ATE425259T1 - Nachweis von amplifizierten nukleinsäuresequenzen durch bifunktionelle haptenisierung und farbige mikropartikel - Google Patents
Nachweis von amplifizierten nukleinsäuresequenzen durch bifunktionelle haptenisierung und farbige mikropartikelInfo
- Publication number
- ATE425259T1 ATE425259T1 AT96924465T AT96924465T ATE425259T1 AT E425259 T1 ATE425259 T1 AT E425259T1 AT 96924465 T AT96924465 T AT 96924465T AT 96924465 T AT96924465 T AT 96924465T AT E425259 T1 ATE425259 T1 AT E425259T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- bifunctional
- acid sequences
- detection
- haptenization
- Prior art date
Links
- 150000007523 nucleic acids Chemical group 0.000 title abstract 4
- 230000001588 bifunctional effect Effects 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title abstract 2
- 239000011859 microparticle Substances 0.000 title 1
- 230000003321 amplification Effects 0.000 abstract 2
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 2
- 238000012216 screening Methods 0.000 abstract 2
- 108091093088 Amplicon Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000009395 genetic defect Effects 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 238000002372 labelling Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
- 230000000007 visual effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US224595P | 1995-07-13 | 1995-07-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE425259T1 true ATE425259T1 (de) | 2009-03-15 |
Family
ID=21699886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96924465T ATE425259T1 (de) | 1995-07-13 | 1996-07-12 | Nachweis von amplifizierten nukleinsäuresequenzen durch bifunktionelle haptenisierung und farbige mikropartikel |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5989813A (de) |
| EP (1) | EP0837946B1 (de) |
| AT (1) | ATE425259T1 (de) |
| AU (1) | AU715857B2 (de) |
| CA (1) | CA2226721C (de) |
| DE (1) | DE69637864D1 (de) |
| WO (1) | WO1997003207A1 (de) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6153425A (en) * | 1995-07-13 | 2000-11-28 | Xtrana, Inc. | Self-contained device integrating nucleic acid extraction, amplification and detection |
| US5667994A (en) * | 1996-02-28 | 1997-09-16 | Becton, Dickinson And Company | Amplification and detection of mycobacterium avium complex species |
| US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| US6399334B1 (en) * | 1997-09-24 | 2002-06-04 | Invitrogen Corporation | Normalized nucleic acid libraries and methods of production thereof |
| JP2002509443A (ja) * | 1997-10-31 | 2002-03-26 | ジェン−プローブ・インコーポレーテッド | 核酸検出法 |
| FR2786786A1 (fr) * | 1998-12-07 | 2000-06-09 | Microdiag | Procede et kit pour l'amplification, la detection et/ou la quantification de populations de genomes |
| CN1373812B (zh) * | 1999-09-13 | 2012-04-11 | 纽亘技术公司 | 用于多核苷酸序列线性等温扩增的方法及组合物 |
| EP2351853A1 (de) | 2000-06-06 | 2011-08-03 | Life Technologies Corporation | Methode und Vorrichtungen für multiplex Amplifizierungsreaktionen |
| US6605451B1 (en) | 2000-06-06 | 2003-08-12 | Xtrana, Inc. | Methods and devices for multiplexing amplification reactions |
| US7846733B2 (en) | 2000-06-26 | 2010-12-07 | Nugen Technologies, Inc. | Methods and compositions for transcription-based nucleic acid amplification |
| US6706474B1 (en) * | 2000-06-27 | 2004-03-16 | Board Of Trustees Of The University Of Illinois | Nucleic acid enzyme biosensors for ions |
| US6803196B1 (en) * | 2000-10-13 | 2004-10-12 | Affymetrix, Inc. | Methods and compositions for detecting signals in binding assays using microparticles |
| DE60142709D1 (de) | 2000-12-13 | 2010-09-09 | Nugen Technologies Inc | Methoden und zusammensetzungen zur generierung einer vielzahl von kopien von nukleinsäuresequenzen und methoden zur detektion derselben |
| US7083951B2 (en) * | 2001-02-14 | 2006-08-01 | The Regents Of The University Of California | Flow cytometric detection method for DNA samples |
| IL153504A0 (en) | 2001-03-09 | 2003-07-06 | Nugen Technologies Inc | Methods and compositions for amplification of rna sequences |
| US6890719B2 (en) | 2002-05-10 | 2005-05-10 | The Board Of Trustess Of The University Of Illinois | Fluorescence based biosensor |
| US7534560B2 (en) * | 2002-05-10 | 2009-05-19 | The Board Of Trustees Of The University Of Illinois | Simple catalytic DNA biosensors for ions based on color changes |
| US7122384B2 (en) * | 2002-11-06 | 2006-10-17 | E. I. Du Pont De Nemours And Company | Resonant light scattering microparticle methods |
| US7612185B2 (en) * | 2003-03-07 | 2009-11-03 | The Board Of Trustees Of The University Of Illinois | Nucleic acid biosensors |
| CA2521084A1 (en) | 2003-04-14 | 2004-10-28 | Nugen Technologies, Inc. | Global amplification using a randomly primed composite primer |
| US7485419B2 (en) * | 2004-01-13 | 2009-02-03 | The Board Of Trustees Of The University Of Illinois | Biosensors based on directed assembly of particles |
| CN105087777A (zh) * | 2004-04-07 | 2015-11-25 | 安克塞斯生物公司 | 核酸检测系统 |
| US20060094026A1 (en) * | 2004-11-03 | 2006-05-04 | Yi Lu | Nucleic acid enzyme light-up sensor utilizing invasive DNA |
| US20060166222A1 (en) * | 2005-01-21 | 2006-07-27 | Yi Lu | Nucleic acid enzyme ligation sensor |
| US8669052B2 (en) | 2008-06-10 | 2014-03-11 | Rapid Pathogen Screening, Inc. | Lateral flow nucleic acid detector |
| US20090291508A1 (en) * | 2008-05-20 | 2009-11-26 | Rapid Pathogen Screening Inc. | Nanoparticles in diagnostic tests |
| US20070072205A1 (en) * | 2005-06-09 | 2007-03-29 | Yi Lu | Nanomaterial error correction |
| US7892734B2 (en) * | 2005-08-11 | 2011-02-22 | The Board Of Trustees Of The University Of Illinois | Aptamer based colorimetric sensor systems |
| WO2007030759A2 (en) | 2005-09-07 | 2007-03-15 | Nugen Technologies, Inc. | Improved nucleic acid amplification procedure |
| AU2007225038B2 (en) * | 2006-03-15 | 2013-08-29 | Revvity Health Sciences, Inc. | Integrated nucleic acid assays |
| WO2007109500A1 (en) * | 2006-03-16 | 2007-09-27 | The Board Of Trustees Of The University Of Illinois | Lateral flow devices |
| AU2007235649A1 (en) * | 2006-04-10 | 2007-10-18 | 3M Innovative Properties Company | Nucleic acid detection using lateral flow methods |
| US8980561B1 (en) | 2006-08-22 | 2015-03-17 | Los Alamos National Security, Llc. | Nucleic acid detection system and method for detecting influenza |
| WO2008105814A2 (en) | 2006-08-22 | 2008-09-04 | Los Alamos National Security, Llc | Miniturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
| AU2007297164A1 (en) * | 2006-09-12 | 2008-03-20 | 3M Innovative Properties Company | Nucleic acid detection using flow through methods |
| WO2008127410A2 (en) * | 2006-11-07 | 2008-10-23 | New York University | Holographic microfabrication and characterization system for soft matter and biological systems |
| WO2008076414A2 (en) * | 2006-12-15 | 2008-06-26 | New York University | Self-replicating materials |
| US8415461B2 (en) * | 2007-01-19 | 2013-04-09 | The Board Of Trustees Of The University Of Illinois | Amphiphilic substances and functionalized lipid vesicles including the same |
| US8058415B2 (en) | 2007-04-24 | 2011-11-15 | The Board Of Trustees Of The University Of Illinois | Aptamer- and nucleic acid enzyme-based systems for simultaneous detection of multiple analytes |
| WO2009012309A2 (en) * | 2007-07-16 | 2009-01-22 | The Board Of Trustees Of The University Of Illinois | Nucleic acid based fluorescent sensor for divalent copper ion detection |
| US8568690B2 (en) * | 2007-07-31 | 2013-10-29 | The Board Of Trustees Of The University Of Illinois | MRI contrast agents and high-throughput screening by MRI |
| US8367416B2 (en) | 2007-08-10 | 2013-02-05 | The Board Of Trustees Of The University Of Illinois | Nucleic acid based fluorescent sensor for mercury detection |
| WO2009049268A1 (en) | 2007-10-12 | 2009-04-16 | Rheonix, Inc. | Integrated microfluidic device and methods |
| US20090203531A1 (en) | 2008-02-12 | 2009-08-13 | Nurith Kurn | Method for Archiving and Clonal Expansion |
| US8174742B2 (en) | 2008-03-14 | 2012-05-08 | New York University | System for applying optical forces from phase gradients |
| US7846666B2 (en) | 2008-03-21 | 2010-12-07 | Nugen Technologies, Inc. | Methods of RNA amplification in the presence of DNA |
| JP2011522521A (ja) | 2008-05-05 | 2011-08-04 | ロスアラモス ナショナル セキュリティ，エルエルシー | 高度に単純化された側方流動ベースの核酸サンプル調製および受動的流体流動制御 |
| US9068981B2 (en) | 2009-12-04 | 2015-06-30 | Rapid Pathogen Screening, Inc. | Lateral flow assays with time delayed components |
| US8815609B2 (en) | 2008-05-20 | 2014-08-26 | Rapid Pathogen Screening, Inc. | Multiplanar lateral flow assay with diverting zone |
| US20130196310A1 (en) | 2008-05-20 | 2013-08-01 | Rapid Pathogen Screening, Inc. | Method and Device for Combined Detection of Viral and Bacterial Infections |
| US8609433B2 (en) | 2009-12-04 | 2013-12-17 | Rapid Pathogen Screening, Inc. | Multiplanar lateral flow assay with sample compressor |
| US8962260B2 (en) | 2008-05-20 | 2015-02-24 | Rapid Pathogen Screening, Inc. | Method and device for combined detection of viral and bacterial infections |
| US20100105039A1 (en) * | 2008-06-03 | 2010-04-29 | Yi Lu | Label-free colorimetric detection |
| US20110086359A1 (en) | 2008-06-10 | 2011-04-14 | Rapid Pathogen Screening, Inc. | Lateral flow assays |
| US8062893B2 (en) | 2008-10-10 | 2011-11-22 | The Board Of Trustees Of The University Of Illinois | Fluorescent sensor for mercury |
| JP2012514461A (ja) * | 2009-01-06 | 2012-06-28 | ヨウ，キミン | 標的核酸の交差プライミング増幅 |
| EP2528687B1 (de) | 2010-01-29 | 2018-08-22 | Micronics, Inc. | System beinhaltend ein wirtinstrument und eine mikrofluidische kartusche für untersuchungen |
| US8815156B2 (en) | 2010-07-19 | 2014-08-26 | Andalyze, Inc. | Sensor housing and reagent chemistry |
| CA2856304C (en) | 2011-04-20 | 2017-05-16 | Mesa Tech International, Inc. | Oscillating amplification reaction for nucleic acids |
| EP2852841B1 (de) * | 2012-05-23 | 2017-10-11 | King Abdullah University Of Science And Technology | Mikrokügelchenagglutinierungs-assays |
| JP6498125B2 (ja) | 2012-12-21 | 2019-04-10 | マイクロニクス， インコーポレイテッド | 流体回路および関連する製造方法 |
| WO2014100725A1 (en) | 2012-12-21 | 2014-06-26 | Micronics, Inc. | Portable fluorescence detection system and microassay cartridge |
| CN107824233B (zh) | 2012-12-21 | 2020-06-30 | 珀金埃尔默健康科学有限公司 | 用于微流体用途的低弹性膜 |
| JP6472788B2 (ja) | 2013-05-07 | 2019-02-20 | マイクロニクス， インコーポレイテッド | 粘土鉱物およびアルカリ性溶液を使用して核酸含有試料を調製するための方法 |
| EP2994750B1 (de) | 2013-05-07 | 2020-08-12 | PerkinElmer Health Sciences, Inc. | Mikrofluidische vorrichtungen und verfahren zur durchführung von serumtrennung und blutkreuzproben |
| CA2911308C (en) | 2013-05-07 | 2021-10-19 | Micronics, Inc. | Device for preparation and analysis of nucleic acids |
| US9745633B2 (en) * | 2013-06-28 | 2017-08-29 | Diacarta Ltd | Detection of PNA clamping |
| AU2014373622B2 (en) | 2013-12-23 | 2021-05-27 | The University Of Queensland | Nucleic acid detection method and kit |
| SG10202005427PA (en) | 2015-04-24 | 2020-07-29 | Mesa Biotech Inc | Fluidic test cassette |
| WO2016196691A2 (en) | 2015-06-01 | 2016-12-08 | California Institute Of Technology | Compositions and methods for screening t cells with antigens for specific populations |
| US10808287B2 (en) | 2015-10-23 | 2020-10-20 | Rapid Pathogen Screening, Inc. | Methods and devices for accurate diagnosis of infections |
| US12258613B2 (en) | 2017-03-08 | 2025-03-25 | California Institute Of Technology | Pairing antigen specificity of a T cell with T cell receptor sequences |
| CN108490171A (zh) * | 2018-03-02 | 2018-09-04 | 北京库尔科技有限公司 | 一种高灵敏唾液抗体检测试剂盒 |
| WO2021231607A1 (en) * | 2020-05-12 | 2021-11-18 | Godx, Inc. | Point of need diagnostic device and methods of use thereof |
| KR102625074B1 (ko) * | 2021-04-20 | 2024-01-16 | 재단법인 아산사회복지재단 | 마이크로입자 기반 핵산 검출용 키트 및 핵산 증폭산물 검출 방법 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1219824A (en) * | 1981-04-17 | 1987-03-31 | David C. Ward | Modified nucleotides and methods of preparing and using same |
| US4687732A (en) * | 1983-06-10 | 1987-08-18 | Yale University | Visualization polymers and their application to diagnostic medicine |
| US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| AU622426B2 (en) * | 1987-12-11 | 1992-04-09 | Abbott Laboratories | Assay using template-dependent nucleic acid probe reorganization |
| DE3813278A1 (de) * | 1988-01-12 | 1989-07-20 | Boehringer Mannheim Gmbh | Verfahren zum nachweis von nukleinsaeuren |
| US5374524A (en) * | 1988-05-10 | 1994-12-20 | E. I. Du Pont De Nemours And Company | Solution sandwich hybridization, capture and detection of amplified nucleic acids |
| US5489507A (en) * | 1988-11-30 | 1996-02-06 | Perkin-Elmer Corporation | DNA detection by color complementation |
| IE67038B1 (en) * | 1988-12-22 | 1996-02-21 | Patrick Joseph Joyce | Immunodiagnostic assays for use in the detection and determination of mastitis |
| US5232829A (en) * | 1989-09-29 | 1993-08-03 | Hoffmann-La Roche Inc. | Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes |
| US5231015A (en) * | 1989-10-18 | 1993-07-27 | Eastman Kodak Company | Methods of extracting nucleic acids and pcr amplification without using a proteolytic enzyme |
| CA2031659A1 (en) * | 1990-01-26 | 1991-07-27 | John B. Findlay | Water-insoluble reagent, nucleic acid probe, test kit and diagnostic and purification methods |
| US5147777A (en) * | 1990-06-18 | 1992-09-15 | Eastman Kodak Company | Biologically active reagents prepared from carboxy-containing polymer, analytical element and methods of use |
| US5200315A (en) * | 1990-07-25 | 1993-04-06 | Eastman Kodak Company | Particulate biologically active reagent containing polyoxyalkylene side chains, analytical element and methods for use of the reagent |
| US5455166A (en) * | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5387510A (en) * | 1991-10-02 | 1995-02-07 | Eastman Kodak Company | Detection of amplified nucleic acid using secondary capture oligonucleotides and test kit |
| IL102486A (en) * | 1991-10-04 | 1997-11-20 | Orgenics Ltd | Method and apparatus for detection of nucleic acid sequences with a nucleic acid probe |
| US5541069A (en) * | 1992-02-28 | 1996-07-30 | Quidel Corporation | Assay having improved dose response curve |
| US5415839A (en) * | 1993-10-21 | 1995-05-16 | Abbott Laboratories | Apparatus and method for amplifying and detecting target nucleic acids |
-
1996
- 1996-06-17 US US08/664,863 patent/US5989813A/en not_active Expired - Lifetime
- 1996-07-12 AU AU64906/96A patent/AU715857B2/en not_active Ceased
- 1996-07-12 EP EP96924465A patent/EP0837946B1/de not_active Expired - Lifetime
- 1996-07-12 CA CA002226721A patent/CA2226721C/en not_active Expired - Fee Related
- 1996-07-12 DE DE69637864T patent/DE69637864D1/de not_active Expired - Lifetime
- 1996-07-12 WO PCT/US1996/011619 patent/WO1997003207A1/en not_active Ceased
- 1996-07-12 AT AT96924465T patent/ATE425259T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0837946A4 (de) | 2004-10-13 |
| CA2226721C (en) | 2008-09-23 |
| AU6490696A (en) | 1997-02-10 |
| DE69637864D1 (de) | 2009-04-23 |
| EP0837946B1 (de) | 2009-03-11 |
| EP0837946A1 (de) | 1998-04-29 |
| AU715857B2 (en) | 2000-02-10 |
| CA2226721A1 (en) | 1997-01-30 |
| US5989813A (en) | 1999-11-23 |
| WO1997003207A1 (en) | 1997-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |