ATE428412T1 - Behandlung von augenkrankheiten mit harnstoff und harnstoffderivaten - Google Patents

Behandlung von augenkrankheiten mit harnstoff und harnstoffderivaten

Info

Publication number: ATE428412T1
Authority: AT; Austria
Prior art keywords: urea; derivatives; treatment; compound; eye diseases
Prior art date: 2002-02-13

Application number

AT03709127T

Other languages

English (en)

Inventor

Vicken Karageozian

David Castillejos

John Park

Original Assignee

Vitreo Retinal Technologies In

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-13

Filing date

2003-02-13

Publication date

2009-05-15

2003-02-13 Application filed by Vitreo Retinal Technologies In filed Critical Vitreo Retinal Technologies In

2009-05-15 Application granted granted Critical

2009-05-15 Publication of ATE428412T1 publication Critical patent/ATE428412T1/de

Links

XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title abstract 5
239000004202 carbamide Substances 0.000 title abstract 2
208000030533 eye disease Diseases 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
206010038848 Retinal detachment Diseases 0.000 abstract 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
150000002357 guanidines Chemical class 0.000 abstract 1
229940083094 guanine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
210000005036 nerve Anatomy 0.000 abstract 1
150000003585 thioureas Chemical class 0.000 abstract 1
150000003672 ureas Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Ophthalmology & Optometry (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Surgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

AT03709127T 2002-02-13 2003-02-13 Behandlung von augenkrankheiten mit harnstoff und harnstoffderivaten ATE428412T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US35734702P	2002-02-13	2002-02-13
US35757402P	2002-02-15	2002-02-15
PCT/US2003/004617 WO2003068166A2 (en)	2002-02-13	2003-02-13	Treatment of ophthalmic disorders using urea and urea derivatives

Publications (1)

Publication Number	Publication Date
ATE428412T1 true ATE428412T1 (de)	2009-05-15

Family

ID=27737587

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03709127T ATE428412T1 (de)	2002-02-13	2003-02-13	Behandlung von augenkrankheiten mit harnstoff und harnstoffderivaten

Country Status (15)

Country	Link
EP (1)	EP1480678B1 (de)
JP (1)	JP2005521681A (de)
KR (1)	KR20040094687A (de)
CN (1)	CN1633308A (de)
AT (1)	ATE428412T1 (de)
AU (1)	AU2003213084B2 (de)
BR (1)	BR0307611A (de)
CA (1)	CA2475338C (de)
DE (1)	DE60327179D1 (de)
ES (1)	ES2325360T3 (de)
IL (1)	IL163374A (de)
MX (1)	MXPA04007802A (de)
NZ (1)	NZ535165A (de)
RU (1)	RU2339369C2 (de)
WO (1)	WO2003068166A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7977385B2 (en)	2000-03-02	2011-07-12	Numoda Biotechnologies, Inc.	Agents for corneal or intrastromal administration to treat or prevent disorders of the eye
US20030199574A1 (en)	2000-03-02	2003-10-23	Vitreo-Retinal Technologies, Inc.	Treatment of ophthalmic disorders using urea and urea derivatives
EP1482922A4 (de) *	2002-03-14	2005-06-08	Vitreo Retinal Technologies In	Mittel für die corneale oder intrastromale verabreichung zur behandlung oder prävention von erkrankungen des auges
IL264842B (en) *	2016-08-18	2022-08-01	Troy Bremer	Delivery of urea to cells of the macula and retina using liposome constructs
US10632211B2 (en) *	2018-06-11	2020-04-28	The Regents Of The University Of California	Demethylation to treat eye disease

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5A (en) *		1836-08-10	Thomas Blanchard	Machine for mortising solid wooden shells of ships' tackle-blocks
GB8908063D0 (en) *	1989-04-11	1989-05-24	Beecham Group Plc	Novel compounds
ES2204920T3 (es) *	1993-05-27	2004-05-01	Cenes Limited	Guanidinas substituidas terapeuticas.
US5470881A (en) *	1993-09-09	1995-11-28	West Virginia University Research Corporation	Urea ophthalmic ointment and solution
AU705487B2 (en) *	1993-11-23	1999-05-20	Cambridge Neuroscience, Inc.	Therapeutic substituted guanidines
US5441984A (en) *	1994-01-06	1995-08-15	Eli Lilly And Company	Urea, thiourea and guanidine derivatives
FR2728169A1 (fr) *	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
US6395758B1 (en) *	1998-08-14	2002-05-28	Gpi Nil Holdings, Inc.	Small molecule carbamates or ureas for vision and memory disorders
CN1377272A (zh) *	1999-03-02	2002-10-30	透明视网膜技术公司	玻璃体内给药的用于治疗或预防眼科疾病的药剂
EP1165064B1 (de) *	1999-04-05	2004-02-25	City of Hope	Neue hemmern von fortgeschrittenen glykosilierung-endprodukten
US6545182B2 (en) *	2000-04-13	2003-04-08	Allergan Sales, Inc.	Methods and compositions for modulating alpha adrenergic receptor activity
US6313172B1 (en) *	2000-04-13	2001-11-06	Allergan Sales, Inc.	Methods and compositions for modulating alpha adrenergic receptor activity

2003
- 2003-02-13 AT AT03709127T patent/ATE428412T1/de not_active IP Right Cessation
- 2003-02-13 RU RU2004127610/14A patent/RU2339369C2/ru not_active IP Right Cessation
- 2003-02-13 DE DE60327179T patent/DE60327179D1/de not_active Expired - Lifetime
- 2003-02-13 AU AU2003213084A patent/AU2003213084B2/en not_active Ceased
- 2003-02-13 CA CA2475338A patent/CA2475338C/en not_active Expired - Lifetime
- 2003-02-13 MX MXPA04007802A patent/MXPA04007802A/es not_active Application Discontinuation
- 2003-02-13 EP EP03709127A patent/EP1480678B1/de not_active Expired - Lifetime
- 2003-02-13 JP JP2003567351A patent/JP2005521681A/ja active Pending
- 2003-02-13 NZ NZ535165A patent/NZ535165A/en not_active IP Right Cessation
- 2003-02-13 BR BR0307611-3A patent/BR0307611A/pt not_active Application Discontinuation
- 2003-02-13 KR KR10-2004-7012481A patent/KR20040094687A/ko not_active Ceased
- 2003-02-13 ES ES03709127T patent/ES2325360T3/es not_active Expired - Lifetime
- 2003-02-13 WO PCT/US2003/004617 patent/WO2003068166A2/en not_active Ceased
- 2003-02-13 CN CNA038038668A patent/CN1633308A/zh active Pending
2004
- 2004-08-05 IL IL163374A patent/IL163374A/en active IP Right Grant

Also Published As

Publication number	Publication date
AU2003213084A1 (en)	2003-09-04
RU2004127610A (ru)	2005-06-27
KR20040094687A (ko)	2004-11-10
IL163374A (en)	2012-01-31
EP1480678A2 (de)	2004-12-01
NZ535165A (en)	2006-08-31
JP2005521681A (ja)	2005-07-21
CA2475338A1 (en)	2003-08-21
CA2475338C (en)	2014-08-19
WO2003068166A2 (en)	2003-08-21
AU2003213084B2 (en)	2008-06-26
CN1633308A (zh)	2005-06-29
DE60327179D1 (de)	2009-05-28
ES2325360T3 (es)	2009-09-02
EP1480678B1 (de)	2009-04-15
RU2339369C2 (ru)	2008-11-27
BR0307611A (pt)	2004-12-21
WO2003068166A3 (en)	2003-12-24
EP1480678A4 (de)	2005-08-24
MXPA04007802A (es)	2005-04-19

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Legal Events

Date	Code	Title	Description
2009-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties