ATE430571T1 - Wässrige pharmazeutische formulierungen von wasserlöslichen prodrugs von propofol- verbindungen - Google Patents
Wässrige pharmazeutische formulierungen von wasserlöslichen prodrugs von propofol- verbindungenInfo
- Publication number
- ATE430571T1 ATE430571T1 AT02799315T AT02799315T ATE430571T1 AT E430571 T1 ATE430571 T1 AT E430571T1 AT 02799315 T AT02799315 T AT 02799315T AT 02799315 T AT02799315 T AT 02799315T AT E430571 T1 ATE430571 T1 AT E430571T1
- Authority
- AT
- Austria
- Prior art keywords
- formulations
- propofol
- water soluble
- pharmaceutical formulations
- aqueous pharmaceutical
- Prior art date
Links
- 239000000651 prodrug Substances 0.000 title abstract 4
- 229940002612 prodrug Drugs 0.000 title abstract 4
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical class CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 6
- 239000000203 mixture Substances 0.000 abstract 6
- 229960004134 propofol Drugs 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 239000008181 tonicity modifier Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34275501P | 2001-12-28 | 2001-12-28 | |
| PCT/US2002/041468 WO2003057153A2 (en) | 2001-12-28 | 2002-12-26 | Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE430571T1 true ATE430571T1 (de) | 2009-05-15 |
Family
ID=23343142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02799315T ATE430571T1 (de) | 2001-12-28 | 2002-12-26 | Wässrige pharmazeutische formulierungen von wasserlöslichen prodrugs von propofol- verbindungen |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20050042280A1 (de) |
| EP (1) | EP1458355B1 (de) |
| JP (2) | JP2005517679A (de) |
| KR (2) | KR20100112632A (de) |
| CN (1) | CN1329036C (de) |
| AT (1) | ATE430571T1 (de) |
| AU (1) | AU2002364238B2 (de) |
| BR (1) | BR0215303A (de) |
| CA (1) | CA2470500C (de) |
| DE (1) | DE60232271D1 (de) |
| ES (1) | ES2325918T3 (de) |
| HU (1) | HU229293B1 (de) |
| IL (3) | IL162692A0 (de) |
| MX (1) | MXPA04006325A (de) |
| NO (1) | NO334424B1 (de) |
| NZ (1) | NZ533536A (de) |
| PL (1) | PL205271B1 (de) |
| RU (1) | RU2316317C2 (de) |
| UA (1) | UA76802C2 (de) |
| WO (1) | WO2003057153A2 (de) |
| ZA (1) | ZA200404616B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7250412B2 (en) * | 2003-10-24 | 2007-07-31 | Auspex Pharmaceuticals, Inc. | PH sensitive prodrugs of 2,6-Diisopropylphenol |
| US7589239B2 (en) | 2005-09-02 | 2009-09-15 | Auspex Pharmaceuticals | Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders |
| KR20090059136A (ko) * | 2006-10-05 | 2009-06-10 | 에이자이 코포레이션 오브 노쓰아메리카 | 프로포폴의 수용성 프로드럭의 수성 약제학적 제제 |
| MX2009012125A (es) | 2007-05-09 | 2010-02-18 | Pharmacofore Inc | Compuestos terapeuticos. |
| EP2301908B8 (de) | 2007-05-09 | 2014-09-03 | Sowood Healthcare LLC | (-)-Stereoisomer von 2,6-di-sec-butylphenol und Analoga davon für die Förderung antiemetische Wirkung und Behandlung von Übelkeit und Erbrechen und Behandlung von Migräne |
| US20090098209A1 (en) * | 2007-10-15 | 2009-04-16 | University Of Kansas | Pharmaceutical compositions containing water-soluble derivatives of propofol and methods of administering same via pulmonary administration |
| GB0905834D0 (en) | 2009-04-03 | 2009-05-20 | Seps Pharma Nv | Phosphonyl-containing phenolic derivatives useful as medicaments |
| UY34072A (es) | 2011-05-17 | 2013-01-03 | Novartis Ag | Derivados sustituidos de indol |
| CN110063947A (zh) * | 2018-01-24 | 2019-07-30 | 四川海思科制药有限公司 | 苯酚衍生物用于制备麻醉药物中的用途 |
| US11439653B1 (en) | 2021-03-30 | 2022-09-13 | Epalex Corporation | Fospropofol formulations |
| US11628178B2 (en) | 2019-03-26 | 2023-04-18 | Epalex Corporation | Fospropofol methods and compositions |
| US11547714B2 (en) | 2020-02-05 | 2023-01-10 | Epalex Corporation | Fospropofol salts, methods and compositions |
| US11478490B1 (en) | 2021-03-30 | 2022-10-25 | Epalex Corporation | Fospropofol formulations |
| JP7608179B2 (ja) * | 2021-01-12 | 2025-01-06 | 日本光電工業株式会社 | 生体情報処理装置、生体情報処理方法、プログラム及び記憶媒体 |
| CN114129578A (zh) * | 2021-09-28 | 2022-03-04 | 瑞普（天津）生物药业有限公司 | 甲磷丙泊酚钠在制备宠物麻醉、镇静药物中的应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2829151A (en) * | 1952-11-03 | 1958-04-01 | Dow Chemical Co | Chlorotoloxy-ethyl phosphates |
| US3271314A (en) * | 1958-12-04 | 1966-09-06 | Ethyl Corp | 2, 6-diisopropylphenol |
| GB1146173A (en) * | 1966-06-18 | 1969-03-19 | Geigy Uk Ltd | Production of triaryl phosphates |
| US3723578A (en) * | 1970-10-13 | 1973-03-27 | Gaf Corp | Phosphate esters of ethers of thiol substituted phenols |
| GB1472793A (en) * | 1974-03-28 | 1977-05-04 | Ici Ltd | Pharmaceutical compositions |
| US4171272A (en) * | 1977-12-02 | 1979-10-16 | Fmc Corporation | Turbine lubricant |
| FR2601259B1 (fr) * | 1986-07-11 | 1990-06-22 | Rhone Poulenc Chimie | Nouvelles compositions tensio-actives a base d'esters phosphoriques leur procede de preparation et leur application a la formulation de matieres actives. |
| MY103951A (en) * | 1988-01-12 | 1993-10-30 | Kao Corp | Detergent composition |
| US5091211A (en) * | 1989-08-17 | 1992-02-25 | Lord Corporation | Coating method utilizing phosphoric acid esters |
| DE69021673T2 (de) * | 1989-08-21 | 1996-05-02 | American Cyanamid Co | Stabile injizierbare pharmazeutische Formulation mit Folinsäure und Leukovorinsalze und Verfahren. |
| US5110503A (en) * | 1990-05-15 | 1992-05-05 | Elliot Cohen | Demulsifying |
| JP2869186B2 (ja) * | 1990-10-17 | 1999-03-10 | 株式会社トーメン | 植物における生物活性剤の吸収移行を促進する方法及び組成物 |
| EP0673373A1 (de) * | 1992-12-11 | 1995-09-27 | Smithkline Beecham Plc | Bizyklisch verbindungen mit pharmazeutische wirkung |
| US5646176A (en) * | 1992-12-24 | 1997-07-08 | Bristol-Myers Squibb Company | Phosphonooxymethyl ethers of taxane derivatives |
| KR960008645B1 (ko) * | 1993-09-08 | 1996-06-28 | 동국제약 주식회사 | 오르토-이소프로필화 페놀 유도체의 제조방법 |
| US5731356A (en) * | 1994-03-22 | 1998-03-24 | Zeneca Limited | Pharmaceutical compositions of propofol and edetate |
| GB9405593D0 (en) * | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
| IT1270093B (it) * | 1994-09-28 | 1997-04-28 | Zambon Spa | Processo per la purificazione di 2,6-diisopropilfenolo |
| US5804682A (en) * | 1995-11-29 | 1998-09-08 | Henkel Corporation | Aqueous dispersions of polyamides |
| US5637625A (en) * | 1996-03-19 | 1997-06-10 | Research Triangle Pharmaceuticals Ltd. | Propofol microdroplet formulations |
| US5723538A (en) * | 1996-06-14 | 1998-03-03 | Henkel Corporation | Aqueous dispersions of polyamides |
| US5746973A (en) * | 1996-07-10 | 1998-05-05 | Naraghi; Ali | Method for reducing odorant depletion |
| US6254853B1 (en) * | 1998-05-08 | 2001-07-03 | Vyrex Corporation | Water soluble pro-drugs of propofol |
| US6204257B1 (en) * | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| US6177477B1 (en) * | 1999-03-24 | 2001-01-23 | American Home Products Corporation | Propofol formulation containing TRIS |
| MXPA02007191A (es) * | 2000-02-04 | 2002-12-09 | Lilly Co Eli | Composicion farmaceutica que comprende permetrexed junto con monotioglicerol, l-cisteina o acido tioglicolico. |
| EP1289518A2 (de) * | 2000-05-25 | 2003-03-12 | AstraZeneca AB | Pharmazeutische zusammensetzung welche ein sedatives freie radikalefangendes mittel und einen metallionen chelator enthält |
| IN187686B (de) * | 2000-06-21 | 2002-06-08 | Bharat Serums & Vaccines Ltd | |
| US6362234B1 (en) * | 2000-08-15 | 2002-03-26 | Vyrex Corporation | Water-soluble prodrugs of propofol for treatment of migrane |
| US7034013B2 (en) * | 2001-03-20 | 2006-04-25 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
-
2002
- 2002-12-26 ES ES02799315T patent/ES2325918T3/es not_active Expired - Lifetime
- 2002-12-26 BR BR0215303-3A patent/BR0215303A/pt active Search and Examination
- 2002-12-26 NZ NZ533536A patent/NZ533536A/en not_active IP Right Cessation
- 2002-12-26 KR KR1020107018913A patent/KR20100112632A/ko not_active Ceased
- 2002-12-26 US US10/498,801 patent/US20050042280A1/en not_active Abandoned
- 2002-12-26 AT AT02799315T patent/ATE430571T1/de not_active IP Right Cessation
- 2002-12-26 KR KR10-2004-7009936A patent/KR20040080444A/ko not_active Ceased
- 2002-12-26 MX MXPA04006325A patent/MXPA04006325A/es not_active Application Discontinuation
- 2002-12-26 WO PCT/US2002/041468 patent/WO2003057153A2/en not_active Ceased
- 2002-12-26 IL IL16269202A patent/IL162692A0/xx active IP Right Grant
- 2002-12-26 PL PL372324A patent/PL205271B1/pl unknown
- 2002-12-26 AU AU2002364238A patent/AU2002364238B2/en not_active Ceased
- 2002-12-26 JP JP2003557512A patent/JP2005517679A/ja not_active Withdrawn
- 2002-12-26 EP EP02799315A patent/EP1458355B1/de not_active Expired - Lifetime
- 2002-12-26 UA UA20040604686A patent/UA76802C2/uk unknown
- 2002-12-26 DE DE60232271T patent/DE60232271D1/de not_active Expired - Lifetime
- 2002-12-26 CA CA2470500A patent/CA2470500C/en not_active Expired - Fee Related
- 2002-12-26 CN CNB028259955A patent/CN1329036C/zh not_active Expired - Fee Related
- 2002-12-26 RU RU2004119056/15A patent/RU2316317C2/ru not_active IP Right Cessation
- 2002-12-26 HU HU0500439A patent/HU229293B1/hu not_active IP Right Cessation
-
2004
- 2004-06-10 ZA ZA2004/04616A patent/ZA200404616B/en unknown
- 2004-06-14 NO NO20042459A patent/NO334424B1/no not_active IP Right Cessation
- 2004-06-23 IL IL162692A patent/IL162692A/en not_active IP Right Cessation
-
2010
- 2010-06-23 JP JP2010142118A patent/JP2010235622A/ja active Pending
- 2010-10-14 IL IL208697A patent/IL208697A0/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |