ATE427499T1 - Zusammensetzungen und verfahren zur quantifizierung von serumglykoproteinen - Google Patents

Zusammensetzungen und verfahren zur quantifizierung von serumglykoproteinen

Info

Publication number
ATE427499T1
ATE427499T1 AT05751819T AT05751819T ATE427499T1 AT E427499 T1 ATE427499 T1 AT E427499T1 AT 05751819 T AT05751819 T AT 05751819T AT 05751819 T AT05751819 T AT 05751819T AT E427499 T1 ATE427499 T1 AT E427499T1
Authority
AT
Austria
Prior art keywords
compositions
methods
serum glycoproteins
quantifying serum
quantifying
Prior art date
Application number
AT05751819T
Other languages
English (en)
Inventor
Rudolph Aebersold
Hui Zhang
Original Assignee
Inst Systems Biology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Systems Biology filed Critical Inst Systems Biology
Application granted granted Critical
Publication of ATE427499T1 publication Critical patent/ATE427499T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material
    • G01N2458/15Non-radioactive isotope labels, e.g. for detection by mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)
AT05751819T 2004-05-21 2005-05-20 Zusammensetzungen und verfahren zur quantifizierung von serumglykoproteinen ATE427499T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57359304P 2004-05-21 2004-05-21

Publications (1)

Publication Number Publication Date
ATE427499T1 true ATE427499T1 (de) 2009-04-15

Family

ID=35429005

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05751819T ATE427499T1 (de) 2004-05-21 2005-05-20 Zusammensetzungen und verfahren zur quantifizierung von serumglykoproteinen

Country Status (6)

Country Link
US (2) US20060141528A1 (de)
EP (4) EP1766412B1 (de)
AT (1) ATE427499T1 (de)
DE (1) DE602005013670D1 (de)
DK (1) DK1766412T3 (de)
WO (1) WO2005114221A2 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE344456T1 (de) * 2000-05-05 2006-11-15 Purdue Research Foundation Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen
EP1432992A2 (de) * 2001-09-27 2004-06-30 Purdue Research Foundation Kontrolle von isotopeneffekten während der analytfraktionierung
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
US7384754B2 (en) * 2003-10-31 2008-06-10 Agilent Technologies, Inc. Enrichment and tagging of glycosylated proteins
DE102004024617A1 (de) 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
US20070099251A1 (en) * 2005-10-17 2007-05-03 Institute For Systems Biology Tissue-and serum-derived glycoproteins and methods of their use
EP1790664A1 (de) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoklonale Antikörper gegen Claudin-18 zur Behandlung von Krebs
JP5244103B2 (ja) 2006-08-09 2013-07-24 ホームステッド クリニカル コーポレイション 器官特異的蛋白質およびその使用方法
US7879799B2 (en) * 2006-08-10 2011-02-01 Institute For Systems Biology Methods for characterizing glycoproteins and generating antibodies for same
DK2155228T3 (da) 2007-01-10 2014-07-07 Purdue Research Foundation Polypeptidinhibitorer af HSP27-kinase og anvendelser herfor
US20100184049A1 (en) * 2007-04-27 2010-07-22 Steve Goodison Glycoprotein Profiling of Bladder Cancer
US8603734B2 (en) * 2007-06-04 2013-12-10 The Johns Hopkins University Biomarkers for prostate cancer
US20100168382A1 (en) * 2007-06-12 2010-07-01 Vladimir Berezin Neuroplastin derived peptides
JP2010530962A (ja) * 2007-06-12 2010-09-16 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 血漿においてタンパク質を検出する方法
EP2174134B1 (de) * 2007-07-03 2013-10-09 NorthEastern University Biomarker für diabetes, obesität und/oder bluthochdruck
US20100204128A1 (en) * 2007-07-24 2010-08-12 Sanare Investment As Novel peptides
JP5703466B2 (ja) 2007-08-07 2015-04-22 パーデュー・リサーチ・ファウンデーションPurdue Research Foundation キナーゼ阻害薬およびその使用
AU2009208607B2 (en) * 2008-01-31 2013-08-01 Compugen Ltd. Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
AU2009324661A1 (en) 2008-12-10 2011-07-07 Purdue Research Foundation Cell-permeant peptide-based inhibitor of kinases
EP2427844A4 (de) 2009-05-08 2016-11-02 Thermo Finnigan Llc Verfahren und systeme zur abstimmung von produkten und vorläuferionen
WO2011007764A1 (ja) * 2009-07-14 2011-01-20 独立行政法人産業技術総合研究所 肝疾患病態指標糖鎖マーカー
WO2011017132A2 (en) 2009-07-27 2011-02-10 Purdue Research, Foundation Mk2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration
WO2011143386A1 (en) * 2010-05-14 2011-11-17 Dh Technologies Development Pte. Ltd. Systems and methods for calculating protein confidence values
US8969524B2 (en) * 2010-10-27 2015-03-03 Baxter International Inc. FVIII peptides for immune tolerance induction and immunodiagnostics
US9403889B2 (en) 2010-11-29 2016-08-02 Integrated Diagnostics, Inc. Diagnostic lung cancer panel and methods for its use
US8772043B2 (en) 2010-12-23 2014-07-08 Pioneer Hi Bred International Inc Universal peptide tags for transgene polypeptide analysis by mass spectrometry
JP6047150B2 (ja) * 2011-05-13 2016-12-21 キングス・カレッジ・ロンドン 血小板感受性に関係する方法と組成物
US8455624B2 (en) 2011-06-03 2013-06-04 University Of South Alabama Methods and compositions for detecting endometrial or ovarian cancer
US9506167B2 (en) 2011-07-29 2016-11-29 Ginkgo Bioworks, Inc. Methods and systems for cell state quantification
CA2848162C (en) 2011-09-12 2023-03-14 Creatics Llc Non-invasive methods of detecting target molecules
CN103134874B (zh) * 2011-12-01 2015-05-20 成都康弘生物科技有限公司 一种测定蛋白中糖基的方法
US9304137B2 (en) 2011-12-21 2016-04-05 Integrated Diagnostics, Inc. Compositions, methods and kits for diagnosis of lung cancer
US11913957B2 (en) 2011-12-21 2024-02-27 Biodesix, Inc. Compositions, methods and kits for diagnosis of lung cancer
AU2012358246B2 (en) 2011-12-21 2018-01-25 Integrated Diagnostics, Inc. Methods for diagnosis of lung cancer
JP6416627B2 (ja) * 2012-01-09 2018-10-31 セルピン ファーマ リミテッド ライアビリティ カンパニー ペプチドおよびその使用法
WO2013134636A1 (en) 2012-03-09 2013-09-12 Purdue Research Foundation Compositions and methods for delivery of kinase inhibiting peptides
WO2013167153A1 (en) 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Antibodies useful in cancer diagnosis
EP2918600B1 (de) * 2012-11-06 2019-04-24 University of Miyazaki Neuartiges peptid und verwendung davon
WO2014100717A2 (en) 2012-12-21 2014-06-26 Integrated Diagnostics, Inc. Compositions, methods and kits for diagnosis of lung cancer
CA2902841A1 (en) 2013-03-13 2014-10-02 Creatics Llc Methods and compositions for detecting pancreatic cancer
GB201310150D0 (en) * 2013-06-07 2013-07-24 Electrophoretics Ltd Methods and compositions relating to alzheimer's disease
CN105793710B (zh) 2013-07-26 2019-04-09 佰欧迪塞克斯公司 用于肺癌诊断的组合物、方法和试剂盒
US9594085B2 (en) 2014-02-03 2017-03-14 Integrated Diagnostics, Inc. Integrated quantification method for protein measurements in clinical proteomics
HRP20200967T1 (hr) 2014-06-20 2020-10-16 Immatics Biotechnologies Gmbh Nova imunoterapija protiv nekoliko tumora krvi, posebice kronične limfoidne leukemije (cll)
GB201411037D0 (en) * 2014-06-20 2014-08-06 Immatics Biotechnologies Gmbh Novel immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemai (CLL)
WO2016038608A1 (en) * 2014-09-08 2016-03-17 Carmel Haifa University Economic Corporation Ltd. Peptides derived from angiotensin receptor and use thereof
WO2016054114A1 (en) 2014-09-29 2016-04-07 The Regents Of The University Of California Compositions for expanding regulatory t cells (treg), and treating autoimmune and inflammatory diseases and conditions
GB201505305D0 (en) 2015-03-27 2015-05-13 Immatics Biotechnologies Gmbh Novel Peptides and combination of peptides for use in immunotherapy against various tumors
FI3273986T3 (fi) 2015-03-27 2024-02-07 Immatics Biotechnologies Gmbh Uusia peptidejä ja peptidien yhdistelmiä käytettäväksi immunoterapiassa eri syöpiä vastaan
CN113429455B (zh) 2015-08-28 2024-11-22 赛品制药有限责任公司 用于疾病治疗的方法
GB201520550D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520559D0 (en) * 2015-11-23 2016-01-06 Immunocore Ltd & Adaptimmune Ltd Peptides
GB201520568D0 (en) 2015-11-23 2016-01-06 Immunocore Ltd Peptides
US10802027B2 (en) 2016-05-05 2020-10-13 Biodesix, Inc. Compositions, methods and kits for diagnosis of lung cancer
US9960027B2 (en) 2016-05-25 2018-05-01 Thermo Finnigan Llc Analyzing a complex sample by MS/MS using isotopically-labeled standards
AU2018324195B2 (en) * 2017-09-01 2024-12-12 Venn Biosciences Corporation Identification and use of glycopeptides as biomarkers for diagnosis and treatment monitoring
ES2710321A1 (es) * 2017-10-20 2019-04-24 Consejo Superior Investigacion Adn polimerasas independientes de cebador y su uso para la sintesis de adn
WO2020223646A1 (en) 2019-05-02 2020-11-05 Creatics Llc Methods for cancer detection by evaluation of alpha-1-antitrypsin (aat) and chymotrypsin-like elastase in gastrointestinal lavage fluid samples
CN110563844A (zh) * 2019-09-04 2019-12-13 华中农业大学 一种抗犬白介素31受体的多克隆抗体及其应用
WO2021050510A1 (en) * 2019-09-09 2021-03-18 The Wistar Institute Of Anatomy And Biology Engineered peptide and peptide mimetic compositions and methods
ES2984813T3 (es) * 2020-04-28 2024-10-31 Janssen Pharmaceuticals Inc Método para la identificación y la cuantificación de polisacáridos en composiciones de glicoconjugados complejas
US12105093B2 (en) 2020-07-28 2024-10-01 University Of Washington Quantitation of GLA proteins by mass spectrometric analysis
EP4053559A1 (de) * 2021-03-01 2022-09-07 Consorcio Centro de Investigación Biomédica en Red, M.P. (CIBER) Verfahren zur messung von protein c und aktiviertem protein c
US20240219400A1 (en) * 2021-04-29 2024-07-04 Seer, Inc. Peptide decorated nanoparticles for enrichment of specific protein subsets
CN113480629B (zh) * 2021-06-16 2022-08-19 复旦大学 区分肝癌和正常人的末端唾液酸化异构糖肽标志物及其筛查方法
CN115490763A (zh) * 2021-06-18 2022-12-20 佛山热休生物技术有限公司 Lum的表位肽及所述表位肽与热休克蛋白的复合物
US11542340B1 (en) 2021-10-29 2023-01-03 Biodesix, Inc. Antibodies targeting pulmonary nodule specific biomarkers and uses thereof
NL2030990B1 (en) * 2022-02-17 2023-09-01 Academisch Ziekenhuis Leiden T cell receptors directed against jchain and uses thereof
WO2023164697A2 (en) * 2022-02-28 2023-08-31 PrognomIQ, Inc. Glycoprotein assessment
JP2025535396A (ja) * 2022-10-21 2025-10-24 クアンタム-エスアイ インコーポレイテッド ポリペプチジルリンカー
CN117969642B (zh) * 2024-04-02 2024-07-23 浙江大学 一种植物n-糖链的精准相对定量分析方法及应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2226032B (en) * 1988-12-16 1993-08-18 Urs Heimgartner Detection of glycoproteins
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5079336A (en) * 1989-06-23 1992-01-07 The Trustees Of The University Of Pennsylvania α-1-antichymotrypsin, analogues and methods of production
US5264563A (en) 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
GB9112504D0 (en) * 1991-06-11 1991-07-31 Merck Sharp & Dohme Cell line
US5986076A (en) 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
JPH10507160A (ja) 1994-06-23 1998-07-14 アフィマックス テクノロジーズ エヌ.ブイ. 光活性化合物およびその使用方法
JP4503706B2 (ja) * 1996-06-07 2010-07-14 ポニアード ファーマシューティカルズ,インコーポレイティド グリコシル化が改質されたヒト化抗体
EP0959893A4 (de) * 1996-12-10 2004-11-10 Sloan Kettering Institutefor C Stimulierung einer immunantwort auf ein differentiationsantigen, das durch ein verändertes antigen stimuliert wird
US6046013A (en) * 1997-08-01 2000-04-04 Gti Process for identifying specific antibodies associated with HLA
EP1329513B1 (de) 1998-08-25 2011-12-07 University of Washington Schnelle quantitative Analyse von Proteinen oder Proteinfunktionen in komplexen Gemischen
US6407210B1 (en) * 1998-11-09 2002-06-18 University Of Utah Research Foundation Nematode neuromuscular junction GABA receptors and methods related thereto
JP2003518364A (ja) * 1999-05-28 2003-06-10 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ 乳癌、胃癌および前立腺癌関連抗原ならびにそれらの使用
WO2002052259A1 (en) 2000-12-26 2002-07-04 The Institute For Systems Biology Rapid and quantitative proteome analysis and related methods
CA2444882A1 (en) * 2001-04-30 2002-11-07 Vertex Pharmaceuticals Incorporated Inhibitors of gsk-3 and crystal structures of gsk-3.beta. protein and protein complexes
EP1432992A2 (de) * 2001-09-27 2004-06-30 Purdue Research Foundation Kontrolle von isotopeneffekten während der analytfraktionierung
WO2003102018A2 (en) * 2002-06-03 2003-12-11 The Institute For Systems Biology Methods for quantitative proteome analysis of glycoproteins
WO2005007677A2 (en) * 2003-07-10 2005-01-27 The Institute For Systems Biology Affinity capture of peptides by microarray and related methods
US7593336B2 (en) * 2003-10-31 2009-09-22 Brocade Communications Systems, Inc. Logical ports in trunking
US7348416B2 (en) * 2003-11-21 2008-03-25 Applera Corporation Selective capture and enrichment of proteins expressed on the cell surface

Also Published As

Publication number Publication date
EP2302394A1 (de) 2011-03-30
EP1766412A2 (de) 2007-03-28
EP1766412B1 (de) 2009-04-01
EP2093569A3 (de) 2009-11-11
DE602005013670D1 (de) 2009-05-14
WO2005114221A2 (en) 2005-12-01
EP2302393A1 (de) 2011-03-30
WO2005114221A8 (en) 2006-05-04
EP2093569A2 (de) 2009-08-26
EP2302393A8 (de) 2011-08-03
WO2005114221A3 (en) 2006-12-21
DK1766412T3 (da) 2009-05-25
US20060141528A1 (en) 2006-06-29
US20100279382A1 (en) 2010-11-04

Similar Documents

Publication Publication Date Title
DE602005013670D1 (de) Zusammensetzungen und verfahren zur quantifizierung von serumglykoproteinen
DE60335733D1 (de) Verfahren zur solubilisierung von protein
EP1254267A4 (de) Zusammensetzungen und methoden zur früherkennung von eierstockkrebs
DE60222864D1 (de) Verfahren und vorrichtung zur untersuchung von fluiden
DE60027551D1 (de) Zusammensetzungen und verfahren zur regulierung des serumcholesterins
ATE269295T1 (de) Btk inhibitoren und verfahren zur identifizierung und verwendung
DE60026452D1 (de) Verfahren zur Identifizierung von Peptidensequenzen und Proteinensequenzen mittels Massenspektromterie
DE60326012D1 (de) Verfahren zur Konzentration von Proteinen
WO2005012574A3 (en) Biological bar-code
DE60237905D1 (de) Set zur Entnahme von Knochenmark
DE60023936D1 (de) Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen
EP1468287A4 (de) Automatische systeme und verfahren zur analyse der posttranslationalen proteinmodifikation
ATE520466T1 (de) Apparat und verfahren zur modifizierung von magnetisch inmmobilizierte biomolekulen
DE50213709D1 (de) Verfahren zur bereitstellung von zielführungshinweisen
ATA1112001A (de) Verfahren zur tragekontrolle von regulierungen
DE60229204D1 (de) Prozessor und Verfahren zur Urladung desselben
DE50214217D1 (de) Verfahren zur ermittlung des ladezustands und/oder
DE50203510D1 (de) Verfahren zur erkennung und identifizierung von objekten
DE50207337D1 (de) Anordnung und verfahren zur ermittlung von kenngrössen
ATE506370T1 (de) Reagenzien und verfahren zur bildung von disulfid-bindungen und glykosylierung von proteinen
ATE487792T1 (de) Verfahren und zusammensetzungen zur identifikation von rna-bindenden proteinen
DE60315575D1 (de) Verfahren und Vorrichtung zur Untersuchung von Oberflächen
DE69916247D1 (de) Vorrichtung zur fixierung von knochenbrüchen
EP1385947A4 (de) Zusammensetzungen und verfahren zur blutungskontrolle
DE60212032D1 (de) Systemen und Verfahren zur Koordinierung von Quälitätssicherungsereignissen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties