ATE435013T1 - Histon deazetylase enzym-hemmende hydroxamsäurederivate als neue entzündungshemmer zur hemmung der zytokinsynthese - Google Patents

Histon deazetylase enzym-hemmende hydroxamsäurederivate als neue entzündungshemmer zur hemmung der zytokinsynthese

Info

Publication number: ATE435013T1
Authority: AT; Austria
Prior art keywords: inhibiting; enzyme; histone; deazetylase; hydroxamic acid
Prior art date: 2001-08-07

Application number

AT02764796T

Other languages

English (en)

Inventor

Paolo Mascagni

Flavio Leoni

Giulia Porro

Paolo Pagani

Giancarlo Dona

Pietro Pozzi

Charles Dinarello

Giamila Fantuzzi

Britta Siegmund

Leonid Reznikov

Philip Bufler

Soo-Hyun Kim

Benjamin Pomerantz

Original Assignee

Italfarmaco Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-07

Filing date

2002-07-26

Publication date

2009-07-15

2002-07-26 Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa

2009-07-15 Application granted granted Critical

2009-07-15 Publication of ATE435013T1 publication Critical patent/ATE435013T1/de

Links

NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
239000002253 acid Substances 0.000 title abstract 2
230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
230000002401 inhibitory effect Effects 0.000 title abstract 2
102000004127 Cytokines Human genes 0.000 title 1
108090000695 Cytokines Proteins 0.000 title 1
108010033040 Histones Proteins 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
102000003964 Histone deacetylase Human genes 0.000 abstract 1
108090000353 Histone deacetylase Proteins 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT02764796T 2001-08-07 2002-07-26 Histon deazetylase enzym-hemmende hydroxamsäurederivate als neue entzündungshemmer zur hemmung der zytokinsynthese ATE435013T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2001MI001733A ITMI20011733A1 (it)	2001-08-07	2001-08-07	Derivati dell'acido idrossamico inibitori degli enzimi istone deacetilasi, quali nuovi farmaci antiinfiammatori inibenti la sintesi di citoc
PCT/EP2002/008379 WO2003013493A1 (en)	2001-08-07	2002-07-26	Histone deacetylase enzyme-inhibiting derivatives of hydroxamic acid as new cytokine synthesis-inhibiting anti-inflammatory drugs

Publications (1)

Publication Number	Publication Date
ATE435013T1 true ATE435013T1 (de)	2009-07-15

Family

ID=11448251

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02764796T ATE435013T1 (de)	2001-08-07	2002-07-26	Histon deazetylase enzym-hemmende hydroxamsäurederivate als neue entzündungshemmer zur hemmung der zytokinsynthese

Country Status (23)

Country	Link
US (1)	US20040157930A1 (de)
EP (1)	EP1414428B1 (de)
JP (1)	JP2005506320A (de)
KR (1)	KR20040035724A (de)
CN (1)	CN1538838A (de)
AT (1)	ATE435013T1 (de)
BR (1)	BR0212014A (de)
CA (1)	CA2456533A1 (de)
CY (1)	CY1109391T1 (de)
DE (1)	DE60232797D1 (de)
DK (1)	DK1414428T3 (de)
ES (1)	ES2328468T3 (de)
HU (1)	HUP0401167A2 (de)
IL (1)	IL160075A0 (de)
IS (1)	IS7124A (de)
IT (1)	ITMI20011733A1 (de)
MX (1)	MXPA04001190A (de)
NO (1)	NO20040513L (de)
PL (1)	PL365391A1 (de)
PT (1)	PT1414428E (de)
RU (1)	RU2004106605A (de)
SI (1)	SI1414428T1 (de)
WO (1)	WO2003013493A1 (de)

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US8026280B2 (en)	2001-03-27	2011-09-27	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
US7312247B2 (en)	2001-03-27	2007-12-25	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
US7842727B2 (en)	2001-03-27	2010-11-30	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
JP2005525345A (ja) *	2002-02-15	2005-08-25	スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ	Ｔｒｘ媒介性疾患を処置する方法
JPWO2003070691A1 (ja) *	2002-02-21	2005-06-09	財団法人大阪産業振興機構	Ｎ−ヒドロキシカルボキサミド誘導体
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US7456219B2 (en)	2002-03-04	2008-11-25	Merck Hdac Research, Llc	Polymorphs of suberoylanilide hydroxamic acid
WO2003099272A1 (en)	2002-05-22	2003-12-04	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
US7154002B1 (en)	2002-10-08	2006-12-26	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7250514B1 (en)	2002-10-21	2007-07-31	Takeda San Diego, Inc.	Histone deacetylase inhibitors
WO2004046104A2 (en)	2002-11-20	2004-06-03	Errant Gene Therapeutics, Llc	Treatment of lung cells with histone deacetylase inhibitors
ITMI20030025A1 (it) *	2003-01-10	2004-07-11	Italfarmaco Spa	Derivati dell'acido idrossammico ad attivita' antinfiammatoria.
ITMI20030064A1 (it)	2003-01-17	2004-07-18	Italfarmaco Spa	Uso dei derivati dell'acido idrossamico per la preparazione
CA2518318A1 (en)	2003-03-17	2004-09-30	Takeda San Diego, Inc.	Histone deacetylase inhibitors
SI1611088T1 (sl)	2003-04-07	2009-12-31	Pharmacyclics Inc	Hidroksamati kot terapevtska sredstva
EP1491188A1 (de) *	2003-06-25	2004-12-29	G2M Cancer Drugs AG	Topische Verwendung von Valproinsäure zur Behandlung von Hauterkrankungen
KR100924737B1 (ko) *	2003-08-26	2009-11-04	슬로안-케테링인스티튜트퍼캔서리서치	Ｈｄａｃ 억제제를 이용한 암의 치료 방법
DK1696898T3 (en) *	2003-12-02	2016-02-22	Univ Ohio State Res Found	ZN2 + -CHELATING DESIGN-BASED SHORT-CHAIN FAT ACIDS AS AN UNKNOWN CLASS OF HISTONDEACETYLASE INHIBITORS
US7368476B2 (en) *	2004-04-07	2008-05-06	Pharmacyclics, Inc.	Hydroxamates as therapeutic agents
JP2008505969A (ja) *	2004-07-12	2008-02-28	メルク　エンド　カムパニー　インコーポレーテッド	ヒストン脱アセチル化酵素の阻害剤
GB2417682A (en) *	2004-08-18	2006-03-08	Univ East Anglia	Histone deacetylse inhibitor for treating connective tissue disorders
JP2008524246A (ja)	2004-12-16	2008-07-10	タケダサンディエゴインコーポレイテッド	ヒストンデアセチラーゼ阻害剤
US7642253B2 (en)	2005-05-11	2010-01-05	Takeda San Diego, Inc.	Histone deacetylase inhibitors
EA200800321A1 (ru)	2005-07-14	2008-06-30	Такеда Сан Диего, Инк.	Ингибиторы гистондеацетилазы
US8338416B2 (en)	2006-03-16	2012-12-25	Pharmacylics, Inc.	Indole derivatives as inhibitors of histone deacetylase
WO2008060721A1 (en) *	2006-11-14	2008-05-22	Pharmacyclics, Inc.	Uses of selective inhibitors of hdac8 for treatment of t-cell proliferative disorders
US20110150825A1 (en) *	2006-11-14	2011-06-23	Pharmacyclics, Inc.	Uses of selective inhibitors of hdac8 for treatment of inflammatory conditions
RU2446796C2 (ru) *	2006-12-26	2012-04-10	Фармасайкликс, Инк.	Способ использования ингибиторов гистондеацетилазы и мониторинга биомаркеров в комбинированной терапии
EP2993473A1 (de)	2007-01-30	2016-03-09	Pharmacyclics, Inc.	Verfahren zur bestimmung der krebsresistenz gegen histondeacetylasehemmer
US9827212B2 (en) *	2009-03-18	2017-11-28	The Trustees Of The University Of Pennsylvania	Compositions and methods for treating asthma and other lung diseases
US8603521B2 (en)	2009-04-17	2013-12-10	Pharmacyclics, Inc.	Formulations of histone deacetylase inhibitor and uses thereof
EP2464967B1 (de) *	2009-08-14	2013-06-12	Cellzome Ag	Verfahren zur Identifikation und Charakterisierung von HDAC-interagierenden Verbindungen
RU2440830C1 (ru) *	2010-06-25	2012-01-27	Государственное образовательное учреждение высшего профессионального образования "Дагестанская государственная медицинская академия федерального агентства по здравоохранению и социальному развитию"	Способ рассасывания жидкости при туберкулезных плевритах
WO2012018499A2 (en) *	2010-08-05	2012-02-09	Acetylon Pharmaceuticals	Specific regulation of cytokine levels by hdac6 inhibitors
CA2866333C (en) *	2011-03-09	2020-12-29	Cereno Scientific Ab	Compounds and methods for improving impaired endogenous fibrinolysis using histone deacetylase inhibitors
AU2011376953B2 (en)	2011-09-13	2017-08-24	Pharmacyclics Llc	Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof
CN107007580A (zh) *	2012-02-03	2017-08-04	意大发马克股份公司	用于治疗肌肉萎缩症的化合物
CN102793693A (zh) *	2012-09-07	2012-11-28	天津医科大学	伏立诺他在制备治疗自身免疫及炎症性疾病药物方面的应用
GB201417828D0 (en)	2014-10-08	2014-11-19	Cereno Scient Ab	New methods and compositions
RU2760304C2 (ru)	2016-04-08	2021-11-23	Серено Сайентифик Аб	Фармацевтические составы с отсроченным высвобождением, содержащие вальпроевую кислоту, и их применение

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US6777217B1 (en) *	1996-03-26	2004-08-17	President And Fellows Of Harvard College	Histone deacetylases, and uses related thereto
IT1283637B1 (it) *	1996-05-14	1998-04-23	Italfarmaco Spa	Composti ad attivita' antinfiammatoria ed immunosoppressiva
WO2002055017A2 (en) *	2000-11-21	2002-07-18	Wake Forest University	Method of treating autoimmune diseases

2001
- 2001-08-07 IT IT2001MI001733A patent/ITMI20011733A1/it unknown
2002
- 2002-07-26 EP EP02764796A patent/EP1414428B1/de not_active Expired - Lifetime
- 2002-07-26 RU RU2004106605/15A patent/RU2004106605A/ru not_active Application Discontinuation
- 2002-07-26 HU HU0401167A patent/HUP0401167A2/hu unknown
- 2002-07-26 PT PT02764796T patent/PT1414428E/pt unknown
- 2002-07-26 DK DK02764796T patent/DK1414428T3/da active
- 2002-07-26 JP JP2003518503A patent/JP2005506320A/ja active Pending
- 2002-07-26 IL IL16007502A patent/IL160075A0/xx unknown
- 2002-07-26 BR BR0212014-3A patent/BR0212014A/pt not_active IP Right Cessation
- 2002-07-26 WO PCT/EP2002/008379 patent/WO2003013493A1/en not_active Ceased
- 2002-07-26 DE DE60232797T patent/DE60232797D1/de not_active Expired - Lifetime
- 2002-07-26 AT AT02764796T patent/ATE435013T1/de active
- 2002-07-26 MX MXPA04001190A patent/MXPA04001190A/es unknown
- 2002-07-26 SI SI200230840T patent/SI1414428T1/sl unknown
- 2002-07-26 KR KR10-2004-7001946A patent/KR20040035724A/ko not_active Withdrawn
- 2002-07-26 CN CNA028154363A patent/CN1538838A/zh active Pending
- 2002-07-26 ES ES02764796T patent/ES2328468T3/es not_active Expired - Lifetime
- 2002-07-26 PL PL02365391A patent/PL365391A1/xx not_active Application Discontinuation
- 2002-07-26 US US10/486,152 patent/US20040157930A1/en not_active Abandoned
- 2002-07-26 CA CA002456533A patent/CA2456533A1/en not_active Abandoned
2004
- 2004-01-26 IS IS7124A patent/IS7124A/is unknown
- 2004-01-29 NO NO20040513A patent/NO20040513L/no unknown
2009
- 2009-09-21 CY CY20091100978T patent/CY1109391T1/el unknown

Also Published As

Publication number	Publication date
ES2328468T3 (es)	2009-11-13
CY1109391T1 (el)	2014-07-02
KR20040035724A (ko)	2004-04-29
PT1414428E (pt)	2009-08-25
US20040157930A1 (en)	2004-08-12
EP1414428A1 (de)	2004-05-06
ITMI20011733A1 (it)	2003-02-07
WO2003013493A8 (en)	2004-02-26
WO2003013493A1 (en)	2003-02-20
CA2456533A1 (en)	2003-02-20
ITMI20011733A0 (it)	2001-08-07
EP1414428B1 (de)	2009-07-01
PL365391A1 (en)	2005-01-10
IL160075A0 (en)	2004-06-20
SI1414428T1 (sl)	2009-10-31
MXPA04001190A (es)	2005-02-17
DE60232797D1 (de)	2009-08-13
HUP0401167A2 (hu)	2004-11-29
DK1414428T3 (da)	2009-08-31
JP2005506320A (ja)	2005-03-03
CN1538838A (zh)	2004-10-20
IS7124A (is)	2004-01-26
NO20040513L (no)	2004-03-24
BR0212014A (pt)	2004-08-03
RU2004106605A (ru)	2005-05-10

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Publication	Publication Date	Title
ATE435013T1 (de)	2009-07-15	Histon deazetylase enzym-hemmende hydroxamsäurederivate als neue entzündungshemmer zur hemmung der zytokinsynthese
WO2002046129A3 (en)	2003-01-16	Inhibitors of histone deacetylase
FI950309A0 (fi)	1995-01-24	Proliiniamidijohdannaisia
TR200101859T2 (tr)	2001-12-21	Kemokin alıcı aktivitesinin modülatörleri olarak N-üreidoalkil-piperidinler
ES2196917T3 (es)	2003-12-16	Amidas heteroaromaticas como inhibidores del factor xa`.
BR0206738A (pt)	2004-02-03	Derivados tricìclicos de lactama e de sultama e uso dos mesmos como inibidores de histona desacetilase
BR9907300A (pt)	2000-10-24	Inibidores do fator xa oxoaza-heterociclila substituìdos
ATE306261T1 (de)	2005-10-15	Antithrombosemittel
NO20045065L (no)	2005-01-07	Nytt formatsalt av o-desmetyl-venlafaxin
NO20024005D0 (no)	2002-08-22	Pteridinforbindelser for behandling av psoriasis
BR0307575A (pt)	2004-12-21	Derivados de sulfonila como inibidores de histona desacetilase
EA200000920A1 (ru)	2001-02-26	Производные бициклических гидроксамовых кислот
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