ATE428696T1 - Nitroxyderivate mit entzündungshemmender, analgetischer und antithrombotischer wirkung - Google Patents
Nitroxyderivate mit entzündungshemmender, analgetischer und antithrombotischer wirkungInfo
- Publication number
- ATE428696T1 ATE428696T1 AT00909234T AT00909234T ATE428696T1 AT E428696 T1 ATE428696 T1 AT E428696T1 AT 00909234 T AT00909234 T AT 00909234T AT 00909234 T AT00909234 T AT 00909234T AT E428696 T1 ATE428696 T1 AT E428696T1
- Authority
- AT
- Austria
- Prior art keywords
- analgesic
- inflammatory
- antithrombotic effects
- nitroxy derivatives
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI000413A IT1308633B1 (it) | 1999-03-02 | 1999-03-02 | Nitrossiderivati. |
| PCT/EP2000/001454 WO2000051988A1 (en) | 1999-03-02 | 2000-02-23 | Nitroxyderivatives having antiinflammatory, analgesic and antithrombotic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE428696T1 true ATE428696T1 (de) | 2009-05-15 |
Family
ID=11382095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00909234T ATE428696T1 (de) | 1999-03-02 | 2000-02-23 | Nitroxyderivate mit entzündungshemmender, analgetischer und antithrombotischer wirkung |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6613784B1 (de) |
| EP (1) | EP1154999B1 (de) |
| JP (1) | JP2002538142A (de) |
| KR (1) | KR100614600B1 (de) |
| CN (1) | CN1225459C (de) |
| AT (1) | ATE428696T1 (de) |
| AU (1) | AU770642B2 (de) |
| BR (1) | BR0008582A (de) |
| CA (1) | CA2361164A1 (de) |
| DE (1) | DE60042013D1 (de) |
| ES (1) | ES2324329T3 (de) |
| HU (1) | HUP0200386A3 (de) |
| IL (1) | IL144686A0 (de) |
| IT (1) | IT1308633B1 (de) |
| RU (1) | RU2240997C2 (de) |
| WO (1) | WO2000051988A1 (de) |
| ZA (1) | ZA200106650B (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1288123B1 (it) | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
| IT1303671B1 (it) * | 1998-07-28 | 2001-02-23 | Nicox Sa | Sali dell'acido nitrico con farmaci attivi nel trattamento dipatologie del sistema respiratorio |
| EP1126838A4 (de) | 1998-10-30 | 2005-02-16 | Nitromed Inc | Nitrosierte und nitrosylierte nichtsteroidale antiphlogistishe verbindungen, zusammenstellungen und verwendungsmethoden |
| JP2003523958A (ja) | 1999-12-23 | 2003-08-12 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−２の阻害剤、組成物ならびに使用法 |
| US8519005B2 (en) | 2000-07-27 | 2013-08-27 | Thomas N. Thomas | Compositions and methods to prevent toxicity of antiinflammatory agents and enhance their efficacy |
| IT1318673B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Farmaci per le disfunzioni sessuali. |
| IT1318674B1 (it) * | 2000-08-08 | 2003-08-27 | Nicox Sa | Faramaci per l'incontinenza. |
| IT1319201B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per il diabete. |
| IT1319202B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per le malattie a base infiammatoria. |
| CA2432642A1 (en) | 2000-12-21 | 2002-08-08 | Subhash P. Khanapure | Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| ATE437637T1 (de) | 2001-05-02 | 2009-08-15 | Nitromed Inc | Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren |
| ITMI20011240A1 (it) * | 2001-06-13 | 2002-12-13 | Nicox Sa | Farmaci per le vasculopatie |
| ITMI20011307A1 (it) * | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per l'epilessia |
| ITMI20011744A1 (it) * | 2001-08-09 | 2003-02-09 | Nicox Sa | Farmaci per le vasculopatie |
| US7220749B2 (en) | 2002-06-11 | 2007-05-22 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| ITMI20021399A1 (it) * | 2002-06-25 | 2003-12-29 | Nicox Sa | Inibitori della cicloossigenasi 2 |
| ITMI20021391A1 (it) | 2002-06-25 | 2003-12-29 | Nicox Sa | Nitroderivati di inibitori della cicloossigenasi-2 |
| JP2005535642A (ja) | 2002-06-28 | 2005-11-24 | ニトロメッド インコーポレーティッド | オキシムおよび／またはヒドラゾンを含有するニトロソ化および／またはニトロシル化シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法 |
| JP2005539089A (ja) * | 2002-07-03 | 2005-12-22 | ニトロメッド インコーポレーティッド | ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法 |
| CA2493156A1 (en) | 2002-07-29 | 2004-02-05 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| DK1891447T3 (da) | 2005-05-23 | 2011-10-17 | Phadia Ab | Totrins laterale flowassayfremgangsmåder og -anordninger |
| WO2007060112A1 (en) | 2005-11-23 | 2007-05-31 | Nicox S.A. | Salicylic acid derivatives |
| JP2007275193A (ja) * | 2006-04-04 | 2007-10-25 | Fujifilm Corp | 光プローブおよび光断層画像化装置 |
| WO2011012400A2 (en) | 2009-07-28 | 2011-02-03 | Nicox S.A. | Nitric oxide releasing naproxen |
| AU2011243947A1 (en) | 2010-04-23 | 2012-12-06 | Piramal Enterprises Limited | Nitric oxide releasing prodrugs of therapeutic agents |
| US9844599B2 (en) | 2013-01-21 | 2017-12-19 | Apparao Satyam | Nitric oxide releasing produgs of therapeutic agents |
| CN105985283B (zh) * | 2015-01-30 | 2018-08-24 | 安徽省新星药物开发有限责任公司 | 一种布洛芬吡甲酯的合成方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2396145A (en) | 1940-12-14 | 1946-03-05 | Pharmscia Ab | Heterocyclic sulphonamido azo compounds |
| US2998450A (en) | 1958-05-19 | 1961-08-29 | Warner Lambert Pharmaceutical | Process of preparing nu-acetyl-p-amino phenol |
| GB971700A (en) | 1961-02-02 | 1964-09-30 | Boots Pure Drug Co Ltd | Anti-Inflammatory Agents |
| AT290523B (de) | 1962-01-05 | 1971-06-11 | Merck & Co Inc | Verfahren zur Herstellung neuer α-(3-Indolyl)-carbonsäuren |
| GB1091403A (en) | 1964-01-24 | 1967-11-15 | Boots Pure Drug Co Ltd | Therapeutically active phenylalkane derivatives |
| US3558690A (en) | 1965-04-08 | 1971-01-26 | Gelgy Chemical Corp | Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation |
| US3337570A (en) | 1965-10-23 | 1967-08-22 | Schering Corp | Substituted nicotinic acids and method for the manufacture thereof |
| US3904682A (en) | 1967-01-13 | 1975-09-09 | Syntex Corp | 2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid |
| FR1546478A (fr) | 1967-01-27 | 1968-11-22 | Rhone Poulenc Sa | Nouveaux dérivés de l'acide benzoyl-3 phénylacétique et leur préparation |
| GB1195628A (en) | 1967-07-26 | 1970-06-17 | Mcneilab Inc | Aroyl-Substituted Pyrroles |
| US3652589A (en) | 1967-07-27 | 1972-03-28 | Gruenenthal Chemie | 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols |
| US3600437A (en) | 1969-05-28 | 1971-08-17 | Lilly Co Eli | Substituted phenylalkanoic acids and derivatives thereof |
| US3591584A (en) | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
| US3689653A (en) | 1970-07-06 | 1972-09-05 | Schering Corp | Compositions and methods for treating inflammation using substituted nicotinic acids |
| US3784701A (en) | 1970-09-21 | 1974-01-08 | American Cyanamid Co | Compositions containing substituted benzoylpropionic acids and method of use to treat inflammation and pain |
| US3843681A (en) | 1971-06-01 | 1974-10-22 | American Home Prod | 1-carboxamido pyrano(thiopyrano)(3,4-6)indole derivatives |
| GB1403487A (en) | 1972-07-21 | 1975-08-28 | Yoshitomi Pharmaceutical | Heterocyclic substituted alkanoic acids and derivatives |
| US3896145A (en) | 1972-07-24 | 1975-07-22 | Hoffmann La Roche | Carbazoles |
| US4035376A (en) | 1972-10-24 | 1977-07-12 | Janssen Pharmaceutica N.V. | Aroyl-substituted phenylacetic acid derivatives |
| US3997669A (en) | 1972-12-26 | 1976-12-14 | Ciba-Geigy Corporation | Tertiary aminoacids |
| US4061779A (en) | 1973-09-11 | 1977-12-06 | Beecham Group Limited | Naphthalene derivatives having anti-inflammatory activity |
| IL47877A (en) | 1974-08-26 | 1978-10-31 | Sparamedica Ag | Thienothiazine carboxamide derivatives,their manufacture and pharmaceutical compositions containing them |
| US4089969A (en) | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
| US4161538A (en) | 1977-04-05 | 1979-07-17 | Sankyo Company Limited | Substituted phenylacetic acid derivatives and process for the preparation thereof |
| JPS5432460A (en) | 1977-08-16 | 1979-03-09 | Sankyo Co Ltd | Cycloalkylidenemethylphenylacetic acid derivative and their preparation |
| AU518216B2 (en) | 1977-09-06 | 1981-09-17 | Hafslund Nycomed Pharma Aktiengesellschaft | Thienothiazine derivatives |
| DE2756113A1 (de) | 1977-12-16 | 1979-06-21 | Thomae Gmbh Dr K | Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| JPS54122284A (en) | 1978-02-17 | 1979-09-21 | Dainippon Pharmaceut Co Ltd | Dibenzb,foxepin derivative |
| JPS5553282A (en) | 1978-10-17 | 1980-04-18 | Nippon Chemiphar Co Ltd | Dibenzothiepin derivative and its preparation |
| CA1128526A (en) | 1979-10-05 | 1982-07-27 | Cdc Life Sciences Inc. | 3,4-diarylisoxazol-5-acetic acids |
| SE8002321L (sv) | 1980-03-26 | 1981-09-27 | Pharmacia Ab | Sett och mellanprodukter for framstellning av bensoesyraderivat |
| DE3049405A1 (de) | 1980-12-23 | 1982-07-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue derivate von antiphlogistisch wirksamen carbonsaeuren, ihre herstellung und medizinische anwendung |
| US4551452A (en) | 1983-12-21 | 1985-11-05 | Pfizer Inc. | Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor |
| US4556672A (en) | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
| IE59728B1 (en) | 1986-03-11 | 1994-03-23 | American Home Prod | Substituted 1,3,4,9-tetrahydropyrano[3,4-b] indole-1-acetic acids |
| IT1243367B (it) | 1990-07-26 | 1994-06-10 | Italfarmaco Spa | Derivati acidi benzoici sostituiti ad attivita' cardiovascolare |
| IT1256345B (it) * | 1992-08-20 | 1995-12-01 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione | |
| JP3775796B2 (ja) * | 1993-10-06 | 2006-05-17 | ニコックス エス エイ | 抗炎症活性及び／又は鎮痛活性を有する硝酸エステル類及びそれらの製造方法 |
| GB2283238B (en) | 1993-10-06 | 1997-11-26 | Hct Health Care Trading Ltd | Nitric esters of derivatives of propionic acid and process for their preparation |
| RU2145595C1 (ru) | 1994-05-10 | 2000-02-20 | Никокс С.А. | Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности |
| IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
-
1999
- 1999-03-02 IT IT1999MI000413A patent/IT1308633B1/it active
-
2000
- 2000-02-23 CA CA002361164A patent/CA2361164A1/en not_active Abandoned
- 2000-02-23 HU HU0200386A patent/HUP0200386A3/hu unknown
- 2000-02-23 BR BR0008582-0A patent/BR0008582A/pt not_active Application Discontinuation
- 2000-02-23 AT AT00909234T patent/ATE428696T1/de not_active IP Right Cessation
- 2000-02-23 WO PCT/EP2000/001454 patent/WO2000051988A1/en not_active Ceased
- 2000-02-23 JP JP2000602215A patent/JP2002538142A/ja active Pending
- 2000-02-23 DE DE60042013T patent/DE60042013D1/de not_active Expired - Lifetime
- 2000-02-23 RU RU2001124271/04A patent/RU2240997C2/ru not_active IP Right Cessation
- 2000-02-23 EP EP00909234A patent/EP1154999B1/de not_active Expired - Lifetime
- 2000-02-23 IL IL14468600A patent/IL144686A0/xx not_active IP Right Cessation
- 2000-02-23 ES ES00909234T patent/ES2324329T3/es not_active Expired - Lifetime
- 2000-02-23 US US09/926,095 patent/US6613784B1/en not_active Expired - Fee Related
- 2000-02-23 KR KR1020017011034A patent/KR100614600B1/ko not_active Expired - Fee Related
- 2000-02-23 AU AU31588/00A patent/AU770642B2/en not_active Ceased
- 2000-02-23 CN CNB008044600A patent/CN1225459C/zh not_active Expired - Fee Related
-
2001
- 2001-08-13 ZA ZA200106650A patent/ZA200106650B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0200386A3 (en) | 2002-11-28 |
| EP1154999B1 (de) | 2009-04-15 |
| AU770642B2 (en) | 2004-02-26 |
| HUP0200386A2 (en) | 2002-06-29 |
| ES2324329T3 (es) | 2009-08-05 |
| RU2240997C2 (ru) | 2004-11-27 |
| ITMI990413A1 (it) | 2000-09-02 |
| EP1154999A1 (de) | 2001-11-21 |
| WO2000051988A1 (en) | 2000-09-08 |
| AU3158800A (en) | 2000-09-21 |
| JP2002538142A (ja) | 2002-11-12 |
| IT1308633B1 (it) | 2002-01-09 |
| ZA200106650B (en) | 2002-11-13 |
| BR0008582A (pt) | 2002-02-13 |
| DE60042013D1 (de) | 2009-05-28 |
| US6613784B1 (en) | 2003-09-02 |
| KR100614600B1 (ko) | 2006-08-25 |
| CN1225459C (zh) | 2005-11-02 |
| CA2361164A1 (en) | 2000-09-08 |
| CN1342147A (zh) | 2002-03-27 |
| IL144686A0 (en) | 2002-06-30 |
| KR20010103782A (ko) | 2001-11-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60042013D1 (de) | Nitroxyderivate mit entzündungshemmender, analgetischer und antithrombotischer wirkung | |
| AP2003002841A0 (en) | Quinazolines as MMP-13 inhibitors | |
| ES8603408A1 (es) | Un procedimiento para la preparacion de un compuesto de 2-oxindol-1-carboxamida | |
| DK0412404T3 (da) | Thiazolderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater omfattende derivaterne | |
| NO942452D0 (no) | Amid- og ureaderivater med antihyperkolesteremisk aktivitet, deres fremstilling og terapeutiske anvendelser | |
| DK0641767T3 (da) | Cytotoksiske stilbenderivater og farmaceutisk præparat indeholdende disse derivater | |
| ES2187473T3 (es) | Triarylimidazoles. | |
| BR9813835A (pt) | Composto, composição farmacêutica e método de tratamento ou prevenção de uma desordem tromboembólica | |
| DK1104760T3 (da) | Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler | |
| NO933376D0 (no) | Morfinan-derivater og medisinsk anvendelse derav | |
| DK1113011T3 (da) | Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer | |
| HUP0402454A2 (hu) | Szubsztituált kinazolinszármazékok mint az aurora kinázok inhibitorai, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények | |
| DK1104759T3 (da) | Heteroarylphenylpyrazolforbindelser som antiinflammatoriske/analgetiske midler | |
| GB9408185D0 (en) | New benzamide derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | |
| GB1535967A (en) | Antilipidemic para-(aryl(alkyl or alkenyl)-amino)-benzoic acid derivatives | |
| NO944371L (no) | Kjemisk forbindelse med blodplateaggregeringsinhibiotoraktivitet | |
| ES2021182A6 (es) | Procedimiento para preparar derivados de capsaicina. | |
| ES8801211A1 (es) | Un procedimiento para preparar derivados de quinolona | |
| DK0637583T3 (da) | 1-Aryloxy-3-alkylamino-2-propanol-nitratestere, anvendelse heraf og tilsvarende farmaceutisk præparat | |
| DE3684457D1 (de) | Organische verbindungen und ihre pharmazeutische verwendung. | |
| PT92540A (pt) | Processo para a preparacao de derivados de anfotericina b | |
| DE68927554D1 (de) | Cephalosporinverbindungen und Verfahren zu ihrer Herstellung | |
| PT1040096E (pt) | Agentes neuroprotectores | |
| ES435274A1 (es) | Procedimiento de preparacion de n-(2-pirrolidinilalcohil)- benzamidas sustituidas. | |
| ES445339A1 (es) | Un procedimiento para la preparacion de derivados pirrolidi-nicos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |