ATE431351T1 - NEUE SUBSTITUIERTE THIOPHENPYRIMIDINONDERIVATE ALS INHIBITOREN VON 17ß- HYDROXYSTEROIDDEHYDROGENASE - Google Patents
NEUE SUBSTITUIERTE THIOPHENPYRIMIDINONDERIVATE ALS INHIBITOREN VON 17ß- HYDROXYSTEROIDDEHYDROGENASEInfo
- Publication number
- ATE431351T1 ATE431351T1 AT04804787T AT04804787T ATE431351T1 AT E431351 T1 ATE431351 T1 AT E431351T1 AT 04804787 T AT04804787 T AT 04804787T AT 04804787 T AT04804787 T AT 04804787T AT E431351 T1 ATE431351 T1 AT E431351T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- thiophenpyrimidinone
- hydroxysteroiddehydrogenase
- inhibitors
- new substituted
- Prior art date
Links
- 108010070743 3(or 17)-beta-hydroxysteroid dehydrogenase Proteins 0.000 title abstract 2
- 102100034067 Dehydrogenase/reductase SDR family member 11 Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 4
- 230000001419 dependent effect Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 239000003270 steroid hormone Substances 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2004/053424 WO2006063615A1 (en) | 2004-12-13 | 2004-12-13 | NOVEL SUBSTITUTED THIOPHENEPYRIMIDINONE DERIVATIVES AS INHIBITORS OF 17β-HYDROXYSTEROID DEHYDROGENASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE431351T1 true ATE431351T1 (de) | 2009-05-15 |
Family
ID=34959788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04804787T ATE431351T1 (de) | 2004-12-13 | 2004-12-13 | NEUE SUBSTITUIERTE THIOPHENPYRIMIDINONDERIVATE ALS INHIBITOREN VON 17ß- HYDROXYSTEROIDDEHYDROGENASE |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP1828197B1 (de) |
| JP (1) | JP4686549B2 (de) |
| CN (1) | CN101087793B (de) |
| AT (1) | ATE431351T1 (de) |
| AU (1) | AU2004325692B2 (de) |
| BR (1) | BRPI0419229A (de) |
| CA (1) | CA2590233A1 (de) |
| DE (1) | DE602004021145D1 (de) |
| ES (1) | ES2327240T3 (de) |
| MX (1) | MX2007007051A (de) |
| NO (1) | NO20073610L (de) |
| PL (1) | PL1828197T3 (de) |
| WO (1) | WO2006063615A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8080540B2 (en) | 2006-09-19 | 2011-12-20 | Abbott Products Gmbh | Therapeutically active triazoles and their use |
| TW201520219A (zh) * | 2013-03-12 | 2015-06-01 | Lilly Co Eli | 咪唑並吡啶化合物 |
| US9884839B2 (en) | 2014-01-03 | 2018-02-06 | Elexopharm Gmbh | Inhibitors of 17Beta-hydroxysteroid dehydrogenases type 1 and type 2 |
| IL315794A (en) * | 2022-04-28 | 2024-11-01 | Enanta Pharm Inc | Pyrimidine containing 17-beta-hydrosteroid dehydrogenase type 13 inhibitors |
| CN120114459B (zh) * | 2025-05-14 | 2025-07-29 | 南京工业大学 | 苯并呋喃嘧啶酮或苯并噻吩嘧啶酮类化合物的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4054656A (en) * | 1975-09-10 | 1977-10-18 | Mead Johnson & Company | Thieno[2,3-d]pyrimidine antiallergic agents |
| JPS62132884A (ja) * | 1985-12-05 | 1987-06-16 | Mitsubishi Chem Ind Ltd | ２−ベンジルチエノ〔２，３−ｄ〕ピリミジン−４（３Ｈ）−オン誘導体 |
| EP0364598A4 (en) * | 1988-03-02 | 1992-01-15 | Yoshitomi Pharmaceutical Industries, Ltd. | 3,4-dihydrothieno 2,3-d¨pyrimidine compounds and pharmaceutical application thereof |
| US5597823A (en) * | 1995-01-27 | 1997-01-28 | Abbott Laboratories | Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists |
| FI20030393A7 (fi) * | 2003-03-14 | 2004-09-15 | Molekyyliendokrinologian Tutkimusyksikkoe | Menetelmiä, joilla voidaan ennustaa rintasyövän kehistyskulku ja yhdisteitä, joita voidaan käyttää sen ehkäisemiseksi tai hoitamiseksi |
| US7465739B2 (en) * | 2003-06-10 | 2008-12-16 | Solvay Pharmaceuticals B.V. | Compounds and their use in therapy |
| US7754709B2 (en) * | 2003-06-10 | 2010-07-13 | Solvay Pharmaceuticals Bv | Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds |
-
2004
- 2004-12-13 MX MX2007007051A patent/MX2007007051A/es active IP Right Grant
- 2004-12-13 AU AU2004325692A patent/AU2004325692B2/en not_active Expired - Fee Related
- 2004-12-13 ES ES04804787T patent/ES2327240T3/es not_active Expired - Lifetime
- 2004-12-13 CN CN200480044596XA patent/CN101087793B/zh not_active Expired - Fee Related
- 2004-12-13 BR BRPI0419229-0A patent/BRPI0419229A/pt not_active IP Right Cessation
- 2004-12-13 EP EP04804787A patent/EP1828197B1/de not_active Expired - Lifetime
- 2004-12-13 AT AT04804787T patent/ATE431351T1/de not_active IP Right Cessation
- 2004-12-13 WO PCT/EP2004/053424 patent/WO2006063615A1/en not_active Ceased
- 2004-12-13 DE DE602004021145T patent/DE602004021145D1/de not_active Expired - Lifetime
- 2004-12-13 JP JP2007545846A patent/JP4686549B2/ja not_active Expired - Fee Related
- 2004-12-13 CA CA002590233A patent/CA2590233A1/en not_active Abandoned
- 2004-12-13 PL PL04804787T patent/PL1828197T3/pl unknown
-
2007
- 2007-07-12 NO NO20073610A patent/NO20073610L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL1828197T3 (pl) | 2009-11-30 |
| JP4686549B2 (ja) | 2011-05-25 |
| AU2004325692B2 (en) | 2012-01-19 |
| CA2590233A1 (en) | 2006-06-22 |
| EP1828197B1 (de) | 2009-05-13 |
| ES2327240T3 (es) | 2009-10-27 |
| EP1828197A1 (de) | 2007-09-05 |
| CN101087793B (zh) | 2011-09-07 |
| JP2008523117A (ja) | 2008-07-03 |
| AU2004325692A1 (en) | 2006-06-22 |
| NO20073610L (no) | 2007-09-12 |
| DE602004021145D1 (de) | 2009-06-25 |
| CN101087793A (zh) | 2007-12-12 |
| BRPI0419229A (pt) | 2007-12-18 |
| MX2007007051A (es) | 2007-06-26 |
| WO2006063615A1 (en) | 2006-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |