ATE427316T1 - Verfahren zur reinigung von rohem vancomycin - Google Patents

Verfahren zur reinigung von rohem vancomycin

Info

Publication number: ATE427316T1
Authority: AT; Austria
Prior art keywords: vancomycin; hydrochloride; vancomycin hydrochloride; impurities; substantially free
Prior art date: 2004-12-07

Application number

AT05816363T

Other languages

English (en)

Inventor

Rok Grahek

Andrej Bastarda

Original Assignee

Lek Pharmaceuticals

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-07

Filing date

2005-12-05

Publication date

2009-04-15

2005-12-05 Application filed by Lek Pharmaceuticals filed Critical Lek Pharmaceuticals

2009-04-15 Application granted granted Critical

2009-04-15 Publication of ATE427316T1 publication Critical patent/ATE427316T1/de

Links

108010059993 Vancomycin Proteins 0.000 title abstract 7
238000000034 method Methods 0.000 title abstract 2
229960003165 vancomycin Drugs 0.000 title abstract 2
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 title abstract 2
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 title abstract 2
229960001572 vancomycin hydrochloride Drugs 0.000 abstract 5
LCTORFDMHNKUSG-XTTLPDOESA-N vancomycin monohydrochloride Chemical compound Cl.O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 LCTORFDMHNKUSG-XTTLPDOESA-N 0.000 abstract 5
239000012535 impurity Substances 0.000 abstract 4
230000003115 biocidal effect Effects 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 abstract 1
206010041925 Staphylococcal infections Diseases 0.000 abstract 1
238000004458 analytical method Methods 0.000 abstract 1
238000002086 displacement chromatography Methods 0.000 abstract 1
238000004128 high performance liquid chromatography Methods 0.000 abstract 1
229960003085 meticillin Drugs 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
108010032807 vancomycin B Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

AT05816363T 2004-12-07 2005-12-05 Verfahren zur reinigung von rohem vancomycin ATE427316T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SI200400334A SI21924A (sl)	2004-12-07	2004-12-07	Cist vankomicin hidroklorid

Publications (1)

Publication Number	Publication Date
ATE427316T1 true ATE427316T1 (de)	2009-04-15

Family

ID=35583459

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05816363T ATE427316T1 (de)	2004-12-07	2005-12-05	Verfahren zur reinigung von rohem vancomycin

Country Status (9)

Country	Link
US (1)	US8435938B2 (de)
EP (1)	EP1824874B1 (de)
JP (1)	JP4729047B2 (de)
AT (1)	ATE427316T1 (de)
DE (1)	DE602005013691D1 (de)
ES (1)	ES2322961T3 (de)
PL (1)	PL1824874T3 (de)
SI (2)	SI21924A (de)
WO (1)	WO2006061166A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1798237A1 (de)	2005-12-16	2007-06-20	Pharmatex Italia Srl	Prozess zur Reinigung von Makrolid-Antibiotika
KR101101663B1 (ko) *	2009-01-13	2011-12-30	(주) 제노텍	반코마이신 습체의 정제방법
CN104610434B (zh)	2013-11-01	2019-06-07	浙江医药股份有限公司新昌制药厂	一种盐酸万古霉素的分离纯化方法
WO2020081599A1 (en) *	2018-10-15	2020-04-23	Savara Inc.	Separation of vancomycin and its degradation products
WO2020182203A1 (zh) *	2019-03-14	2020-09-17	浙江医药股份有限公司新昌制药厂	一种万古霉素类似物的分离纯化方法
EP3962929B1 (de) *	2019-04-30	2023-03-01	Huvepharma Italia S.r.l.	Verfahren zur reinigung von lipoglykopeptid-antibiotika
CN114112612A (zh) *	2021-10-28	2022-03-01	丽珠集团福州福兴医药有限公司	一种替考拉宁i5杂质的分离纯化方法及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL73746A (en) *	1983-12-12	1988-07-31	Lilly Co Eli	Crystalline vancomycin diphosphate,its preparation,pharmaceutical compositions containing it and its conversion to vancomycin hydrochloride
JPH0260598A (ja) *	1988-08-22	1990-03-01	Glaxo Group Ltd	抗生物質の製造
US5258495A (en) *	1990-07-10	1993-11-02	Abbott Laboratories	Process for making vancomycin HC1
US5149784A (en) *	1990-07-10	1992-09-22	Abbott Laboratories	Process for making vancomycin
SI9500040B (sl) *	1995-02-07	2002-02-28	Lek,	Kromatografsko čiščenje Vankomicin hidroklorida z uporabo preparativne HPLC
US6391851B1 (en) *	1997-03-10	2002-05-21	Fujisawa Pharmaceutical Co., Ltd.	Hydrochlorides of vancomycin antibiotics and process for producing the same
CN1415758A (zh) *	2001-10-30	2003-05-07	上海医药工业研究院	盐酸万古霉素原料生产工艺
KR100554481B1 (ko) *	2004-06-30	2006-03-03	씨제이 주식회사	반코마이신 염산염의 정제방법

2004
- 2004-12-07 SI SI200400334A patent/SI21924A/sl not_active IP Right Cessation
2005
- 2005-12-05 WO PCT/EP2005/012998 patent/WO2006061166A1/en not_active Ceased
- 2005-12-05 PL PL05816363T patent/PL1824874T3/pl unknown
- 2005-12-05 SI SI200530700T patent/SI1824874T1/sl unknown
- 2005-12-05 AT AT05816363T patent/ATE427316T1/de active
- 2005-12-05 EP EP05816363A patent/EP1824874B1/de not_active Expired - Lifetime
- 2005-12-05 DE DE602005013691T patent/DE602005013691D1/de not_active Expired - Lifetime
- 2005-12-05 US US11/720,893 patent/US8435938B2/en not_active Expired - Fee Related
- 2005-12-05 JP JP2007544794A patent/JP4729047B2/ja not_active Expired - Fee Related
- 2005-12-05 ES ES05816363T patent/ES2322961T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US8435938B2 (en)	2013-05-07
JP2008523003A (ja)	2008-07-03
SI21924A (sl)	2006-06-30
EP1824874A1 (de)	2007-08-29
PL1824874T3 (pl)	2009-08-31
US20100190958A1 (en)	2010-07-29
ES2322961T3 (es)	2009-07-02
DE602005013691D1 (de)	2009-05-14
JP4729047B2 (ja)	2011-07-20
WO2006061166A1 (en)	2006-06-15
EP1824874B1 (de)	2009-04-01
SI1824874T1 (sl)	2009-08-31

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