ATE427954T1 - Abtrennung von lipopolysacchariden aus lipopolysaccharidkomplexen mit hilfe von nicht- entzundbaren lísungsmitteln - Google Patents

Abtrennung von lipopolysacchariden aus lipopolysaccharidkomplexen mit hilfe von nicht- entzundbaren lísungsmitteln

Info

Publication number
ATE427954T1
ATE427954T1 AT04755271T AT04755271T ATE427954T1 AT E427954 T1 ATE427954 T1 AT E427954T1 AT 04755271 T AT04755271 T AT 04755271T AT 04755271 T AT04755271 T AT 04755271T AT E427954 T1 ATE427954 T1 AT E427954T1
Authority
AT
Austria
Prior art keywords
lps
protein
alkanediols
complexes
separation
Prior art date
Application number
AT04755271T
Other languages
English (en)
Inventor
Philip Ropp
Michael Murray
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Application granted granted Critical
Publication of ATE427954T1 publication Critical patent/ATE427954T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT04755271T 2003-06-24 2004-06-15 Abtrennung von lipopolysacchariden aus lipopolysaccharidkomplexen mit hilfe von nicht- entzundbaren lísungsmitteln ATE427954T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48089903P 2003-06-24 2003-06-24
US48859603P 2003-07-18 2003-07-18

Publications (1)

Publication Number Publication Date
ATE427954T1 true ATE427954T1 (de) 2009-04-15

Family

ID=33567625

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04755271T ATE427954T1 (de) 2003-06-24 2004-06-15 Abtrennung von lipopolysacchariden aus lipopolysaccharidkomplexen mit hilfe von nicht- entzundbaren lísungsmitteln

Country Status (8)

Country Link
US (3) US20060189790A1 (de)
EP (1) EP1638990B1 (de)
JP (1) JP2007526225A (de)
AT (1) ATE427954T1 (de)
CA (1) CA2530454A1 (de)
DE (1) DE602004020473D1 (de)
ES (1) ES2323642T3 (de)
WO (1) WO2005003152A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399570B1 (en) * 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
EP1638990B1 (de) * 2003-06-24 2009-04-08 N.V. Organon Abtrennung von lipopolysacchariden aus lipopolysaccharidkomplexen mit hilfe von nicht-entzündbaren lösungsmitteln
ATE529448T1 (de) 2007-02-28 2011-11-15 Lipoxen Technologies Ltd Verringerung von endotoxin in polysialinsäuren
AU2014201943B2 (en) * 2007-07-10 2016-07-28 Glanbia Nutritionals Method for removing endotoxin from proteins
EP2173770B1 (de) * 2007-07-10 2015-05-27 Glanbia Nutritionals (Ireland) Limited Verfahren zur entfernung von endotoxin aus proteinen
WO2010089385A1 (en) * 2009-02-06 2010-08-12 Novozymes Biopharma Dk A/S Purification process
WO2010123386A1 (en) 2009-04-24 2010-10-28 Westland Co-Operative Dairy Company Limited Method of preparing low-iron lactoferrin
CN103880947B (zh) * 2012-12-21 2016-01-13 武汉禾元生物科技股份有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
ES2662957T3 (es) 2014-06-12 2018-04-10 Hyglos Invest Gmbh Desenmascaramiento de endotoxinas en disolución
ES2736024T5 (es) * 2014-06-12 2022-07-01 Biomerieux Deutschland Gmbh Desenmascarar endotoxinas en solución
ES2694276T3 (es) 2014-09-24 2018-12-19 Basf Se Procedimiento para la producción de diésteres del ácido tereftálico
CA2962162A1 (en) 2014-09-24 2016-03-31 Basf Se Method for producing diesters of terephthalic acid with circulation of the reaction mixture
RU2668223C1 (ru) 2014-09-24 2018-09-27 Басф Се Способ получения сложных диэфиров терефталевой кислоты с обезвоживанием возвратного спирта
CN107074721B (zh) 2014-09-24 2021-01-08 巴斯夫欧洲公司 以回流醇富集制备对苯二甲酸二酯的方法
CN105251049B (zh) * 2015-09-29 2018-04-10 浙江星月生物科技股份有限公司 一种去除生物医用材料中细菌内毒素的离子缓冲液及应用
DE102016106271B4 (de) 2016-04-06 2018-03-29 Axagarius Gmbh & Co. Kg Aufreinigung von Nukleinsäure aus einer Nukleinsäure und Endotoxin enthaltenden Probe
WO2017205166A1 (en) 2016-05-26 2017-11-30 Cytosorbents Corporation The use of a hemocompatible porous polymer bead sorbent for removal of endotoxemia-inducing molecules

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004137B1 (de) * 1978-02-17 1981-11-11 National Research Development Corporation Immunologische Zellhüllepräparate
US4832751A (en) * 1987-07-01 1989-05-23 The United States Of America As Represented By The Secretary Of Agriculture Method for reduction of endotoxin in cotton lint or dust
JP2577237B2 (ja) * 1988-02-05 1997-01-29 雪印乳業株式会社 樹脂担体からパイロジェンを除去する方法
EP0407037B1 (de) * 1989-06-12 1994-09-21 Merck & Co. Inc. Verfahren zur Entfernung von bakteriellen Endotoxinen aus gram-negativen Polysacchariden
US5045456A (en) * 1989-06-12 1991-09-03 Merck & Co., Inc. Process for removing bacterial endotoxin from gram-negative polysaccharides
DK0775150T3 (da) * 1994-02-07 1999-11-08 Qiagen Gmbh Fremgangsmåde til reduktion eller fjernelse af endotoksiner
US6265542B1 (en) * 1997-10-24 2001-07-24 Genentech, Inc. Purification of molecules
AU4314099A (en) * 1998-06-01 1999-12-20 Immune Response Corporation, The Novel method of large scale plasmid purification
DE10010342A1 (de) * 2000-03-06 2001-09-20 Merck Patent Gmbh Verfahren zur Abreicherung von Endotoxinen
US6966992B2 (en) * 2001-03-19 2005-11-22 Akzo Nobel Nv Method of purification of molecules using unbranched terminal alkyldiols
EP1638990B1 (de) * 2003-06-24 2009-04-08 N.V. Organon Abtrennung von lipopolysacchariden aus lipopolysaccharidkomplexen mit hilfe von nicht-entzündbaren lösungsmitteln

Also Published As

Publication number Publication date
EP1638990B1 (de) 2009-04-08
WO2005003152A8 (en) 2005-03-10
DE602004020473D1 (de) 2009-05-20
CA2530454A1 (en) 2005-01-13
US20110003976A1 (en) 2011-01-06
ES2323642T3 (es) 2009-07-22
WO2005003152A1 (en) 2005-01-13
US20060189790A1 (en) 2006-08-24
US8399633B2 (en) 2013-03-19
EP1638990A1 (de) 2006-03-29
JP2007526225A (ja) 2007-09-13
US20130267691A1 (en) 2013-10-10

Similar Documents

Publication Publication Date Title
ATE427954T1 (de) Abtrennung von lipopolysacchariden aus lipopolysaccharidkomplexen mit hilfe von nicht- entzundbaren lísungsmitteln
Kubra et al. Enhanced toxic dye removal from wastewater using biodegradable polymeric natural adsorbent
Huang et al. Separation of long double-stranded DNA by nanoparticle-filled capillary electrophoresis
Mazzola et al. Liquid–liquid extraction of biomolecules: an overview and update of the main techniques
CY1111817T1 (el) Απομακρυνση του διαλυτη με μια διαδικασια προσθιας οσμωσης
ATE419629T1 (de) Poröse ferro- oder ferrimagnetische glasteilchen für molekültrennung
EA200300137A1 (ru) Анти-il-12-антитела, композиции, способы и применения
Wilson et al. Understanding copper-thiolate containing electron transfer centers by incorporation of unnatural amino acids and the CuA center into the type 1 copper protein azurin
ATE463560T1 (de) Fad4, fad5, fad5-2, and fad6, mitglieder der fettsäuredesaturasefamilie und ihre verwendungen
BR0106117A (pt) Polìmeros enxertados de polivinilacetal
WO2008139902A1 (ja) 分子応答性ゲル微粒子およびその製造方法ならびにその利用
CN104551738A (zh) 一种多件联动夹紧装置
JP2006501215A5 (de)
CA2414516A1 (en) Dispersal of polyacrylamides
EP1543007A4 (de) Neue zwitterionische fluoreszierende farbstoffe zur markierung bei proteomischen und anderen biologischen analysen
Chen et al. Glycogen: a novel branched polysaccharide chiral selector in CE
Bohlin et al. Separation of conjugated trienoic fatty acid isomers by capillary electrophoresis
EA200501276A1 (ru) Агломерированные адсорбенты, способ их получения и их применение для сушки органических соединений
Wedyan et al. Isomer-selective adsorption of amino acids by components of natural sediments
ATE274576T1 (de) 2,5-diketo-d-gluconsäure-reduktasen und deren anwendungen
MX2008004899A (es) Compuestos y métodos para partículas de condensado de ácido ribonucleico de péptido para terapéuticos de arn.
ATE463296T1 (de) Adsorptives filtermaterial
DE50008101D1 (de) Verfahren zur Aufreinigung von Nukleinsäuren sowie Anionenaustauscher zur Durchführung dieses Verfahrens
Yusuf et al. Effect of sporopollenin microparticle incorporation into the hexyl methacrylate-based monolithic columns for capillary liquid chromatography
BR0015776B1 (pt) partÍculas irreversivelmente recobertas, processo para preparar ditas partÍculas e composiÇÕes contendo as mesmas.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties