BRPI0515885A - derivados de ftalazinona, sua preparação e uso como agentes farmacêuticos - Google Patents

derivados de ftalazinona, sua preparação e uso como agentes farmacêuticos

Info

Publication number
BRPI0515885A
BRPI0515885A BRPI0515885-0A BRPI0515885A BRPI0515885A BR PI0515885 A BRPI0515885 A BR PI0515885A BR PI0515885 A BRPI0515885 A BR PI0515885A BR PI0515885 A BRPI0515885 A BR PI0515885A
Authority
BR
Brazil
Prior art keywords
preparation
pharmaceutical agents
phthalazinone derivatives
derivatives
compounds
Prior art date
Application number
BRPI0515885-0A
Other languages
English (en)
Inventor
Edward Boyd
Frederick Brookfield
Guy Georges
Bernhard Goller
Sabine Huensch
Petra Rueger
Matthias Rueth
Stefan Scheiblich
Christine Schuell
Der Saal Wolfgang Von
Justin Warne
Stefan Weigand
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0515885A publication Critical patent/BRPI0515885A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"DERIVADOS DE FTALAZINONA, SUA PREPARAçãO E USO COMO AGENTES FARMACêUTICOS". Os objetivos da presente invenção são os compostos de fórmula I seus sais farmaceuticamente aceitáveis, formas enantioméricas, diastereoisómeros e racematos, a preparação dos compostos acima mencionados, medicamentos contendo-os e sua preparação, bem como o uso dos compostos acima mencionados no controle ou prevenção de tal como câncer.
BRPI0515885-0A 2004-09-24 2005-09-23 derivados de ftalazinona, sua preparação e uso como agentes farmacêuticos BRPI0515885A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04022755 2004-09-24
PCT/EP2005/010311 WO2006032518A1 (en) 2004-09-24 2005-09-23 Novel phthalazinone derivatives, as aurora-a kinase inhibitors

Publications (1)

Publication Number Publication Date
BRPI0515885A true BRPI0515885A (pt) 2008-08-12

Family

ID=34926696

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515885-0A BRPI0515885A (pt) 2004-09-24 2005-09-23 derivados de ftalazinona, sua preparação e uso como agentes farmacêuticos

Country Status (16)

Country Link
US (1) US7226923B2 (pt)
EP (1) EP1794148B1 (pt)
JP (1) JP2008514564A (pt)
KR (1) KR100907202B1 (pt)
CN (1) CN101027290B (pt)
AR (1) AR050948A1 (pt)
AT (1) ATE428708T1 (pt)
AU (1) AU2005287458A1 (pt)
BR (1) BRPI0515885A (pt)
CA (1) CA2580198A1 (pt)
DE (1) DE602005013985D1 (pt)
ES (1) ES2323885T3 (pt)
MX (1) MX2007003104A (pt)
RU (1) RU2397166C2 (pt)
TW (1) TW200624431A (pt)
WO (1) WO2006032518A1 (pt)

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BRPI0616630B8 (pt) 2005-09-30 2021-05-25 Miikana Therapeutics Inc compostos de pirazol substituídos
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
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WO2007107469A1 (en) * 2006-03-20 2007-09-27 F. Hoffmann-La Roche Ag Methods of inhibiting btk and syk protein kinases
EP2043970B1 (en) * 2006-07-05 2018-04-18 Centre National De La Recherche Scientifique (C.N.R.S.) Iron-copper co-catalyzed process for carbon-carbon or carbon-heteroatom bonding
GB0619342D0 (en) * 2006-09-30 2006-11-08 Vernalis R&D Ltd New chemical compounds
JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
DE102008000872A1 (de) 2007-04-11 2008-11-13 Basf Se Fungizide Pyridazine, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekämpfung von Schadpilzen sowie sie enthaltende Mittel
EP2688565A1 (en) 2011-03-23 2014-01-29 Semorex Technologies Ltd. Treatment of proliferative disorders with a chemiluminescent agent
WO2012154760A1 (en) * 2011-05-10 2012-11-15 Gilead Sciences, Inc. Fused heterocyclic compounds as sodium channel modulators
UY34171A (es) 2011-07-01 2013-01-31 Gilead Sciences Inc Compuestos heterocíclicos fusionados como moduladores del canal iónico
NO3175985T3 (pt) 2011-07-01 2018-04-28
EP2968323A4 (en) 2013-03-13 2016-12-14 Flatley Discovery Lab PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
WO2015095284A1 (en) 2013-12-18 2015-06-25 Monsanto Technology Llc Processes for the diazotization of 2,5-dichloroanilines
WO2016130460A2 (en) * 2015-02-09 2016-08-18 The Johns Hopkins University Phthalazinone pyrazole derivatives for treating retinal degenerative disease
US9957267B2 (en) 2015-07-01 2018-05-01 Crinetics Pharmaceuticals, Inc. Somatostatin modulators and uses thereof
RU2674761C2 (ru) * 2016-12-21 2018-12-13 федеральное государственное бюджетное образовательное учреждение высшего образования "Тольяттинский государственный университет" Способ получения анилина и катализатор для него
WO2019023278A1 (en) 2017-07-25 2019-01-31 Crinetics Pharmaceuticals, Inc. MODULATORS OF SOMATOSTATIN AND USES THEREOF
CN108250150B (zh) * 2018-03-15 2020-12-29 兰州大学 一种肽嗪酮化合物及其制备方法与应用
CN111039940B (zh) * 2019-12-31 2022-10-21 北京鑫开元医药科技有限公司 一种Aurora A激酶抑制剂、制备方法、药物组合物及其用途
CN113773263B (zh) * 2020-06-10 2023-09-19 兰州大学 一种4-胺取代酞嗪酮极光激酶b抑制剂及其制备与应用
GB202106871D0 (en) * 2021-05-13 2021-06-30 Addex Pharmaceuticals Sa Novel compounds

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CA2183655C (en) 1994-02-23 2001-03-06 Lee D. Arnold 4-polycyclic amino-substituted quinazoline derivatives
US6716575B2 (en) * 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
JP3944241B2 (ja) 1995-12-18 2007-07-11 スージェン・インコーポレーテッド Ａｕｒ―１および／またはａｕｒ―２関連疾患の診断および処置
GB9707800D0 (en) 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
ZA986729B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
ITMI981671A1 (it) 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodisterasi 4
US6180629B1 (en) * 1998-08-14 2001-01-30 Cell Pathways, Inc. [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia
UA71945C2 (en) 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
EE05345B1 (et) 1999-02-10 2010-10-15 Astrazeneca Ab Kinasoliini derivaadid angiogeneesi inhibiitoritena
GB9922171D0 (en) 1999-09-21 1999-11-17 Zeneca Ltd Chemical compounds
EE200200119A (et) 1999-09-21 2003-04-15 Astrazeneca Ab Kinasoliini derivaadid ja nende kasutamine ravimitena
HK1046688A1 (zh) 1999-09-21 2003-01-24 Astrazeneca Ab 喹唑啉化合物和含有喹唑啉化合物的藥物組合物
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AU2001290912A1 (en) 2000-09-15 2002-03-26 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
BR0116493A (pt) 2000-12-21 2003-09-30 Vertex Pharma Compostos de pirazol úteis como inibidores de proteìna cinase
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KR100957516B1 (ko) 2001-08-15 2010-05-14 이코스 코포레이션 2ｈ-프탈라진-1-온 및 이것의 사용 방법
ATE446093T1 (de) * 2001-12-24 2009-11-15 Astrazeneca Ab Substituierte chinazolin-derivate als aurora- kinase inhibitoren
RS63204A (sr) * 2002-01-17 2006-10-27 Neurogen Corporation Supstituisani analozi hinazolin-4-ilamina kao modulatori kapsaicina
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Also Published As

Publication number Publication date
TW200624431A (en) 2006-07-16
RU2397166C2 (ru) 2010-08-20
KR100907202B1 (ko) 2009-07-10
WO2006032518A1 (en) 2006-03-30
JP2008514564A (ja) 2008-05-08
ATE428708T1 (de) 2009-05-15
CN101027290B (zh) 2010-05-12
MX2007003104A (es) 2007-06-07
RU2007115161A (ru) 2008-11-10
US20060089359A1 (en) 2006-04-27
DE602005013985D1 (de) 2009-05-28
KR20070046193A (ko) 2007-05-02
US7226923B2 (en) 2007-06-05
AR050948A1 (es) 2006-12-06
EP1794148A1 (en) 2007-06-13
ES2323885T3 (es) 2009-07-27
CN101027290A (zh) 2007-08-29
AU2005287458A1 (en) 2006-03-30
EP1794148B1 (en) 2009-04-15
CA2580198A1 (en) 2006-03-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2168 DE 24/07/2012.