ATE42747T1 - N-(2-(tetrahydro-3,5-dioxo-1h-pyrrolizin-7a(5h) yl)ethyl>aminderivate. - Google Patents

N-(2-(tetrahydro-3,5-dioxo-1h-pyrrolizin-7a(5h) yl)ethyl>aminderivate.

Info

Publication number: ATE42747T1
Authority: AT; Austria
Prior art keywords: radical; phenyl; compounds; phenylmethyl; chlorine
Prior art date: 1984-07-20

Application number

AT85305022T

Other languages

English (en)

Inventor

Donald E Butler

James D Leonard

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-07-20

Filing date

1985-07-15

Publication date

1989-05-15

1985-07-15 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1989-05-15 Application granted granted Critical

1989-05-15 Publication of ATE42747T1 publication Critical patent/ATE42747T1/de

Links

150000001412 amines Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
-1 N,N-bis (1-methylethyl)- aminoethyl Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
239000000460 chlorine Substances 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
229910052731 fluorine Inorganic materials 0.000 abstract 2
239000011737 fluorine Substances 0.000 abstract 2
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
208000000044 Amnesia Diseases 0.000 abstract 1
208000031091 Amnestic disease Diseases 0.000 abstract 1
239000012190 activator Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
230000006986 amnesia Effects 0.000 abstract 1
230000019771 cognition Effects 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT85305022T 1984-07-20 1985-07-15 N-(2-(tetrahydro-3,5-dioxo-1h-pyrrolizin-7a(5h) yl)ethyl>aminderivate. ATE42747T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/632,917 US4563469A (en)	1984-07-20	1984-07-20	Derivatives of N-[2-(tetrahydro-3,5-dioxo-1H-pyrrolizin-7a(5H)-yl)ethyl]amine as cognition activators
EP85305022A EP0170460B1 (de)	1984-07-20	1985-07-15	N-[2-(Tetrahydro-3,5-dioxo-1H-pyrrolizin-7a(5H)-yl)ethyl]aminderivate

Publications (1)

Publication Number	Publication Date
ATE42747T1 true ATE42747T1 (de)	1989-05-15

Family

ID=24537512

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT85305022T ATE42747T1 (de)	1984-07-20	1985-07-15	N-(2-(tetrahydro-3,5-dioxo-1h-pyrrolizin-7a(5h) yl)ethyl>aminderivate.

Country Status (5)

Country	Link
US (1)	US4563469A (de)
EP (1)	EP0170460B1 (de)
JP (1)	JPS6137786A (de)
AT (1)	ATE42747T1 (de)
DE (1)	DE3569926D1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4607043A (en) *	1983-02-09	1986-08-19	Warner-Lambert Company	Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-carboxylic acids and derivatives as cognition activators
US4638006A (en) *	1985-09-24	1987-01-20	Warner Lambert Company	Amnesia reversal with N,N-dialkylaminoalkyl-hexahydro-5-oxo 1H-pyrrolizine-3-carboxamides
US4663464A (en) *	1986-03-21	1987-05-05	Warner-Lambert Company	Process for the preparation of dihydro-1H-pyrrolizine-3,5-(2H,6H)-dione
US4895840A (en) *	1987-06-10	1990-01-23	A. H. Robins Company, Incorporated	N-(aryl-,aryloxy-,arylthio-arylsulfinyl-and arylsulfonyl-)alkyl-N,N'-(or n'n')alkylaminoalkyl ureas and cyanoguanidines
DE3918895A1 (de) *	1989-06-09	1990-12-13	Bayer Ag	Hochwaermeformbestaendige polycarbonat /abs-formmassen
US5428043A (en) *	1990-02-08	1995-06-27	Pfizer Inc.	Tricyclic-cyclic amines as novel cholinesterase inhibitors
TW197442B (de) *	1990-02-08	1993-01-01	Pfizer
US5434165A (en) *	1991-11-18	1995-07-18	Sanawa Kagaku Kenkyusho Company, Ltd.	Nootropic agents, compositions of, and method of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4547519A (en) *	1982-05-24	1985-10-15	Warner-Lambert Company	Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-carboxylic acid and benzyl esters and amides thereof and their use in reversing amnesia

1984
- 1984-07-20 US US06/632,917 patent/US4563469A/en not_active Expired - Fee Related
1985
- 1985-07-15 DE DE8585305022T patent/DE3569926D1/de not_active Expired
- 1985-07-15 EP EP85305022A patent/EP0170460B1/de not_active Expired
- 1985-07-15 AT AT85305022T patent/ATE42747T1/de not_active IP Right Cessation
- 1985-07-19 JP JP15848685A patent/JPS6137786A/ja active Pending

Also Published As

Publication number	Publication date
US4563469A (en)	1986-01-07
DE3569926D1 (de)	1989-06-08
EP0170460A1 (de)	1986-02-05
JPS6137786A (ja)	1986-02-22
EP0170460B1 (de)	1989-05-03

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Legal Events

Date	Code	Title	Description
1989-10-15	UEP	Publication of translation of european patent specification
1991-04-15	REN	Ceased due to non-payment of the annual fee