ATE426018T1 - Pca3, pca3-gene und verfahren zu ihrer verwendung - Google Patents
Pca3, pca3-gene und verfahren zu ihrer verwendungInfo
- Publication number
- ATE426018T1 ATE426018T1 AT98916696T AT98916696T ATE426018T1 AT E426018 T1 ATE426018 T1 AT E426018T1 AT 98916696 T AT98916696 T AT 98916696T AT 98916696 T AT98916696 T AT 98916696T AT E426018 T1 ATE426018 T1 AT E426018T1
- Authority
- AT
- Austria
- Prior art keywords
- pca3
- nucleic acid
- antibodies
- polypeptides
- proteins
- Prior art date
Links
- 108091033411 PCA3 Proteins 0.000 title abstract 8
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 6
- 102000004169 proteins and genes Human genes 0.000 abstract 6
- 108020004707 nucleic acids Proteins 0.000 abstract 5
- 102000039446 nucleic acids Human genes 0.000 abstract 5
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108020004711 Nucleic Acid Probes Proteins 0.000 abstract 2
- 206010060862 Prostate cancer Diseases 0.000 abstract 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 2
- 239000002853 nucleic acid probe Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 108091005461 Nucleic proteins Proteins 0.000 abstract 1
- 102000007066 Prostate-Specific Antigen Human genes 0.000 abstract 1
- 108010072866 Prostate-Specific Antigen Proteins 0.000 abstract 1
- 238000004166 bioassay Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4183697P | 1997-04-10 | 1997-04-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE426018T1 true ATE426018T1 (de) | 2009-04-15 |
Family
ID=21918594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98916696T ATE426018T1 (de) | 1997-04-10 | 1998-04-09 | Pca3, pca3-gene und verfahren zu ihrer verwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US7008765B1 (de) |
| EP (2) | EP2060630B1 (de) |
| JP (2) | JP3981416B2 (de) |
| AT (1) | ATE426018T1 (de) |
| AU (1) | AU7019498A (de) |
| CA (1) | CA2286304C (de) |
| DE (1) | DE69840669D1 (de) |
| ES (2) | ES2402947T3 (de) |
| WO (1) | WO1998045420A1 (de) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329505B1 (en) | 1997-02-25 | 2001-12-11 | Corixa Corporation | Compositions and methods for therapy and diagnosis of prostate cancer |
| US7270980B2 (en) * | 1997-02-25 | 2007-09-18 | Corixa Corporation | Compounds for immunodiagnosis of prostate cancer and methods for their use |
| AU7019498A (en) * | 1997-04-10 | 1998-10-30 | Diagnocure Inc. | Pca3, pca3 genes, and methods of use |
| DE19836559A1 (de) * | 1998-08-12 | 2000-03-23 | Antigen Gmbh | Gefäß zur Entnahme von Blut |
| US20060204989A1 (en) * | 1998-09-22 | 2006-09-14 | Kopreski Michael S | Comparative analysis of extracellular RNA species |
| CA2376361A1 (en) * | 1999-08-19 | 2001-03-01 | Genset S.A. | Prostate cancer-related gene 3 (pg-3) and biallelic markers thereof |
| DK1222266T3 (da) * | 1999-09-29 | 2006-07-10 | Diagnocure Inc | PCA3-messenger-RNA i benigne og maligne prostatavæv |
| US6897024B2 (en) | 2001-05-31 | 2005-05-24 | Stichting Katholieke Universiteit More Particularly The University Medical Centre Nijmegen | Nucleic acid molecules comprising the promoter for PCA3, and uses thereof |
| US20100159464A1 (en) * | 2001-11-05 | 2010-06-24 | Oncomedx, Inc. | Method for Detection of DNA Methyltransferase RNA in Plasma and Serum |
| DE10230692A1 (de) * | 2002-07-08 | 2004-02-12 | Epigenomics Ag | Verfahren und Nukleinsäuren für die Analyse von Methylierungsmustern innerhalb des DD3-Gens |
| JP4824540B2 (ja) * | 2003-02-07 | 2011-11-30 | ダイアノキュアー インク. | サンプル中の前立腺癌を検出する方法 |
| CA2432365A1 (en) | 2003-06-30 | 2004-12-30 | Jack A. Schalken | Specific method of prostate cancer detection based on pca3, and kits therefore |
| US10066268B2 (en) * | 2004-05-07 | 2018-09-04 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Methods of diagnosing or treating prostate cancer using the ERG gene, alone or in combination with other over or under expressed genes in prostate cancer |
| US11105808B2 (en) | 2004-11-12 | 2021-08-31 | Health Discovery Corporation | Methods for screening, predicting and monitoring prostate cancer |
| CA2491067A1 (en) | 2004-12-24 | 2006-06-24 | Stichting Katholieke Universiteit | Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer |
| US7496340B1 (en) * | 2005-06-02 | 2009-02-24 | Rf Micro Devices, Inc. | I/Q mismatch calibration of direct conversion receivers using radio frequency noise |
| US9957569B2 (en) | 2005-09-12 | 2018-05-01 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
| CA2622295C (en) | 2005-09-12 | 2019-01-15 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
| US8338109B2 (en) | 2006-11-02 | 2012-12-25 | Mayo Foundation For Medical Education And Research | Predicting cancer outcome |
| CN103233063A (zh) * | 2006-11-08 | 2013-08-07 | 密歇根大学董事会 | 前列腺癌标志物spink1及其应用 |
| EP3095873B1 (de) | 2006-12-21 | 2018-04-18 | Gen-Probe Incorporated | Verfahren und zusammensetzungen zur amplifizierung von nukleinsäuren |
| CA2692441C (en) | 2007-07-06 | 2020-01-21 | The Regents Of The University Of Michigan | Solute carrier family 45 member 3 (slc45a3) and ets family gene fusions in prostate cancer |
| US9303291B2 (en) * | 2007-07-06 | 2016-04-05 | The Regents Of The University Of Michigan | MIPOL1-ETV1 gene rearrangements |
| EP2597464B1 (de) | 2007-08-16 | 2015-02-25 | The Regents of the University of Michigan | Metabolomische Profilierung von Prostatakrebs |
| DK2187965T3 (da) | 2007-08-17 | 2020-01-20 | Purdue Research Foundation | Psma-bindingsligand-linker-konjugater og fremgangsmåder til anvendelse |
| WO2009140741A1 (en) * | 2008-05-23 | 2009-11-26 | The University Of Queensland | Agents and methods for diagnosing the presence or risk of prostate cancer |
| CA2725978A1 (en) | 2008-05-28 | 2009-12-03 | Genomedx Biosciences, Inc. | Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer |
| US10407731B2 (en) | 2008-05-30 | 2019-09-10 | Mayo Foundation For Medical Education And Research | Biomarker panels for predicting prostate cancer outcomes |
| US8202690B2 (en) | 2008-11-28 | 2012-06-19 | Hisamitsu Pharmaceutical Co., Inc. | Cancer marker and therapeutic agent for cancer |
| AU2010203517B2 (en) | 2009-01-09 | 2012-08-16 | The Regents Of The University Of Michigan | Recurrent gene fusions in cancer |
| US20100311815A1 (en) * | 2009-02-23 | 2010-12-09 | The Regents Of The University Of Michigan | Mir-101 cancer markers |
| CA2766391C (en) | 2009-07-01 | 2021-04-20 | Gen-Probe Incorporated | Methods and compositions for multiplex nucleic acid amplification |
| US9938582B2 (en) | 2009-09-17 | 2018-04-10 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| EP2407555A1 (de) | 2010-07-14 | 2012-01-18 | Fundació Institut de Recerca Hospital Universitari Vall d'Hebron, Fundació Privada | Verfahren und Kits zur Diagnose von Prostatakrebs |
| EP2407554A1 (de) | 2010-07-14 | 2012-01-18 | Fundacio Institut de Recerca de l'Hospital Universitari Vall d'Hebron | Verfahren und Kits zur Diagnose von Prostatakrebs |
| US20130267443A1 (en) | 2010-11-19 | 2013-10-10 | The Regents Of The University Of Michigan | ncRNA AND USES THEREOF |
| US8945556B2 (en) | 2010-11-19 | 2015-02-03 | The Regents Of The University Of Michigan | RAF gene fusions |
| AU2011329753B2 (en) | 2010-11-19 | 2015-07-23 | The Regents Of The University Of Michigan | ncRNA and uses thereof |
| EP2791359B1 (de) | 2011-12-13 | 2020-01-15 | Decipher Biosciences, Inc. | Krebsdiagnostik mit nichtcodierenden transkripten |
| ES3015226T3 (en) | 2012-08-16 | 2025-04-30 | Veracyte Sd Inc | Prostate cancer prognosis using biomarkers |
| KR102318999B1 (ko) | 2012-11-15 | 2021-10-29 | 엔도사이트, 인코포레이티드 | Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트 |
| AU2014336638C1 (en) | 2013-10-18 | 2020-09-17 | Novartis Ag | Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| WO2015073678A1 (en) | 2013-11-14 | 2015-05-21 | Endocyte, Inc. | Compounds for positron emission tomography |
| EP3243077B1 (de) | 2015-01-05 | 2019-09-04 | University Of Oslo | Prostatakrebsmarker und verwendungen davon |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| US9528096B1 (en) * | 2016-06-30 | 2016-12-27 | Fornia Biosolutions, Inc. | Phytases and uses thereof |
| US9605245B1 (en) | 2016-06-30 | 2017-03-28 | Fornia BioSoultions, Inc. | Phytases and uses thereof |
| US10351832B2 (en) | 2016-06-30 | 2019-07-16 | Fornia Biosolutions, Inc. | Phytases and uses thereof |
| EP3504348B1 (de) | 2016-08-24 | 2022-12-14 | Decipher Biosciences, Inc. | Verwendung von genomischen signaturen zur vorhersage des ansprechens von patienten mit prostatakrebs auf postoperative strahlentherapie |
| WO2018132916A1 (en) | 2017-01-20 | 2018-07-26 | Genomedx Biosciences, Inc. | Molecular subtyping, prognosis, and treatment of bladder cancer |
| AU2018230784A1 (en) | 2017-03-09 | 2019-10-10 | Decipher Biosciences, Inc. | Subtyping prostate cancer to predict response to hormone therapy |
| WO2018205035A1 (en) | 2017-05-12 | 2018-11-15 | Genomedx Biosciences, Inc | Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness |
| WO2019028285A2 (en) | 2017-08-04 | 2019-02-07 | Genomedx, Inc. | USE OF SPECIFIC GENE EXPRESSION OF IMMUNE CELLS FOR THE PROGNOSIS OF PROSTATE CANCER AND THE PREDICTION OF SENSITIVITY TO RADIOTHERAPY |
| MX2020010813A (es) | 2018-04-17 | 2021-01-08 | Endocyte Inc | Metodos de tratamiento de cancer. |
| EP3972627A4 (de) | 2019-05-20 | 2023-06-21 | Endocyte, Inc. | Verfahren zur herstellung von psma-konjugaten |
| WO2022106629A1 (en) | 2020-11-19 | 2022-05-27 | Novartis Ag | Synthesis of prostate specific membrane antigen (psma) ligands |
| WO2024054924A1 (en) | 2022-09-08 | 2024-03-14 | Gen-Probe Incorporated | Method of detecting nucleic acid analytes using dual-specificity primers |
Family Cites Families (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US763243A (en) * | 1903-10-26 | 1904-06-21 | William P Bartholow | Self-heating soldering-iron. |
| FR2422956A1 (fr) | 1978-04-13 | 1979-11-09 | Pasteur Institut | Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4690890A (en) * | 1984-04-04 | 1987-09-01 | Cetus Corporation | Process for simultaneously detecting multiple antigens using dual sandwich immunometric assay |
| US4786600A (en) | 1984-05-25 | 1988-11-22 | The Trustees Of Columbia University In The City Of New York | Autocatalytic replication of recombinant RNA |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (de) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimäre Rezeptoren durch Verbindung und Expression von DNS |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| DE3689123T2 (de) | 1985-11-01 | 1994-03-03 | Xoma Corp | Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung. |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US4851331A (en) | 1986-05-16 | 1989-07-25 | Allied Corporation | Method and kit for polynucleotide assay including primer-dependant DNA polymerase |
| FR2602592B1 (fr) | 1986-08-06 | 1989-06-30 | Alain Baret | Utilisation du systeme enzymatique xanthine-oxydase en immuno-analyse, procedes de dosage correspondants et coffrets de reactifs necessaires pour la mise en oeuvre de ces procedes. |
| US5541308A (en) | 1986-11-24 | 1996-07-30 | Gen-Probe Incorporated | Nucleic acid probes for detection and/or quantitation of non-viral organisms |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| US5149625A (en) | 1987-08-11 | 1992-09-22 | President And Fellows Of Harvard College | Multiplex analysis of DNA |
| US5283174A (en) | 1987-09-21 | 1994-02-01 | Gen-Probe, Incorporated | Homogenous protection assay |
| US5585481A (en) | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
| US5639604A (en) | 1987-09-21 | 1997-06-17 | Gen-Probe Incorporated | Homogeneous protection assay |
| CA1323293C (en) | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| US5002867A (en) | 1988-04-25 | 1991-03-26 | Macevicz Stephen C | Nucleic acid sequence determination by multiple mixed oligonucleotide probes |
| NL8801147A (nl) | 1988-05-02 | 1989-12-01 | Tno | Werkwijze voor het detecteren van genetische variatie, en daarvoor geschikte kit. |
| DK167254B1 (da) | 1988-07-21 | 1993-09-27 | Hartmann As Brdr | Fremgangsmaade til fremstilling af formede genstande af et fluidiseret cellulosefibermateriale |
| US5183949A (en) | 1988-09-22 | 1993-02-02 | The United States Of America As Represented By The Department Of Health And Human Services | Rabbit model for diagnosing and testing vaccines or therapeutic agents against aids |
| US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| US5219989A (en) | 1988-12-13 | 1993-06-15 | Mcgill University | Bifunctional protein for the isolation of capped mRNA |
| US5082670A (en) | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| US5175383A (en) | 1989-02-17 | 1992-12-29 | President And Fellows Of Harvard College | Animal model for benign prostatic disease |
| US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5112736A (en) | 1989-06-14 | 1992-05-12 | University Of Utah | Dna sequencing using fluorescence background electroblotting membrane |
| US5656207A (en) | 1989-06-24 | 1997-08-12 | Gen Probe Incorporated | Detecting or quantifying multiple analytes using labelling techniques |
| US5174986A (en) | 1989-07-05 | 1992-12-29 | Genpharm International, Inc. | Method for determining oncogenic potential of a chemical compound |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| IE911869A1 (en) | 1990-06-01 | 1991-12-04 | Regeneron Pharma | A family of map2 protein kinases |
| WO1992006693A1 (en) | 1990-10-22 | 1992-04-30 | Fox Chase Cancer Center | Dna construct for providing rna therapy |
| AU662906B2 (en) * | 1991-06-26 | 1995-09-21 | F. Hoffmann-La Roche Ag | Methods for detection of carcinoma metastases by nucleic acid amplification |
| CA2082411A1 (en) | 1991-06-28 | 1992-12-29 | Robert D. Rosenberg | Localized oligonucleotide therapy |
| AU2468992A (en) | 1991-08-16 | 1993-03-16 | General Hospital Corporation, The | Method of gene delivery to post-mitotic cells |
| WO1993008845A1 (en) | 1991-11-08 | 1993-05-13 | Massachusetts Institute Of Technology | Localized oligonucleotide therapy |
| WO1993012236A1 (en) | 1991-12-16 | 1993-06-24 | E.I. Du Pont De Nemours And Company | Constitutive expression of p450soy and ferredoxin-soy in streptomyces, and biotransformation of chemicals by recombinant organisms |
| ATE515510T1 (de) | 1991-12-24 | 2011-07-15 | Isis Pharmaceuticals Inc | Durch dna-abschnitte unterbrochene modifizierte oligonukleotide |
| WO1993022461A1 (en) | 1992-05-06 | 1993-11-11 | Gen-Probe Incorporated | Nucleic acid sequence amplification method, composition and kit |
| US5674682A (en) | 1992-10-29 | 1997-10-07 | Thomas Jefferson University | Nucleic acid primers for detecting micrometastasis of prostate cancer |
| EP1757695A3 (de) | 1992-11-05 | 2008-02-27 | Sloan Kettering Institute For Cancer Research | Prostata-spezifisches Membranantigen |
| US5503980A (en) | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| WO1994012627A1 (en) | 1992-11-25 | 1994-06-09 | Cephalon, Inc. | Transgenic animal model for alzheimer's disease |
| US5773705A (en) | 1992-12-31 | 1998-06-30 | Wisconsin Alumni Research Foundation | Ubiquitin fusion protein system for protein production in plants |
| BR9405707A (pt) | 1993-01-07 | 1996-08-06 | Univ Jefferson | Inibiçao anti-sentido de c-myc para modular a proliferaçao de células de músculo liso |
| US5422252A (en) | 1993-06-04 | 1995-06-06 | Becton, Dickinson And Company | Simultaneous amplification of multiple targets |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US5861242A (en) | 1993-06-25 | 1999-01-19 | Affymetrix, Inc. | Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same |
| CA2167804A1 (en) * | 1993-07-20 | 1995-02-02 | Robert H. Singer | In vivo nucleic acid hybridization method |
| US6323184B1 (en) | 1993-10-15 | 2001-11-27 | Thomas Jefferson University | Arteriovenous and venous graft treatments: methods and compositions |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| CA2185239C (en) | 1994-03-16 | 2002-12-17 | Nanibhushan Dattagupta | Isothermal strand displacement nucleic acid amplification |
| US5976794A (en) * | 1994-04-15 | 1999-11-02 | The Trustees Of Columbia University In The City Of New York | Method for molecular staging of prostate cancer |
| EP0760008A1 (de) | 1994-05-19 | 1997-03-05 | Dako A/S | Pna-sonden zum nachweis von neisseria gonorrhoeae und chlamydia trachomatis |
| AU3889595A (en) | 1994-10-05 | 1996-05-02 | Amgen, Inc. | Method for inhibiting smooth muscle cell proliferation and oligonucleotides for use therein |
| EP0709466B1 (de) | 1994-10-28 | 2006-09-27 | Gen-Probe Incorporated | Zusammensetzungen und Verfahren für die gleichzeitige Detektion und Quantifizierung von einer Mehrheit spezifischer Nuklein Säure Sequenzen |
| US5919652A (en) | 1994-11-09 | 1999-07-06 | The Regents Of The University Of California | Nucleic acid molecules comprising the prostate specific antigen (PSA) promoter and uses thereof |
| DE19513152A1 (de) | 1995-04-07 | 1996-10-10 | Bundesrep Deutschland | Verwendung eines "Immundefizienzvirus-supprimierenden Lymphokins (ISL)" zur Hemmung der Virusvermehrung, insbesondere von Retroviren |
| US5731148A (en) | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
| EP0912767B1 (de) | 1996-07-16 | 2006-09-13 | Gen-Probe Incorporated | Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm) |
| US6479263B1 (en) | 1996-11-14 | 2002-11-12 | Baylor College Of Medicine | Method for detection of micrometastatic prostate cancer |
| US6800746B2 (en) | 1997-02-25 | 2004-10-05 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US6395278B1 (en) | 1997-02-25 | 2002-05-28 | Corixa Corporation | Prostate specific fusion protein compositions |
| US6465611B1 (en) | 1997-02-25 | 2002-10-15 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| US6261562B1 (en) | 1997-02-25 | 2001-07-17 | Corixa Corporation | Compounds for immunotherapy of prostate cancer and methods for their use |
| EP1005546A2 (de) | 1997-02-25 | 2000-06-07 | Corixa Corporation | Verbindungen für die immuntherapie von prostatkrebs und verfahren zu deren verwendung |
| AU7019498A (en) * | 1997-04-10 | 1998-10-30 | Diagnocure Inc. | Pca3, pca3 genes, and methods of use |
| US6534273B2 (en) | 1997-05-02 | 2003-03-18 | Gen-Probe Incorporated | Two-step hybridization and capture of a polynucleotide |
| DK0975807T3 (da) | 1997-05-02 | 2007-01-29 | Gen Probe Inc | To-trins hybridisering og indfangning af et polynukleotid |
| PT2216416E (pt) | 1997-05-30 | 2012-08-16 | Trovagene Inc | Métodos para detecção de sequências de ácido nucleico na urina |
| US20020035244A1 (en) | 1997-09-09 | 2002-03-21 | Maurice Cohen | Reagents and methods useful for detecting diseases of the prostate |
| TR200100916T2 (de) | 1998-07-14 | 2002-06-21 | Corixa@@Corporation | |
| US6037130A (en) | 1998-07-28 | 2000-03-14 | The Public Health Institute Of The City Of New York, Inc. | Wavelength-shifting probes and primers and their use in assays and kits |
| JP4495349B2 (ja) | 1999-01-28 | 2010-07-07 | ジェン−プローブ・インコーポレーテッド | 癌の遺伝マーカーを生物学的サンプルにおいて検出するための核酸配列 |
| FI990382A0 (fi) | 1999-02-23 | 1999-02-23 | Arctic Partners Oy Ab | Uusi diagnostinen menetelmä |
| US6528260B1 (en) | 1999-03-25 | 2003-03-04 | Genset, S.A. | Biallelic markers related to genes involved in drug metabolism |
| ATE466938T1 (de) | 1999-03-26 | 2010-05-15 | Jackson H M Found Military Med | Prostata-spezifisches gen pcgem1 und methoden zu dessen verwendung zur erkennung, behandlung und prävention von prostatakrebs |
| DK1222266T3 (da) | 1999-09-29 | 2006-07-10 | Diagnocure Inc | PCA3-messenger-RNA i benigne og maligne prostatavæv |
| WO2001025273A2 (en) | 1999-10-04 | 2001-04-12 | Corixa Corporation | Compositions and methods for wt1 specific immunotherapy |
| WO2001025272A2 (en) | 1999-10-04 | 2001-04-12 | Corixa Corporation | Compositions and methods for therapy and diagnosis of prostate cancer |
| AU1656501A (en) | 1999-11-12 | 2001-06-06 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| HK1050551A1 (zh) | 1999-12-17 | 2003-06-27 | Bio Merieux | 标记核酸的方法 |
| EP1261708A2 (de) | 2000-01-14 | 2002-12-04 | Corixa Corporation | Zusammensetzungen und verfahren zur behandlung und diagnose von prostatkrebs |
| US20020168638A1 (en) | 2000-01-24 | 2002-11-14 | Robert Schlegel | Compositions, kits, and methods for identification, assessment, prevention, and therapy of human prostate cancer |
| AU2001241541A1 (en) | 2000-02-17 | 2001-08-27 | Millennium Predictive Medicine, Inc. | Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of human prostate cancer |
| WO2001073032A2 (en) | 2000-03-27 | 2001-10-04 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| FR2810114B1 (fr) | 2000-06-13 | 2002-08-23 | Bio Merieux | Methode, procede, test immunologique et kit de diagnostic d'un adenocarcinome de la prostate ou d'une hypertrophie benigne de la prostate |
| AU2001292842A1 (en) | 2000-09-19 | 2002-04-02 | Diadexus, Inc. | Compositions and methods relating to prostate specific genes and proteins |
| EP1474528A4 (de) | 2000-10-13 | 2006-06-14 | Protein Design Labs Inc | Methoden zur diagnose von prostatakrebs, zusammensetzungen und methoden zur untersuchung auf prostatakrebs-modulatoren |
| US6897024B2 (en) | 2001-05-31 | 2005-05-24 | Stichting Katholieke Universiteit More Particularly The University Medical Centre Nijmegen | Nucleic acid molecules comprising the promoter for PCA3, and uses thereof |
| JP4824540B2 (ja) | 2003-02-07 | 2011-11-30 | ダイアノキュアー インク. | サンプル中の前立腺癌を検出する方法 |
| CA2432365A1 (en) | 2003-06-30 | 2004-12-30 | Jack A. Schalken | Specific method of prostate cancer detection based on pca3, and kits therefore |
| CA2491067A1 (en) | 2004-12-24 | 2006-06-24 | Stichting Katholieke Universiteit | Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer |
| IT1395574B1 (it) | 2009-09-14 | 2012-10-16 | Guala Dispensing Spa | Dispositivo di erogazione |
| EP3434784A1 (de) * | 2013-06-14 | 2019-01-30 | Nanostring Technologies, Inc | Multiplexierbares etikettbasiertes reportersystem |
-
1998
- 1998-04-09 AU AU70194/98A patent/AU7019498A/en not_active Abandoned
- 1998-04-09 EP EP09003774A patent/EP2060630B1/de not_active Expired - Lifetime
- 1998-04-09 ES ES09003774T patent/ES2402947T3/es not_active Expired - Lifetime
- 1998-04-09 AT AT98916696T patent/ATE426018T1/de active
- 1998-04-09 CA CA002286304A patent/CA2286304C/en not_active Expired - Lifetime
- 1998-04-09 WO PCT/CA1998/000346 patent/WO1998045420A1/en not_active Ceased
- 1998-04-09 EP EP98916696A patent/EP1007650B1/de not_active Expired - Lifetime
- 1998-04-09 DE DE69840669T patent/DE69840669D1/de not_active Expired - Lifetime
- 1998-04-09 JP JP54219498A patent/JP3981416B2/ja not_active Expired - Lifetime
- 1998-04-09 US US09/402,713 patent/US7008765B1/en not_active Expired - Lifetime
- 1998-04-09 ES ES98916696T patent/ES2324503T3/es not_active Expired - Lifetime
-
2005
- 2005-10-28 US US11/260,282 patent/US7632643B2/en not_active Expired - Fee Related
-
2007
- 2007-05-10 JP JP2007125170A patent/JP2007275069A/ja active Pending
-
2009
- 2009-10-30 US US12/609,483 patent/US8551699B2/en not_active Expired - Fee Related
-
2013
- 2013-09-23 US US14/033,699 patent/US9540696B2/en not_active Expired - Fee Related
-
2016
- 2016-11-30 US US15/364,962 patent/US20170073776A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1007650B1 (de) | 2009-03-18 |
| US9540696B2 (en) | 2017-01-10 |
| JP2001522240A (ja) | 2001-11-13 |
| US20140017774A1 (en) | 2014-01-16 |
| EP2060630A2 (de) | 2009-05-20 |
| US20060099658A1 (en) | 2006-05-11 |
| CA2286304A1 (en) | 1998-10-15 |
| US7632643B2 (en) | 2009-12-15 |
| EP1007650A1 (de) | 2000-06-14 |
| JP3981416B2 (ja) | 2007-09-26 |
| US20100047809A1 (en) | 2010-02-25 |
| CA2286304C (en) | 2007-08-07 |
| JP2007275069A (ja) | 2007-10-25 |
| EP2060630A3 (de) | 2010-04-14 |
| ES2324503T3 (es) | 2009-08-07 |
| ES2402947T3 (es) | 2013-05-10 |
| US7008765B1 (en) | 2006-03-07 |
| US8551699B2 (en) | 2013-10-08 |
| US20170073776A1 (en) | 2017-03-16 |
| EP2060630B1 (de) | 2012-10-24 |
| DE69840669D1 (de) | 2009-04-30 |
| WO1998045420A1 (en) | 1998-10-15 |
| AU7019498A (en) | 1998-10-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69840669D1 (de) | Pca3, pca3-gene und verfahren zu ihrer verwendung | |
| Shimura et al. | Affinity probe capillary electrophoresis: analysis of recombinant human growth hormone with a fluorescent labeled antibody fragment | |
| WO1998049313A3 (en) | Characterization of granulocytic ehrlichia and methods of use | |
| ATE397660T1 (de) | Zelloberflächen-antigen aus säugetieren und verwandte reagenzien | |
| LU91756I2 (fr) | Denosumab | |
| CA2131826A1 (en) | MN Gene and Protein | |
| CO4870792A1 (es) | Compuestos y conjunto de medios de diagnostico para detectar y vigilar la progresion de cancer de prostata | |
| Hatzfeld et al. | Cytokeratin domains involved in heterotypic complex formation determined by in-vitro binding assays | |
| CA2413857A1 (en) | Pd-l2 molecules: pd-1 ligands and uses therefor | |
| ATE446511T1 (de) | Neue fusionsproteine und molekulare bindungsassays | |
| ATE310819T1 (de) | Säugetieren apoptosis inhibitorprotein genfamilie,primers, probes und verfahren zur nachweis | |
| SE9500023D0 (sv) | Method of detecting cancer | |
| Rask et al. | The subunit structure of human thyroxine-binding prealbumin | |
| WO1998057984A3 (en) | Torsin, torsin genes, and methods of use | |
| WO1999043808A8 (en) | Human c-maf compositions and methods of use thereof | |
| DE69535921D1 (de) | Alk-7 (aktivin-rezeptor-ähnliche kinase), ein serin/threonin kinase rezeptor | |
| DK0975755T3 (da) | CRSP-protein (cysteinrige udskilte proteiner), nukleinsyremolekyler der koder herfor samt anvendelser deraf | |
| Chen | Characterization of charge-modified and fluorescein-labeled antibody by capillary electrophoresis using laser-induced fluorescence Application to immunoassay of low level immunoglobulin A | |
| ATE433463T1 (de) | Monospezifische antikörper gegen fibrinogen und fibrinopeptide b | |
| BR9815090A (pt) | "moléculas de ácido nucléico correlacionadas com o fenótipo rhesus d fraco" | |
| BR9713632A (pt) | Citocina de mamìfero relacionada com a il-10 | |
| US20090017556A1 (en) | Methods and complexes involving immunoglobulin molecule | |
| EA200300420A1 (ru) | Выделенная молекула нуклеиновой кислоты, выделенный полипептид и способ его получения, способ обнаружения их присутствия в образце (варианты), клетка-хозяин (варианты), антитело, набор (варианты), способ модулирования активности полипептида, способ идентификации (варианты) и применение соединения, способ выявления субъекта (варианты) и способ лечения субъекта с нарушением, связанным с калиевыми каналами (варианты) | |
| Chataway et al. | Studies on the iodination of a ras protein and the detection of ras polymers | |
| AR013326A1 (es) | POLIPEPTIDO AISLADO, MOLECULA DE ADN, VECTOR DE EXPRESION RECOMBINANTE, CELULA HUESPED, METODO PARa DETECTAR LA INFECCION DE M.TUBERCULOSIS EN UNAMUESTRA BIOLOGICA, EQUIPO PARA DIAGNOSTICO, ANTICUERPO MONOCLONAL, Y ANTICUERPO POLICLONAL, PROTEINAS DE FUSION |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1007650 Country of ref document: EP |