ATE432267T1 - Verfahren zur herstellung von n-(2,6- dimethylphenyl)-2-piperazin-1-ylacetamid - Google Patents

Verfahren zur herstellung von n-(2,6- dimethylphenyl)-2-piperazin-1-ylacetamid

Info

Publication number: ATE432267T1
Authority: AT; Austria
Prior art keywords: piperazine; solvent; xylidine; haloacetyl; piperazin
Prior art date: 2002-06-24

Application number

AT03760705T

Other languages

English (en)

Inventor

M J M A Guillaume

J L J Cuypers

I J M Vervest

S M H Leurs

Smaele D De

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-06-24

Filing date

2003-06-19

Publication date

2009-06-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29797257&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE432267(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-06-19 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2009-06-15 Application granted granted Critical

2009-06-15 Publication of ATE432267T1 publication Critical patent/ATE432267T1/de

Links

NJKRFQIWDJSYOK-UHFFFAOYSA-N n-(2,6-dimethylphenyl)-2-piperazin-1-ylacetamide Chemical compound CC1=CC=CC(C)=C1NC(=O)CN1CCNCC1 NJKRFQIWDJSYOK-UHFFFAOYSA-N 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 4
239000002904 solvent Substances 0.000 abstract 3
239000003125 aqueous solvent Substances 0.000 abstract 2
239000000706 filtrate Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000007787 solid Substances 0.000 abstract 2
229960004194 lidocaine Drugs 0.000 abstract 1
230000003472 neutralizing effect Effects 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT03760705T 2002-06-24 2003-06-19 Verfahren zur herstellung von n-(2,6- dimethylphenyl)-2-piperazin-1-ylacetamid ATE432267T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02077749		2002-06-24
PCT/EP2003/050241 WO2004000824A1 (en)	2002-06-24	2003-06-19	Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide

Publications (1)

Publication Number	Publication Date
ATE432267T1 true ATE432267T1 (de)	2009-06-15

Family

ID=29797257

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03760705T ATE432267T1 (de)	2002-06-24	2003-06-19	Verfahren zur herstellung von n-(2,6- dimethylphenyl)-2-piperazin-1-ylacetamid

Country Status (12)

Country	Link
US (1)	US8541578B2 (de)
EP (1)	EP1517900B1 (de)
JP (1)	JP4846234B2 (de)
CN (1)	CN1326846C (de)
AT (1)	ATE432267T1 (de)
AU (1)	AU2003255511B2 (de)
BR (1)	BRPI0312001B1 (de)
CA (1)	CA2487141C (de)
DE (1)	DE60327765D1 (de)
ES (1)	ES2326800T3 (de)
IL (1)	IL165916A (de)
WO (1)	WO2004000824A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101747294B (zh) *	2008-12-10	2011-09-28	上海医药工业研究院	一种n-(2,6-二甲苯基)-2-(1-哌嗪基)乙酰胺的纯化方法
EP3233814A4 (de) *	2015-03-10	2018-07-18	Unichem Laboratories Limited	Neuartiges verfahren zur herstellung von ranolazin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US458129A (en) *		1891-08-18		papin
GB840358A (en)	1957-10-11	1960-07-06	British Drug Houses Ltd	Improvements in or relating to the manufacture of n-mono-substituted piperazines
US3953448A (en) *	1972-12-07	1976-04-27	Delmar Chemicals Limited	Piperazino-anilido compounds
IT1054961B (it) *	1976-01-23	1981-11-30	Corvi Camillo Spa	Derivati della piperazina adatti come agenti anti ulcera
US4567264A (en)	1983-05-18	1986-01-28	Syntex (U.S.A.) Inc.	Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
US4558129A (en) *	1983-05-18	1985-12-10	Syntex (U.S.A.) Inc.	Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade
ATE174913T1 (de)	1992-07-31	1999-01-15	Bristol Myers Squibb Co	Diphenyl oxazole-, thiazole- und imidazole- derivate als inhibitoren der wiederaufnahme des adenosins
EP0775128A1 (de) *	1995-06-07	1997-05-28	Dade Chemistry Systems Inc.	Verfahren zur herstellung von immunogenen und anderen arzneimittelkonjugaten
NZ321575A (en)	1995-10-30	1999-05-28	Janssen Pharmaceutica Nv	1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives

2003
- 2003-06-19 EP EP03760705A patent/EP1517900B1/de not_active Expired - Lifetime
- 2003-06-19 CA CA2487141A patent/CA2487141C/en not_active Expired - Lifetime
- 2003-06-19 AU AU2003255511A patent/AU2003255511B2/en not_active Expired
- 2003-06-19 CN CNB038146673A patent/CN1326846C/zh not_active Expired - Lifetime
- 2003-06-19 ES ES03760705T patent/ES2326800T3/es not_active Expired - Lifetime
- 2003-06-19 JP JP2004514875A patent/JP4846234B2/ja not_active Expired - Fee Related
- 2003-06-19 AT AT03760705T patent/ATE432267T1/de not_active IP Right Cessation
- 2003-06-19 WO PCT/EP2003/050241 patent/WO2004000824A1/en not_active Ceased
- 2003-06-19 DE DE60327765T patent/DE60327765D1/de not_active Expired - Lifetime
- 2003-06-19 US US10/518,887 patent/US8541578B2/en not_active Expired - Fee Related
- 2003-06-19 BR BRPI0312001-5A patent/BRPI0312001B1/pt not_active IP Right Cessation
2004
- 2004-12-22 IL IL165916A patent/IL165916A/en active IP Right Grant

Also Published As

Publication number	Publication date
US20050240018A1 (en)	2005-10-27
AU2003255511A1 (en)	2004-01-06
JP2005530837A (ja)	2005-10-13
AU2003255511B2 (en)	2009-02-05
BRPI0312001B1 (pt)	2015-04-07
WO2004000824A1 (en)	2003-12-31
CN1662517A (zh)	2005-08-31
ES2326800T3 (es)	2009-10-20
IL165916A0 (en)	2006-01-15
IL165916A (en)	2012-12-31
DE60327765D1 (de)	2009-07-09
CA2487141A1 (en)	2003-12-31
US8541578B2 (en)	2013-09-24
CN1326846C (zh)	2007-07-18
BR0312001A (pt)	2005-03-22
JP4846234B2 (ja)	2011-12-28
EP1517900B1 (de)	2009-05-27
CA2487141C (en)	2011-08-02
EP1517900A1 (de)	2005-03-30
HK1081966A1 (zh)	2006-05-26

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Legal Events

Date	Code	Title	Description
2009-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties