ATE428708T1 - Neue phthalazinonderivate als aurora-a- kinaseinhibitoren - Google Patents
Neue phthalazinonderivate als aurora-a- kinaseinhibitorenInfo
- Publication number
- ATE428708T1 ATE428708T1 AT05785230T AT05785230T ATE428708T1 AT E428708 T1 ATE428708 T1 AT E428708T1 AT 05785230 T AT05785230 T AT 05785230T AT 05785230 T AT05785230 T AT 05785230T AT E428708 T1 ATE428708 T1 AT E428708T1
- Authority
- AT
- Austria
- Prior art keywords
- aurora
- new
- kinase inhibitors
- phthalazinone derivatives
- phthalazinone
- Prior art date
Links
- 102000004000 Aurora Kinase A Human genes 0.000 title 1
- 108090000461 Aurora Kinase A Proteins 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- IJAPPYDYQCXOEF-UHFFFAOYSA-N phthalazin-1(2H)-one Chemical class C1=CC=C2C(=O)NN=CC2=C1 IJAPPYDYQCXOEF-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04022755 | 2004-09-24 | ||
| PCT/EP2005/010311 WO2006032518A1 (en) | 2004-09-24 | 2005-09-23 | Novel phthalazinone derivatives, as aurora-a kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE428708T1 true ATE428708T1 (de) | 2009-05-15 |
Family
ID=34926696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05785230T ATE428708T1 (de) | 2004-09-24 | 2005-09-23 | Neue phthalazinonderivate als aurora-a- kinaseinhibitoren |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7226923B2 (de) |
| EP (1) | EP1794148B1 (de) |
| JP (1) | JP2008514564A (de) |
| KR (1) | KR100907202B1 (de) |
| CN (1) | CN101027290B (de) |
| AR (1) | AR050948A1 (de) |
| AT (1) | ATE428708T1 (de) |
| AU (1) | AU2005287458A1 (de) |
| BR (1) | BRPI0515885A (de) |
| CA (1) | CA2580198A1 (de) |
| DE (1) | DE602005013985D1 (de) |
| ES (1) | ES2323885T3 (de) |
| MX (1) | MX2007003104A (de) |
| RU (1) | RU2397166C2 (de) |
| TW (1) | TW200624431A (de) |
| WO (1) | WO2006032518A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101084214A (zh) | 2004-11-17 | 2007-12-05 | 迈卡纳治疗股份有限公司 | 激酶抑制剂 |
| KR101487027B1 (ko) | 2005-09-30 | 2015-01-28 | 미카나 테라퓨틱스, 인크. | 치환된 피라졸 화합물 |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| CN101405001A (zh) * | 2006-03-20 | 2009-04-08 | 霍夫曼-拉罗奇有限公司 | 抑制btk和syk蛋白质激酶的方法 |
| CA2645728A1 (en) * | 2006-03-20 | 2007-09-27 | Edward Boyd (Deceased) | Phthalazinone pyrazole derivatives, their manufacture and use as pharmaceutical agents |
| WO2008004088A2 (en) * | 2006-07-05 | 2008-01-10 | Centre National De La Recherche Scientifique (C.N.R.S.) | Iron-copper co-catalyzed process for carbon-carbon or carbon-heteroatom bonding |
| GB0619342D0 (en) * | 2006-09-30 | 2006-11-08 | Vernalis R&D Ltd | New chemical compounds |
| SG158147A1 (en) | 2006-10-09 | 2010-01-29 | Takeda Pharmaceutical | Kinase inhibitors |
| DE102008000872A1 (de) | 2007-04-11 | 2008-11-13 | Basf Se | Fungizide Pyridazine, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Schadpilzen sowie sie enthaltende Mittel |
| AU2012232670A1 (en) | 2011-03-23 | 2013-09-12 | Ariel-University Research And Development Company Ltd. | Treatment of proliferative disorders with a chemiluminescent agent |
| KR20140033377A (ko) | 2011-05-10 | 2014-03-18 | 길리애드 사이언시즈, 인코포레이티드 | 나트륨 채널 조절제로서의 융합된 헤테로시클릭 화합물 |
| UY34171A (es) | 2011-07-01 | 2013-01-31 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como moduladores del canal iónico |
| NO3175985T3 (de) | 2011-07-01 | 2018-04-28 | ||
| EP2968323A4 (de) | 2013-03-13 | 2016-12-14 | Flatley Discovery Lab | Pyridazinonverbindungen und verfahren zur behandlung von zystischer fibrose |
| EP3438089A1 (de) | 2013-12-18 | 2019-02-06 | Monsanto Technology LLC | Verfahren zur diazotierung von 2,5dichloroanilinen |
| WO2016130460A2 (en) * | 2015-02-09 | 2016-08-18 | The Johns Hopkins University | Phthalazinone pyrazole derivatives for treating retinal degenerative disease |
| US9957267B2 (en) | 2015-07-01 | 2018-05-01 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| RU2674761C2 (ru) * | 2016-12-21 | 2018-12-13 | федеральное государственное бюджетное образовательное учреждение высшего образования "Тольяттинский государственный университет" | Способ получения анилина и катализатор для него |
| EP3658560A4 (de) | 2017-07-25 | 2021-01-06 | Crinetics Pharmaceuticals, Inc. | Somatostatinmodulatoren und verwendungen davon |
| CN108250150B (zh) * | 2018-03-15 | 2020-12-29 | 兰州大学 | 一种肽嗪酮化合物及其制备方法与应用 |
| CN111039940B (zh) * | 2019-12-31 | 2022-10-21 | 北京鑫开元医药科技有限公司 | 一种Aurora A激酶抑制剂、制备方法、药物组合物及其用途 |
| CN113773263B (zh) * | 2020-06-10 | 2023-09-19 | 兰州大学 | 一种4-胺取代酞嗪酮极光激酶b抑制剂及其制备与应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5700823A (en) | 1994-01-07 | 1997-12-23 | Sugen, Inc. | Treatment of platelet derived growth factor related disorders such as cancers |
| RU2137762C1 (ru) | 1994-02-23 | 1999-09-20 | Пфайзер Инк. | 4-гетероциклил-замещенные производные хиназолина, фармацевтическая композиция |
| US6716575B2 (en) | 1995-12-18 | 2004-04-06 | Sugen, Inc. | Diagnosis and treatment of AUR1 and/or AUR2 related disorders |
| KR100459052B1 (ko) | 1995-12-18 | 2005-01-15 | 서젠, 인크. | Aur-1및(또는)aur-2관련질병의진단및치료 |
| GB9707800D0 (en) | 1996-05-06 | 1997-06-04 | Zeneca Ltd | Chemical compounds |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| ITMI981671A1 (it) | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodisterasi 4 |
| US6180629B1 (en) * | 1998-08-14 | 2001-01-30 | Cell Pathways, Inc. | [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia |
| UA71945C2 (en) | 1999-01-27 | 2005-01-17 | Pfizer Prod Inc | Substituted bicyclic derivatives being used as anticancer agents |
| PT1154774E (pt) | 1999-02-10 | 2005-10-31 | Astrazeneca Ab | Derivados de quinazolina como inibidores de angiogenese |
| GB9922173D0 (en) | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
| CA2384291A1 (en) | 1999-09-21 | 2001-03-29 | Astrazeneca Ab | Quinazoline derivatives and their use as pharmaceuticals |
| GB9922171D0 (en) | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
| CA2384282A1 (en) | 1999-09-21 | 2001-03-29 | Astrazeneca Ab | Quinazoline compounds and pharmaceutical compositions containing them |
| WO2001055116A2 (en) | 2000-01-28 | 2001-08-02 | Astrazeneca Ab | Quinoline derivatives and their use as aurora 2 kinase inhibitors |
| ES2267748T3 (es) | 2000-04-07 | 2007-03-16 | Astrazeneca Ab | Compuestos de quinazolina. |
| WO2002022605A1 (en) | 2000-09-15 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6989385B2 (en) | 2000-12-21 | 2006-01-24 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| ES2274035T3 (es) | 2001-06-01 | 2007-05-16 | Vertex Pharmaceuticals Incorporated | Compuestos de tiazol utiles como inhibidores de proteina quinasas. |
| AU2002331621B2 (en) | 2001-08-15 | 2008-06-05 | Icos Corporation | 2H-phthalazin-1-ones and methods for use thereof |
| WO2003055491A1 (en) * | 2001-12-24 | 2003-07-10 | Astrazeneca Ab | Substituted quinazoline derivatives as inhibitors of aurora kinases |
| HUP0500200A2 (hu) * | 2002-01-17 | 2005-07-28 | Neurogen Corporation | Szubsztituált kinazolin-4-ilamin analógok, mint kapszaicin modulátorok és ezeket tartalmazó gyógyszerkészítmények |
| DE60332433D1 (de) | 2002-03-15 | 2010-06-17 | Vertex Pharma | Azolylaminoazine als proteinkinasehemmer |
| EP1485381B8 (de) | 2002-03-15 | 2010-05-12 | Vertex Pharmaceuticals Incorporated | Azolylaminoazine als inhibitoren von proteinkinasen |
| US6846928B2 (en) | 2002-03-15 | 2005-01-25 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
| US20040009981A1 (en) | 2002-03-15 | 2004-01-15 | David Bebbington | Compositions useful as inhibitors of protein kinases |
| MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| US7361665B2 (en) | 2002-07-09 | 2008-04-22 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases |
-
2005
- 2005-09-21 AR ARP050103956A patent/AR050948A1/es unknown
- 2005-09-21 TW TW094132585A patent/TW200624431A/zh unknown
- 2005-09-23 KR KR1020077006776A patent/KR100907202B1/ko not_active Expired - Fee Related
- 2005-09-23 RU RU2007115161/04A patent/RU2397166C2/ru not_active IP Right Cessation
- 2005-09-23 AT AT05785230T patent/ATE428708T1/de active
- 2005-09-23 MX MX2007003104A patent/MX2007003104A/es active IP Right Grant
- 2005-09-23 AU AU2005287458A patent/AU2005287458A1/en not_active Abandoned
- 2005-09-23 DE DE602005013985T patent/DE602005013985D1/de not_active Expired - Lifetime
- 2005-09-23 EP EP05785230A patent/EP1794148B1/de not_active Expired - Lifetime
- 2005-09-23 CN CN2005800319622A patent/CN101027290B/zh not_active Expired - Fee Related
- 2005-09-23 WO PCT/EP2005/010311 patent/WO2006032518A1/en not_active Ceased
- 2005-09-23 JP JP2007532843A patent/JP2008514564A/ja active Pending
- 2005-09-23 CA CA002580198A patent/CA2580198A1/en not_active Abandoned
- 2005-09-23 BR BRPI0515885-0A patent/BRPI0515885A/pt not_active IP Right Cessation
- 2005-09-23 US US11/233,311 patent/US7226923B2/en not_active Expired - Fee Related
- 2005-09-23 ES ES05785230T patent/ES2323885T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1794148B1 (de) | 2009-04-15 |
| MX2007003104A (es) | 2007-06-07 |
| AU2005287458A1 (en) | 2006-03-30 |
| TW200624431A (en) | 2006-07-16 |
| CA2580198A1 (en) | 2006-03-30 |
| BRPI0515885A (pt) | 2008-08-12 |
| CN101027290A (zh) | 2007-08-29 |
| RU2007115161A (ru) | 2008-11-10 |
| KR100907202B1 (ko) | 2009-07-10 |
| ES2323885T3 (es) | 2009-07-27 |
| RU2397166C2 (ru) | 2010-08-20 |
| KR20070046193A (ko) | 2007-05-02 |
| DE602005013985D1 (de) | 2009-05-28 |
| WO2006032518A1 (en) | 2006-03-30 |
| CN101027290B (zh) | 2010-05-12 |
| US20060089359A1 (en) | 2006-04-27 |
| EP1794148A1 (de) | 2007-06-13 |
| JP2008514564A (ja) | 2008-05-08 |
| US7226923B2 (en) | 2007-06-05 |
| AR050948A1 (es) | 2006-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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