ATE426594T1 - Verfahren zur herstellung von inhibitoren der hmg-coa-reduktase - Google Patents

Verfahren zur herstellung von inhibitoren der hmg-coa-reduktase

Info

Publication number: ATE426594T1
Authority: AT; Austria
Prior art keywords: coa reductase; reductase inhibitors; sub; img; hmg
Prior art date: 2002-01-31

Application number

AT03734716T

Other languages

English (en)

Inventor

Murat Acemoglu

Bernhard Riss

Original Assignee

Novartis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-31

Filing date

2003-01-30

Publication date

2009-04-15

2003-01-30 Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh

2009-04-15 Application granted granted Critical

2009-04-15 Publication of ATE426594T1 publication Critical patent/ATE426594T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
229940121710 HMGCoA reductase inhibitor Drugs 0.000 title 1
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title 1
229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 title 1
150000003839 salts Chemical class 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
150000002596 lactones Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Quinoline Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT03734716T 2002-01-31 2003-01-30 Verfahren zur herstellung von inhibitoren der hmg-coa-reduktase ATE426594T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US35378702P	2002-01-31	2002-01-31

Publications (1)

Publication Number	Publication Date
ATE426594T1 true ATE426594T1 (de)	2009-04-15

Family

ID=27663254

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03734716T ATE426594T1 (de)	2002-01-31	2003-01-30	Verfahren zur herstellung von inhibitoren der hmg-coa-reduktase

Country Status (22)

Country	Link
US (2)	US7371865B2 (de)
EP (1)	EP1472228B1 (de)
JP (1)	JP4524111B2 (de)
KR (1)	KR20040081161A (de)
CN (1)	CN1305853C (de)
AT (1)	ATE426594T1 (de)
AU (1)	AU2003226971B2 (de)
BR (1)	BR0307303A (de)
CA (1)	CA2472776C (de)
CO (1)	CO5601005A2 (de)
DE (1)	DE60326819D1 (de)
EC (1)	ECSP045214A (de)
ES (1)	ES2323267T3 (de)
IL (1)	IL162980A (de)
MX (1)	MXPA04007396A (de)
NO (1)	NO327091B1 (de)
NZ (1)	NZ534232A (de)
PL (1)	PL370658A1 (de)
PT (1)	PT1472228E (de)
RU (1)	RU2299196C2 (de)
WO (1)	WO2003064392A1 (de)
ZA (1)	ZA200405322B (de)

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EP1592668A1 (de)	2003-02-12	2005-11-09	Ciba SC Holding AG	Kristalline formen von pitavastatin-calcium
DE602004028599D1 (de) *	2003-04-24	2010-09-23	Daicel Chem	Verfahren zur herstellung von (3r,5s,6e)-7-ä2-cyclopropyl-4-(4-fluorphenyl)chinolin-3-ylü -3,5-dihydroxy-6-heptensäureethylester
TWI328006B (en) *	2003-12-26	2010-08-01	Nissan Chemical Ind Ltd	Crystal form of quinoline compound and process for its production
WO2006035286A2 (en) *	2004-09-27	2006-04-06	Ranbaxy Laboratories Limited	Process for preparating enantiomerically pure fluvastatin sodium and a novel polymorphic form thereof
WO2007125547A2 (en) *	2006-05-03	2007-11-08	Manne Satyanarayana Reddy	Novel process for statins and its pharmaceutically acceptable salts thereof
US8404841B2 (en) *	2006-10-09	2013-03-26	Msn Laboratories Limited	Process for the preparation of statins and their pharmaceutically acceptable salts thereof
JP2009531466A (ja)	2007-04-18	2009-09-03	テバファーマシューティカルインダストリーズリミティド	ＨＭＧ−ＣｏＡ還元酵素阻害剤の中間体の製造方法
EP2178890A1 (de) *	2007-07-12	2010-04-28	Teva Pharmaceutical Industries Ltd.	Reinigung eines rosuvastatinzwischenprodukts mittels dünnschichtverdampfung und chemisches verfahren
US8487105B2 (en) *	2009-01-19	2013-07-16	Msn Laboratories Limited	Process for preparing pitavastatin, intermediates and pharmaceuctically acceptable salts thereof
KR101160152B1 (ko) *	2009-02-24	2012-06-27	한미사이언스 주식회사	스타틴 화합물 또는 그 염의 신규 제조방법, 및 이에 사용되는 중간체 화합물
US8987444B2 (en)	2010-01-18	2015-03-24	Msn Laboratories Private Limited	Process for the preparation of amide intermediates and their use thereof
JP2013519666A (ja) *	2010-02-23	2013-05-30	カディラ・ヘルスケア・リミテッド	Ｈｍｇ−ｃｏａレダクターゼ阻害剤およびその調製のための方法
EP2383260A3 (de)	2010-04-30	2011-12-28	Dipharma Francis S.r.l.	Verfahren zur Herstellung von Statine
WO2011141934A1 (en)	2010-05-13	2011-11-17	Matrix Laboratories Ltd.	An improved process for the preparation of an intermediate of hmg-coa reductase inhibitors
WO2012002741A2 (en) *	2010-07-01	2012-01-05	Yuhan Corporation	Process for the preparation of hmg-coa reductase inhibitors and intermediates thereof
WO2012063254A1 (en) *	2010-11-12	2012-05-18	Hetero Research Foundation	Novel polymorphs of pitavastatin calcium
JP6181063B2 (ja)	2011-11-28	2017-08-16	マイランラボラトリーズリミテッドＭｙｌａｎＬａｂｏｒａｔｏｒｉｅｓＬｉｍｉｔｅｄ	ＨＭＧ−ＣｏＡレダクターゼ阻害剤の中間体の新規な製造方法
CN103288871A (zh) *	2012-02-28	2013-09-11	浙江京新药业股份有限公司	一种制备二羟基酸HMG-CoA还原酶抑制剂用的中间体及其制备方法和应用
ITVI20130039A1 (it)	2013-02-20	2014-08-21	F I S Fabbrica Italiana Sint I S P A	Processo per la preparazione di intermedi chiave per la sintesi di statine
CN103172656B (zh) *	2013-04-02	2015-07-08	浙江科技学院	3-二甲基叔丁基硅氧基戊二酸酐的合成工艺
CN111518035A (zh) *	2020-06-18	2020-08-11	安徽鼎旺医药有限公司	一种瑞舒伐他汀叔丁胺盐及其制备方法
CN113683539B (zh) *	2021-09-23	2023-05-16	上海裕兰生物科技有限公司	一种聚酮中间体的合成方法

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US5354772A (en) *	1982-11-22	1994-10-11	Sandoz Pharm. Corp.	Indole analogs of mevalonolactone and derivatives thereof
US4650890A (en) *	1984-04-03	1987-03-17	Sandoz Corp.	Preparation of olefinic compounds and intermediates thereof
JP2569746B2 (ja)	1987-08-20	1997-01-08	日産化学工業株式会社	キノリン系メバロノラクトン類
CA1336714C (en)	1987-08-20	1995-08-15	Yoshihiro Fujikawa	Quinoline type mevalonolactone inhibitors of cholesterol biosynthesis
US4804770A (en) *	1988-04-29	1989-02-14	E. R. Squibb & Sons, Inc.	Process for preparing a keto-phosphonate intermediate useful in preparing HMG-CoA reductase inhibitors
DE3911064A1 (de) *	1989-04-06	1990-10-11	Bayer Ag	Substituierte 1,8-naphthyridine
US5049577A (en) *	1990-01-29	1991-09-17	E. R. Squibb & Sons, Inc.	2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkynoic acids, compositions and HMG-CoA reductase inhibition therewith
ES2072468T3 (es) *	1990-05-11	1995-07-16	American Cyanamid Co	Nuevos arilpirroles n-acilados utiles como agentes insecticidas, acaricidas, nematicidas y molusquicidas.
JP3528186B2 (ja)	1991-06-24	2004-05-17	日産化学工業株式会社	光学活性キノリンメバロン酸のジアステレオマー塩
IL155890A0 (en) *	2000-11-16	2003-12-23	Teva Pharma	HYDROLYSIS OF [R(R,R)]-2-(4-FLUOROPHENYL)-beta,delta-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID ESTERS WITH CALCIUM HYDROXIDE
CN1329520C (zh) *	2001-02-02	2007-08-01	三菱化学株式会社	制备(3r,5s)－(e)－7－[2－环丙基－4－(4－氟苯基)－喹啉－3－基]－3,5－二羟基庚－6－烯酸酯的方法
DK1466905T3 (da) *	2001-11-14	2011-08-22	Nissan Chemical Ind Ltd	Fremgangsmåde til fremstilling af en optisk aktiv oxoheptensyreester
US6835838B2 (en) *	2002-01-28	2004-12-28	Novartis Ag	Process for the manufacture of organic compounds
GB0210234D0 (en) *	2002-05-03	2002-06-12	Novartis Ag	Process for the manufacture of organic compounds

2003
- 2003-01-30 BR BR0307303-3A patent/BR0307303A/pt not_active IP Right Cessation
- 2003-01-30 CN CNB038027402A patent/CN1305853C/zh not_active Expired - Lifetime
- 2003-01-30 EP EP03734716A patent/EP1472228B1/de not_active Expired - Lifetime
- 2003-01-30 CA CA2472776A patent/CA2472776C/en not_active Expired - Fee Related
- 2003-01-30 MX MXPA04007396A patent/MXPA04007396A/es active IP Right Grant
- 2003-01-30 PT PT03734716T patent/PT1472228E/pt unknown
- 2003-01-30 DE DE60326819T patent/DE60326819D1/de not_active Expired - Lifetime
- 2003-01-30 WO PCT/EP2003/000954 patent/WO2003064392A1/en not_active Ceased
- 2003-01-30 KR KR10-2004-7011808A patent/KR20040081161A/ko not_active Abandoned
- 2003-01-30 AU AU2003226971A patent/AU2003226971B2/en not_active Ceased
- 2003-01-30 AT AT03734716T patent/ATE426594T1/de active
- 2003-01-30 NZ NZ534232A patent/NZ534232A/xx not_active IP Right Cessation
- 2003-01-30 US US10/502,177 patent/US7371865B2/en not_active Expired - Lifetime
- 2003-01-30 RU RU2004126442/04A patent/RU2299196C2/ru not_active IP Right Cessation
- 2003-01-30 PL PL03370658A patent/PL370658A1/xx not_active Application Discontinuation
- 2003-01-30 ES ES03734716T patent/ES2323267T3/es not_active Expired - Lifetime
- 2003-01-30 JP JP2003564015A patent/JP4524111B2/ja not_active Expired - Lifetime
2004
- 2004-07-05 ZA ZA2004/05322A patent/ZA200405322B/en unknown
- 2004-07-12 IL IL162980A patent/IL162980A/en not_active IP Right Cessation
- 2004-07-30 EC EC2004005214A patent/ECSP045214A/es unknown
- 2004-08-10 CO CO04077715A patent/CO5601005A2/es not_active Application Discontinuation
- 2004-08-30 NO NO20043611A patent/NO327091B1/no not_active IP Right Cessation
2008
- 2008-03-24 US US12/054,193 patent/US20080182873A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1472228A1 (de)	2004-11-03
PT1472228E (pt)	2009-06-24
EP1472228B1 (de)	2009-03-25
RU2299196C2 (ru)	2007-05-20
CN1305853C (zh)	2007-03-21
PL370658A1 (en)	2005-05-30
NO327091B1 (no)	2009-04-20
JP4524111B2 (ja)	2010-08-11
US7371865B2 (en)	2008-05-13
CN1622937A (zh)	2005-06-01
RU2004126442A (ru)	2005-06-10
US20080182873A1 (en)	2008-07-31
DE60326819D1 (de)	2009-05-07
HK1070651A1 (en)	2005-06-24
IL162980A (en)	2010-02-17
ECSP045214A (es)	2004-09-28
CO5601005A2 (es)	2006-01-31
CA2472776C (en)	2011-01-25
ES2323267T3 (es)	2009-07-10
NO20043611L (no)	2004-08-30
AU2003226971B2 (en)	2006-11-30
NZ534232A (en)	2006-03-31
BR0307303A (pt)	2005-01-11
US20050070605A1 (en)	2005-03-31
JP2005520814A (ja)	2005-07-14
CA2472776A1 (en)	2003-08-07
MXPA04007396A (es)	2004-10-11
ZA200405322B (en)	2005-07-27
WO2003064392A1 (en)	2003-08-07
KR20040081161A (ko)	2004-09-20

Legal Events

Date

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Title

Description

2009-11-15

UEP

Publication of translation of european patent specification

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