ATE426021T1 - Verfahren zur herstellung von biopterinen - Google Patents

Verfahren zur herstellung von biopterinen

Info

Publication number
ATE426021T1
ATE426021T1 AT01958584T AT01958584T ATE426021T1 AT E426021 T1 ATE426021 T1 AT E426021T1 AT 01958584 T AT01958584 T AT 01958584T AT 01958584 T AT01958584 T AT 01958584T AT E426021 T1 ATE426021 T1 AT E426021T1
Authority
AT
Austria
Prior art keywords
present
transformed
biopterin compound
biopterins
producing
Prior art date
Application number
AT01958584T
Other languages
English (en)
Inventor
Masayuki Yabuta
Kazuaki Furukawa
Nobue Miyamoto
Katsuhiko Yamamoto
Kazuhiro Ohsuye
Original Assignee
Asubio Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asubio Pharma Co Ltd filed Critical Asubio Pharma Co Ltd
Application granted granted Critical
Publication of ATE426021T1 publication Critical patent/ATE426021T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT01958584T 2000-08-31 2001-08-28 Verfahren zur herstellung von biopterinen ATE426021T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000262973 2000-08-31

Publications (1)

Publication Number Publication Date
ATE426021T1 true ATE426021T1 (de) 2009-04-15

Family

ID=18750574

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01958584T ATE426021T1 (de) 2000-08-31 2001-08-28 Verfahren zur herstellung von biopterinen

Country Status (13)

Country Link
US (2) US20040014167A1 (de)
EP (1) EP1314782B1 (de)
JP (1) JP4817590B2 (de)
KR (1) KR100916163B1 (de)
CN (1) CN1247778C (de)
AT (1) ATE426021T1 (de)
AU (1) AU2001280215B9 (de)
BR (1) BR0113411A (de)
CA (1) CA2420374A1 (de)
DE (1) DE60138029D1 (de)
ES (1) ES2320531T3 (de)
IL (2) IL154530A0 (de)
WO (1) WO2002018587A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7442372B2 (en) 2003-08-29 2008-10-28 Biomarin Pharmaceutical Inc. Delivery of therapeutic compounds to the brain and other tissues
KR20070005550A (ko) 2003-11-17 2007-01-10 바이오마린 파머수티컬 인크. 대사 장애 치료를 위한 조성물 및 방법
BRPI0517088A (pt) 2004-11-17 2008-09-30 Biomarin Pharm Inc formulação de comprimido estável
JPWO2006085535A1 (ja) * 2005-02-09 2008-06-26 株式会社カネカ テトラヒドロビオプテリン生合成酵素を用いたビオプテリン類の製造方法
SI3461503T1 (sl) * 2007-04-11 2022-04-29 Biomarin Pharmaceutical Inc. Postopki za dajanje tetrahidrobiopterina, povezani sestavki in postopki merjenja
JP5084481B2 (ja) * 2007-12-10 2012-11-28 花王株式会社 血圧調節剤のスクリーニング方法及び評価方法
WO2009088530A1 (en) 2008-01-03 2009-07-16 Biomarin Pharmaceutical Inc. Pterin analog for treating bh4 responsive condition
WO2009088979A1 (en) 2008-01-07 2009-07-16 Biomarin Pharmaceutical Inc. Method of synthesizing tetrahydrobiopterin
WO2012135389A2 (en) 2011-03-28 2012-10-04 The Regents Of The University Of California Host cells and methods for oxidizing aromatic amino acids
KR101229912B1 (ko) * 2011-04-06 2013-02-05 강원대학교산학협력단 재조합 대장균을 이용한 세피아프테린의 제조방법
US9216178B2 (en) 2011-11-02 2015-12-22 Biomarin Pharmaceutical Inc. Dry blend formulation of tetrahydrobiopterin
CN102516246B (zh) * 2011-11-30 2014-08-06 安徽农业大学 一种从蚕体中提取纯化高纯度墨蝶呤的方法
WO2013127914A1 (en) * 2012-02-29 2013-09-06 Danmarks Tekniske Universitet Microorganisms for the production of 5-hydroxytryptophan
EP2820121A1 (de) * 2012-02-29 2015-01-07 Danmarks Tekniske Universitet Mikroorganismen zur herstellung von melatonin
CN102925476B (zh) * 2012-11-15 2014-12-03 中国科学院上海巴斯德研究所 酵母中自组装的具有免疫原性的肠道病毒病毒样颗粒的制备方法及其应用
CN103215216B (zh) * 2013-04-16 2015-05-20 中国人民解放军军事医学科学院基础医学研究所 黑色素瘤治疗性质粒DNA疫苗pSVK-CAVA的制备方法及其专用工程菌及发酵培养基
US20160230200A1 (en) * 2013-09-05 2016-08-11 Danmarks Tekniske Universitet Microorganisms for efficient production of melatonin and related compounds
EP3143153A4 (de) * 2014-05-16 2018-01-03 The University Of Georgia Research Foundation, Inc. Mikrobieller ansatz zur herstellung von 5-hydroxytryptophan
WO2016109769A1 (en) 2015-01-02 2016-07-07 Georgia Tech Research Corporation Pterin-dependent biocatalysts and uses thereof
US10851365B2 (en) 2016-03-31 2020-12-01 Danmarks Tekniske Universitet Optimized microbial cells for production of melatonin and other compounds
EP3436595B1 (de) 2016-03-31 2024-02-28 Danmarks Tekniske Universitet Optimierte mikrobielle zellen zur herstellung von melatonin und anderen verbindungen
US10883127B2 (en) 2016-05-24 2021-01-05 Danmarks Tekniske Universitet Variants of acetylserotonin O-methyltransferase and uses thereof
WO2018108966A1 (en) 2016-12-13 2018-06-21 Danmarks Tekniske Universitet Arylalkylamine n-acetyltransferase and uses thereof
WO2019175328A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4pathwayactivationandusethereoffortreatingcancer
WO2019175332A1 (en) 2018-03-14 2019-09-19 Imba - Institut Für Molekulare Biotechnologie Gmbh Bh4 pathway inhibition and use thereof for treating t-cell mediated autoimmune diseases or hypersensitivity
JP7553906B2 (ja) * 2018-11-01 2024-09-19 宏 一瀬 Ｓｐｒをコードするポリヌクレオチドを含む組換えベクター、及びそれを含む組成物
WO2020187739A1 (en) 2019-03-15 2020-09-24 Danmarks Tekniske Universitet Engineered cells for production of indole-derivatives
CN111073884A (zh) * 2020-02-14 2020-04-28 昆明理工大学 提高非编码区域距离＜50bp的SNP中具有功能效应的SNP位点检测准确率的方法
CN111505179B (zh) * 2020-04-07 2021-07-13 厦门大学 海洋水体中生物蝶呤的检测方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60178887A (ja) * 1984-02-23 1985-09-12 Kanegafuchi Chem Ind Co Ltd ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法
JPS619296A (ja) * 1984-06-22 1986-01-16 Kanegafuchi Chem Ind Co Ltd 微生物によるｌ−エリスロ−ビオプテリンの製造法
JPS6152296A (ja) * 1984-08-21 1986-03-14 Kanegafuchi Chem Ind Co Ltd 微生物によるｌ−エリスロ−ビオプテリンの製造法
CA1334654C (en) * 1987-11-30 1995-03-07 Masayasu Kurono Intermediates for synthesizing bh _and its derivatives
JP2674707B2 (ja) * 1988-06-22 1997-11-12 株式会社ビタミン研究所 Ｌ‐ビオプテリンの製法
JP2575781B2 (ja) * 1988-02-29 1997-01-29 日清製粉株式会社 ２，３−ジアシルオキシ−４−ヒドロキシ−トペンタナールおよびその製造方法
JP3137333B2 (ja) * 1990-07-21 2001-02-19 サントリー株式会社 テトラヒドロビオプテリンの製法およびそれに用いる酵素
JP2754959B2 (ja) 1991-07-24 1998-05-20 三菱電機株式会社 空気調和機のセンサ識別装置
KR100456062B1 (ko) * 2001-06-18 2004-11-08 박영식 재조합 대장균에 의한 테리딘 화합물의 제조방법

Also Published As

Publication number Publication date
JP4817590B2 (ja) 2011-11-16
EP1314782B1 (de) 2009-03-18
US20040014167A1 (en) 2004-01-22
CA2420374A1 (en) 2003-02-24
IL154530A0 (en) 2003-09-17
ES2320531T3 (es) 2009-05-25
CN1247778C (zh) 2006-03-29
BR0113411A (pt) 2004-01-06
AU2001280215B2 (en) 2006-08-03
EP1314782A4 (de) 2005-01-12
KR20030033042A (ko) 2003-04-26
WO2002018587A1 (fr) 2002-03-07
AU8021501A (en) 2002-03-13
CN1449442A (zh) 2003-10-15
DE60138029D1 (de) 2009-04-30
KR100916163B1 (ko) 2009-09-08
EP1314782A1 (de) 2003-05-28
JPWO2002018587A1 (ja) 2004-01-15
US7807421B2 (en) 2010-10-05
AU2001280215B9 (en) 2007-03-22
US20060008869A1 (en) 2006-01-12
IL154530A (en) 2011-02-28

Similar Documents

Publication Publication Date Title
DE60138029D1 (de) Verfahren zur herstellung von biopterinen
ATE282710T1 (de) Verfahren zur fermentativen herstellung von cytostatika und deren kristallformen
ATE367436T1 (de) Verfahren und materialien zur produktion von d- milchsäure in hefe
DE60323340D1 (de) Verfahren zur herstellung interferierender rna-moleküle in säugetierzellen und therapeutische anwendungen solcher moleküle
DE60030988D1 (de) Verfahren zur Herstellung Von L-Aminosäuren durch Erhöhung des zellulären NADPH
ATE347739T1 (de) Hybridmaterial, verwendung des hybridmaterials und verfahren zu seiner herstellung
FR2804971B1 (fr) Adn codant une acetohydroxyacide synthase, bacterie le contenant et procede de production de l-valine par culture de cette bacterie
DE602007013447D1 (de) Glutaminsäure in hoher ausbeute produzierender mikroorganismus und verfahren zur produktion von glutaminsäure damit
ATE318813T1 (de) Neue kristalline formen von meloxicam, deren herstellung und verfahren zu deren umwandlung ineinander
ATE392962T1 (de) Verfahren zur herstellung von stützpfeilern
AU2724895A (en) Nucleic acid sequence encoding trypsin-like enzyme and process for producing the enzyme
DE602004028054D1 (de) Verfahren zur herstellung von bernsteinsäure aus rohhydrolysaten
ATE402200T1 (de) Verfahren zur bildung von vorgebildeten stabilisatorpolyolen
DE60104807D1 (de) Verfahren mit hoher Produktionskapazität von Prenylalkohol durch Mikroorganismen
DE60207914D1 (de) Verfahren zur Herstellung von L-Glutaminsäure
ATE391787T1 (de) Verfahren zur herstellung von ubiquinon-10
ATE401407T1 (de) Verfahren zur herstellung von cytosin- nukleosidverbindungen
WO2005012498A3 (en) Production of porphyrins
ATE359287T1 (de) Ein verfahren zur herstellung von clopidogrel
DE60307403D1 (de) Bakterien und Verfahren zur Herstellung von Riboflavin durch Fermentation
ATE389010T1 (de) Verfahren zur herstellung von optisch aktiven pyridinethanol-derivaten
ATE417919T1 (de) Mikrobiologisches verfahren zur herstellung von amiden
ATE326545T1 (de) Verfahren zur herstellung von d- oder l-menthol
DE59904461D1 (de) Verfahren zur stereoselektiven herstellung von substituierten cyclohexylcyanhydrinen
ATE155530T1 (de) Mikrobiologisches verfahren zur herstellung von 6-hydroxypicolinsäure

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1314782

Country of ref document: EP