ATE430751T1 - Thienopyridinderivate als allostere gaba-b- enhancer - Google Patents

Thienopyridinderivate als allostere gaba-b- enhancer

Info

Publication number
ATE430751T1
ATE430751T1 AT05815262T AT05815262T ATE430751T1 AT E430751 T1 ATE430751 T1 AT E430751T1 AT 05815262 T AT05815262 T AT 05815262T AT 05815262 T AT05815262 T AT 05815262T AT E430751 T1 ATE430751 T1 AT E430751T1
Authority
AT
Austria
Prior art keywords
allostere
gaba
enhancers
thienopyridine derivatives
thienopyridine
Prior art date
Application number
AT05815262T
Other languages
English (en)
Inventor
Parichehr Malherbe
Raffaello Masciadri
Roger Norcross
Hasane Ratni
Andrew Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE430751T1 publication Critical patent/ATE430751T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
AT05815262T 2004-12-17 2005-12-09 Thienopyridinderivate als allostere gaba-b- enhancer ATE430751T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04106665 2004-12-17
PCT/EP2005/013194 WO2006063732A1 (en) 2004-12-17 2005-12-09 Thieno-pyridine derivatives as gaba-b allosteric enhancers

Publications (1)

Publication Number Publication Date
ATE430751T1 true ATE430751T1 (de) 2009-05-15

Family

ID=35702999

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05815262T ATE430751T1 (de) 2004-12-17 2005-12-09 Thienopyridinderivate als allostere gaba-b- enhancer

Country Status (17)

Country Link
US (1) US7390903B2 (de)
EP (1) EP1828199B1 (de)
JP (1) JP2008524134A (de)
KR (1) KR100912145B1 (de)
CN (1) CN101120003B (de)
AR (1) AR051995A1 (de)
AT (1) ATE430751T1 (de)
AU (1) AU2005315937A1 (de)
BR (1) BRPI0519521A2 (de)
CA (1) CA2591211A1 (de)
DE (1) DE602005014383D1 (de)
ES (1) ES2324231T3 (de)
MX (1) MX2007007026A (de)
PL (1) PL1828199T3 (de)
RU (1) RU2388761C2 (de)
TW (1) TW200633708A (de)
WO (1) WO2006063732A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0622472D0 (en) * 2006-11-10 2006-12-20 Addex Pharmaceuticals Sa Novel heterocyclic derivatives
US8633186B2 (en) 2007-06-08 2014-01-21 Senomyx Inc. Modulation of chemosensory receptors and ligands associated therewith
AU2013202912B2 (en) * 2007-06-08 2016-10-27 Firmenich Incorporated Modulation of chemosensory receptors and ligands associated therewith
US9603848B2 (en) * 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
US7928111B2 (en) 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
CA2993967A1 (en) 2008-07-31 2010-02-04 Senomyx, Inc. Processes and intermediates for making sweet taste enhancers
US8609173B2 (en) 2008-07-31 2013-12-17 Senomyx Inc. Compositions comprising sweetness enhancers and methods of making them
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
CA2792068A1 (en) 2010-04-02 2011-10-06 Senomyx, Inc. Sweet flavor modifier
US9000054B2 (en) 2010-08-12 2015-04-07 Senomyx, Inc. Method of improving stability of sweet enhancer and composition containing stabilized sweet enhancer
MX343274B (es) * 2010-11-15 2016-10-31 Viiv Healthcare Uk Ltd Inhibidores de la replicacion del vih.
MX2013005478A (es) 2010-11-15 2013-08-29 Univ Leuven Kath Compuestos heterociclicos condensados antivirales.
RU2617700C2 (ru) 2011-08-12 2017-04-26 Синомикс, Инк. Производные 4-аминохинолин-3-карбоновой кислоты и содержащие их композиции для усиления сладкого вкуса
LT2812337T (lt) * 2012-02-09 2016-11-25 Merck Patent Gmbh Furo[3,2-b]piridino dariniai, kaip tbk1 ir ikk inhibitoriai
KR20200028050A (ko) 2012-08-06 2020-03-13 피르메니히 인코포레이티드 단맛 향미 개질제
JO3155B1 (ar) 2013-02-19 2017-09-20 Senomyx Inc معدِّل نكهة حلوة
WO2014199195A1 (en) 2013-06-11 2014-12-18 Latvian Institute Of Organic Synthesis THIENO[2,3-b]PYRIDINES AS MULTIDRUG RESISTANCE MODULATORS
KR20160040295A (ko) 2013-08-08 2016-04-12 갈라파고스 엔.브이. Ｃｆｔｒ 조정자로서의 티에노[2,3-ｃ]피란
TWI648281B (zh) * 2013-10-17 2019-01-21 日商安斯泰來製藥股份有限公司 含硫二環式化合物
TW201623257A (zh) 2014-05-09 2016-07-01 奧利安公司 藥理活性之喹唑啉二酮衍生物
CA2963901A1 (en) 2014-11-07 2016-05-12 Senomyx, Inc. Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers
MA46899A (fr) * 2016-11-07 2021-04-14 Univ Vanderbilt Modulateurs allostériques positifs du récepteur muscarinique de l'acétylcholine m4
JP7453210B2 (ja) 2018-08-07 2024-03-19 フィルメニッヒ インコーポレイテッド ５－置換４－アミノ－１Ｈ－ベンゾ［ｃ］［１，２，６］チアジアジン２，２－ジオキシド並びにその配合物及び使用
CN109081846A (zh) * 2018-10-08 2018-12-25 浙江工业大学上虞研究院有限公司 4-氨基噻吩[2,3-b]吡啶类化合物的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1003419A (en) * 1971-11-23 1977-01-11 Theodor Denzel Process for the production of pyrazolo (3,4-b) pyridines
GB8801491D0 (en) * 1988-01-22 1988-02-24 Beecham Group Plc Novel compounds
GB8804448D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8921304D0 (en) * 1989-09-20 1989-11-08 Wyeth John & Brother Ltd New method of treatment and heterocyclic compounds used therein
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
PT101034A (pt) * 1991-11-07 1994-02-28 Smithkline Beecham Plc Composicoes farmaceuticas contendo tetra-hidropiridinas, tetra-hidropiridinas ai utilizadas , processo para a sua preparacao e sua utilizacao como medicamentos
DE69528470T2 (de) * 1994-11-08 2003-08-21 Takeda Chemical Industries, Ltd. Thienopyridin und thienopyrimidinderivate und ihre verwendung als entzündungshemmende mittel
FR2800072B1 (fr) 1999-10-22 2002-01-11 Centre Nat Rech Scient 1-(2-butyrolactones et 2-thiobutyrolactones)-isoquinolines n-substituees utiles comme stimulant de l'activite de l'acide gamma-aminobutyrique et dans le traitement des troubles nerveux et leur procede de preparation
EP1255735A2 (de) 2000-02-03 2002-11-13 Eli Lilly And Company Pyridin-derivate als potenzierungsmittel von glutamatrezeptoren
TW591031B (en) * 2000-02-29 2004-06-11 Takeda Chemical Industries Ltd Thienopyridine derivatives, their production and use
ES2250464T3 (es) * 2000-08-16 2006-04-16 Neurogen Corporation Derivados de piridina 2,4- sustituidos.
GB0209481D0 (en) 2002-04-24 2002-06-05 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
KR100912145B1 (ko) 2009-08-14
RU2007121908A (ru) 2009-01-27
MX2007007026A (es) 2007-07-04
KR20070091016A (ko) 2007-09-06
EP1828199B1 (de) 2009-05-06
EP1828199A1 (de) 2007-09-05
CN101120003B (zh) 2010-06-16
US20060135552A1 (en) 2006-06-22
WO2006063732A1 (en) 2006-06-22
TW200633708A (en) 2006-10-01
PL1828199T3 (pl) 2009-10-30
JP2008524134A (ja) 2008-07-10
ES2324231T3 (es) 2009-08-03
CN101120003A (zh) 2008-02-06
CA2591211A1 (en) 2006-06-22
RU2388761C2 (ru) 2010-05-10
AU2005315937A1 (en) 2006-06-22
BRPI0519521A2 (pt) 2009-02-10
DE602005014383D1 (en) 2009-06-18
AR051995A1 (es) 2007-02-21
US7390903B2 (en) 2008-06-24

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