CR9622A - Derivados de pirazolo[3,4-d]azepina como antagonistas de histamina h3 - Google Patents

Derivados de pirazolo[3,4-d]azepina como antagonistas de histamina h3

Info

Publication number
CR9622A
CR9622A CR9622A CR9622A CR9622A CR 9622 A CR9622 A CR 9622A CR 9622 A CR9622 A CR 9622A CR 9622 A CR9622 A CR 9622A CR 9622 A CR9622 A CR 9622A
Authority
CR
Costa Rica
Prior art keywords
derivatives
pirazolo
azepin
histamine antagonists
antagonists
Prior art date
Application number
CR9622A
Other languages
English (en)
Inventor
James Bamford Mark
Matthew Wilson David
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CR9622A publication Critical patent/CR9622A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invencion se refiere a derivados de pirazol novedosos de formula I que tienen actividad farmacologica de H3 a procedimientos para su preparacion, a composiciones que los contienen y a su uso en el tratamiento de trastornos neurologicos y psiquiatricos.
CR9622A 2005-07-06 2007-12-20 Derivados de pirazolo[3,4-d]azepina como antagonistas de histamina h3 CR9622A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0513886.2A GB0513886D0 (en) 2005-07-06 2005-07-06 Novel compounds

Publications (1)

Publication Number Publication Date
CR9622A true CR9622A (es) 2008-04-10

Family

ID=34856781

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9622A CR9622A (es) 2005-07-06 2007-12-20 Derivados de pirazolo[3,4-d]azepina como antagonistas de histamina h3

Country Status (27)

Country Link
US (1) US7888347B2 (es)
EP (1) EP1899350B1 (es)
JP (1) JP5145218B2 (es)
KR (1) KR20080037651A (es)
CN (1) CN101258154B (es)
AT (1) ATE467636T1 (es)
AU (1) AU2006286897A1 (es)
BR (1) BRPI0612719A2 (es)
CA (1) CA2614232A1 (es)
CR (1) CR9622A (es)
CY (1) CY1110711T1 (es)
DE (1) DE602006014273D1 (es)
DK (1) DK1899350T3 (es)
EA (1) EA013600B1 (es)
ES (1) ES2345841T3 (es)
GB (1) GB0513886D0 (es)
HR (1) HRP20100401T1 (es)
IL (1) IL188184A0 (es)
MA (1) MA29623B1 (es)
MX (1) MX2008000383A (es)
NO (1) NO20080563L (es)
PL (1) PL1899350T3 (es)
PT (1) PT1899350E (es)
SI (1) SI1899350T1 (es)
UA (1) UA93047C2 (es)
WO (1) WO2007025596A1 (es)
ZA (1) ZA200710798B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2008016343A (es) 2006-06-23 2009-01-19 Abbott Lab Derivados ciclopropil amina como moduladores del receptro de histamina h3.
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
CA2699787A1 (en) 2007-09-24 2009-04-02 Comentis, Inc. (3-hydroxy-4-amino-butan-2-yl)-3-(2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives
CN102952139B (zh) * 2011-08-30 2016-08-10 上海药明康德新药开发有限公司 反式-3a-氟吡咯烷[3,4-C]并环化合物及其制备方法
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
EP2647377A1 (en) 2012-04-06 2013-10-09 Sanofi Use of an h3 receptor antagonist for the treatment of alzheimer's disease
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
US9910887B2 (en) * 2013-04-25 2018-03-06 Facebook, Inc. Variable search query vertical access
JP2019520335A (ja) * 2016-05-25 2019-07-18 アカーナ・セラピューティクス・リミテッドＡｋａｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｌｔｄ． 疾患治療用の縮合二環式化合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6573218B1 (en) 1998-09-09 2003-06-03 Ishihara Sangyo Kaisha, Ltd. Fused-benzene derivatives useful as herbicides
JP2002542245A (ja) * 1999-04-16 2002-12-10 ノボ ノルディスク アクティーゼルスカブ 置換イミダゾール、それらの製造および使用
JP2001220390A (ja) 2000-02-09 2001-08-14 Yamanouchi Pharmaceut Co Ltd 縮合ピラゾール誘導体
EP1513842B1 (en) * 2002-06-06 2007-03-07 Novo Nordisk A/S Substituted hexahydropyrrolo (1,2-a)pyrazines, octahydropyrido(1,2-a)pyrazines and decahydropyrazino(1,2-a)azepines
US6770597B2 (en) 2002-07-17 2004-08-03 Ishihara Sangyo Kaisha, Ltd. Benzohydrazide derivatives as herbicides and desiccant compositions containing them
AU2003244649A1 (en) 2002-07-25 2004-02-23 Pharmacia Italia Spa Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
EP1539704A1 (en) * 2002-08-20 2005-06-15 Eli Lilly And Company Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses
GB0224083D0 (en) 2002-10-16 2002-11-27 Glaxo Group Ltd Novel compounds
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
ATE441417T1 (de) 2002-12-20 2009-09-15 Glaxo Group Ltd Benzoädüazepinderivate für die behandlung von neurologischen krankheiten
MXPA06003150A (es) * 2003-09-17 2006-08-31 Johnson & Johnson Compuestos heterociclicos fusionados.
GB0329214D0 (en) 2003-12-17 2004-01-21 Glaxo Group Ltd Novel compounds
GB0405628D0 (en) 2004-03-12 2004-04-21 Glaxo Group Ltd Novel compounds
GB0408083D0 (en) 2004-04-08 2004-05-12 Glaxo Group Ltd Novel compounds
PE20060302A1 (es) 2004-06-18 2006-04-08 Glaxo Group Ltd Derivados de benzazepina como antagonistas del receptor h3
GB0418267D0 (en) 2004-08-16 2004-09-15 Glaxo Group Ltd Novel compounds
JP2008523006A (ja) 2004-12-07 2008-07-03 グラクソ グループ リミテッド インデニル誘導体および神経学的障害の治療のためのそれらの使用
ATE420091T1 (de) 2005-03-14 2009-01-15 Glaxo Group Ltd Kondensierte thiazolderivate mit affinität für den histamin-h3-rezeptor

Also Published As

Publication number Publication date
JP5145218B2 (ja) 2013-02-13
US20080176832A1 (en) 2008-07-24
GB0513886D0 (en) 2005-08-10
CN101258154A (zh) 2008-09-03
CY1110711T1 (el) 2015-06-10
CN101258154B (zh) 2011-01-19
PT1899350E (pt) 2010-07-21
HRP20100401T1 (hr) 2010-09-30
CA2614232A1 (en) 2007-03-08
KR20080037651A (ko) 2008-04-30
EP1899350A1 (en) 2008-03-19
EA013600B1 (ru) 2010-06-30
US7888347B2 (en) 2011-02-15
JP2009500366A (ja) 2009-01-08
DK1899350T3 (da) 2010-09-06
DE602006014273D1 (de) 2010-06-24
WO2007025596A1 (en) 2007-03-08
SI1899350T1 (sl) 2010-09-30
IL188184A0 (en) 2008-03-20
AU2006286897A1 (en) 2007-03-08
UA93047C2 (ru) 2011-01-10
ATE467636T1 (de) 2010-05-15
EA200800264A1 (ru) 2008-06-30
ES2345841T3 (es) 2010-10-04
BRPI0612719A2 (pt) 2010-11-30
MX2008000383A (es) 2008-03-07
EP1899350B1 (en) 2010-05-12
NO20080563L (no) 2008-02-01
PL1899350T3 (pl) 2010-10-29
MA29623B1 (fr) 2008-07-01
ZA200710798B (en) 2008-11-26

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)