ATE432918T1 - Verfahren zur herstellung von cpla 2-inhibitoren - Google Patents

Verfahren zur herstellung von cpla 2-inhibitoren

Info

Publication number: ATE432918T1
Authority: AT; Austria
Prior art keywords: cpla; inhibitors; producing; producing cpla
Prior art date: 2003-07-25

Application number

AT04778654T

Other languages

English (en)

Inventor

Yanzhong Wu

Panolil Raveendranath

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-25

Filing date

2004-07-19

Publication date

2009-06-15

2004-07-19 Application filed by Wyeth Corp filed Critical Wyeth Corp

2009-06-15 Application granted granted Critical

2009-06-15 Publication of ATE432918T1 publication Critical patent/ATE432918T1/de

Links

239000003112 inhibitor Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

AT04778654T 2003-07-25 2004-07-19 Verfahren zur herstellung von cpla 2-inhibitoren ATE432918T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US49000503P	2003-07-25	2003-07-25
PCT/US2004/023247 WO2005012238A1 (en)	2003-07-25	2004-07-19	Process for the preparation of cpla2 inhibitors

Publications (1)

Publication Number	Publication Date
ATE432918T1 true ATE432918T1 (de)	2009-06-15

Family

ID=34115341

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04778654T ATE432918T1 (de)	2003-07-25	2004-07-19	Verfahren zur herstellung von cpla 2-inhibitoren

Country Status (14)

Country	Link
US (2)	US6891065B2 (de)
EP (1)	EP1648861B1 (de)
JP (1)	JP4607877B2 (de)
CN (1)	CN100577640C (de)
AR (1)	AR045089A1 (de)
AT (1)	ATE432918T1 (de)
AU (1)	AU2004261567A1 (de)
BR (1)	BRPI0412904A (de)
CA (1)	CA2528174C (de)
DE (1)	DE602004021388D1 (de)
ES (1)	ES2325265T3 (de)
MX (1)	MXPA06000406A (de)
TW (1)	TW200510305A (de)
WO (1)	WO2005012238A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7605156B2 (en)	2001-12-03	2009-10-20	Wyeth	Methods for the use of inhibitors of cytosolic phospholipase A2
US7713964B2 (en)	2001-12-03	2010-05-11	Wyeth Llc	Methods for treating asthmatic conditions
TW200510305A (en)	2003-07-25	2005-03-16	Wyeth Corp	Process for the preparation of CPLA2 inhibitors
US7342119B2 (en) *	2003-09-30	2008-03-11	Wyeth Holdings Corporation	Process for the synthesis of a CPLA2 inhibitor
HN2004000536A (es) *	2003-12-16	2009-02-18	Wyeth Corp	Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
AR053410A1 (es) *	2004-08-19	2007-05-09	Wyeth Corp	Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos. compuestos intermediarios
TW200718687A (en)	2005-05-27	2007-05-16	Wyeth Corp	Inhibitors of cytosolic phospholipase A2
KR100746342B1 (ko)	2006-04-10	2007-08-03	한국과학기술원	구리 촉매 존재하에서 ｎ―설포닐아미드 화합물의 제조방법
CN100363341C (zh) *	2006-05-12	2008-01-23	北京化工大学	旋光性n-炔丙磺酰胺聚合物及其制备方法
CL2007003143A1 (es) *	2006-10-31	2008-01-25	Wyeth Corp	Composicion farmaceutica que comprende un compuesto derivado de indol y un sistema portador que comprende 10-50% de un primer solubilizante, 5-50% de un segundo solubilizante, 10-30% de un primer diluyente y 1-15% de un segundo diluyente; proceso de prepracion; y forma de dosificacion.
WO2008055148A2 (en) *	2006-10-31	2008-05-08	Wyeth	Semi-solid formulations of phospholipase enzyme inhibitors
US8113207B2 (en) *	2008-08-22	2012-02-14	Kimberly-Clark Worldwide, Inc.	Self-conforming sound attenuation earplug
CN102617558A (zh) *	2012-03-26	2012-08-01	上海泛凯生物医药科技有限公司	一种维拉佐酮的制备方法
CN110437125B (zh) *	2019-09-06	2021-03-12	苏州旺山旺水生物医药有限公司	一种Tezacaftor中间体II的制备方法

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US5186736A (en) *	1988-08-02	1993-02-16	Hoechst Aktiengesellschaft	Heterocyclic N-acylsulfonamides and their use as herbicides or growth regulators
DE3826230A1 (de) *	1988-08-02	1990-02-08	Hoechst Ag	Heterocyclische n-acylsufonamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren
JPH02115157A (ja) *	1988-10-24	1990-04-27	Hokko Chem Ind Co Ltd	スルホニルグリシン誘導体および除草剤
CA2017383A1 (en)	1989-06-08	1990-12-08	Raymond R. Martodam	Use of vanilloids for the treatment of respiratory diseases or disorders
DE3935277A1 (de) *	1989-10-24	1991-05-02	Hoechst Ag	Sulfonierte heterocyclische carboxamide, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als herbizide oder wachstumsregulatoren
GB9201755D0 (en)	1992-01-28	1992-03-11	British Bio Technology	Compounds
DK0736014T3 (da) *	1993-12-20	2001-05-07	Bayer Ag	N-Cyanoaryl-nitrogenheterocycler med svovlholdige grupperinger
DE4431218A1 (de) *	1994-09-02	1996-03-07	Bayer Ag	Substituierte Pyrimidin(thi)one
DE19528305A1 (de)	1995-08-02	1997-02-06	Bayer Ag	Substituierte Phenyluracile
DE19601626A1 (de)	1996-01-18	1997-07-24	Bayer Ag	Substituierte N-Aryl-Stickstoffheterocyclen
DE19606594A1 (de)	1996-02-22	1997-08-28	Bayer Ag	Substituierte 2-Aryl-1,2,4-triazin-3,5-di(thi)one
JP2000516958A (ja) *	1996-08-26	2000-12-19	ジェネティックス・インスチチュート・インコーポレーテッド	ホスホリパーゼ酵素の阻害剤
ID27280A (id) *	1998-02-25	2001-03-22	Genetics Inst	Inhibitor-inhibitor dari enzim-enzim fosfolipase
GB9912411D0 (en) *	1999-05-28	1999-07-28	Pfizer Ltd	Compounds useful in therapy
WO2002002517A1 (fr) *	2000-07-05	2002-01-10	Ajinomoto Co.,Inc.	Derives d'acylsulfonamides
DE10043790A1 (de)	2000-09-06	2002-03-14	Bayer Ag	Substituierte 1-Aryl-pyridin-2-(thi)one
AU2002225767A1 (en)	2000-11-28	2002-06-11	Guilford Pharmaceuticals Inc.	Bisubstituted carbocyclic cyclophilin binding compounds and theirus
MXPA03006666A (es) *	2001-01-25	2004-05-31	Guilford Pharm Inc	Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso.
CA2453259A1 (en)	2001-09-06	2003-03-20	Syngenta Participations Ag	Herbicidal n-alkylsulfonamino derivatives
HUP0402577A3 (en) *	2001-12-03	2011-05-30	Wyeth Corp	Indole derivatives as inhibitors of cytosolic phospholipase a2, process for producing them and pharmaceutical compositions containing them
US6984735B2 (en)	2001-12-03	2006-01-10	Wyeth	Process for making an aldehyde
US7101875B2 (en)	2001-12-03	2006-09-05	Wyeth	Methods for treating arthritic disorders
US6635771B2 (en)	2001-12-03	2003-10-21	Wyeth	N-benzhydryl indole compounds
US7713964B2 (en)	2001-12-03	2010-05-11	Wyeth Llc	Methods for treating asthmatic conditions
US6797708B2 (en) *	2001-12-03	2004-09-28	Wyeth	Inhibitors of cytosolic phospholipase A2
US7605156B2 (en)	2001-12-03	2009-10-20	Wyeth	Methods for the use of inhibitors of cytosolic phospholipase A2
TW200510305A (en)	2003-07-25	2005-03-16	Wyeth Corp	Process for the preparation of CPLA2 inhibitors
US7582771B2 (en)	2003-09-03	2009-09-01	Wyeth	Process for the synthesis of cPLA2 inhibitors
US7342119B2 (en)	2003-09-30	2008-03-11	Wyeth Holdings Corporation	Process for the synthesis of a CPLA2 inhibitor
HN2004000536A (es)	2003-12-16	2009-02-18	Wyeth Corp	Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles

2004
- 2004-06-29 TW TW093119031A patent/TW200510305A/zh unknown
- 2004-07-19 EP EP04778654A patent/EP1648861B1/de not_active Expired - Lifetime
- 2004-07-19 AT AT04778654T patent/ATE432918T1/de not_active IP Right Cessation
- 2004-07-19 BR BRPI0412904-0A patent/BRPI0412904A/pt not_active IP Right Cessation
- 2004-07-19 MX MXPA06000406A patent/MXPA06000406A/es active IP Right Grant
- 2004-07-19 CA CA2528174A patent/CA2528174C/en not_active Expired - Lifetime
- 2004-07-19 CN CN200480018618A patent/CN100577640C/zh not_active Expired - Fee Related
- 2004-07-19 DE DE602004021388T patent/DE602004021388D1/de not_active Expired - Lifetime
- 2004-07-19 AU AU2004261567A patent/AU2004261567A1/en not_active Abandoned
- 2004-07-19 JP JP2006521893A patent/JP4607877B2/ja not_active Expired - Fee Related
- 2004-07-19 ES ES04778654T patent/ES2325265T3/es not_active Expired - Lifetime
- 2004-07-19 WO PCT/US2004/023247 patent/WO2005012238A1/en not_active Ceased
- 2004-07-21 US US10/896,318 patent/US6891065B2/en not_active Expired - Fee Related
- 2004-07-23 AR ARP040102620A patent/AR045089A1/es unknown
2005
- 2005-03-08 US US11/076,117 patent/US7259277B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2528174A1 (en)	2005-02-10
EP1648861A1 (de)	2006-04-26
US20050020858A1 (en)	2005-01-27
CA2528174C (en)	2012-03-13
EP1648861B1 (de)	2009-06-03
ES2325265T3 (es)	2009-08-31
WO2005012238A1 (en)	2005-02-10
TW200510305A (en)	2005-03-16
AU2004261567A1 (en)	2005-02-10
US7259277B2 (en)	2007-08-21
US20050159613A1 (en)	2005-07-21
DE602004021388D1 (de)	2009-07-16
US6891065B2 (en)	2005-05-10
MXPA06000406A (es)	2006-03-17
JP2007500190A (ja)	2007-01-11
BRPI0412904A (pt)	2006-09-26
JP4607877B2 (ja)	2011-01-05
CN1816522A (zh)	2006-08-09
AR045089A1 (es)	2005-10-12
CN100577640C (zh)	2010-01-06

Legal Events

Date	Code	Title	Description
2009-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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