ATE432365T1 - Verfahren, kits und reagenzien zur nukleinsäuresequenzierung - Google Patents
Verfahren, kits und reagenzien zur nukleinsäuresequenzierungInfo
- Publication number
- ATE432365T1 ATE432365T1 AT04713125T AT04713125T ATE432365T1 AT E432365 T1 ATE432365 T1 AT E432365T1 AT 04713125 T AT04713125 T AT 04713125T AT 04713125 T AT04713125 T AT 04713125T AT E432365 T1 ATE432365 T1 AT E432365T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- methods
- kits
- reagents
- acid sequencing
- Prior art date
Links
- 150000007523 nucleic acids Chemical class 0.000 title abstract 5
- 102000039446 nucleic acids Human genes 0.000 title abstract 5
- 108020004707 nucleic acids Proteins 0.000 title abstract 5
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000012163 sequencing technique Methods 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 230000000295 complement effect Effects 0.000 abstract 1
- 239000005547 deoxyribonucleotide Substances 0.000 abstract 1
- -1 deoxyribonucleotide triphosphates Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000009830 intercalation Methods 0.000 abstract 1
- 238000003203 nucleic acid sequencing method Methods 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000001226 triphosphate Substances 0.000 abstract 1
- 235000011178 triphosphate Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Nanotechnology (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Mathematical Physics (AREA)
- Theoretical Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0303964A GB0303964D0 (en) | 2003-02-21 | 2003-02-21 | FRET based sequencing technology |
| GB0305525A GB0305525D0 (en) | 2003-03-11 | 2003-03-11 | Inhibitor based sequencing technology |
| GB0306119A GB0306119D0 (en) | 2003-03-18 | 2003-03-18 | Non-incorporable label determined sequencing |
| GB0307515A GB0307515D0 (en) | 2003-04-01 | 2003-04-01 | Non-incorporable label determined sequencing process |
| GB0310294A GB0310294D0 (en) | 2003-05-03 | 2003-05-03 | Non-incorporable label determined sequencing-2 |
| GB0313689A GB0313689D0 (en) | 2003-06-13 | 2003-06-13 | Sequencing method-j |
| GB0320157A GB0320157D0 (en) | 2003-08-28 | 2003-08-28 | Sequencing method-M |
| GB0322245A GB0322245D0 (en) | 2003-09-23 | 2003-09-23 | Nucleic acid sequencing method |
| GB0325657A GB0325657D0 (en) | 2003-11-04 | 2003-11-04 | Nucleic acid sequencing method |
| GB0329053A GB0329053D0 (en) | 2003-12-16 | 2003-12-16 | Dye conjugate based sequencing |
| PCT/GB2004/000709 WO2004074503A2 (en) | 2003-02-21 | 2004-02-20 | Nucleic acid sequencing methods, kits and reagents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE432365T1 true ATE432365T1 (de) | 2009-06-15 |
Family
ID=32913446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04713125T ATE432365T1 (de) | 2003-02-21 | 2004-02-20 | Verfahren, kits und reagenzien zur nukleinsäuresequenzierung |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8399196B2 (de) |
| EP (1) | EP1594987B1 (de) |
| AT (1) | ATE432365T1 (de) |
| DE (1) | DE602004021235D1 (de) |
| WO (1) | WO2004074503A2 (de) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7875440B2 (en) | 1998-05-01 | 2011-01-25 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| US6780591B2 (en) | 1998-05-01 | 2004-08-24 | Arizona Board Of Regents | Method of determining the nucleotide sequence of oligonucleotides and DNA molecules |
| US7501245B2 (en) | 1999-06-28 | 2009-03-10 | Helicos Biosciences Corp. | Methods and apparatuses for analyzing polynucleotide sequences |
| US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
| US6982146B1 (en) | 1999-08-30 | 2006-01-03 | The United States Of America As Represented By The Department Of Health And Human Services | High speed parallel molecular nucleic acid sequencing |
| JP2004523243A (ja) | 2001-03-12 | 2004-08-05 | カリフォルニア インスティチュート オブ テクノロジー | 非同期性塩基伸長によってポリヌクレオチド配列を分析するための方法および装置 |
| GB0324456D0 (en) * | 2003-10-20 | 2003-11-19 | Isis Innovation | Parallel DNA sequencing methods |
| US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
| WO2005080605A2 (en) | 2004-02-19 | 2005-09-01 | Helicos Biosciences Corporation | Methods and kits for analyzing polynucleotide sequences |
| US7476734B2 (en) | 2005-12-06 | 2009-01-13 | Helicos Biosciences Corporation | Nucleotide analogs |
| US7635562B2 (en) | 2004-05-25 | 2009-12-22 | Helicos Biosciences Corporation | Methods and devices for nucleic acid sequence determination |
| US7220549B2 (en) | 2004-12-30 | 2007-05-22 | Helicos Biosciences Corporation | Stabilizing a nucleic acid for nucleic acid sequencing |
| US7482120B2 (en) | 2005-01-28 | 2009-01-27 | Helicos Biosciences Corporation | Methods and compositions for improving fidelity in a nucleic acid synthesis reaction |
| US7666593B2 (en) | 2005-08-26 | 2010-02-23 | Helicos Biosciences Corporation | Single molecule sequencing of captured nucleic acids |
| US8703734B2 (en) | 2005-12-12 | 2014-04-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nanoprobes for detection or modification of molecules |
| DE602006016984D1 (de) | 2005-12-12 | 2010-10-28 | Us Gov Health & Human Serv | Sonde zum sequenzieren von nukleinsäure und verwendungsverfahren |
| US20080145844A1 (en) * | 2006-01-25 | 2008-06-19 | Evrogen Joint Stock Company | Methods of cDNA preparation |
| US20070202521A1 (en) * | 2006-02-14 | 2007-08-30 | Applera Corporation | Single Molecule DNA Sequencing Using Fret Based Dynamic Labeling |
| US7397546B2 (en) | 2006-03-08 | 2008-07-08 | Helicos Biosciences Corporation | Systems and methods for reducing detected intensity non-uniformity in a laser beam |
| EP2130835B1 (de) * | 2007-03-09 | 2012-05-23 | Riken | Verbindung mit aus einem mononukleosid oder mononukleotid abgeleiteter struktur, nukleinsäure-etikettierungssubstanz sowie verfahren und kit zur nukleinsäure-erkennung |
| CA2622649C (en) | 2007-03-09 | 2018-04-24 | Riken | Nucleic acid amplification method using primer exhibiting exciton effect |
| AU2009215193A1 (en) * | 2008-02-12 | 2009-08-20 | Pacific Biosciences Of California, Inc. | Compositions and methods for use in analytical reactions |
| US8354233B2 (en) | 2008-04-01 | 2013-01-15 | University Of Washington | Sequence data by reduction of noise due to carry-over primer |
| US20110281740A1 (en) * | 2008-06-30 | 2011-11-17 | Joseph Beechem | Methods for Real Time Single Molecule Sequencing |
| US20100036110A1 (en) * | 2008-08-08 | 2010-02-11 | Xiaoliang Sunney Xie | Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides |
| US20100227327A1 (en) * | 2008-08-08 | 2010-09-09 | Xiaoliang Sunney Xie | Methods and compositions for continuous single-molecule nucleic acid sequencing by synthesis with fluorogenic nucleotides |
| GB0901593D0 (en) | 2009-01-30 | 2009-03-11 | Touchlight Genetics Ltd | Production of closed linear DNA |
| EP2425023B1 (de) | 2009-04-27 | 2015-12-23 | Pacific Biosciences of California, Inc. | Echtzeit-sequenzierungsverfahren und systeme |
| WO2010141390A2 (en) | 2009-06-05 | 2010-12-09 | Life Technologies Corporation | Nucleotide transient binding for sequencing methods |
| GB201013153D0 (en) | 2010-08-04 | 2010-09-22 | Touchlight Genetics Ltd | Primer for production of closed linear DNA |
| JP6040775B2 (ja) * | 2011-12-01 | 2016-12-07 | 三菱レイヨン株式会社 | 核酸増幅用基材及び核酸増幅方法 |
| GB201301178D0 (en) * | 2013-01-23 | 2013-03-06 | Dynamic Biosensors Gmbh | Method for sequencing a template nucleic acid immobilized on a substrate |
| RU2015139609A (ru) * | 2013-02-20 | 2017-03-24 | Ив Байомедикал, Инк. | Способы и композиции для секвенирования нуклеиновой кислоты, основанные на наноструктуре |
| US9146248B2 (en) | 2013-03-14 | 2015-09-29 | Intelligent Bio-Systems, Inc. | Apparatus and methods for purging flow cells in nucleic acid sequencing instruments |
| US9591268B2 (en) | 2013-03-15 | 2017-03-07 | Qiagen Waltham, Inc. | Flow cell alignment methods and systems |
| WO2014142981A1 (en) * | 2013-03-15 | 2014-09-18 | Illumina, Inc. | Enzyme-linked nucleotides |
| US9546398B2 (en) * | 2013-11-14 | 2017-01-17 | Agilent Technologies, Inc. | Polymerase idling method for single molecule DNA sequencing |
| US9909167B2 (en) | 2014-06-23 | 2018-03-06 | The Board Of Trustees Of The Leland Stanford Junior University | On-slide staining by primer extension |
| GB201415789D0 (en) | 2014-09-05 | 2014-10-22 | Touchlight Genetics Ltd | Synthesis of DNA |
| US10077470B2 (en) | 2015-07-21 | 2018-09-18 | Omniome, Inc. | Nucleic acid sequencing methods and systems |
| WO2017177017A1 (en) | 2016-04-07 | 2017-10-12 | Omniome, Inc. | Methods of quantifying target nucleic acids and identifying sequence variants |
| EP3449012B1 (de) | 2016-04-29 | 2020-12-23 | Omniome, Inc. | Sequenzierungsverfahren mit destabilisierung eines ternären komplexes zur identifizierung von verwandten nukleotiden |
| AU2017302300B2 (en) | 2016-07-27 | 2023-08-17 | The Board Of Trustees Of The Leland Stanford Junior University | Highly-multiplexed fluorescent imaging |
| EP3497236B1 (de) | 2016-08-15 | 2021-11-03 | Omniome, Inc. | Verfahren zur sequenzierung von nukleinsäuren |
| US10428378B2 (en) | 2016-08-15 | 2019-10-01 | Omniome, Inc. | Sequencing method for rapid identification and processing of cognate nucleotide pairs |
| EP3562962B1 (de) | 2016-12-30 | 2022-01-05 | Omniome, Inc. | Verfahren und system unter verwendung von unterscheidbaren polymerasen zum nachweis von ternären komplexen und zur identifizierung von verwandten nukleotiden |
| ES3026859T3 (en) * | 2017-01-04 | 2025-06-12 | Mgi Tech Co Ltd | Stepwise sequencing by non-labeled reversible terminators or natural nucleotides |
| AU2018208462B2 (en) | 2017-01-10 | 2021-07-29 | Pacific Biosciences Of California, Inc. | Polymerases engineered to reduce nucleotide-independent DNA binding |
| WO2018136487A1 (en) * | 2017-01-20 | 2018-07-26 | Omniome, Inc. | Process for cognate nucleotide detection in a nucleic acid sequencing workflow |
| CN110249059B (zh) | 2017-01-20 | 2021-04-13 | 欧姆尼欧美公司 | 核酸的等位基因特异性捕获 |
| US9932631B1 (en) | 2017-09-11 | 2018-04-03 | Omniome, Inc. | Genotyping by polymerase binding |
| WO2018187013A1 (en) | 2017-04-04 | 2018-10-11 | Omniome, Inc. | Fluidic apparatus and methods useful for chemical and biological reactions |
| US10161003B2 (en) | 2017-04-25 | 2018-12-25 | Omniome, Inc. | Methods and apparatus that increase sequencing-by-binding efficiency |
| US9951385B1 (en) | 2017-04-25 | 2018-04-24 | Omniome, Inc. | Methods and apparatus that increase sequencing-by-binding efficiency |
| WO2018232086A1 (en) * | 2017-06-14 | 2018-12-20 | Board Of Regents, The University Of Texas System | Chip hybridized association-mapping platform and methods of use |
| EP3697932A1 (de) | 2017-10-19 | 2020-08-26 | Omniome, Inc. | Gleichzeitige hintergrundreduktion und komplexstabilisierung in bindungsassayarbeitsflüssen |
| JP2021512648A (ja) * | 2018-02-06 | 2021-05-20 | オムニオム・インコーポレイテッド | 核酸プライマー伸長のための組成物および技術 |
| WO2019203986A1 (en) * | 2018-04-19 | 2019-10-24 | Omniome, Inc. | Improving accuracy of base calls in nucleic acid sequencing methods |
| EP4234718A3 (de) | 2018-04-26 | 2023-11-29 | Pacific Biosciences Of California, Inc. | Verfahren und zusammensetzungen zur stabilisierung von nukleinsäure-nukleotid-polymerase-komplexen |
| JP2021525078A (ja) | 2018-05-31 | 2021-09-24 | オムニオム インコーポレイテッドOmniome, Inc. | 核酸配列決定におけるシグナル対ノイズの増加 |
| US11180794B2 (en) | 2018-05-31 | 2021-11-23 | Omniome, Inc. | Methods and compositions for capping nucleic acids |
| WO2019241305A1 (en) | 2018-06-12 | 2019-12-19 | Element Biosciences, Inc. | Improved reverse transcriptase for nucleic acid sequencing |
| WO2020023362A1 (en) | 2018-07-24 | 2020-01-30 | Omniome, Inc. | Serial formation of ternary complex species |
| EP3853358A1 (de) | 2018-09-17 | 2021-07-28 | Omniome, Inc. | Manipulierte polymerasen zur verbesserten sequenzierung |
| US10768173B1 (en) | 2019-09-06 | 2020-09-08 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| US10704094B1 (en) | 2018-11-14 | 2020-07-07 | Element Biosciences, Inc. | Multipart reagents having increased avidity for polymerase binding |
| US10876148B2 (en) | 2018-11-14 | 2020-12-29 | Element Biosciences, Inc. | De novo surface preparation and uses thereof |
| WO2020102766A2 (en) | 2018-11-15 | 2020-05-22 | Element Biosciences, Inc. | Methods for generating circular nucleic acid molecules |
| AU2019392932B2 (en) | 2018-12-07 | 2023-11-02 | Element Biosciences, Inc. | Flow cell device and use thereof |
| US12467085B2 (en) | 2019-03-07 | 2025-11-11 | The Trustees Of Columbia University In The City Of New York | High accuracy nanopore-based single molecule sequencing by synthesis with tagged nucleotides |
| US12313627B2 (en) | 2019-05-01 | 2025-05-27 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| US12391929B2 (en) | 2019-05-24 | 2025-08-19 | Element Biosciences, Inc. | Polymerase-nucleotide conjugates for sequencing by trapping |
| WO2021041874A1 (en) | 2019-08-29 | 2021-03-04 | Martin David C | Biofunctional thiophene monomers |
| US11287422B2 (en) | 2019-09-23 | 2022-03-29 | Element Biosciences, Inc. | Multivalent binding composition for nucleic acid analysis |
| EP4055155A1 (de) | 2019-11-08 | 2022-09-14 | Pacific Biosciences of California, Inc. | Modifizierte polymerasen zur verbesserten sequenzierung durch bindung |
| US11060138B1 (en) | 2020-01-17 | 2021-07-13 | Element Biosciences, Inc. | Nucleic acid sequencing systems |
| US11198121B1 (en) * | 2020-06-10 | 2021-12-14 | Element Biosciences, Inc. | Flow cell systems and devices |
| WO2023280156A1 (zh) * | 2021-07-08 | 2023-01-12 | 深圳华大生命科学研究院 | 修饰的核苷或核苷酸 |
| AU2022316142A1 (en) | 2021-07-21 | 2024-02-22 | Element Biosciences, Inc. | Optical systems for nucleic acid sequencing and methods thereof |
| WO2023129887A1 (en) * | 2021-12-29 | 2023-07-06 | Co-Diagnostics, Inc. | Methods and systems for analyzing nucleic acids using increased ifret with multiple acceptor fluorophores |
| CN116926178B (zh) * | 2022-04-02 | 2025-10-24 | 深圳市真迈生物科技有限公司 | 荧光检测试剂及其制备方法及应用 |
| EP4573213A1 (de) | 2022-08-15 | 2025-06-25 | Element Biosciences, Inc. | Ortsaufgelöste oberflächenerfassung von nukleinsäuren |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6358931B1 (en) * | 1990-01-11 | 2002-03-19 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulating RNA |
| DE4140463A1 (de) * | 1991-12-09 | 1993-06-17 | Boehringer Mannheim Gmbh | 2'-desoxy-isoguanosin, dessen isostere analoge sowie anwendung derselben |
| JP4236812B2 (ja) * | 1997-09-12 | 2009-03-11 | エクシコン エ/エス | オリゴヌクレオチド類似体 |
| ATE556149T1 (de) * | 1999-02-23 | 2012-05-15 | Caliper Life Sciences Inc | Manipulation von mikropartikeln in mikrofluidischen systemen |
| KR20020013513A (ko) * | 1999-03-18 | 2002-02-20 | 추후제출 | Xylo-lna 유사체 |
| US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
| AU2002358464B2 (en) * | 2001-12-18 | 2006-04-27 | Human Genetic Signatures Pty Ltd | Pseudonucleotide comprising an intercalator |
| US7166478B2 (en) * | 2002-03-12 | 2007-01-23 | Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. | Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses |
| SE0202867D0 (sv) * | 2002-09-27 | 2002-09-27 | Pyrosequencing Ab | New sequencing method |
-
2004
- 2004-02-20 AT AT04713125T patent/ATE432365T1/de not_active IP Right Cessation
- 2004-02-20 WO PCT/GB2004/000709 patent/WO2004074503A2/en not_active Ceased
- 2004-02-20 EP EP04713125A patent/EP1594987B1/de not_active Expired - Lifetime
- 2004-02-20 DE DE602004021235T patent/DE602004021235D1/de not_active Expired - Lifetime
- 2004-02-20 US US10/546,268 patent/US8399196B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1594987A2 (de) | 2005-11-16 |
| EP1594987B1 (de) | 2009-05-27 |
| WO2004074503A2 (en) | 2004-09-02 |
| US8399196B2 (en) | 2013-03-19 |
| US20070148645A1 (en) | 2007-06-28 |
| DE602004021235D1 (de) | 2009-07-09 |
| WO2004074503A3 (en) | 2005-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |