ATE432365T1 - Verfahren, kits und reagenzien zur nukleinsäuresequenzierung - Google Patents
Verfahren, kits und reagenzien zur nukleinsäuresequenzierungInfo
- Publication number
- ATE432365T1 ATE432365T1 AT04713125T AT04713125T ATE432365T1 AT E432365 T1 ATE432365 T1 AT E432365T1 AT 04713125 T AT04713125 T AT 04713125T AT 04713125 T AT04713125 T AT 04713125T AT E432365 T1 ATE432365 T1 AT E432365T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- methods
- kits
- reagents
- acid sequencing
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 5
- 102000039446 nucleic acids Human genes 0.000 title abstract 5
- 108020004707 nucleic acids Proteins 0.000 title abstract 5
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000012163 sequencing technique Methods 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 230000000295 complement effect Effects 0.000 abstract 1
- 239000005547 deoxyribonucleotide Substances 0.000 abstract 1
- -1 deoxyribonucleotide triphosphates Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000009830 intercalation Methods 0.000 abstract 1
- 238000003203 nucleic acid sequencing method Methods 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000001226 triphosphate Substances 0.000 abstract 1
- 235000011178 triphosphate Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0303964A GB0303964D0 (en) | 2003-02-21 | 2003-02-21 | FRET based sequencing technology |
| GB0305525A GB0305525D0 (en) | 2003-03-11 | 2003-03-11 | Inhibitor based sequencing technology |
| GB0306119A GB0306119D0 (en) | 2003-03-18 | 2003-03-18 | Non-incorporable label determined sequencing |
| GB0307515A GB0307515D0 (en) | 2003-04-01 | 2003-04-01 | Non-incorporable label determined sequencing process |
| GB0310294A GB0310294D0 (en) | 2003-05-03 | 2003-05-03 | Non-incorporable label determined sequencing-2 |
| GB0313689A GB0313689D0 (en) | 2003-06-13 | 2003-06-13 | Sequencing method-j |
| GB0320157A GB0320157D0 (en) | 2003-08-28 | 2003-08-28 | Sequencing method-M |
| GB0322245A GB0322245D0 (en) | 2003-09-23 | 2003-09-23 | Nucleic acid sequencing method |
| GB0325657A GB0325657D0 (en) | 2003-11-04 | 2003-11-04 | Nucleic acid sequencing method |
| GB0329053A GB0329053D0 (en) | 2003-12-16 | 2003-12-16 | Dye conjugate based sequencing |
| PCT/GB2004/000709 WO2004074503A2 (en) | 2003-02-21 | 2004-02-20 | Nucleic acid sequencing methods, kits and reagents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE432365T1 true ATE432365T1 (de) | 2009-06-15 |
Family
ID=32913446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04713125T ATE432365T1 (de) | 2003-02-21 | 2004-02-20 | Verfahren, kits und reagenzien zur nukleinsäuresequenzierung |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8399196B2 (de) |
| EP (1) | EP1594987B1 (de) |
| AT (1) | ATE432365T1 (de) |
| DE (1) | DE602004021235D1 (de) |
| WO (1) | WO2004074503A2 (de) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
| US7501245B2 (en) | 1999-06-28 | 2009-03-10 | Helicos Biosciences Corp. | Methods and apparatuses for analyzing polynucleotide sequences |
| US6982146B1 (en) | 1999-08-30 | 2006-01-03 | The United States Of America As Represented By The Department Of Health And Human Services | High speed parallel molecular nucleic acid sequencing |
| EP1368497A4 (de) | 2001-03-12 | 2007-08-15 | California Inst Of Techn | Verfahren und vorrichtung zur analyse von polynukleotidsequenzen durch asynchrone basenverlängerung |
| GB0324456D0 (en) * | 2003-10-20 | 2003-11-19 | Isis Innovation | Parallel DNA sequencing methods |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| EP1716254B1 (de) | 2004-02-19 | 2010-04-07 | Helicos Biosciences Corporation | Verfahren zur analyse von polynukleotidsequenzen |
| JP2008512084A (ja) | 2004-05-25 | 2008-04-24 | ヘリコス バイオサイエンシーズ コーポレイション | 核酸の配列決定のための方法およびデバイス |
| US7476734B2 (en) | 2005-12-06 | 2009-01-13 | Helicos Biosciences Corporation | Nucleotide analogs |
| US7220549B2 (en) | 2004-12-30 | 2007-05-22 | Helicos Biosciences Corporation | Stabilizing a nucleic acid for nucleic acid sequencing |
| US7482120B2 (en) * | 2005-01-28 | 2009-01-27 | Helicos Biosciences Corporation | Methods and compositions for improving fidelity in a nucleic acid synthesis reaction |
| US7666593B2 (en) | 2005-08-26 | 2010-02-23 | Helicos Biosciences Corporation | Single molecule sequencing of captured nucleic acids |
| US8703734B2 (en) | 2005-12-12 | 2014-04-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nanoprobes for detection or modification of molecules |
| WO2007070572A2 (en) * | 2005-12-12 | 2007-06-21 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Probe for nucleic acid sequencing and methods of use |
| US20080145844A1 (en) * | 2006-01-25 | 2008-06-19 | Evrogen Joint Stock Company | Methods of cDNA preparation |
| US20070202521A1 (en) * | 2006-02-14 | 2007-08-30 | Applera Corporation | Single Molecule DNA Sequencing Using Fret Based Dynamic Labeling |
| US7397546B2 (en) | 2006-03-08 | 2008-07-08 | Helicos Biosciences Corporation | Systems and methods for reducing detected intensity non-uniformity in a laser beam |
| CA2622649C (en) | 2007-03-09 | 2018-04-24 | Riken | Nucleic acid amplification method using primer exhibiting exciton effect |
| EP2130835B1 (de) * | 2007-03-09 | 2012-05-23 | Riken | Verbindung mit aus einem mononukleosid oder mononukleotid abgeleiteter struktur, nukleinsäure-etikettierungssubstanz sowie verfahren und kit zur nukleinsäure-erkennung |
| WO2009102470A2 (en) * | 2008-02-12 | 2009-08-20 | Pacific Biosciences Of California, Inc. | Compositions and methods for use in analytical reactions |
| US8354233B2 (en) | 2008-04-01 | 2013-01-15 | University Of Washington | Sequence data by reduction of noise due to carry-over primer |
| US20110281740A1 (en) * | 2008-06-30 | 2011-11-17 | Joseph Beechem | Methods for Real Time Single Molecule Sequencing |
| US20100227327A1 (en) * | 2008-08-08 | 2010-09-09 | Xiaoliang Sunney Xie | Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides |
| US20100036110A1 (en) * | 2008-08-08 | 2010-02-11 | Xiaoliang Sunney Xie | Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides |
| GB0901593D0 (en) | 2009-01-30 | 2009-03-11 | Touchlight Genetics Ltd | Production of closed linear DNA |
| EP2425023B1 (de) | 2009-04-27 | 2015-12-23 | Pacific Biosciences of California, Inc. | Echtzeit-sequenzierungsverfahren und systeme |
| US8632975B2 (en) * | 2009-06-05 | 2014-01-21 | Life Technologies Corporation | Nucleotide transient binding for sequencing methods |
| GB201013153D0 (en) | 2010-08-04 | 2010-09-22 | Touchlight Genetics Ltd | Primer for production of closed linear DNA |
| WO2013080941A1 (ja) * | 2011-12-01 | 2013-06-06 | 三菱レイヨン株式会社 | 核酸増幅用基材及び核酸増幅方法 |
| GB201301178D0 (en) * | 2013-01-23 | 2013-03-06 | Dynamic Biosensors Gmbh | Method for sequencing a template nucleic acid immobilized on a substrate |
| CA2900921A1 (en) * | 2013-02-20 | 2014-08-28 | Eve Biomedical, Inc. | Methods and compositions for nanostructure-based nucleic acid sequencing |
| US9146248B2 (en) | 2013-03-14 | 2015-09-29 | Intelligent Bio-Systems, Inc. | Apparatus and methods for purging flow cells in nucleic acid sequencing instruments |
| EP2971071B1 (de) * | 2013-03-15 | 2018-02-28 | Illumina, Inc. | Mit enzymen verknüpfte nukleotide |
| US9591268B2 (en) | 2013-03-15 | 2017-03-07 | Qiagen Waltham, Inc. | Flow cell alignment methods and systems |
| US9546398B2 (en) * | 2013-11-14 | 2017-01-17 | Agilent Technologies, Inc. | Polymerase idling method for single molecule DNA sequencing |
| US9909167B2 (en) | 2014-06-23 | 2018-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | On-slide staining by primer extension |
| GB201415789D0 (en) | 2014-09-05 | 2014-10-22 | Touchlight Genetics Ltd | Synthesis of DNA |
| US10077470B2 (en) | 2015-07-21 | 2018-09-18 | Omniome, Inc. | Nucleic acid sequencing methods and systems |
| US11326206B2 (en) | 2016-04-07 | 2022-05-10 | Pacific Biosciences Of California, Inc. | Methods of quantifying target nucleic acids and identifying sequence variants |
| CA3021769C (en) | 2016-04-29 | 2021-11-23 | Omniome, Inc. | Sequencing method employing ternary complex destabilization to identify cognate nucleotides |
| WO2018022809A1 (en) | 2016-07-27 | 2018-02-01 | The Board Of Trustees Of The Leland Stanford Junior University | Highly-multiplexed fluorescent imaging |
| WO2018034780A1 (en) | 2016-08-15 | 2018-02-22 | Omniome, Inc. | Sequencing method for rapid identification and processing of cognate nucleotide pairs |
| EP4039824A1 (de) | 2016-08-15 | 2022-08-10 | Pacific Biosciences of California, Inc. | Verfahren und systeme zur sequenzierung von nukleinsäuren |
| US11248254B2 (en) | 2016-12-30 | 2022-02-15 | Omniome, Inc. | Method and system employing distinguishable polymerases for detecting ternary complexes and identifying cognate nucleotides |
| EP4575499A3 (de) * | 2017-01-04 | 2025-07-09 | MGI Tech Co., Ltd. | Schrittweise sequenzierung durch nichtmarkierte reversible terminatoren oder natürliche nukleotide |
| AU2018208462B2 (en) | 2017-01-10 | 2021-07-29 | Pacific Biosciences Of California, Inc. | Polymerases engineered to reduce nucleotide-independent DNA binding |
| EP3571313B1 (de) | 2017-01-20 | 2020-12-23 | Omniome, Inc. | Allelspezifische erfassung von nukleinsäuren |
| AU2018210944B2 (en) * | 2017-01-20 | 2021-07-22 | Pacific Biosciences Of California, Inc. | Process for cognate nucleotide detection in a nucleic acid sequencing workflow |
| US9932631B1 (en) | 2017-09-11 | 2018-04-03 | Omniome, Inc. | Genotyping by polymerase binding |
| US10737267B2 (en) | 2017-04-04 | 2020-08-11 | Omniome, Inc. | Fluidic apparatus and methods useful for chemical and biological reactions |
| US9951385B1 (en) | 2017-04-25 | 2018-04-24 | Omniome, Inc. | Methods and apparatus that increase sequencing-by-binding efficiency |
| US10161003B2 (en) | 2017-04-25 | 2018-12-25 | Omniome, Inc. | Methods and apparatus that increase sequencing-by-binding efficiency |
| WO2018232086A1 (en) * | 2017-06-14 | 2018-12-20 | Board Of Regents, The University Of Texas System | Chip hybridized association-mapping platform and methods of use |
| AU2018353136B2 (en) | 2017-10-19 | 2022-05-19 | Pacific Biosciences Of California, Inc. | Simultaneous background reduction and complex stabilization in binding assay workflows |
| KR20200139671A (ko) * | 2018-02-06 | 2020-12-14 | 옴니옴 인코포레이티드 | 핵산 프라이머 연장을 위한 조성물 및 기술 |
| AU2019255987A1 (en) * | 2018-04-19 | 2020-12-10 | Pacific Biosciences Of California, Inc. | Improving accuracy of base calls in nucleic acid sequencing methods |
| WO2019209426A1 (en) | 2018-04-26 | 2019-10-31 | Omniome, Inc. | Methods and compositions for stabilizing nucleic acid-nucleotide-polymerase complexes |
| US11180794B2 (en) | 2018-05-31 | 2021-11-23 | Omniome, Inc. | Methods and compositions for capping nucleic acids |
| WO2019231568A1 (en) | 2018-05-31 | 2019-12-05 | Omniome, Inc. | Increased signal to noise in nucleic acid sequencing |
| GB2589496B (en) | 2018-06-12 | 2023-01-25 | Element Biosciences Inc | Improved reverse transcriptase for nucleic acid sequencing |
| WO2020023362A1 (en) | 2018-07-24 | 2020-01-30 | Omniome, Inc. | Serial formation of ternary complex species |
| GB2574746B (en) | 2018-09-17 | 2020-06-03 | Omniome Inc | Engineered polymerases for improved sequencing |
| US10704094B1 (en) | 2018-11-14 | 2020-07-07 | Element Biosciences, Inc. | Multipart reagents having increased avidity for polymerase binding |
| US10768173B1 (en) | 2019-09-06 | 2020-09-08 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| US10876148B2 (en) | 2018-11-14 | 2020-12-29 | Element Biosciences, Inc. | De novo surface preparation and uses thereof |
| GB2613480B (en) | 2018-11-15 | 2023-11-22 | Element Biosciences Inc | Methods for generating circular nucleic acid molecules |
| KR102892507B1 (ko) | 2018-12-07 | 2025-11-27 | 엘리먼트 바이오사이언스, 인크. | 플로우 셀 디바이스 및 그의 용도 |
| WO2020181129A1 (en) * | 2019-03-07 | 2020-09-10 | The Trustees Of Columbia University In The City Of New York | High accuracy nanopore-based single molecule sequencing by synthesis with tagged nucleotides |
| US12313627B2 (en) | 2019-05-01 | 2025-05-27 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| US12391929B2 (en) | 2019-05-24 | 2025-08-19 | Element Biosciences, Inc. | Polymerase-nucleotide conjugates for sequencing by trapping |
| US12252582B2 (en) | 2019-08-29 | 2025-03-18 | University Of Delaware | Biofunctional thiophene monomers and polymers thereof for electronic biomedical devices |
| US11287422B2 (en) | 2019-09-23 | 2022-03-29 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| WO2021092431A1 (en) | 2019-11-08 | 2021-05-14 | Omniome, Inc. | Engineered polymerases for improved sequencing by binding |
| US11060138B1 (en) | 2020-01-17 | 2021-07-13 | Element Biosciences, Inc. | Nucleic acid sequencing systems |
| US11198121B1 (en) * | 2020-06-10 | 2021-12-14 | Element Biosciences, Inc. | Flow cell systems and devices |
| WO2023280156A1 (zh) * | 2021-07-08 | 2023-01-12 | 深圳华大生命科学研究院 | 修饰的核苷或核苷酸 |
| EP4373968A4 (de) | 2021-07-21 | 2025-05-14 | Element Biosciences, Inc. | Optische systeme zur nukleinsäuresequenzierung und verfahren dafür |
| CN121160847A (zh) * | 2022-04-02 | 2025-12-19 | 深圳市真迈生物科技有限公司 | 荧光检测试剂及其制备方法及应用 |
| EP4573213A1 (de) | 2022-08-15 | 2025-06-25 | Element Biosciences, Inc. | Ortsaufgelöste oberflächenerfassung von nukleinsäuren |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6358931B1 (en) * | 1990-01-11 | 2002-03-19 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulating RNA |
| DE4140463A1 (de) * | 1991-12-09 | 1993-06-17 | Boehringer Mannheim Gmbh | 2'-desoxy-isoguanosin, dessen isostere analoge sowie anwendung derselben |
| DE69829760T3 (de) | 1997-09-12 | 2016-04-14 | Exiqon A/S | Bi- und tri-zyklische - nukleosid, nukleotid und oligonukleotid-analoga |
| ATE556149T1 (de) | 1999-02-23 | 2012-05-15 | Caliper Life Sciences Inc | Manipulation von mikropartikeln in mikrofluidischen systemen |
| HK1048639A1 (zh) | 1999-03-18 | 2003-04-11 | 埃克西库恩公司 | 木-lna类似物 |
| US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| CN1653079B (zh) * | 2001-12-18 | 2010-06-16 | 人类遗传标记控股有限公司 | 包括嵌入剂的假核苷酸 |
| US7166478B2 (en) * | 2002-03-12 | 2007-01-23 | Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. | Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses |
| SE0202867D0 (sv) * | 2002-09-27 | 2002-09-27 | Pyrosequencing Ab | New sequencing method |
-
2004
- 2004-02-20 DE DE602004021235T patent/DE602004021235D1/de not_active Expired - Lifetime
- 2004-02-20 WO PCT/GB2004/000709 patent/WO2004074503A2/en not_active Ceased
- 2004-02-20 EP EP04713125A patent/EP1594987B1/de not_active Expired - Lifetime
- 2004-02-20 AT AT04713125T patent/ATE432365T1/de not_active IP Right Cessation
- 2004-02-20 US US10/546,268 patent/US8399196B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004074503A3 (en) | 2005-03-24 |
| US8399196B2 (en) | 2013-03-19 |
| US20070148645A1 (en) | 2007-06-28 |
| WO2004074503A2 (en) | 2004-09-02 |
| DE602004021235D1 (de) | 2009-07-09 |
| EP1594987B1 (de) | 2009-05-27 |
| EP1594987A2 (de) | 2005-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |