ATE427973T1 - Polypeptide mit fahigkeit zum einfangen und kontrollierten freisetzen von wirkstoffen - Google Patents
Polypeptide mit fahigkeit zum einfangen und kontrollierten freisetzen von wirkstoffenInfo
- Publication number
- ATE427973T1 ATE427973T1 AT05751092T AT05751092T ATE427973T1 AT E427973 T1 ATE427973 T1 AT E427973T1 AT 05751092 T AT05751092 T AT 05751092T AT 05751092 T AT05751092 T AT 05751092T AT E427973 T1 ATE427973 T1 AT E427973T1
- Authority
- AT
- Austria
- Prior art keywords
- controlled way
- polypeptides
- catch
- ability
- active ingredients
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 239000004480 active ingredient Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 229920000642 polymer Polymers 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 235000003704 aspartic acid Nutrition 0.000 abstract 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- 235000018977 lysine Nutrition 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Inorganic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57892904P | 2004-06-10 | 2004-06-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE427973T1 true ATE427973T1 (de) | 2009-04-15 |
Family
ID=35079310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05751092T ATE427973T1 (de) | 2004-06-10 | 2005-06-09 | Polypeptide mit fahigkeit zum einfangen und kontrollierten freisetzen von wirkstoffen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050276783A1 (de) |
| EP (1) | EP1753803B1 (de) |
| AT (1) | ATE427973T1 (de) |
| CA (1) | CA2569672A1 (de) |
| DE (1) | DE602005013773D1 (de) |
| ES (1) | ES2325331T3 (de) |
| WO (1) | WO2005121215A2 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070134335A1 (en) * | 2005-06-08 | 2007-06-14 | Lledo Ernest G | Polypeptides with the capacity to entrap drugs and release them in a controlled way |
| CA2631704A1 (en) | 2005-12-05 | 2007-06-14 | Nitto Denko Corporation | Polyglutamate-amino acid conjugates and methods |
| CA2683590A1 (en) | 2007-05-09 | 2008-11-20 | Nitto Denko Corporation | Compositions that include a hydrophobic compound and a polyamino acid conjugate |
| WO2009027998A2 (en) * | 2007-08-27 | 2009-03-05 | Natco Pharma Limited | A process for the preparation of alanine-nca (alanine-n-carboxyanhydride) from alanine with tri phosgene |
| JP2012505906A (ja) * | 2008-10-15 | 2012-03-08 | 日東電工株式会社 | ポリグルタメートコンジュゲートの調製方法 |
| JP2013514443A (ja) * | 2009-12-16 | 2013-04-25 | 日東電工株式会社 | ポリグルタミン酸の制御された合成 |
| EP2942348B1 (de) * | 2014-05-07 | 2017-10-25 | Johannes Gutenberg-Universität Mainz | Thiol-geschützte Aminosäurederivate und ihre Verwendungen |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3529625A1 (de) * | 1985-03-01 | 1986-09-04 | Consortium für elektrochemische Industrie GmbH, 8000 München | Phytochelatine, verfahren zu deren herstellung und ihre verwendung |
| US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| EP1065233A1 (de) * | 1998-02-27 | 2001-01-03 | Ono Pharmaceutical Co., Ltd. | Trägerpolymere, die in zielorgane wandern sowie arzneistoffhaltige polymere |
| US7018654B2 (en) * | 1999-03-05 | 2006-03-28 | New River Pharmaceuticals Inc. | Pharmaceutical composition containing an active agent in an amino acid copolymer structure |
| WO2000052078A1 (en) * | 1999-03-05 | 2000-09-08 | Innovative Technologies, Llc | Use of protein conformation for the protection and release of chemical compounds |
| US7060708B2 (en) * | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| JP2001323059A (ja) * | 2000-05-18 | 2001-11-20 | Hisamitsu Pharmaceut Co Inc | ポリペプチド誘導体および核酸運搬体 |
| US20070134335A1 (en) * | 2005-06-08 | 2007-06-14 | Lledo Ernest G | Polypeptides with the capacity to entrap drugs and release them in a controlled way |
-
2005
- 2005-06-08 US US11/147,569 patent/US20050276783A1/en not_active Abandoned
- 2005-06-09 AT AT05751092T patent/ATE427973T1/de not_active IP Right Cessation
- 2005-06-09 DE DE602005013773T patent/DE602005013773D1/de not_active Expired - Lifetime
- 2005-06-09 CA CA002569672A patent/CA2569672A1/en not_active Abandoned
- 2005-06-09 WO PCT/IB2005/001613 patent/WO2005121215A2/en not_active Ceased
- 2005-06-09 ES ES05751092T patent/ES2325331T3/es not_active Expired - Lifetime
- 2005-06-09 EP EP05751092A patent/EP1753803B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2569672A1 (en) | 2005-12-22 |
| US20050276783A1 (en) | 2005-12-15 |
| EP1753803B1 (de) | 2009-04-08 |
| EP1753803A2 (de) | 2007-02-21 |
| DE602005013773D1 (de) | 2009-05-20 |
| ES2325331T3 (es) | 2009-09-01 |
| WO2005121215A3 (en) | 2006-08-10 |
| WO2005121215A2 (en) | 2005-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |