ATE435214T1 - Als ionenkanalmodulatoren geeignete chinazoline - Google Patents

Als ionenkanalmodulatoren geeignete chinazoline

Info

Publication number: ATE435214T1
Authority: AT; Austria
Prior art keywords: chinazolines; ion channel; channel modulators; compositions; compounds
Prior art date: 2004-09-02

Application number

AT05807734T

Other languages

English (en)

Inventor

Dean Wilson

Andreas Termin

Jesus Gonzalez

Lev Fanning

Timothy Neubert

Paul Krenitsky

Pramod Joshi

Dennis Hurley

Urvi Sheth

Joshua Boger

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-09-02

Filing date

2005-08-31

Publication date

2009-07-15

2005-08-31 Application filed by Vertex Pharma filed Critical Vertex Pharma

2009-07-15 Application granted granted Critical

2009-07-15 Publication of ATE435214T1 publication Critical patent/ATE435214T1/de

Links

150000001875 compounds Chemical class 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
102000016913 Voltage-Gated Sodium Channels Human genes 0.000 abstract 1
108010053752 Voltage-Gated Sodium Channels Proteins 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Hematology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Dermatology (AREA)
Reproductive Health (AREA)
Anesthesiology (AREA)
Cardiology (AREA)
Psychology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)

AT05807734T 2004-09-02 2005-08-31 Als ionenkanalmodulatoren geeignete chinazoline ATE435214T1 (de)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US60703304P	2004-09-02	2004-09-02
US60715004P	2004-09-02	2004-09-02
US60724504P	2004-09-02	2004-09-02
US60703704P	2004-09-02	2004-09-02
US60703604P	2004-09-02	2004-09-02
PCT/US2005/031146 WO2006028904A1 (en)	2004-09-02	2005-08-31	Quinazolines useful as modulators of ion channels

Publications (1)

Publication Number	Publication Date
ATE435214T1 true ATE435214T1 (de)	2009-07-15

Family

ID=35517001

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05807734T ATE435214T1 (de)	2004-09-02	2005-08-31	Als ionenkanalmodulatoren geeignete chinazoline

Country Status (18)

Country	Link
EP (1)	EP1784393B1 (de)
JP (1)	JP5014994B2 (de)
KR (1)	KR20070057914A (de)
CN (1)	CN101068794B (de)
AT (1)	ATE435214T1 (de)
AU (1)	AU2005282761B2 (de)
BR (1)	BRPI0514893A (de)
CA (1)	CA2578739A1 (de)
DE (1)	DE602005015231D1 (de)
ES (1)	ES2327945T4 (de)
IL (1)	IL181700A0 (de)
MA (1)	MA28909B1 (de)
MX (1)	MX2007002582A (de)
NO (1)	NO20071742L (de)
NZ (1)	NZ589252A (de)
RU (1)	RU2440991C2 (de)
WO (1)	WO2006028904A1 (de)
ZA (1)	ZA200702375B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7910593B2 (en)	2004-04-09	2011-03-22	Chugai Seiyaku Kabushiki Kaisha	Water-soluble prodrugs
US7928107B2 (en)	2004-09-02	2011-04-19	Vertex Pharmaceuticals Incorporated	Quinazolines useful as modulators of ion channels
TW200744603A (en)	2005-08-22	2007-12-16	Chugai Pharmaceutical Co Ltd	Novel anticancer concomitant drug
WO2007046456A1 (ja) *	2005-10-19	2007-04-26	Chugai Seiyaku Kabushiki Kaisha	新規水溶性プロドラッグを含有する、膵臓癌、卵巣癌または肝臓癌の予防または治療剤
NZ568393A (en)	2005-11-14	2011-08-26	Vertex Pharma	Quinazolines useful as modulators of voltage gated ion channels
WO2007071055A1 (en) *	2005-12-21	2007-06-28	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
WO2007146284A2 (en)	2006-06-12	2007-12-21	Vertex Pharmaceuticals Incorporated	Thienopyrimidines useful as modulators of ion channels
EP2099458A4 (de) *	2006-12-01	2011-05-11	Harvard College	Verbindungen und verfahren zur enzym-vermittelten tumordarstellung und therapie
WO2008147864A2 (en) *	2007-05-22	2008-12-04	Xenon Pharmaceuticals Inc.	Methods of using piperazine compounds in treating sodium channel-mediated diseases or conditions
WO2008157500A1 (en) *	2007-06-17	2008-12-24	Kalypsys, Inc.	Aminoquinazoline cannabinoid receptor modulators for treatment of disease
JP2013540130A (ja)	2010-10-05	2013-10-31	パーデュー、ファーマ、リミテッド、パートナーシップ	ナトリウムチャネル遮断剤としてのキナゾリン化合物
US20140080810A1 (en)	2010-11-15	2014-03-20	Exelixis, Inc.	Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture
ES2610556T3 (es)	2011-01-31	2017-04-28	Council Of Scientific & Industrial Research	1-(4-metilfenilmetil)-5-oxo-{N-[(3-t-butoxicarbonil-aminometil)]-piperidin-1-il}-pirrolidin-2-carboxamidas quirales como inhibidores de la activación y adhesión de plaquetas inducidas por colágeno
WO2013000651A1 (en)	2011-06-27	2013-01-03	Newron Pharmaceuticals S.P.A.	Fluorinated arylalkylaminocarboxamide derivatives
PL3438096T3 (pl) *	2016-04-01	2021-05-17	Impact Therapeutics, Inc	Sposób wytwarzania 1-(arylometylo)chinazolino-2,4(1H,3H)-dionu
MA49858A (fr)	2017-08-09	2021-04-28	Denali Therapeutics Inc	Composés, compositions et procédés
DK3676297T3 (da)	2017-09-01	2023-08-14	Denali Therapeutics Inc	Forbindelser, sammensætninger og fremgangsmåder
WO2019183589A1 (en) *	2018-03-23	2019-09-26	Denali Therapeutics Inc.	Modulators of eukaryotic initiation factor 2
EP3825303A4 (de) *	2018-07-17	2022-07-06	Nippon Chemiphar Co., Ltd.	T-calciumkanalblocker
SG11202108552QA (en)	2019-02-13	2021-09-29	Denali Therapeutics Inc	Compounds, compositions and methods
MA54959A (fr)	2019-02-13	2021-12-22	Denali Therapeutics Inc	Composés, compositions et procédés
CN114502549B (zh) *	2019-10-10	2024-10-25	埃斯特韦制药股份公司	针对疼痛具有多模态活性的高哌嗪基和高哌啶基喹唑啉-4(3h)-酮衍生物
DK4069691T3 (da)	2019-12-06	2024-10-28	Vertex Pharma	Substituerede tetrahydrofuraner som modulatorer af natriumkanaler
MA64853B1 (fr)	2021-06-04	2025-11-28	Vertex Pharmaceuticals Incorporated	N-(hydroxyalkyl (hétéro)aryl) tétrahydrofuran carboxamides utilisés en tant que modulateurs de canaux sodiques
CN119757730A (zh) *	2024-12-24	2025-04-04	浙江省海洋水产研究所	一种河豚毒素的胶体金检测卡

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH083144A (ja) *	1994-06-21	1996-01-09	Chugai Pharmaceut Co Ltd	キナゾリン及びキノリン誘導体
GB9718972D0 (en) *	1996-09-25	1997-11-12	Zeneca Ltd	Chemical compounds
SV2002000205A (es) *	1999-11-01	2002-06-07	Lilly Co Eli	Compuestos farmaceuticos ref. x-01095
SE0004054D0 (sv) *	2000-11-06	2000-11-06	Astrazeneca Ab	N-type calcium channel antagonists for the treatment of pain
SE0004055D0 (sv) *	2000-11-06	2000-11-06	Astrazeneca Ab	N-type calcium channel antagonists for the treatment of pain
JP2005516005A (ja) *	2001-12-07	2005-06-02	バーテクスファーマスーティカルズインコーポレイテッド	Ｇｓｋ−３阻害剤として有用なピリミジンベースの化合物
CL2004000409A1 (es) *	2003-03-03	2005-01-07	Vertex Pharma	Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu
AR045445A1 (es) *	2003-08-05	2005-10-26	Vertex Pharma	Compuestos ihinibidores de canales ionicos regulados por voltaje
JP5112297B2 (ja) *	2005-05-20	2013-01-09	バーテックスファーマシューティカルズインコーポレイテッド	イオンチャネルのモジュレーターとして有用なキノリン誘導体

2005
- 2005-08-31 CN CN2005800374969A patent/CN101068794B/zh not_active Expired - Fee Related
- 2005-08-31 CA CA002578739A patent/CA2578739A1/en not_active Abandoned
- 2005-08-31 EP EP05807734A patent/EP1784393B1/de not_active Expired - Lifetime
- 2005-08-31 KR KR1020077007601A patent/KR20070057914A/ko not_active Ceased
- 2005-08-31 AT AT05807734T patent/ATE435214T1/de active
- 2005-08-31 AU AU2005282761A patent/AU2005282761B2/en not_active Ceased
- 2005-08-31 ES ES05807734T patent/ES2327945T4/es not_active Expired - Lifetime
- 2005-08-31 NZ NZ589252A patent/NZ589252A/en not_active IP Right Cessation
- 2005-08-31 JP JP2007530356A patent/JP5014994B2/ja not_active Expired - Fee Related
- 2005-08-31 ZA ZA200702375A patent/ZA200702375B/xx unknown
- 2005-08-31 MX MX2007002582A patent/MX2007002582A/es unknown
- 2005-08-31 RU RU2007111897/04A patent/RU2440991C2/ru not_active IP Right Cessation
- 2005-08-31 WO PCT/US2005/031146 patent/WO2006028904A1/en not_active Ceased
- 2005-08-31 DE DE602005015231T patent/DE602005015231D1/de not_active Expired - Lifetime
- 2005-08-31 BR BRPI0514893-6A patent/BRPI0514893A/pt not_active IP Right Cessation
2007
- 2007-03-02 MA MA29735A patent/MA28909B1/fr unknown
- 2007-03-04 IL IL181700A patent/IL181700A0/en unknown
- 2007-04-02 NO NO20071742A patent/NO20071742L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU2005282761B2 (en)	2012-02-02
ES2327945T3 (es)	2009-11-05
WO2006028904A9 (en)	2006-06-22
ES2327945T4 (es)	2010-07-02
JP5014994B2 (ja)	2012-08-29
CN101068794B (zh)	2012-12-19
WO2006028904A1 (en)	2006-03-16
NZ589252A (en)	2012-06-29
CA2578739A1 (en)	2006-03-16
RU2007111897A (ru)	2008-10-10
MX2007002582A (es)	2008-01-14
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