CA2430329A1 (en) | 2000-12-13 | 2002-06-20 | Nugen Technologies, Inc. | Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof |
| US7083951B2 (en) * | 2001-02-14 | 2006-08-01 | The Regents Of The University Of California | Flow cytometric detection method for DNA samples |
| MXPA02012739A (es) | 2001-03-09 | 2004-04-20 | Nugen Technologies Inc | Metodos y composiciones para amplificacion de secuencias de arn. |
| US6890719B2 (en) | 2002-05-10 | 2005-05-10 | The Board Of Trustess Of The University Of Illinois | Fluorescence based biosensor |
| US7534560B2 (en) * | 2002-05-10 | 2009-05-19 | The Board Of Trustees Of The University Of Illinois | Simple catalytic DNA biosensors for ions based on color changes |
| US7122384B2 (en) * | 2002-11-06 | 2006-10-17 | E. I. Du Pont De Nemours And Company | Resonant light scattering microparticle methods |
| US7612185B2 (en) * | 2003-03-07 | 2009-11-03 | The Board Of Trustees Of The University Of Illinois | Nucleic acid biosensors |
| US7402386B2 (en) | 2003-04-14 | 2008-07-22 | Nugen Technologies, Inc. | Global amplification using random priming by a composite primer |
| US7485419B2 (en) * | 2004-01-13 | 2009-02-03 | The Board Of Trustees Of The University Of Illinois | Biosensors based on directed assembly of particles |
| EP1737985B1 (de) * | 2004-04-07 | 2015-12-30 | Access Bio, Inc. | System für den nachweis von nukleinsäuren |
| US20060094026A1 (en) * | 2004-11-03 | 2006-05-04 | Yi Lu | Nucleic acid enzyme light-up sensor utilizing invasive DNA |
| US20060166222A1 (en) * | 2005-01-21 | 2006-07-27 | Yi Lu | Nucleic acid enzyme ligation sensor |
| US20090291508A1 (en) * | 2008-05-20 | 2009-11-26 | Rapid Pathogen Screening Inc. | Nanoparticles in diagnostic tests |
| US8669052B2 (en) | 2008-06-10 | 2014-03-11 | Rapid Pathogen Screening, Inc. | Lateral flow nucleic acid detector |
| US20070072205A1 (en) * | 2005-06-09 | 2007-03-29 | Yi Lu | Nanomaterial error correction |
| US7892734B2 (en) * | 2005-08-11 | 2011-02-22 | The Board Of Trustees Of The University Of Illinois | Aptamer based colorimetric sensor systems |
| CA2621267A1 (en) | 2005-09-07 | 2007-03-15 | Nugen Technologies, Inc. | Improved nucleic acid amplification procedure |
| ES2393758T3 (es) * | 2006-03-15 | 2012-12-27 | Micronics, Inc. | Ensayos integrados de ácidos nucleicos |
| US7799554B2 (en) * | 2006-03-16 | 2010-09-21 | The Board Of Trustees Of The University Of Illinois | Lateral flow devices |
| WO2007116298A2 (en) * | 2006-04-10 | 2007-10-18 | 3M Innovative Properties Company | Nucleic acid detection using lateral flow methods |
| US8980561B1 (en) | 2006-08-22 | 2015-03-17 | Los Alamos National Security, Llc. | Nucleic acid detection system and method for detecting influenza |
| US20090047673A1 (en) | 2006-08-22 | 2009-02-19 | Cary Robert B | Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
| WO2008032205A2 (en) * | 2006-09-12 | 2008-03-20 | 3M Innovative Properties Company | Nucleic acid detection using flow through methods |
| WO2008127410A2 (en) * | 2006-11-07 | 2008-10-23 | New York University | Holographic microfabrication and characterization system for soft matter and biological systems |
| WO2008076414A2 (en) * | 2006-12-15 | 2008-06-26 | New York University | Self-replicating materials |
| US8415461B2 (en) * | 2007-01-19 | 2013-04-09 | The Board Of Trustees Of The University Of Illinois | Amphiphilic substances and functionalized lipid vesicles including the same |
| US8058415B2 (en) | 2007-04-24 | 2011-11-15 | The Board Of Trustees Of The University Of Illinois | Aptamer- and nucleic acid enzyme-based systems for simultaneous detection of multiple analytes |
| WO2009012309A2 (en) * | 2007-07-16 | 2009-01-22 | The Board Of Trustees Of The University Of Illinois | Nucleic acid based fluorescent sensor for divalent copper ion detection |
| US8568690B2 (en) * | 2007-07-31 | 2013-10-29 | The Board Of Trustees Of The University Of Illinois | MRI contrast agents and high-throughput screening by MRI |
| US8367416B2 (en) | 2007-08-10 | 2013-02-05 | The Board Of Trustees Of The University Of Illinois | Nucleic acid based fluorescent sensor for mercury detection |
| JP5523327B2 (ja) | 2007-10-12 | 2014-06-18 | レオニックス，インコーポレイテッド | 統合型マイクロ流体デバイスおよび方法 |
| US8034568B2 (en) | 2008-02-12 | 2011-10-11 | Nugen Technologies, Inc. | Isothermal nucleic acid amplification methods and compositions |
| US8174742B2 (en) | 2008-03-14 | 2012-05-08 | New York University | System for applying optical forces from phase gradients |
| WO2009117698A2 (en) | 2008-03-21 | 2009-09-24 | Nugen Technologies, Inc. | Methods of rna amplification in the presence of dna |
| EP2279403B1 (de) | 2008-05-05 | 2016-03-16 | Los Alamos National Security, LLC | Höchst vereinfachte vorbereitung von nukleinsäureproben auf lateralflussbasis und passive strömungssteuerung |
| US9068981B2 (en) | 2009-12-04 | 2015-06-30 | Rapid Pathogen Screening, Inc. | Lateral flow assays with time delayed components |
| US8962260B2 (en) | 2008-05-20 | 2015-02-24 | Rapid Pathogen Screening, Inc. | Method and device for combined detection of viral and bacterial infections |
| US8815609B2 (en) | 2008-05-20 | 2014-08-26 | Rapid Pathogen Screening, Inc. | Multiplanar lateral flow assay with diverting zone |
| US20130196310A1 (en) | 2008-05-20 | 2013-08-01 | Rapid Pathogen Screening, Inc. | Method and Device for Combined Detection of Viral and Bacterial Infections |
| US8609433B2 (en) | 2009-12-04 | 2013-12-17 | Rapid Pathogen Screening, Inc. | Multiplanar lateral flow assay with sample compressor |
| US20100105039A1 (en) * | 2008-06-03 | 2010-04-29 | Yi Lu | Label-free colorimetric detection |
| US20110086359A1 (en) * | 2008-06-10 | 2011-04-14 | Rapid Pathogen Screening, Inc. | Lateral flow assays |
| US8062893B2 (en) | 2008-10-10 | 2011-11-22 | The Board Of Trustees Of The University Of Illinois | Fluorescent sensor for mercury |
| WO2010080691A1 (en) * | 2009-01-06 | 2010-07-15 | Qimin You | Cross priming amplification of target nucleic acids |
| CA2786569C (en) | 2010-01-29 | 2019-04-09 | Perkinelmer Health Sciences, Inc. | Sample-to-answer microfluidic cartridge |
| US8815156B2 (en) | 2010-07-19 | 2014-08-26 | Andalyze, Inc. | Sensor housing and reagent chemistry |
| CN103608467B (zh) | 2011-04-20 | 2017-07-21 | 美飒生物技术公司 | 用于核酸的振荡扩增反应 |
| WO2013175318A2 (en) * | 2012-05-23 | 2013-11-28 | King Abdullah University Of Science And Technology | Microbead agglutination based assays |
| JP6498125B2 (ja) | 2012-12-21 | 2019-04-10 | マイクロニクス， インコーポレイテッド | 流体回路および関連する製造方法 |
| CN104919035B (zh) | 2012-12-21 | 2017-08-11 | 精密公司 | 便携式荧光检测系统和微测定盒 |
| KR20150096788A (ko) | 2012-12-21 | 2015-08-25 | 마이크로닉스 인코포레이티드. | 마이크로 유체공학 용도를 위한 저탄성 막 |
| CA2911303C (en) | 2013-05-07 | 2021-02-16 | Micronics, Inc. | Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions |
| WO2014182844A1 (en) | 2013-05-07 | 2014-11-13 | Micronics, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
| EP2994543B1 (de) | 2013-05-07 | 2018-08-15 | Micronics, Inc. | Vorrichtung zur herstellung und analyse von nukleinsäuren |
| US9745633B2 (en) * | 2013-06-28 | 2017-08-29 | Diacarta Ltd | Detection of PNA clamping |
| US10465236B2 (en) | 2013-12-23 | 2019-11-05 | University Of Queensland | Nucleic acid detection method and kit |
| EP3286546B1 (de) | 2015-04-24 | 2023-07-19 | Mesa Biotech, Inc. | Fluidische testkassette |
| JP6752231B2 (ja) | 2015-06-01 | 2020-09-09 | カリフォルニア インスティテュート オブ テクノロジー | 抗原を用いて特異的集団に関してｔ細胞をスクリーニングするための組成物および方法 |
| US10808287B2 (en) | 2015-10-23 | 2020-10-20 | Rapid Pathogen Screening, Inc. | Methods and devices for accurate diagnosis of infections |
| WO2018165475A1 (en) | 2017-03-08 | 2018-09-13 | California Institute Of Technology | Pairing antigen specificity of a t cell with t cell receptor sequences |
| CN108490171A (zh) * | 2018-03-02 | 2018-09-04 | 北京库尔科技有限公司 | 一种高灵敏唾液抗体检测试剂盒 |
| WO2021231607A1 (en) * | 2020-05-12 | 2021-11-18 | Godx, Inc. | Point of need diagnostic device and methods of use thereof |
| KR102625074B1 (ko) * | 2021-04-20 | 2024-01-16 | 재단법인 아산사회복지재단 | 마이크로입자 기반 핵산 검출용 키트 및 핵산 증폭산물 검출 방법 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1219824A (en) * | 1981-04-17 | 1987-03-31 | David C. Ward | Modified nucleotides and methods of preparing and using same |
| US4687732A (en) * | 1983-06-10 | 1987-08-18 | Yale University | Visualization polymers and their application to diagnostic medicine |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| CA1323293C (en) * | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| DE3813278A1 (de) * | 1988-01-12 | 1989-07-20 | Boehringer Mannheim Gmbh | Verfahren zum nachweis von nukleinsaeuren |
| US5374524A (en) * | 1988-05-10 | 1994-12-20 | E. I. Du Pont De Nemours And Company | Solution sandwich hybridization, capture and detection of amplified nucleic acids |
| US5489507A (en) * | 1988-11-30 | 1996-02-06 | Perkin-Elmer Corporation | DNA detection by color complementation |
| IE67038B1 (en) * | 1988-12-22 | 1996-02-21 | Patrick Joseph Joyce | Immunodiagnostic assays for use in the detection and determination of mastitis |
| US5232829A (en) * | 1989-09-29 | 1993-08-03 | Hoffmann-La Roche Inc. | Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes |
| US5231015A (en) * | 1989-10-18 | 1993-07-27 | Eastman Kodak Company | Methods of extracting nucleic acids and pcr amplification without using a proteolytic enzyme |
| CA2031659A1 (en) * | 1990-01-26 | 1991-07-27 | John B. Findlay | Water-insoluble reagent, nucleic acid probe, test kit and diagnostic and purification methods |
| US5147777A (en) * | 1990-06-18 | 1992-09-15 | Eastman Kodak Company | Biologically active reagents prepared from carboxy-containing polymer, analytical element and methods of use |
| US5200315A (en) * | 1990-07-25 | 1993-04-06 | Eastman Kodak Company | Particulate biologically active reagent containing polyoxyalkylene side chains, analytical element and methods for use of the reagent |
| US5455166A (en) * | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5387510A (en) * | 1991-10-02 | 1995-02-07 | Eastman Kodak Company | Detection of amplified nucleic acid using secondary capture oligonucleotides and test kit |
| IL102486A (en) * | 1991-10-04 | 1997-11-20 | Orgenics Ltd | Method and apparatus for detection of nucleic acid sequences with a nucleic acid probe |
| US5541069A (en) * | 1992-02-28 | 1996-07-30 | Quidel Corporation | Assay having improved dose response curve |
| US5415839A (en) * | 1993-10-21 | 1995-05-16 | Abbott Laboratories | Apparatus and method for amplifying and detecting target nucleic acids |
-
1996
- 1996-06-17 US US08/664,863 patent/US5989813A/en not_active Expired - Lifetime
- 1996-07-12 DE DE69637864T patent/DE69637864D1/de not_active Expired - Lifetime
- 1996-07-12 WO PCT/US1996/011619 patent/WO1997003207A1/en not_active Ceased
- 1996-07-12 CA CA002226721A patent/CA2226721C/en not_active Expired - Fee Related
- 1996-07-12 AT AT96924465T patent/ATE425259T1/de not_active IP Right Cessation
- 1996-07-12 AU AU64906/96A patent/AU715857B2/en not_active Ceased
- 1996-07-12 EP EP96924465A patent/EP0837946B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU715857B2 (en) | 2000-02-10 |
| US5989813A (en) | 1999-11-23 |
| WO1997003207A1 (en) | 1997-01-30 |
| EP0837946B1 (de) | 2009-03-11 |
| DE69637864D1 (de) | 2009-04-23 |
| EP0837946A1 (de) | 1998-04-29 |
| AU6490696A (en) | 1997-02-10 |
| EP0837946A4 (de) | 2004-10-13 |
| CA2226721C (en) | 2008-09-23 |
| CA2226721A1 (en) | 1997-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |