ATE432066T1 - Arzneimittel für die dickdarmverabreichung von wirkstoffen - Google Patents

Arzneimittel für die dickdarmverabreichung von wirkstoffen

Info

Publication number
ATE432066T1
ATE432066T1 AT03758212T AT03758212T ATE432066T1 AT E432066 T1 ATE432066 T1 AT E432066T1 AT 03758212 T AT03758212 T AT 03758212T AT 03758212 T AT03758212 T AT 03758212T AT E432066 T1 ATE432066 T1 AT E432066T1
Authority
AT
Austria
Prior art keywords
pectin
active ingredients
large intestine
medicinal products
aqueous solution
Prior art date
Application number
AT03758212T
Other languages
English (en)
Inventor
Sandrine Bourgeois
Elias Fattal
Antoine Andremont
Patrick Couvreur
Original Assignee
Centre Nat Rech Scient
Da Volterra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0210151A external-priority patent/FR2843301B1/fr
Application filed by Centre Nat Rech Scient, Da Volterra filed Critical Centre Nat Rech Scient
Application granted granted Critical
Publication of ATE432066T1 publication Critical patent/ATE432066T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
AT03758212T 2002-08-09 2003-08-06 Arzneimittel für die dickdarmverabreichung von wirkstoffen ATE432066T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0210151A FR2843301B1 (fr) 2002-08-09 2002-08-09 Forme galenique pour la delivrance colique de principes actifs
FR0213514A FR2843302B1 (fr) 2002-08-09 2002-10-29 Forme galenique pour la delivrance colique de principes actifs
PCT/FR2003/002474 WO2004016248A2 (fr) 2002-08-09 2003-08-06 Forme galenique pour la delivrance colique de principes actifs

Publications (1)

Publication Number Publication Date
ATE432066T1 true ATE432066T1 (de) 2009-06-15

Family

ID=30772009

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03758212T ATE432066T1 (de) 2002-08-09 2003-08-06 Arzneimittel für die dickdarmverabreichung von wirkstoffen

Country Status (14)

Country Link
US (2) US7485294B2 (de)
EP (2) EP1992336A3 (de)
JP (1) JP2006500359A (de)
KR (1) KR101080577B1 (de)
CN (1) CN1681480B (de)
AT (1) ATE432066T1 (de)
AU (1) AU2003274229B2 (de)
BR (1) BR0313469A (de)
CA (1) CA2495291A1 (de)
DE (1) DE60327772D1 (de)
ES (1) ES2327630T3 (de)
FR (1) FR2843302B1 (de)
MX (1) MXPA05001607A (de)
WO (1) WO2004016248A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4694145B2 (ja) * 2004-05-17 2011-06-08 株式会社 メドレックス 経口腸溶性製剤
US20080317666A1 (en) * 2005-02-09 2008-12-25 Elias Fattal Colonic Delivery of Active Agents
CN101257892B (zh) * 2005-05-18 2013-01-02 达沃尔泰拉公司 吸附剂的结肠递送
US7678817B2 (en) * 2005-06-03 2010-03-16 Medrx Co., Ltd. Enteric medicinal composition for oral use
US8048413B2 (en) 2006-05-17 2011-11-01 Helene Huguet Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules
FI119190B (fi) 2006-06-21 2008-08-29 Ipsat Therapies Oy Modifioitu beta-laktamaasi ja menetelmä sen valmistamiseksi
US20080124279A1 (en) * 2006-11-17 2008-05-29 Antoine Andremont Colonic delivery using Zn/pectin beads with a Eudragit coating
US8273376B2 (en) 2006-11-17 2012-09-25 Da Volterra Colonic delivery of metallo-dependent enzymes
FI119678B (fi) * 2006-11-28 2009-02-13 Ipsat Therapies Oy Beta-laktamaasin käyttö
GB0713116D0 (en) * 2007-07-06 2007-08-15 Therapeutics Ltd E Treatment of melanoma
GB0714226D0 (en) * 2007-07-20 2007-08-29 Therapeutics Ltd E anti-bacterial combination therapy
US20100239682A1 (en) * 2007-09-17 2010-09-23 Antoine Andremont Colonic delivery of antimicrobial agents
GB0719771D0 (en) * 2007-10-10 2007-11-21 Therapeutics Ltd E Dexanabinol in combination with inhibitors of BRAF or MEK for the treatment of melanoma
GB0813211D0 (en) 2008-07-18 2008-08-27 E Therapeutics Plc Antibacterial combination therapy for the treatment of gram positive bacterial infections
FR2950252B1 (fr) * 2009-09-23 2012-01-20 Centre Nat Rech Scient Forme galenique capable d'adsorber de maniere specifique les molecules indesirables
PL2538930T3 (pl) 2010-02-23 2016-11-30 Preparaty do doustnego dostarczania środków adsorbujących do jelita
FI20105572A0 (fi) 2010-05-24 2010-05-24 Prevab R Lcc Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt
BR112016023360B1 (pt) 2014-04-17 2023-03-07 Synthetic Biologics, Inc Beta-lactamase e seu uso
CN106574273B (zh) 2014-08-28 2021-07-02 合成生物制品有限公司 β-内酰胺酶的基于大肠杆菌的生产
CA2962959C (en) 2014-10-08 2023-04-04 Synthetic Biologics, Inc. Beta-lactamase formulations and uses thereof
FR3027307B1 (fr) 2014-10-16 2016-11-04 Azurrx Sas Molecule proteique hybride apte a inhiber au moins un antibiotique et composition pharmaceutique la comportant
US9744221B2 (en) 2014-12-23 2017-08-29 Synthetic Biologics, Inc. Method and compositions for inhibiting or preventing adverse effects of oral antibiotics
EP3261662B1 (de) 2015-02-23 2021-07-21 Synthetic Biologics Inc. Carbapenemasen zur verwendung mit antibiotika zum schutz des intestinalen mikrobioms
US10709773B2 (en) 2015-03-06 2020-07-14 Synthetic Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection
US10182993B2 (en) 2015-04-06 2019-01-22 Patheon Softgels Inc. Compositions for colonic delivery of drugs
WO2017105138A1 (ko) * 2015-12-18 2017-06-22 주식회사 삼양바이오팜 음이온성 약물을 함유하는 고분자 미셀의 제조방법
CA3013166A1 (en) 2016-02-23 2017-08-31 Da Volterra Beta-lactamase variants
US10988749B2 (en) 2016-02-23 2021-04-27 Da Volterra Beta-lactamase variants
MX2020000265A (es) 2017-07-07 2020-07-22 Epicentrx Inc Composiciones para la administración parenteral de agentes terapéuticos.
KR20200074982A (ko) 2017-10-25 2020-06-25 다 볼떼라 베타-락타마아제 변이체
WO2020037262A1 (en) * 2018-08-17 2020-02-20 Cepheid Nucleic acid isolation and related methods

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959457A (en) * 1970-06-05 1976-05-25 Temple University Microparticulate material and method of making such material
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
SE459005B (sv) * 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
FR2608456B1 (fr) * 1986-12-18 1993-06-18 Mero Rousselot Satia Microcapsules a base de gelatine et de polysaccharides et leur procede d'obtention
FR2613624B1 (fr) 1987-04-10 1990-11-23 Roussy Inst Gustave Composition pharmaceutique, administrable par voie orale, destinee a reduire les effets des b-lactamines
US4963368A (en) * 1988-04-18 1990-10-16 Nabisco Brands, Inc. Oxidoreductase enzyme stabilized highly unsaturated fatty acids and derivatives of such acids
HU207940B (en) 1989-02-16 1993-07-28 British Tech Group Feeder apparatus for controlled dissolution of the active components
EP0454044B1 (de) * 1990-04-25 1995-12-06 Hoechst Aktiengesellschaft Pharmakologische Zubereitung, enthaltend Polyelektrolytkomplexe in mikropartikulärer Form und mindestens einen Wirkstoff
JPH0413724A (ja) 1990-05-02 1992-01-17 Chisso Corp 可溶性ポリイミド、その製造法及び液晶配向膜用塗布液
JPH0413741A (ja) * 1990-05-02 1992-01-17 Chisso Corp ペクチン・ポリリシン高分子電解質複合体
SE9002339L (sv) * 1990-07-04 1992-01-05 Kabi Pharmacia Ab Terapeutisk komposition och foerfarande foer dess framstaellning
KR930006431B1 (ko) * 1990-10-11 1993-07-16 재단법인 한국화학연구소 약물의 미세캡슐화 방법
ES2133633T3 (es) * 1992-01-17 1999-09-16 Alfatec Pharma Gmbh Procedimiento para la produccion de polvos, granulados o peletes que contienen una sustancia activa, con una estructura a base de macromoleculas hidrofilas, y su utilizacion.
FI920206A0 (fi) * 1992-01-17 1992-01-17 Pekka Untamo Heino Medicinsk anvaendning, medicinskt foerfarande och preparat.
US5718969A (en) * 1993-08-25 1998-02-17 Fmc Corporation Nonaggregating hydrocolloid microparticulates, intermediates therefor, and processes for their preparation
WO1997027843A2 (en) * 1996-01-30 1997-08-07 Advanced Polymer Systems, Inc. Targeted delivery of drugs to the lower gastrointestinal tract
ES2212085T3 (es) * 1996-10-09 2004-07-16 Givaudan Sa Procedimiento para la preparacion de granulos como aditivo para alimentos.
US6531152B1 (en) * 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
IL130303A0 (en) * 1999-06-03 2000-06-01 M G Novobiotech Ltd A bacterial strain processed plant extracts and probiotic compositions for human and veterinary use
US6632451B2 (en) * 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
IL152127A0 (en) * 2002-10-06 2003-05-29 Bio Balance Corp Probiotic compositions for the treatment of inflammatory bowel disease

Also Published As

Publication number Publication date
BR0313469A (pt) 2005-07-12
KR101080577B1 (ko) 2011-11-04
KR20050083628A (ko) 2005-08-26
MXPA05001607A (es) 2005-09-20
US7833765B2 (en) 2010-11-16
CN1681480B (zh) 2010-04-14
EP1992336A2 (de) 2008-11-19
WO2004016248A3 (fr) 2004-04-08
US7485294B2 (en) 2009-02-03
WO2004016248A2 (fr) 2004-02-26
CN1681480A (zh) 2005-10-12
JP2006500359A (ja) 2006-01-05
DE60327772D1 (de) 2009-07-09
EP1526841A2 (de) 2005-05-04
EP1992336A3 (de) 2009-05-13
US20050249716A1 (en) 2005-11-10
ES2327630T3 (es) 2009-11-02
AU2003274229A1 (en) 2004-03-03
CA2495291A1 (fr) 2004-02-26
EP1526841B1 (de) 2009-05-27
FR2843302A1 (fr) 2004-02-13
AU2003274229B2 (en) 2009-05-21
FR2843302B1 (fr) 2004-10-22
WO2004016248A8 (fr) 2004-05-21
US20090162339A1 (en) 2009-06-25

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Legal Events

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