MA31767B1 - Composes organiques et leurs utilisations - Google Patents

Composes organiques et leurs utilisations

Info

Publication number
MA31767B1
MA31767B1 MA32757A MA32757A MA31767B1 MA 31767 B1 MA31767 B1 MA 31767B1 MA 32757 A MA32757 A MA 32757A MA 32757 A MA32757 A MA 32757A MA 31767 B1 MA31767 B1 MA 31767B1
Authority
MA
Morocco
Prior art keywords
organic compounds
amelioration
prevention
useful
treatment
Prior art date
Application number
MA32757A
Other languages
Arabic (ar)
English (en)
Inventor
Shawn D Britt
Lech Andrzej Ciszewski
Jiping Fu
Subramanian Karur
Yugang Liu
David Thomas Parker
Mahavir Prashad
Prakash Raman
Mohindra Seepersaud
Rui Zheng
Peichao Lu
Pascal Rigollier
Aregahegn Yifru
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA31767B1 publication Critical patent/MA31767B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention décrit des composés organiques qui sont utiles pour le traitement, la prévention et/ou l'amélioration de maladies humaines.
MA32757A 2007-10-10 2010-04-08 Composes organiques et leurs utilisations MA31767B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97897407P 2007-10-10 2007-10-10
PCT/EP2008/063460 WO2009047264A1 (fr) 2007-10-10 2008-10-08 Composés organiques et leurs utilisations

Publications (1)

Publication Number Publication Date
MA31767B1 true MA31767B1 (fr) 2010-10-01

Family

ID=40243948

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32757A MA31767B1 (fr) 2007-10-10 2010-04-08 Composes organiques et leurs utilisations

Country Status (20)

Country Link
US (2) US8008263B2 (fr)
EP (1) EP2205584A1 (fr)
JP (1) JP5095824B2 (fr)
KR (2) KR101218882B1 (fr)
CN (2) CN104016970A (fr)
AR (1) AR068756A1 (fr)
AU (1) AU2008309589B2 (fr)
BR (1) BRPI0817881A2 (fr)
CA (1) CA2702132A1 (fr)
CL (1) CL2008002995A1 (fr)
CO (1) CO6270317A2 (fr)
CR (1) CR11310A (fr)
EA (1) EA020951B1 (fr)
MA (1) MA31767B1 (fr)
MX (1) MX2010003916A (fr)
PE (1) PE20091237A1 (fr)
TN (1) TN2010000137A1 (fr)
TW (1) TW200932737A (fr)
WO (1) WO2009047264A1 (fr)
ZA (1) ZA201001585B (fr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2643680A1 (fr) * 2006-04-11 2007-11-22 Novartis Ag Composes organiques et leurs utilisations
US8293705B2 (en) 2007-12-21 2012-10-23 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
WO2009082697A1 (fr) 2007-12-21 2009-07-02 Avila Therapeutics, Inc. Inhibiteurs de hcv protéase et leurs utilisations
CA2710144A1 (fr) 2007-12-21 2009-07-02 Avila Therapeutics, Inc. Inhibiteurs de hcv protease et leurs utilisations
US8309685B2 (en) 2007-12-21 2012-11-13 Celgene Avilomics Research, Inc. HCV protease inhibitors and uses thereof
CN102216321A (zh) * 2008-10-15 2011-10-12 因特蒙公司 治疗性抗病毒肽
US20110182850A1 (en) * 2009-04-10 2011-07-28 Trixi Brandl Organic compounds and their uses
US8512690B2 (en) * 2009-04-10 2013-08-20 Novartis Ag Derivatised proline containing peptide compounds as protease inhibitors
WO2011038293A1 (fr) * 2009-09-28 2011-03-31 Intermune, Inc. Inhibiteurs peptiques cycliques de la réplication du virus de l'hépatite c
WO2011041551A1 (fr) * 2009-10-01 2011-04-07 Intermune, Inc. Peptides antiviraux thérapeutiques
EP2624826B1 (fr) * 2010-10-08 2018-07-18 Novartis AG Compositions comprenant de la vitamine e et des sulfamides inhibiteurs du ns3
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2013030750A1 (fr) 2011-09-01 2013-03-07 Lupin Limited Composés antiviraux
IN2014MN01547A (fr) 2012-02-10 2015-05-08 Lupin Ltd
CN103420991B (zh) * 2012-05-17 2017-07-07 乳源东阳光药业有限公司 作为丙型肝炎抑制剂的吡咯烷衍生物及其在药物中的应用
TW201408669A (zh) * 2012-08-08 2014-03-01 Merck Sharp & Dohme Ｈｃｖ ｎｓ３蛋白酶抑制劑
TW201412709A (zh) 2012-09-28 2014-04-01 Sunshine Lake Pharma Co Ltd 作為丙型肝炎抑制劑的螺環化合物及其在藥物中的應用
SI2909205T1 (sl) 2012-10-19 2017-02-28 Bristol-Myers Squibb Company 9-metil substituiran heksadekahidrociklopropa(e)pirolo(1,2-A)(1,4)diazaciklopentadecinil karbamat derivati kot nestrukturalni 3 (NS3) proteazni inhibitorji za zdravljenje hepatitis C virusnih infekcij
EP2914613B1 (fr) 2012-11-02 2017-11-22 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
EP2914598B1 (fr) 2012-11-02 2017-10-18 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9409943B2 (en) 2012-11-05 2016-08-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
TWI585082B (zh) * 2012-11-29 2017-06-01 廣東東陽光藥業有限公司 作爲丙型肝炎抑制劑的螺環化合物、藥物組合物及它們的用途
WO2014082380A1 (fr) 2012-11-29 2014-06-05 Sunshine Lake Pharma Co., Ltd. Composés de type noyaux fusionnés utilisables en tant qu'inhibiteurs du virus de l'hépatite c, compositions pharmaceutiques en contenant et leurs utilisations
WO2014082381A1 (fr) * 2012-11-29 2014-06-05 Sunshine Lake Pharma Co., Ltd. Composés de type noyau spiro utilisables en tant qu'inhibiteurs du virus de l'hépatite c, compositions pharmaceutiques en contenant et leurs utilisations
US9580463B2 (en) 2013-03-07 2017-02-28 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9522876B2 (en) 2013-03-15 2016-12-20 Zymeworks Inc. Cytotoxic and anti-mitotic compounds, and methods of using the same
ES2916722T3 (es) 2013-12-27 2022-07-05 Zymeworks Inc Sistemas de enlace que contienen sulfonamida para conjugados de fármacos
SG11201605260VA (en) 2013-12-27 2016-07-28 Zymeworks Inc Var2csa-drug conjugates
US9738629B2 (en) 2014-01-23 2017-08-22 Sunshine Lake Pharma Co., Ltd. Bridged ring compounds as Hepatitis C virus inhibitors, pharmaceutical compositions and uses thereof
EP3194421B1 (fr) 2014-09-17 2021-11-03 Zymeworks Inc. Composés cytotoxiques et antimitotiques et leurs procédés d'utilisation
EP3728266A1 (fr) 2017-12-20 2020-10-28 Novartis AG Composés de pyrazolo-dihydropyrazinyl-pyridone fusionnés tricycliques utilisés en tant qu'agents antiviraux
US12540141B2 (en) 2020-11-23 2026-02-03 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
KR20230124583A (ko) 2020-11-23 2023-08-25 이난타 파마슈티칼스, 인코포레이티드 신규한 스피로피롤리딘 유래 항바이러스제
US20240051950A1 (en) * 2020-12-22 2024-02-15 The Regents Of The University Of California Novel CYP3A4-Specific Inhibitors and Methods of Using Same
WO2022235605A1 (fr) 2021-05-04 2022-11-10 Enanta Pharmaceuticals, Inc. Nouveaux agents antiviraux macrocycliques
US12398147B2 (en) 2021-05-11 2025-08-26 Enanta Pharmaceuticals, Inc. Macrocyclic spiropyrrolidine derived antiviral agents
WO2023003610A1 (fr) * 2021-07-23 2023-01-26 Enanta Pharmaceuticals, Inc. Nouveaux agents antiviraux dérivés de spiropyrrolidine
US12479854B2 (en) 2021-07-29 2025-11-25 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11912714B2 (en) 2021-11-12 2024-02-27 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11858945B2 (en) 2021-11-12 2024-01-02 Enanta Pharmaceuticals, Inc. Alkyne-containing antiviral agents
US11919910B2 (en) 2021-11-12 2024-03-05 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11993600B2 (en) 2021-12-08 2024-05-28 Enanta Pharmaceuticals, Inc. Saturated spirocyclics as antiviral agents
WO2023107417A1 (fr) 2021-12-08 2023-06-15 Enanta Pharmaceuticals, Inc. Agents antiviraux hétérocycliques
US12145942B2 (en) 2022-04-05 2024-11-19 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7244721B2 (en) * 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
MXPA03000627A (es) * 2000-07-21 2004-07-30 Schering Corp Nuevos peptidos como inhibidores de proteasa serina-ns3 del virus de la hepatitis c.
SV2003000617A (es) * 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
AU2003207625B2 (en) * 2002-01-23 2006-09-07 Schering Corporation Proline compounds as NS3-serine protease inhibitors for use in treatment of hepatites C virus infection
MXPA05013752A (es) * 2003-06-17 2006-03-08 Schering Corp Procedimiento e intermediarios para la preparacion de (1r,2s,5s)-6,6-dimetil-3-azabiciclo[3,1,0]exan-2-carboxilatos o sales de los mismos.
WO2005021584A2 (fr) * 2003-08-26 2005-03-10 Schering Corporation Nouveaux inhibiteurs peptidomimetiques de la serine protease ns3 du virus de l'hepatite c
PE20050374A1 (es) * 2003-09-05 2005-05-30 Vertex Pharma Inhibidores de proteasas de serina, en particular proteasa ns3-ns4a del vhc
CA2538791A1 (fr) * 2003-09-18 2005-03-31 Vertex Pharmaceuticals Incorporated Inhibiteurs de serines proteases, en particulier de la protease ns3-ns4a du vhc
EP1677827B1 (fr) * 2003-10-27 2008-12-10 Vertex Pharmaceuticals Incorporated Inhibiteurs combin s destin s au traitement du vhc
CA2549167A1 (fr) 2003-12-11 2005-06-30 Schering Corporation Inhibiteurs de la protease serine ns3/ns4a du virus de l'hepatite c (hcv)
EP2311851A3 (fr) * 2004-02-04 2011-05-25 Vertex Pharmaceuticals Incorporated Inhibitoren der Serinproteasen, insbesondere der HCV-NS3-NS4A-Protease
US7205330B2 (en) * 2004-02-27 2007-04-17 Schering Corporation Inhibitors of hepatitis C virus NS3 protease
US7635694B2 (en) * 2004-02-27 2009-12-22 Schering Corporation Cyclobutenedione-containing compounds as inhibitors of hepatitis C virus NS3 serine protease
AU2005219824B2 (en) * 2004-02-27 2007-11-29 Merck Sharp & Dohme Corp. Novel ketoamides with cyclic p4's as inhibitors of ns3 serine protease of hepatitis c virus
US7192957B2 (en) * 2004-02-27 2007-03-20 Schering Corporation Compounds as inhibitors of hepatitis C virus NS3 serine protease
ES2328589T3 (es) * 2004-02-27 2009-11-16 Schering Corporation Compuestos de la prolina 3,4(ciclopentil) fusionados como inhibidores de la proteasa serina ns3 del virus de la hepatitis c.
MY145081A (en) * 2004-02-27 2011-12-15 Schering Corp Sulfur compounds as inhibitors of hepatitis c virus ns3 serine protease
AR049635A1 (es) * 2004-05-06 2006-08-23 Schering Corp (1r,2s,5s)-n-((1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil)-3-((2s)-2-((((1,1-dimetiletil)amino)carbonil)amino)-3,3-dimetil-1-oxobutil)-6,6-dimetil-3-azabiciclo(3.1.0)hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de la hepatitis c
AU2005253957B2 (en) * 2004-06-08 2011-08-25 Janssen Pharmaceutica Nv Pharmaceutical compositions
CA2577812A1 (fr) * 2004-08-27 2006-03-09 Schering Corporation Composes d'acylsulfonamide inhibiteurs de la serine protease ns3 du virus de l'hepatite c
US7250441B2 (en) * 2004-09-23 2007-07-31 Wyeth Carbazole and cyclopentaindole derivatives to treat infection with Hepatitis C virus
CA2583472A1 (fr) * 2004-10-01 2006-04-13 Chao Lin Inhibition de la protease ns3-ns4a du vhc
MY141025A (en) * 2004-10-29 2010-02-25 Vertex Pharma Dose forms
WO2006130686A2 (fr) * 2005-06-02 2006-12-07 Schering Corporation Administration d'inhibiteurs de protease du vhc en combinaison avec des aliments pour ameliorer la biodisponibilite
US20070004635A1 (en) * 2005-06-02 2007-01-04 Schering Corporation Method of treating interferon non-responders using HCV protease inhibitor
US20060281689A1 (en) * 2005-06-02 2006-12-14 Schering Corporation Method for modulating activity of HCV protease through use of a novel HCV protease inhibitor to reduce duration of treatment period
US20060276404A1 (en) * 2005-06-02 2006-12-07 Anima Ghosal Medicaments and methods combining a HCV protease inhibitor and an AKR competitor
WO2006130687A2 (fr) * 2005-06-02 2006-12-07 Schering Corporation Taux de concentration foie/plasma pour le dosage de l'inhibiteur de protease du virus de l'hepatite c
US7608592B2 (en) * 2005-06-30 2009-10-27 Virobay, Inc. HCV inhibitors
CA2617679A1 (fr) * 2005-08-02 2007-02-08 Steve Lyons Inhibiteurs des serines proteases
AR055395A1 (es) * 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
MX2008013125A (es) * 2006-04-11 2008-10-21 Novartis Ag Compuestos organicos y sus usos.
WO2007120595A2 (fr) * 2006-04-11 2007-10-25 Novartis Ag Composés organiques et leurs utilisations
JP2009533463A (ja) * 2006-04-11 2009-09-17 ノバルティス アクチエンゲゼルシャフト βアミノ酸を含むＨＣＶ阻害剤およびその使用
CA2643680A1 (fr) * 2006-04-11 2007-11-22 Novartis Ag Composes organiques et leurs utilisations
WO2008059367A1 (fr) 2006-11-14 2008-05-22 Pfizer Products Inc. Promédicaments de sulopénème
AR064736A1 (es) 2007-01-04 2009-04-22 Prosidion Ltd Agonistas de gpcr
CL2008000018A1 (es) 2007-01-04 2008-08-01 Prosidion Ltd Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
KR20100090249A (ko) 2007-10-10 2010-08-13 암젠 인크 치환된 비페닐 ｇｒｐ４０ 조절제
EA201070451A1 (ru) 2007-10-10 2010-10-29 Такеда Фармасьютикал Компани Лимитед Амидные соединения
UA100527C2 (en) 2007-10-10 2013-01-10 Астразенека Аб Benzothiazoles as ghrelin receptor modulators

Also Published As

Publication number Publication date
BRPI0817881A2 (pt) 2015-03-31
KR101396696B1 (ko) 2014-05-16
TN2010000137A1 (en) 2011-09-26
US8008263B2 (en) 2011-08-30
CO6270317A2 (es) 2011-04-20
ZA201001585B (en) 2010-12-29
CN104016970A (zh) 2014-09-03
CN101868452B (zh) 2014-08-06
CA2702132A1 (fr) 2009-04-16
MX2010003916A (es) 2010-05-05
CR11310A (es) 2010-05-06
CL2008002995A1 (es) 2009-06-26
AU2008309589A1 (en) 2009-04-16
US20090137495A1 (en) 2009-05-28
EP2205584A1 (fr) 2010-07-14
US20110275819A1 (en) 2011-11-10
JP2011500528A (ja) 2011-01-06
CN101868452A (zh) 2010-10-20
AU2008309589B2 (en) 2012-07-05
KR20120094049A (ko) 2012-08-23
EA201000556A1 (ru) 2010-10-29
EA020951B1 (ru) 2015-03-31
KR101218882B1 (ko) 2013-01-07
WO2009047264A1 (fr) 2009-04-16
US8222425B2 (en) 2012-07-17
KR20100051749A (ko) 2010-05-17
JP5095824B2 (ja) 2012-12-12
TW200932737A (en) 2009-08-01
PE20091237A1 (es) 2009-09-14
AR068756A1 (es) 2009-12-02

Similar Documents

Publication Publication Date Title
MA33155B1 (fr) Composes organiques et leurs utilisations
MA30392B1 (fr) Composes organiques et leurs utilisations
EA200901166A1 (ru) Соединения и композиции в качестве модуляторов активности gpr 119
MA30340B1 (fr) Nouveaux composes
MA30485B1 (fr) Aminothiazoles et leurs utilisations
TW200612926A (en) Compounds and compositions as ppar modulators
TNSN07161A1 (en) Compounds and compositions as inhibitors of cannabinoid receptor 1 activity
EA201100505A1 (ru) Органические соединения для применения для лечения бактериальных инфекций
MA30557B1 (fr) Composés de pyrrolopyrimidine et leurs utilisations.
MX2009006339A (es) Compuestos y composiciones como inhibidores de actividad de receptor 1 de cannabinoide.
MA28935B1 (fr) Preparation et utilisation de derives de biphenyl-4-yl-carbonylamino-acide dans le traitement de l'obesite
MX2009006536A (es) Compuestos de heteroaril-heteroarilo como inhibidores de cdk para el tratamiento de cancer, inflamacion e infecciones virales.
DE602007008434D1 (de) Rezeptoren
EP1606286A4 (fr) Antagonistes benodiazepine spirohydantoin des recepteurs de cgrp
MY145077A (en) Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
EA201071243A1 (ru) Комбинированные композиции для лечения болезни альцгеймера и родственных заболеваний зонизамидом и акампросатом
MA31451B1 (fr) Antagonistes des recepteurs de l'orexine de pyridyl piperidine.
MX2007009356A (es) Compuestos y composiciones como moduladores de ppar.
WO2007022470A3 (fr) Methodes et compositions pour le traitement de maladies neurologiques
MX2010003916A (es) Espiro-pirrolidinas y su uso contra infeccion por el virus de hepatitis c (hcv) y por el virus de inmunodeficiencia humana (vih).
EP2010179A4 (fr) 4-carboxamides d'imidazoles substitués utilisés comme modulateurs des récepteurs de la cholécystokinine-1
TW200602330A (en) Compounds and compositions as PPAR modulators
MA30903B1 (fr) Derives de 2 - phenyl-6-minocarbonyl-pyrimidine
MA33753B1 (fr) Nouveaux camphènes arylés, procédés de préparation et utilisations de ceux-ci
TW200600505A (en) Compounds and compositions as ppar modulators