DK1414428T3 - Histondeacetylaseenzym-inhiberende derivater af hydroxamsyre som hidtil ukendt cytokinsyntese-inhiberende anti-inflammatoriske lægemidler - Google Patents

Histondeacetylaseenzym-inhiberende derivater af hydroxamsyre som hidtil ukendt cytokinsyntese-inhiberende anti-inflammatoriske lægemidler

Info

Publication number: DK1414428T3
Authority: DK; Denmark
Prior art keywords: inhibiting; histone deacetylase; hydroxamic acid; derivatives; inflammatory drugs
Prior art date: 2001-08-07

Application number

DK02764796T

Other languages

English (en)

Inventor

Paolo Mascagni

Flavio Leoni

Giulia Porro

Paolo Pagani

Giancarlo Dona

Pietro Pozzi

Charles Dinarello

Giamila Fantuzzi

Britta Siegmund

Leonid Reznikov

Philip Bufler

Soo-Hyun Kim

Benjamin Pomerantz

Original Assignee

Italfarmaco Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-07

Filing date

2002-07-26

Publication date

2009-08-31

2002-07-26 Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa

2009-08-31 Application granted granted Critical

2009-08-31 Publication of DK1414428T3 publication Critical patent/DK1414428T3/da

Links

230000002401 inhibitory effect Effects 0.000 title abstract 3
NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical class C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
102000003964 Histone deacetylase Human genes 0.000 title abstract 2
108090000353 Histone deacetylase Proteins 0.000 title abstract 2
239000002253 acid Substances 0.000 title abstract 2
102000004127 Cytokines Human genes 0.000 title 1
108090000695 Cytokines Proteins 0.000 title 1
229940124599 anti-inflammatory drug Drugs 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Virology (AREA)
Vascular Medicine (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK02764796T 2001-08-07 2002-07-26 Histondeacetylaseenzym-inhiberende derivater af hydroxamsyre som hidtil ukendt cytokinsyntese-inhiberende anti-inflammatoriske lægemidler DK1414428T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2001MI001733A ITMI20011733A1 (it)	2001-08-07	2001-08-07	Derivati dell'acido idrossamico inibitori degli enzimi istone deacetilasi, quali nuovi farmaci antiinfiammatori inibenti la sintesi di citoc
PCT/EP2002/008379 WO2003013493A1 (en)	2001-08-07	2002-07-26	Histone deacetylase enzyme-inhibiting derivatives of hydroxamic acid as new cytokine synthesis-inhibiting anti-inflammatory drugs

Publications (1)

Publication Number	Publication Date
DK1414428T3 true DK1414428T3 (da)	2009-08-31

Family

ID=11448251

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02764796T DK1414428T3 (da)	2001-08-07	2002-07-26	Histondeacetylaseenzym-inhiberende derivater af hydroxamsyre som hidtil ukendt cytokinsyntese-inhiberende anti-inflammatoriske lægemidler

Country Status (23)

Country	Link
US (1)	US20040157930A1 (da)
EP (1)	EP1414428B1 (da)
JP (1)	JP2005506320A (da)
KR (1)	KR20040035724A (da)
CN (1)	CN1538838A (da)
AT (1)	ATE435013T1 (da)
BR (1)	BR0212014A (da)
CA (1)	CA2456533A1 (da)
CY (1)	CY1109391T1 (da)
DE (1)	DE60232797D1 (da)
DK (1)	DK1414428T3 (da)
ES (1)	ES2328468T3 (da)
HU (1)	HUP0401167A2 (da)
IL (1)	IL160075A0 (da)
IS (1)	IS7124A (da)
IT (1)	ITMI20011733A1 (da)
MX (1)	MXPA04001190A (da)
NO (1)	NO20040513L (da)
PL (1)	PL365391A1 (da)
PT (1)	PT1414428E (da)
RU (1)	RU2004106605A (da)
SI (1)	SI1414428T1 (da)
WO (1)	WO2003013493A1 (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7842727B2 (en)	2001-03-27	2010-11-30	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
US8026280B2 (en)	2001-03-27	2011-09-27	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
US7312247B2 (en)	2001-03-27	2007-12-25	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
US20030235588A1 (en) *	2002-02-15	2003-12-25	Richon Victoria M.	Method of treating TRX mediated diseases
AU2003211362A1 (en) *	2002-02-21	2003-09-09	Osaka Industrial Promotion Organization	N-hydroxycarboxamide derivative
US7456219B2 (en)	2002-03-04	2008-11-25	Merck Hdac Research, Llc	Polymorphs of suberoylanilide hydroxamic acid
MXPA04008577A (es)	2002-03-04	2005-07-13	Aton Pharma Inc	Metodos para inducir diferenciacion terminal.
EP1511477A4 (en)	2002-05-22	2008-04-09	Errant Gene Therapeutics Llc	HISTONE DEACETYLASE INHIBITORS BASED ON ALPHA-KETO-EPOXYDE COMPOUNDS
US7154002B1 (en)	2002-10-08	2006-12-26	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US7250514B1 (en)	2002-10-21	2007-07-31	Takeda San Diego, Inc.	Histone deacetylase inhibitors
JP2006508986A (ja)	2002-11-20	2006-03-16	エルラントゲネセラペウチクスエルエルシー	ヒストンデアセチラーゼ阻害剤による肺細胞の治療方法
ITMI20030025A1 (it)	2003-01-10	2004-07-11	Italfarmaco Spa	Derivati dell'acido idrossammico ad attivita' antinfiammatoria.
ITMI20030064A1 (it) *	2003-01-17	2004-07-18	Italfarmaco Spa	Uso dei derivati dell'acido idrossamico per la preparazione
US7375228B2 (en)	2003-03-17	2008-05-20	Takeda San Diego, Inc.	Histone deacetylase inhibitors
PT1611088E (pt) *	2003-04-07	2009-09-24	Pharmacyclics Inc	Hidroxamatos como agentes terapêuticos
EP1491188A1 (en) *	2003-06-25	2004-12-29	G2M Cancer Drugs AG	Topical use of valproic acid for the prevention or treatment of skin disorders
HRP20060080A2 (en) *	2003-08-26	2006-07-31	Sloan-Kettering Institute For Cancer Research	Method of treating cancer with hdac inhibitors
CA2552279C (en)	2003-12-02	2014-07-15	The Ohio State University Research Foundation	Zn2+-chelating motif-tethered short -chain fatty acids as a novel class of histone deacetylase inhibitors
US7368476B2 (en) *	2004-04-07	2008-05-06	Pharmacyclics, Inc.	Hydroxamates as therapeutic agents
JP2008505969A (ja) *	2004-07-12	2008-02-28	メルク　エンド　カムパニー　インコーポレーテッド	ヒストン脱アセチル化酵素の阻害剤
GB2417682A (en) *	2004-08-18	2006-03-08	Univ East Anglia	Histone deacetylse inhibitor for treating connective tissue disorders
US7642275B2 (en)	2004-12-16	2010-01-05	Takeda San Diego, Inc.	Histone deacetylase inhibitors
JP2008540574A (ja)	2005-05-11	2008-11-20	タケダサンディエゴインコーポレイテッド	ヒストンデアセチラーゼ阻害剤
CA2615105A1 (en)	2005-07-14	2007-01-25	Takeda San Diego, Inc.	Histone deacetylase inhibitors
US8338416B2 (en)	2006-03-16	2012-12-25	Pharmacylics, Inc.	Indole derivatives as inhibitors of histone deacetylase
US20110150825A1 (en) *	2006-11-14	2011-06-23	Pharmacyclics, Inc.	Uses of selective inhibitors of hdac8 for treatment of inflammatory conditions
WO2008060721A1 (en) *	2006-11-14	2008-05-22	Pharmacyclics, Inc.	Uses of selective inhibitors of hdac8 for treatment of t-cell proliferative disorders
PT2099442E (pt)	2006-12-26	2015-02-10	Pharmacyclics Inc	Métodos de utilização de inibidores de histona desacetilase e monitorização de biomarcadores em terapia de combinação
US7838234B2 (en)	2007-01-30	2010-11-23	Pharmacyclics, Inc.	Methods for determining cancer resistance to histone deacetylase inhibitors
US9827212B2 (en) *	2009-03-18	2017-11-28	The Trustees Of The University Of Pennsylvania	Compositions and methods for treating asthma and other lung diseases
US8603521B2 (en)	2009-04-17	2013-12-10	Pharmacyclics, Inc.	Formulations of histone deacetylase inhibitor and uses thereof
US20130071854A1 (en) *	2009-08-14	2013-03-21	Gerard Drewes	Methods for the identification and characterization of hdac interacting compounds
RU2440830C1 (ru) *	2010-06-25	2012-01-27	Государственное образовательное учреждение высшего профессионального образования "Дагестанская государственная медицинская академия федерального агентства по здравоохранению и социальному развитию"	Способ рассасывания жидкости при туберкулезных плевритах
WO2012018499A2 (en) *	2010-08-05	2012-02-09	Acetylon Pharmaceuticals	Specific regulation of cytokine levels by hdac6 inhibitors
PL2683371T3 (pl) *	2011-03-09	2021-04-19	Cereno Scientific Ab	Związki i sposoby poprawy zaburzonej funkcji wewnątrzustrojowej fibrynolizy przy zastosowaniu inhibitorów deacetylazy histonowej
UA110853C2 (uk)	2011-09-13	2016-02-25	Фармасайклікс, Інк.	Лікарські форми інгібітора гістондеацетилази у комбінації з бендамустином та їхнє застосування
PL3858340T3 (pl) *	2012-02-03	2026-07-06	Italfarmaco Spa	Chlorek dietylo-[6-(4-hydroksykarbamoilofenylokarbamoiloksymetylo)naftaleno-2-ylometylo]amoniowy w połączeniu z co najmniej jednym kortykosteroidem glukokortykoidowym do zastosowania w leczeniu dystrofii mięśniowej
CN102793693A (zh) *	2012-09-07	2012-11-28	天津医科大学	伏立诺他在制备治疗自身免疫及炎症性疾病药物方面的应用
GB201417828D0 (en)	2014-10-08	2014-11-19	Cereno Scient Ab	New methods and compositions
US11395808B2 (en)	2016-04-08	2022-07-26	Cereno Scientific Ab	Delayed release pharmaceutical formulations comprising valproic acid, and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5700811A (en)	1991-10-04	1997-12-23	Sloan-Kettering Institute For Cancer Research	Potent inducers of terminal differentiation and method of use thereof
US5318964A (en) *	1992-06-11	1994-06-07	Hoffmann-La Roche Inc.	Hydroxamic derivatives and pharmaceutical compositions
ES2185750T3 (es) *	1995-08-08	2003-05-01	Ono Pharmaceutical Co	Derivados de acido hidroxamico utiles para la inhibicion gelatinasa.
US6777217B1 (en) *	1996-03-26	2004-08-17	President And Fellows Of Harvard College	Histone deacetylases, and uses related thereto
IT1283637B1 (it) *	1996-05-14	1998-04-23	Italfarmaco Spa	Composti ad attivita' antinfiammatoria ed immunosoppressiva
WO2002055017A2 (en) *	2000-11-21	2002-07-18	Wake Forest University	Method of treating autoimmune diseases

2001
- 2001-08-07 IT IT2001MI001733A patent/ITMI20011733A1/it unknown
2002
- 2002-07-26 SI SI200230840T patent/SI1414428T1/sl unknown
- 2002-07-26 DK DK02764796T patent/DK1414428T3/da active
- 2002-07-26 BR BR0212014-3A patent/BR0212014A/pt not_active IP Right Cessation
- 2002-07-26 CN CNA028154363A patent/CN1538838A/zh active Pending
- 2002-07-26 HU HU0401167A patent/HUP0401167A2/hu unknown
- 2002-07-26 JP JP2003518503A patent/JP2005506320A/ja active Pending
- 2002-07-26 PL PL02365391A patent/PL365391A1/xx not_active Application Discontinuation
- 2002-07-26 ES ES02764796T patent/ES2328468T3/es not_active Expired - Lifetime
- 2002-07-26 AT AT02764796T patent/ATE435013T1/de active
- 2002-07-26 WO PCT/EP2002/008379 patent/WO2003013493A1/en not_active Ceased
- 2002-07-26 EP EP02764796A patent/EP1414428B1/en not_active Expired - Lifetime
- 2002-07-26 CA CA002456533A patent/CA2456533A1/en not_active Abandoned
- 2002-07-26 IL IL16007502A patent/IL160075A0/xx unknown
- 2002-07-26 DE DE60232797T patent/DE60232797D1/de not_active Expired - Lifetime
- 2002-07-26 RU RU2004106605/15A patent/RU2004106605A/ru not_active Application Discontinuation
- 2002-07-26 KR KR10-2004-7001946A patent/KR20040035724A/ko not_active Withdrawn
- 2002-07-26 MX MXPA04001190A patent/MXPA04001190A/es unknown
- 2002-07-26 US US10/486,152 patent/US20040157930A1/en not_active Abandoned
- 2002-07-26 PT PT02764796T patent/PT1414428E/pt unknown
2004
- 2004-01-26 IS IS7124A patent/IS7124A/is unknown
- 2004-01-29 NO NO20040513A patent/NO20040513L/no unknown
2009
- 2009-09-21 CY CY20091100978T patent/CY1109391T1/el unknown

Also Published As

Publication number	Publication date
CA2456533A1 (en)	2003-02-20
RU2004106605A (ru)	2005-05-10
EP1414428B1 (en)	2009-07-01
IS7124A (is)	2004-01-26
ATE435013T1 (de)	2009-07-15
DE60232797D1 (de)	2009-08-13
HUP0401167A2 (hu)	2004-11-29
KR20040035724A (ko)	2004-04-29
EP1414428A1 (en)	2004-05-06
PT1414428E (pt)	2009-08-25
ES2328468T3 (es)	2009-11-13
SI1414428T1 (sl)	2009-10-31
JP2005506320A (ja)	2005-03-03
PL365391A1 (en)	2005-01-10
WO2003013493A8 (en)	2004-02-26
CN1538838A (zh)	2004-10-20
MXPA04001190A (es)	2005-02-17
ITMI20011733A1 (it)	2003-02-07
NO20040513L (no)	2004-03-24
WO2003013493A1 (en)	2003-02-20
US20040157930A1 (en)	2004-08-12
BR0212014A (pt)	2004-08-03
CY1109391T1 (el)	2014-07-02
IL160075A0 (en)	2004-06-20
ITMI20011733A0 (it)	2001-08-07

Publication	Publication Date	Title
IL160075A0 (en)	2004-06-20	Histone deacetylase enzyme-inhibiting derivatives of hydroxamic acid as new cytokine synthesis-inhibiting anti-inflammatory drugs
WO2002046129A3 (en)	2003-01-16	Inhibitors of histone deacetylase
DK1207867T3 (da)	2006-06-19	Retarderede, orale farmaceutiske indgivelsesformer med tramadol
NO20012977L (no)	2001-08-20	N-ureidoalkylpiperidiner som modulatorer av chemokinreseptoraktivitet
ATE223378T1 (de)	2002-09-15	Prolineamid-derivate
SE0203654D0 (sv)	2002-12-09	New compounds
NO20045065L (no)	2005-01-07	Nytt formatsalt av o-desmetyl-venlafaxin
AR023972A1 (es)	2002-09-04	Composiciones de medicamentos a base de compuestos anticolinergicamente activos y beta-mimeticos
BRPI0410727A (pt)	2006-06-20	composto, composição farmacêutica, e, uso de um composto
DK0933993T3 (da)	2006-08-14	Substituerede cyclopentanforbindelser, der er egnede som neuraminidaseinhibitorer
HN2003000044A (es)	2003-08-01	Esteres hidroxamato del acido n - (4-fenil sustituido)-antranilico.
HN2003000038A (es)	2003-01-21	Esteres hidroxamato de acido n-(4-fenil-sustituido)-antranilico
SE0102440D0 (sv)	2001-07-05	New compound
DE69819539D1 (de)	2003-12-11	Antithrombotische mittel
EP1426360A4 (en)	2006-04-12	2-PHENYL-3-HETEROARYLPROPIONIC ACID DERIVATIVE OR SALT THEREOF AND MEDICAMENTS CONTAINING THE SAME
DE69828522D1 (de)	2005-02-10	Antithrombotische mittel
BR0009821A (pt)	2002-01-15	Emprego de derivados de maduraftalazina como inibidores de citosinas pró-inflamatórias
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