ATE426167T1 - Auto-antikírper gegen annexin-proteine als marker fur lungenkrebs - Google Patents

Auto-antikírper gegen annexin-proteine als marker fur lungenkrebs

Info

Publication number
ATE426167T1
ATE426167T1 AT06075982T AT06075982T ATE426167T1 AT E426167 T1 ATE426167 T1 AT E426167T1 AT 06075982 T AT06075982 T AT 06075982T AT 06075982 T AT06075982 T AT 06075982T AT E426167 T1 ATE426167 T1 AT E426167T1
Authority
AT
Austria
Prior art keywords
marker
lung cancer
antibodies against
annexin proteins
auto antibodies
Prior art date
Application number
AT06075982T
Other languages
English (en)
Inventor
Samir M Hanash
David Misek
Robert Hinderer
David Beer
Franck Brichory
Original Assignee
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan filed Critical Univ Michigan
Application granted granted Critical
Publication of ATE426167T1 publication Critical patent/ATE426167T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4718—Lipocortins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT06075982T 1999-08-06 2000-08-04 Auto-antikírper gegen annexin-proteine als marker fur lungenkrebs ATE426167T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/370,337 US6645465B2 (en) 1999-08-06 1999-08-06 Annexin proteins and autoantibodies as serum markers for cancer

Publications (1)

Publication Number Publication Date
ATE426167T1 true ATE426167T1 (de) 2009-04-15

Family

ID=23459219

Family Applications (3)

Application Number Title Priority Date Filing Date
AT09151524T ATE529751T1 (de) 1999-08-06 2000-08-04 Annexine als marker für lungenkrebs
AT00952594T ATE326699T1 (de) 1999-08-06 2000-08-04 Annexin-proteine und auto-antikörper als serummarker für lungenkrebs und ösophaguskrebs
AT06075982T ATE426167T1 (de) 1999-08-06 2000-08-04 Auto-antikírper gegen annexin-proteine als marker fur lungenkrebs

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT09151524T ATE529751T1 (de) 1999-08-06 2000-08-04 Annexine als marker für lungenkrebs
AT00952594T ATE326699T1 (de) 1999-08-06 2000-08-04 Annexin-proteine und auto-antikörper als serummarker für lungenkrebs und ösophaguskrebs

Country Status (10)

Country Link
US (5) US6645465B2 (de)
EP (3) EP2051079B1 (de)
JP (1) JP4594575B2 (de)
AT (3) ATE529751T1 (de)
AU (1) AU780772B2 (de)
CA (1) CA2380398C (de)
DE (2) DE60041839D1 (de)
DK (2) DK1200832T3 (de)
ES (2) ES2320585T3 (de)
WO (1) WO2001011372A1 (de)

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GB9810040D0 (en) 1998-05-11 1998-07-08 Univ Nottingham Blood borne tumour markers
GB9827228D0 (en) * 1998-12-10 1999-02-03 Univ Nottingham Cancer detection method and reagents
US6645465B2 (en) * 1999-08-06 2003-11-11 Michigan, University Of The Regents Annexin proteins and autoantibodies as serum markers for cancer
US20030232399A1 (en) * 2000-06-14 2003-12-18 Robertson John Forsyth Russell Cancer detection methods and reagents
CN1250567C (zh) * 2000-07-21 2006-04-12 财团法人化学及血清疗法研究所 钙离子结合蛋白的提纯方法
US7635676B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
US7645739B2 (en) 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
US7635680B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
AU2002252035A1 (en) 2001-02-21 2002-09-12 Surromed, Inc. Modified annexin proteins and methods for preventing thrombosis
US7214498B2 (en) * 2001-03-23 2007-05-08 Benaroya Research Institute At Virginia Mason Tumor associated antigens and methods of using the same
EP1428028A2 (de) * 2001-09-14 2004-06-16 Reinhard Zeidler Identifizierung von antigenen durch xenogene, allogene oder autologe antikörper-vermittelte präzipitation
EP1451587A4 (de) * 2001-11-09 2006-12-06 Benaroya Res Inst At Virginia Antigentafeln und verfahren zu deren verwendung
GB2395270B (en) * 2002-11-14 2006-08-16 Univ Nottingham Tumour marker proteins and uses thereof
WO2004079368A2 (en) 2003-03-08 2004-09-16 Auvation Ltd Markers for colorectal cancer
CA2555866A1 (en) * 2004-02-16 2005-08-25 Proteosys Ag Diagnostic markers for cancer
WO2005114192A1 (en) * 2004-05-13 2005-12-01 Centre National De La Recherche Scientifique A device for binding a target entity to a bait entity and detection methods using the same
US20060024722A1 (en) * 2004-07-30 2006-02-02 Mark Fischer-Colbrie Samples for detection of oncofetal fibronectin and uses thereof
RU2277242C2 (ru) * 2004-08-23 2006-05-27 Александр Владимирович Балюра Способ диагностики опухолей
JP4521575B2 (ja) * 2005-03-17 2010-08-11 国立大学法人 千葉大学 特発性肺線維症の検出マーカー、検出キット及び検出方法
EP1724585A1 (de) * 2005-05-21 2006-11-22 ProteoSys AG Annexin für Krebsrisikofeststellung
EP1724586A3 (de) * 2005-05-21 2007-07-04 ProteoSys AG Annexin für Krebsrisikomanagement
SI1889059T1 (sl) 2005-05-27 2009-12-31 Oncimmune Ltd Izboljšani imunotestni postopek
GB2426581A (en) * 2005-05-27 2006-11-29 Univ Nottingham Immunoassay methods
US20060286074A1 (en) * 2005-05-31 2006-12-21 Yucheng Tang Methods for immunotherapy of cancer
US8999727B2 (en) * 2005-09-26 2015-04-07 Ulrich Loos Innovative TSH-R-Ab-kit
CA2632190A1 (en) * 2005-11-10 2007-07-12 University Of Kentucky Lung cancer diagnostic assay
US9347945B2 (en) * 2005-12-22 2016-05-24 Abbott Molecular Inc. Methods and marker combinations for screening for predisposition to lung cancer
CN101490550A (zh) * 2006-07-08 2009-07-22 肯塔基大学研究基金会 肺癌诊断分析
CN101632020B (zh) 2006-09-13 2013-11-27 昂西免疫有限公司 改进的免疫测定方法
EP2097750A2 (de) * 2006-10-26 2009-09-09 Abbott Laboratories Immunoassay aus analyten in proben mit endogenen antikörpern gegen analyte
US20080305512A1 (en) * 2006-10-26 2008-12-11 Mattingly Phillip G Assay for cardiac troponin autoantibodies
US7776605B2 (en) * 2006-10-26 2010-08-17 Abbott Laboratories Assay for cardiac troponin autoantibodies
US20090047689A1 (en) * 2007-06-20 2009-02-19 John Kolman Autoantigen biomarkers for early diagnosis of lung adenocarcinoma
GB0725239D0 (en) * 2007-12-24 2008-02-06 Oncimmune Ltd Calibrator for autoantibody assay
EP2277049A4 (de) * 2008-05-09 2012-05-30 Univ Duke Autoantikörper für den nachweis und die behandlung von krebs
US9581599B2 (en) 2010-06-28 2017-02-28 The Board Of Regents Of The University Of Texas System Diagnosis of benign and cancerous growths by measuring circulating tumor stem cells and serum AnnexinA2
US9555074B2 (en) 2010-10-08 2017-01-31 Regents Of The University Of Minnesota Annexin II compositions
KR20150010882A (ko) * 2013-07-19 2015-01-29 삼성전자주식회사 아넥신 Ａ2 결합단백질, ｐ53 단백질 및 ｐ18 단백질을 포함하는 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 조성물
WO2015039175A1 (en) 2013-09-18 2015-03-26 Adelaide Research & Innovation Pty Ltd Autoantibody biomarkers of ovarian cancer
PL3068428T3 (pl) 2013-11-13 2023-03-13 Regents Of The University Of Minnesota Sposoby i kompozycje wariantów aneksyny ii
CN104407151B (zh) * 2014-11-19 2016-06-08 汕头大学医学院 Kindlin-2，Myosin-9和Annexin II三蛋白联合预测食管鳞癌患者预后试剂盒
CN113721021B (zh) * 2021-09-16 2023-07-07 郑州大学 Prkcz自身抗体在食管鳞癌辅助诊断中的应用
CN116539885B (zh) * 2023-07-06 2023-09-29 上海秤信生物科技有限公司 用于乳腺癌早期检测的肿瘤自身抗原/抗体组合及应用

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JPH02496A (ja) * 1987-12-24 1990-01-05 Nippon Shinyaku Co Ltd モノクローナル抗体、製法、及び利用法
DE4012341A1 (de) * 1990-04-18 1991-10-24 Behringwerke Ag Monoklonale antikoerper gegen pp4, verfahren zu ihrer herstellung und ihre verwendung
DE4040306A1 (de) 1990-12-17 1992-06-25 Behringwerke Ag Verfahren zur bestimmung von antikoerpern gegen lipocortine
US5405749A (en) * 1991-12-06 1995-04-11 Polans; Arthur S. Method for identifying and purifying a cancer associated retinopathy autoantigen, and testing patient serum for the autoantibody to the autoantigen
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US5658877A (en) * 1995-05-18 1997-08-19 Wisconsin Alumni Research Foundation Method to treat endotoxin effects by administration of 33 kilodalton phospholipid binding protein
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WO1999018435A1 (en) * 1997-10-08 1999-04-15 International Reagents Corporation Method for analyzing annexin v in urine and use thereof
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US6645465B2 (en) * 1999-08-06 2003-11-11 Michigan, University Of The Regents Annexin proteins and autoantibodies as serum markers for cancer

Also Published As

Publication number Publication date
AU780772B2 (en) 2005-04-14
EP2051079A3 (de) 2009-06-10
EP1734368A3 (de) 2007-03-07
JP4594575B2 (ja) 2010-12-08
US20040048320A1 (en) 2004-03-11
CA2380398A1 (en) 2001-02-15
DE60041839D1 (de) 2009-04-30
US20100330587A1 (en) 2010-12-30
WO2001011372A1 (en) 2001-02-15
DE60028040T2 (de) 2006-11-23
ES2320585T3 (es) 2009-05-25
EP2051079A2 (de) 2009-04-22
US20060275845A1 (en) 2006-12-07
EP1200832B1 (de) 2006-05-17
EP1734368A2 (de) 2006-12-20
ATE326699T1 (de) 2006-06-15
JP2003535309A (ja) 2003-11-25
EP1734368B1 (de) 2009-03-18
EP1200832A1 (de) 2002-05-02
EP2051079B1 (de) 2011-10-19
US20020168696A1 (en) 2002-11-14
US7759081B2 (en) 2010-07-20
DE60028040D1 (de) 2006-06-22
US6645465B2 (en) 2003-11-11
AU6526200A (en) 2001-03-05
WO2001011372A9 (en) 2002-04-11
DK1734368T3 (da) 2009-06-02
ES2259609T3 (es) 2006-10-16
US20070037227A1 (en) 2007-02-15
CA2380398C (en) 2017-01-31
DK1200832T3 (da) 2006-09-18
US7955602B2 (en) 2011-06-07
ATE529751T1 (de) 2011-11-15

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