ATE431417T1 - Mutationen in der mit der resistenz gegenüber sti-571 assoziierten bcr-abl-tyrosinkinase - Google Patents

Mutationen in der mit der resistenz gegenüber sti-571 assoziierten bcr-abl-tyrosinkinase

Info

Publication number
ATE431417T1
ATE431417T1 AT02744318T AT02744318T ATE431417T1 AT E431417 T1 ATE431417 T1 AT E431417T1 AT 02744318 T AT02744318 T AT 02744318T AT 02744318 T AT02744318 T AT 02744318T AT E431417 T1 ATE431417 T1 AT E431417T1
Authority
AT
Austria
Prior art keywords
bcr
sti
mutations
resistance
tyrosine kinase
Prior art date
Application number
AT02744318T
Other languages
English (en)
Inventor
Charles Sawyers
Mercedes Gorre
Neil Shah
John Nicoll
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26970843&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE431417(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE431417T1 publication Critical patent/ATE431417T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57575—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02744318T 2001-06-14 2002-06-14 Mutationen in der mit der resistenz gegenüber sti-571 assoziierten bcr-abl-tyrosinkinase ATE431417T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29872801P 2001-06-14 2001-06-14
US33170901P 2001-11-20 2001-11-20
PCT/US2002/018729 WO2002102976A2 (en) 2001-06-14 2002-06-14 Mutations in the bcr-abl tyrosine kinase associated with resistance to sti-571

Publications (1)

Publication Number Publication Date
ATE431417T1 true ATE431417T1 (de) 2009-05-15

Family

ID=26970843

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02744318T ATE431417T1 (de) 2001-06-14 2002-06-14 Mutationen in der mit der resistenz gegenüber sti-571 assoziierten bcr-abl-tyrosinkinase

Country Status (8)

Country Link
US (9) US7521175B2 (de)
EP (4) EP2186901B1 (de)
JP (5) JP4444651B2 (de)
AT (1) ATE431417T1 (de)
AU (1) AU2002345670A1 (de)
CA (3) CA2450473C (de)
DE (1) DE60232370D1 (de)
WO (1) WO2002102976A2 (de)

Families Citing this family (42)

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ATE431417T1 (de) 2001-06-14 2009-05-15 Univ California Mutationen in der mit der resistenz gegenüber sti-571 assoziierten bcr-abl-tyrosinkinase
US20030170851A1 (en) * 2001-10-05 2003-09-11 Christophe Barthe Organic compounds
EP2341133A1 (de) * 2001-10-05 2011-07-06 Novartis AG Mutante der Kinase Domäne des Abl
JP4035600B2 (ja) * 2002-05-22 2008-01-23 国立大学法人 東京大学 イマチニブに対する感受性の判定方法
BRPI0508959A (pt) * 2004-03-23 2007-08-14 Astrazeneca Ab uso de azd2171 ou de um sal do mesmo farmaceuticamente aceitável, uso de sal maleato de azd2171 e oxaliplatina, composição farmacêutica, kit, e, método para a produção de um efeito antiangiogênico e/ou de redução da permeabilidade vascular em um animal de sangue quente
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WO2008033776A1 (en) * 2006-09-11 2008-03-20 Oregon Health & Science University Probes and methods for detecting gleevec-resistant bcr-abl mutations
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JP2012167049A (ja) * 2011-02-14 2012-09-06 Fujifilm Corp がん関連遺伝子発現抑制剤
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JP6531312B2 (ja) * 2014-10-17 2019-06-19 東洋鋼鈑株式会社 Ｂｃｒ−ａｂｌ阻害剤耐性関連変異の検出方法及びこれを用いたｂｃｒ−ａｂｌ阻害剤耐性を予測するためのデータ取得方法
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Also Published As

Publication number Publication date
JP4444651B2 (ja) 2010-03-31
US20090155787A1 (en) 2009-06-18
JP2013099355A (ja) 2013-05-23
US8586291B2 (en) 2013-11-19
US9994910B2 (en) 2018-06-12
JP2016010412A (ja) 2016-01-21
CA2450473C (en) 2011-11-15
JP2009278978A (ja) 2009-12-03
US8697348B2 (en) 2014-04-15
AU2002345670A1 (en) 2003-01-02
JP2004537992A (ja) 2004-12-24
US20190144946A1 (en) 2019-05-16
EP1466174A4 (de) 2005-08-17
EP2186901B1 (de) 2015-06-03
EP2322627A2 (de) 2011-05-18
US7521175B2 (en) 2009-04-21
EP1466174B1 (de) 2009-05-13
US20100055687A1 (en) 2010-03-04
WO2002102976A3 (en) 2004-08-05
US20060269956A1 (en) 2006-11-30
CA2450473A1 (en) 2002-12-27
CA3009793A1 (en) 2002-12-27
CA2753372A1 (en) 2002-12-27
EP2186901A3 (de) 2010-09-08
US20030158105A1 (en) 2003-08-21
WO2002102976A2 (en) 2002-12-27
US20160130655A1 (en) 2016-05-12
US20120021425A1 (en) 2012-01-26
JP2013066489A (ja) 2013-04-18
US20100248241A1 (en) 2010-09-30
US9056924B2 (en) 2015-06-16
CA2753372C (en) 2018-08-07
DE60232370D1 (de) 2009-06-25
EP1466174A2 (de) 2004-10-13
US20120282622A1 (en) 2012-11-08
EP2322628A2 (de) 2011-05-18
US9085644B2 (en) 2015-07-21
EP2322628B1 (de) 2017-03-15
EP2186901A2 (de) 2010-05-19
JP5886180B2 (ja) 2016-03-16
EP2322627A3 (de) 2011-10-12
EP2322628A3 (de) 2011-09-14

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