ATE433452T1 - Imidazoä1,2-cüpyrimidinylessigsäurederivate - Google Patents

Imidazoä1,2-cüpyrimidinylessigsäurederivate

Info

Publication number: ATE433452T1
Authority: AT; Austria
Prior art keywords: diseases; allergic; imidazo; acid derivative; treatment
Prior art date: 2004-01-31

Application number

AT05706922T

Other languages

English (en)

Inventor

Tai-Wei Ly

Takashi Yoshino

Yuki Takekawa

Takuya Shintani

Hiromi Sugimoto

Kevin B Bacon

Klaus Urbahns

Original Assignee

Actimis Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-01-31

Filing date

2005-01-19

Publication date

2009-06-15

2005-01-19 Application filed by Actimis Pharmaceuticals Inc filed Critical Actimis Pharmaceuticals Inc

2009-06-15 Application granted granted Critical

2009-06-15 Publication of ATE433452T1 publication Critical patent/ATE433452T1/de

Links

239000002253 acid Substances 0.000 title 1
201000010099 disease Diseases 0.000 abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
JELCUCXNEYEZOO-UHFFFAOYSA-N 2-imidazo[1,2-c]pyrimidin-2-ylacetic acid Chemical class C1=NC=CC2=NC(CC(=O)O)=CN21 JELCUCXNEYEZOO-UHFFFAOYSA-N 0.000 abstract 2
102000009389 Prostaglandin D receptors Human genes 0.000 abstract 2
108050000258 Prostaglandin D receptors Proteins 0.000 abstract 2
238000011282 treatment Methods 0.000 abstract 2
208000016557 Acute basophilic leukemia Diseases 0.000 abstract 1
208000032671 Allergic granulomatous angiitis Diseases 0.000 abstract 1
208000006344 Churg-Strauss Syndrome Diseases 0.000 abstract 1
206010009900 Colitis ulcerative Diseases 0.000 abstract 1
206010010744 Conjunctivitis allergic Diseases 0.000 abstract 1
208000011231 Crohn disease Diseases 0.000 abstract 1
201000004624 Dermatitis Diseases 0.000 abstract 1
206010012438 Dermatitis atopic Diseases 0.000 abstract 1
208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 abstract 1
102000011652 Formyl peptide receptors Human genes 0.000 abstract 1
108010076288 Formyl peptide receptors Proteins 0.000 abstract 1
108091006027 G proteins Proteins 0.000 abstract 1
102000030782 GTP binding Human genes 0.000 abstract 1
108091000058 GTP-Binding Proteins 0.000 abstract 1
208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
208000019693 Lung disease Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
201000004681 Psoriasis Diseases 0.000 abstract 1
206010039085 Rhinitis allergic Diseases 0.000 abstract 1
210000001744 T-lymphocyte Anatomy 0.000 abstract 1
210000004241 Th2 cell Anatomy 0.000 abstract 1
201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
206010052568 Urticaria chronic Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
208000002205 allergic conjunctivitis Diseases 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
201000010105 allergic rhinitis Diseases 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
206010003246 arthritis Diseases 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
208000024998 atopic conjunctivitis Diseases 0.000 abstract 1
201000008937 atopic dermatitis Diseases 0.000 abstract 1
208000010668 atopic eczema Diseases 0.000 abstract 1
210000003651 basophil Anatomy 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
208000024376 chronic urticaria Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
210000003979 eosinophil Anatomy 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
210000000265 leukocyte Anatomy 0.000 abstract 1
206010024378 leukocytosis Diseases 0.000 abstract 1
230000000414 obstructive effect Effects 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
201000009890 sinusitis Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT05706922T 2004-01-31 2005-01-19 Imidazoä1,2-cüpyrimidinylessigsäurederivate ATE433452T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP04002144		2004-01-31
PCT/EP2005/000475 WO2005073234A2 (en)	2004-01-31	2005-01-19	Imidazo[1,2-c]pyrimidinylacetic acid derivatives

Publications (1)

Publication Number	Publication Date
ATE433452T1 true ATE433452T1 (de)	2009-06-15

Family

ID=34814234

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05706922T ATE433452T1 (de)	2004-01-31	2005-01-19	Imidazoä1,2-cüpyrimidinylessigsäurederivate

Country Status (23)

Country	Link
US (1)	US7750014B2 (de)
EP (1)	EP1718649B1 (de)
JP (1)	JP4996257B2 (de)
KR (1)	KR101207428B1 (de)
CN (1)	CN100584844C (de)
AT (1)	ATE433452T1 (de)
AU (1)	AU2005209381B2 (de)
BR (1)	BRPI0507123A (de)
CA (1)	CA2551778C (de)
CY (1)	CY1109274T1 (de)
DE (1)	DE602005014849D1 (de)
DK (1)	DK1718649T3 (de)
ES (1)	ES2326896T3 (de)
IL (1)	IL177083A (de)
MX (1)	MXPA06007674A (de)
NO (1)	NO20063878L (de)
NZ (1)	NZ548396A (de)
PL (1)	PL1718649T3 (de)
PT (1)	PT1718649E (de)
RU (1)	RU2373208C2 (de)
SI (1)	SI1718649T1 (de)
WO (1)	WO2005073234A2 (de)
ZA (1)	ZA200605387B (de)

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CA2594280C (en)	2004-12-27	2013-04-23	Anja Fecher	2,3,4,9-tetrahydro-1h-carbazole derivatives as crth2 receptor antagonists
ATE530523T1 (de)	2006-08-07	2011-11-15	Actelion Pharmaceuticals Ltd	(3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)- essigsäurederivate
CA2681311A1 (en) *	2007-04-13	2008-10-23	Novartis Ag	Pyridazine-, pyridine- and pyrane-derivatives as gpbar1 agonisis
US8507005B2 (en) *	2007-06-21	2013-08-13	Actimis Pharmaceuticals, Inc.	Particulates of a CRTH2 antagonist
BRPI0817318A2 (pt)	2007-09-25	2015-03-17	Actimis Pharmaceuticals Inc	Composto, composição farmacêutica, e, método para tratar uma doença, ou uma condição, ou sintoma da mesma.
JP5524847B2 (ja) *	2007-09-25	2014-06-18	アクチミスファーマシューティカルズインコーポレーテッド	Ｃｒｔｈ２アンタゴニストとしてのアルキルチオピリミジン
WO2009102893A2 (en)	2008-02-14	2009-08-20	Amira Pharmaceuticals, Inc.	CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors
US8426449B2 (en)	2008-04-02	2013-04-23	Panmira Pharmaceuticals, Llc	Aminoalkylphenyl antagonists of prostaglandin D2 receptors
US8541419B2 (en)	2008-09-02	2013-09-24	Actimis Pharmaceuticals, Inc.	Isotopically enriched pyrimidin-5-yl acetic acid derivatives as CRTH2 antagonists
US8383654B2 (en)	2008-11-17	2013-02-26	Panmira Pharmaceuticals, Llc	Heterocyclic antagonists of prostaglandin D2 receptors
AR080703A1 (es)	2010-03-22	2012-05-02	Actelion Pharmaceuticals Ltd	Derivados de 3-(heteroaril-amino)-1,2,3,4-tetrahidro-9h-carbazol, moduladores de receptores de prostaglandina d2, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de trastornos alergicos o inmunitarios tales como asma.
CN102958914B (zh)	2010-07-05	2015-05-27	埃科特莱茵药品有限公司	1-苯基取代的杂环衍生物及其作为前列腺素d2受体调节剂的用途
EA201390060A1 (ru)	2010-07-09	2013-07-30	Байер Интеллектуэль Проперти Гмбх	Аннелированные пиримидины и триазины и их применение для лечения и/или профилактики сердечно-сосудистых заболеваний
DE102011003315A1 (de)	2011-01-28	2012-08-02	Bayer Schering Pharma Aktiengesellschaft	Annellierte Pyrimindine und Triazine und ihre Verwendung
DE102010031149A1 (de)	2010-07-09	2012-01-12	Bayer Schering Pharma Aktiengesellschaft	Annellierte Pyrimidine und Triazine und ihre Verwendung
EP2627178B1 (de)	2010-10-11	2018-05-02	Merck Sharp & Dohme Corp.	Chinazolinonverbindungen als crth2-antagonisten
EP2457900A1 (de)	2010-11-25	2012-05-30	Almirall, S.A.	Neue Pyrazolderivate mit CRTH2-antagonistischem Verhalten
DK2697223T3 (en)	2011-04-14	2016-09-05	Actelion Pharmaceuticals Ltd	7- (heteroaryl-amino) -6,7,8,9-tetrahydro-pyrido [1,2-a] indole-acetic acid derivatives and their use as prostaglandin D2 receptor
SG11201402796SA (en)	2011-12-16	2014-06-27	Atopix Therapeutics Ltd	Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
TW201331179A (zh)	2011-12-21	2013-08-01	Actelion Pharmaceuticals Ltd	雜環衍生物及其作為前列腺素ｄ２受體調節劑之用途
DE102012200360A1 (de)	2012-01-11	2013-07-11	Bayer Intellectual Property Gmbh	Substituierte Triazine und ihre Verwendung
DE102012200349A1 (de)	2012-01-11	2013-07-11	Bayer Intellectual Property Gmbh	Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung
WO2013131923A1 (de)	2012-03-06	2013-09-12	Bayer Intellectual Property Gmbh	Substituierte azabicyclen und ihre verwendung
CA2876808A1 (en)	2012-07-05	2014-01-09	Actelion Pharmaceuticals Ltd	1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
PE20161177A1 (es)	2014-03-17	2016-11-18	Actelion Pharmaceuticals Ltd	Derivados del acido acetico azaindol y su uso como moduladores del receptor de prostaglandina d2
WO2015140701A1 (en)	2014-03-18	2015-09-24	Actelion Pharmaceuticals Ltd	Azaindole acetic acid derivatives and their use as prostaglandin d2 receptor modulators
KR20180053345A (ko)	2015-09-15	2018-05-21	이도르시아 파마슈티컬스 리미티드	결정질 형태
KR20190103507A (ko)	2018-02-12	2019-09-05	김강민	지하철 혼잡도 알림 시스템
WO2019139462A2 (ko) *	2019-02-21	2019-07-18	엘지전자 주식회사	하차 시점 알림 방법 및 사용자 단말
TW202100015A (zh)	2019-02-28	2021-01-01	瑞士商先正達農作物保護公司	具有含硫取代基之殺有害生物活性雜環衍生物
CN114681438B (zh) *	2022-05-17	2024-03-19	中国医学科学院基础医学研究所	二甲双胍及其它含胍化合物在逆转Gal-10结晶趋势并缓解相关疾病中应用

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BE790679A (fr)	1971-11-03	1973-04-27	Ici Ltd	Derives de l'indole
GB9125842D0 (en)	1991-12-04	1992-02-05	Ici Plc	Heterocyclic derivatives
ES2237470T3 (es) *	1999-11-10	2005-08-01	Ortho-Mcneil Pharmaceutical, Inc.	2-aril-3-(heteroaril)-imidazo(1,2-alfa)pirimidinas sustituidas; y composiciones farmaceuticas y procedimientos asociados.
JP2001302667A (ja)	2000-04-28	2001-10-31	Bayer Ag	イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体
US6878522B2 (en)	2000-07-07	2005-04-12	Baiyong Li	Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
EP1413306A1 (de)	2002-10-21	2004-04-28	Warner-Lambert Company LLC	Tetrahydrochinolin-Derivate als CRTH2 Antagonisten
PL377314A1 (pl) *	2002-12-20	2006-01-23	Amgen Inc.	Modulatory astmy i zapaleń na tle alergicznym
PT1471057E (pt)	2003-04-25	2006-05-31	Actimis Pharmaceuticals Inc	Derivados de acido pirimidinilacetico uteis para o tratamento de doencas mediadas por crth2

2005
- 2005-01-19 CN CN200580010462A patent/CN100584844C/zh not_active Expired - Fee Related
- 2005-01-19 DK DK05706922T patent/DK1718649T3/da active
- 2005-01-19 DE DE602005014849T patent/DE602005014849D1/de not_active Expired - Lifetime
- 2005-01-19 NZ NZ548396A patent/NZ548396A/en not_active IP Right Cessation
- 2005-01-19 US US10/585,429 patent/US7750014B2/en not_active Expired - Fee Related
- 2005-01-19 RU RU2006131304/04A patent/RU2373208C2/ru not_active IP Right Cessation
- 2005-01-19 MX MXPA06007674A patent/MXPA06007674A/es active IP Right Grant
- 2005-01-19 BR BRPI0507123-2A patent/BRPI0507123A/pt not_active IP Right Cessation
- 2005-01-19 EP EP05706922A patent/EP1718649B1/de not_active Expired - Lifetime
- 2005-01-19 ZA ZA200605387A patent/ZA200605387B/en unknown
- 2005-01-19 ES ES05706922T patent/ES2326896T3/es not_active Expired - Lifetime
- 2005-01-19 CA CA2551778A patent/CA2551778C/en not_active Expired - Fee Related
- 2005-01-19 SI SI200530724T patent/SI1718649T1/sl unknown
- 2005-01-19 JP JP2006550019A patent/JP4996257B2/ja not_active Expired - Fee Related
- 2005-01-19 PT PT05706922T patent/PT1718649E/pt unknown
- 2005-01-19 AT AT05706922T patent/ATE433452T1/de active
- 2005-01-19 PL PL05706922T patent/PL1718649T3/pl unknown
- 2005-01-19 WO PCT/EP2005/000475 patent/WO2005073234A2/en not_active Ceased
- 2005-01-19 AU AU2005209381A patent/AU2005209381B2/en not_active Ceased
2006
- 2006-07-25 IL IL177083A patent/IL177083A/en not_active IP Right Cessation
- 2006-08-29 KR KR1020067017478A patent/KR101207428B1/ko not_active Expired - Fee Related
- 2006-08-31 NO NO20063878A patent/NO20063878L/no not_active Application Discontinuation
2009
- 2009-08-06 CY CY20091100834T patent/CY1109274T1/el unknown

Also Published As

Publication number	Publication date
NZ548396A (en)	2010-06-25
BRPI0507123A (pt)	2007-06-19
CY1109274T1 (el)	2014-07-02
DE602005014849D1 (de)	2009-07-23
IL177083A0 (en)	2006-12-10
ZA200605387B (en)	2008-05-28
CN100584844C (zh)	2010-01-27
US7750014B2 (en)	2010-07-06
US20090012102A1 (en)	2009-01-08
PL1718649T3 (pl)	2009-11-30
ES2326896T3 (es)	2009-10-21
HK1101969A1 (en)	2007-11-02
CN1938310A (zh)	2007-03-28
IL177083A (en)	2011-10-31
KR20060130187A (ko)	2006-12-18
WO2005073234A2 (en)	2005-08-11
JP2007519659A (ja)	2007-07-19
RU2006131304A (ru)	2008-03-10
EP1718649A2 (de)	2006-11-08
JP4996257B2 (ja)	2012-08-08
CA2551778C (en)	2013-10-22
MXPA06007674A (es)	2006-09-04
KR101207428B1 (ko)	2012-12-04
PT1718649E (pt)	2009-08-06
SI1718649T1 (sl)	2009-10-31
EP1718649B1 (de)	2009-06-10
NO20063878L (no)	2006-10-11
WO2005073234A3 (en)	2005-10-06
DK1718649T3 (da)	2009-08-24
AU2005209381A1 (en)	2005-08-11
CA2551778A1 (en)	2005-08-11
AU2005209381B2 (en)	2011-06-30
RU2373208C2 (ru)	2009-11-20

Legal Events

Date

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2010-01-15

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Publication	Publication Date	Title
CY1109274T1 (el)	2014-07-02	Παραγωγα ιμιδαζο[1,2-c] πυριμιδινυλοξικου οξεος
TW200505873A (en)	2005-02-16	Pyrimidine derivatives
EP2380891B1 (de)	2013-12-11	Substituierte Piperidino-Dihydrothienopyrimidine
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