ATE381543T1 - Verfahren zur herstellung von 4-aryl- nicotinamidderivaten - Google Patents
Verfahren zur herstellung von 4-aryl- nicotinamidderivatenInfo
- Publication number
- ATE381543T1 ATE381543T1 AT04763155T AT04763155T ATE381543T1 AT E381543 T1 ATE381543 T1 AT E381543T1 AT 04763155 T AT04763155 T AT 04763155T AT 04763155 T AT04763155 T AT 04763155T AT E381543 T1 ATE381543 T1 AT E381543T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- formula
- compound
- sup
- compounds
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- AGJSNMGHAVDLRQ-HUUJSLGLSA-N methyl (2s)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-amino-3-sulfanylpropanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxy-2,3-dimethylphenyl)propanoyl]amino]-4-methylsulfanylbutanoate Chemical compound SC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(=O)N[C@@H](CCSC)C(=O)OC)CC1=CC=C(O)C(C)=C1C AGJSNMGHAVDLRQ-HUUJSLGLSA-N 0.000 abstract 1
- 239000002742 neurokinin 1 receptor antagonist Substances 0.000 abstract 1
- 150000002825 nitriles Chemical group 0.000 abstract 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 abstract 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03015599 | 2003-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE381543T1 true ATE381543T1 (de) | 2008-01-15 |
Family
ID=34042828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04763155T ATE381543T1 (de) | 2003-07-15 | 2004-07-10 | Verfahren zur herstellung von 4-aryl- nicotinamidderivaten |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7288658B2 (de) |
| EP (1) | EP1656351B1 (de) |
| JP (1) | JP4575918B2 (de) |
| KR (1) | KR100742013B1 (de) |
| CN (1) | CN1835922B (de) |
| AT (1) | ATE381543T1 (de) |
| CA (1) | CA2532355C (de) |
| DE (1) | DE602004010820T2 (de) |
| DK (1) | DK1656351T3 (de) |
| ES (1) | ES2297457T3 (de) |
| IL (1) | IL173000A0 (de) |
| MX (1) | MXPA06000405A (de) |
| TW (1) | TWI280239B (de) |
| WO (1) | WO2005014549A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1984891B (zh) * | 2004-07-06 | 2012-08-08 | 弗·哈夫曼-拉罗切有限公司 | 用作合成nk-1受体拮抗剂的中间体的甲酰胺吡啶衍生物的制备方法 |
| EP1844136B1 (de) | 2004-12-29 | 2014-08-27 | Hadasit Medical Research Services And Development Ltd. | Stammzellenkultursysteme |
| US8597947B2 (en) | 2004-12-29 | 2013-12-03 | Hadasit Medical Research Services & Development Limited | Undifferentiated stem cell culture systems |
| EP2147094B2 (de) | 2007-04-18 | 2018-02-21 | Hadasit Medical Research Services & Development Limited | Aus stammzellen erhaltene retinale pigmentepithelzellen |
| EP3916085A1 (de) | 2014-12-30 | 2021-12-01 | Cell Cure Neurosciences Ltd. | Beurteilung von netzhautpigmentepithelzellpopulationen |
| CA2972575A1 (en) | 2014-12-30 | 2016-07-07 | Cell Cure Neurosciences Ltd. | Rpe cell populations and methods of generating same |
| WO2017017686A1 (en) | 2015-07-29 | 2017-02-02 | Hadasit Medical Research Services And Development Ltd. | Large scale production of retinal pigment epithelial cells |
| US11066642B2 (en) | 2015-08-05 | 2021-07-20 | Cell Cure Neurosciences Ltd | Preparation of retinal pigment epithelium cells |
| EP3331995A1 (de) | 2015-08-05 | 2018-06-13 | Cell Cure Neurosciences Ltd. | Zubereitung von fotorezeptoren zur behandlung von netzhauterkrankungen |
| JP6987769B2 (ja) | 2015-10-26 | 2022-01-05 | セル キュア ニューロサイエンシズ リミテッド | 網膜色素上皮細胞の調製法 |
| CN106892864A (zh) * | 2015-12-21 | 2017-06-27 | 上海科胜药物研发有限公司 | 一种奈妥皮坦游离碱的晶型a及其制备方法 |
| CN110520139A (zh) | 2017-02-08 | 2019-11-29 | 哈达西特医疗研究服务和开发有限公司 | 用于治疗视网膜疾病的感光细胞 |
| WO2018170494A1 (en) | 2017-03-16 | 2018-09-20 | Bio Time, Inc. | Methods for measuring therapeutic effects of retinal disease therapies |
| WO2019130061A2 (en) | 2017-12-29 | 2019-07-04 | Cell Cure Neurosciences Ltd. | Retinal pigment epithelium cell compositions |
| CA3112135A1 (en) | 2018-09-20 | 2020-03-26 | Yeda Research And Development Co. Ltd. | Methods of treating amyotrophic lateral sclerosis |
| EP3754014A1 (de) | 2019-06-21 | 2020-12-23 | Centre d'Etude des Cellules Souches (CECS) | Automatisiertes verfahren zur herstellung von retinalen pigmentepithelzellen |
| CN110862364B (zh) * | 2019-11-14 | 2022-12-30 | 中国科学技术大学 | 制备呋喃基醛类化合物的方法 |
| EP4351334A1 (de) | 2021-06-09 | 2024-04-17 | Lineage Cell Therapeutics, Inc. | Verfahren und zusammensetzungen zur behandlung von netzhauterkrankungen und -leiden |
| JP2024527986A (ja) | 2021-07-28 | 2024-07-26 | リネージ セル セラピューティクス インコーポレイテッド | 網膜色素上皮細胞の増殖 |
| CN114181142B (zh) * | 2021-12-31 | 2023-10-20 | 浙江工业大学 | 一种6-(4-甲基哌嗪-1-基)-4-邻甲苯基烟酰胺的合成方法 |
| EP4514949A1 (de) | 2022-04-25 | 2025-03-05 | Hadasit Medical Research Services&Development Ltd. | Verfahren und zusammensetzungen zur behandlung von sehverlust |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1557420A (en) | 1977-03-10 | 1979-12-12 | Soc D Etudes Prod Chimique | Preparation of isobutyramide derivatives |
| KR810001320B1 (ko) | 1977-03-17 | 1981-10-14 | 삐에르 위브 | 신규한 이소부티라미드류의 제조방법 |
| KR810001697B1 (ko) | 1978-02-06 | 1981-10-27 | 삐에르 위브 | 이소부티라미드 유도체의 신규한 제조방법 |
| EP0089765A3 (de) | 1982-03-17 | 1984-05-23 | Smith Kline & French Laboratories Limited | Pyridin-Derivate |
| US4745123A (en) | 1986-02-18 | 1988-05-17 | Warner-Lambert Company | Substituted tetrahydro-3-pyridine-carboxylic acid, ester, and amide cholinergic agents |
| GB8607312D0 (en) | 1986-03-25 | 1986-04-30 | Ici Plc | Therapeutic agents |
| GB8607313D0 (en) * | 1986-03-25 | 1986-04-30 | Ici Plc | Pharmaceutical compositions |
| CA1339423C (en) | 1988-09-14 | 1997-09-02 | Yuji Ono | Pyridine compounds and pharmaceutical use thereof |
| US4994456A (en) | 1989-03-01 | 1991-02-19 | Nisshin Flour Milling Co., Ltd. | Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same |
| US4973597A (en) | 1989-06-30 | 1990-11-27 | Eli Lilly And Company | Anticonvulsant agents |
| HU207047B (en) | 1989-11-07 | 1993-03-01 | Richter Gedeon Vegyeszet | Process for producing new pyridine derivatives and pharmaceutical copositions comprising same |
| US5364943A (en) | 1991-11-27 | 1994-11-15 | Pfizer Inc. | Preparation of substituted piperidines |
| GB9021056D0 (en) | 1990-09-27 | 1990-11-07 | Pfizer Ltd | Antiarrhythmic agents |
| GB9214120D0 (en) | 1991-07-25 | 1992-08-12 | Ici Plc | Therapeutic amides |
| US5719147A (en) * | 1992-06-29 | 1998-02-17 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
| AU4718093A (en) * | 1992-07-31 | 1994-03-03 | Merck Sharp & Dohme Limited | Substituted amines as tachykinin receptor antagonists |
| US5387595A (en) * | 1992-08-26 | 1995-02-07 | Merck & Co., Inc. | Alicyclic compounds as tachykinin receptor antagonists |
| GB9305672D0 (en) | 1993-03-19 | 1993-05-05 | Wyeth John & Brother Ltd | Amide derivatives |
| AU6807994A (en) | 1993-05-28 | 1994-12-20 | Taisho Pharmaceutical Co., Ltd. | Medicinal use of pyridine derivative |
| NZ264063A (en) | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| IL111960A (en) | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
| IL112134A (en) * | 1993-12-29 | 1999-12-22 | Merck Sharp & Dohme | Substituted morpholine derivatives their preparation and pharmaceutical compositions containing them |
| IL112778A0 (en) | 1994-03-04 | 1995-05-26 | Merck & Co Inc | Substituted heterocycles, their preparation and pharmaceutical compositions containing them |
| ES2165915T3 (es) | 1994-06-06 | 2002-04-01 | Warner Lambert Co | Antagonistas del receptor de la taquiquinina (nk 1). |
| WO1996000213A1 (en) | 1994-06-24 | 1996-01-04 | Taisho Pharmaceutical Co., Ltd. | Pyridine derivative |
| US6294537B1 (en) * | 1995-03-17 | 2001-09-25 | Sanofi-Synthelabo | Compounds which are specific antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools |
| EP0733632B1 (de) | 1995-03-24 | 2003-06-04 | Takeda Chemical Industries, Ltd. | Zyklische Verbindungen, ihre Herstellung und ihre Verwendung als Tachykininrezeptorantagonisten |
| AR004735A1 (es) | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
| HUP9902455A3 (en) | 1996-03-29 | 2000-06-28 | Pfizer | 6-phenylpyridyl-2-amine derivatives, pharmaceutical compositions containing them |
| WO1998021185A1 (en) | 1996-11-08 | 1998-05-22 | Sankyo Company, Limited | Arylureas or arylmethylcarbamoyl derivatives |
| US5972938A (en) * | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
| PT1035115E (pt) * | 1999-02-24 | 2005-01-31 | Hoffmann La Roche | Derivados de 4-fenilpiridina e a sua utilizacao como antagonistas do receptor nk-1 |
| TR200102490T2 (tr) | 1999-02-24 | 2001-12-21 | F.Hoffmann-La Roche Ag | Fenil ve piridinil türevleri |
| SI1103545T1 (en) | 1999-11-29 | 2004-02-29 | F. Hoffmann-La Roche Ag | 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramide |
| US6303790B1 (en) * | 1999-11-29 | 2001-10-16 | Hoffman-La Roche Inc. | Process for the preparation of pyridine derivatives |
| TWI287003B (en) | 2000-07-24 | 2007-09-21 | Hoffmann La Roche | 4-phenyl-pyridine derivatives |
-
2004
- 2004-07-09 US US10/888,912 patent/US7288658B2/en not_active Expired - Lifetime
- 2004-07-09 TW TW093120669A patent/TWI280239B/zh not_active IP Right Cessation
- 2004-07-10 MX MXPA06000405A patent/MXPA06000405A/es active IP Right Grant
- 2004-07-10 EP EP04763155A patent/EP1656351B1/de not_active Expired - Lifetime
- 2004-07-10 WO PCT/EP2004/007618 patent/WO2005014549A1/en not_active Ceased
- 2004-07-10 DE DE602004010820T patent/DE602004010820T2/de not_active Expired - Lifetime
- 2004-07-10 DK DK04763155T patent/DK1656351T3/da active
- 2004-07-10 KR KR1020067000860A patent/KR100742013B1/ko not_active Expired - Lifetime
- 2004-07-10 JP JP2006519843A patent/JP4575918B2/ja not_active Expired - Lifetime
- 2004-07-10 ES ES04763155T patent/ES2297457T3/es not_active Expired - Lifetime
- 2004-07-10 CN CN2004800232840A patent/CN1835922B/zh not_active Expired - Lifetime
- 2004-07-10 CA CA2532355A patent/CA2532355C/en not_active Expired - Lifetime
- 2004-07-10 AT AT04763155T patent/ATE381543T1/de active
-
2006
- 2006-01-05 IL IL173000A patent/IL173000A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100742013B1 (ko) | 2007-07-23 |
| US20050014792A1 (en) | 2005-01-20 |
| EP1656351B1 (de) | 2007-12-19 |
| WO2005014549A1 (en) | 2005-02-17 |
| CA2532355C (en) | 2012-05-15 |
| JP2009500292A (ja) | 2009-01-08 |
| KR20060036090A (ko) | 2006-04-27 |
| TW200524872A (en) | 2005-08-01 |
| DK1656351T3 (da) | 2008-04-21 |
| JP4575918B2 (ja) | 2010-11-04 |
| DE602004010820T2 (de) | 2008-12-04 |
| IL173000A0 (en) | 2006-06-11 |
| MXPA06000405A (es) | 2006-03-17 |
| CN1835922B (zh) | 2011-08-31 |
| TWI280239B (en) | 2007-05-01 |
| US7288658B2 (en) | 2007-10-30 |
| CA2532355A1 (en) | 2005-02-17 |
| ES2297457T3 (es) | 2008-05-01 |
| CN1835922A (zh) | 2006-09-20 |
| EP1656351A1 (de) | 2006-05-17 |
| DE602004010820D1 (de) | 2008-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE381543T1 (de) | Verfahren zur herstellung von 4-aryl- nicotinamidderivaten | |
| GB2185013A (en) | Process for the production of 3-phenyl-4-cyanopyrroles | |
| EP0738703A3 (de) | Acryl-Säure-Derivate, Verfahren zur Herstellung von Acryl-Säure-Derivaten und Acryl-Säure-Polymere | |
| DE69706366D1 (de) | Verfahren zur Herstellung von Paroxetine | |
| ATE422200T1 (de) | Verfahren zur herstellung substituierter nikotinsäureester | |
| US20030087930A1 (en) | Process for preparing 2-(4-chlorobenzolamino)-3[ (1h)-quinolinon-4-yl] propionic acid | |
| IS6435A (is) | Aðferð til framleiðslu á sítalóprami | |
| ATE457972T1 (de) | Verfahren zur herstellung von 7-amino-syn-3,5- dihydroxyheptansäurederivaten und zwischenverbindungen diesesverfahrens und deren herestellung | |
| KR100262250B1 (ko) | 3-알콕시메틸퀴놀린, 및 2-알콕시메틸아크롤레인으로부터이의 제조 방법 | |
| DE69802388D1 (de) | Verfahren zur herstellung von nicotinsäuren | |
| US7193086B2 (en) | Process for preparation of a quinolinecarbaldehyde | |
| EP1431278A4 (de) | Verfahren zur herstellung von (2-nitrophenyl)acetonitrilderivaten und zwischenprodukte dafür | |
| KR101404616B1 (ko) | 키랄 감마-플루오로 케톤 화합물의 제조방법 | |
| US6921832B2 (en) | Optically active fluorine-containing compounds and processes for their production | |
| US5688985A (en) | Process for producing keto nitrile derivative | |
| DE69913517D1 (de) | Verfahren zur herstellung einer kristallsuspensionhenonen | |
| KR100469946B1 (ko) | 키랄(s)-2,3-치환-1-프로필아민유도체의제조방법 | |
| PL287202A1 (en) | Method for manufacturing an optically active 2-(tetrahydropyran-2-yloxy)-1-propanol | |
| ATE244228T1 (de) | Verfahren zur herstellung von chloroacetylaminothiazoleaceticsäure derivate | |
| KR970010774A (ko) | 7-아미노-3-클로로-3-세펨-4-카르복실산의 제조방법 | |
| ATE359990T1 (de) | Verfahren zur herstellung von 3,5- bisalkylphenolen | |
| NO790342L (no) | Fremgangsmaate for fremstilling av alkyl-2-arylakrylater | |
| KR20050012406A (ko) | 4-하이드록시-ｎ-벤질-2-피페리디논의 제조방법 | |
| JPH0572381B2 (de) | ||
| JPH03141251A (ja) | １―メチルメルカプト―１―ベンゾイル―２―（ｎ，ｎ―ジメチルアミノ）エテン誘導体およびその製造法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1656351 Country of ref document: EP |