ATE425982T1 - Thienopyrimidin-derivate als kaliumkanal- inhibitoren - Google Patents
Thienopyrimidin-derivate als kaliumkanal- inhibitorenInfo
- Publication number
- ATE425982T1 ATE425982T1 AT04736524T AT04736524T ATE425982T1 AT E425982 T1 ATE425982 T1 AT E425982T1 AT 04736524 T AT04736524 T AT 04736524T AT 04736524 T AT04736524 T AT 04736524T AT E425982 T1 ATE425982 T1 AT E425982T1
- Authority
- AT
- Austria
- Prior art keywords
- potassium channel
- channel inhibitors
- thienopyrimidine derivatives
- thienopyrimidine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47751803P | 2003-06-11 | 2003-06-11 | |
| GBGB0315950.6A GB0315950D0 (en) | 2003-06-11 | 2003-06-11 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE425982T1 true ATE425982T1 (de) | 2009-04-15 |
Family
ID=33554173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04736524T ATE425982T1 (de) | 2003-06-11 | 2004-06-10 | Thienopyrimidin-derivate als kaliumkanal- inhibitoren |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1641803B3 (de) |
| KR (1) | KR101186678B1 (de) |
| CN (1) | CN1823071B (de) |
| AT (1) | ATE425982T1 (de) |
| AU (1) | AU2004247470B2 (de) |
| BR (1) | BRPI0411239A (de) |
| CA (1) | CA2528848C (de) |
| DE (1) | DE602004020070D1 (de) |
| DK (1) | DK1641803T3 (de) |
| ES (1) | ES2324536T7 (de) |
| MX (1) | MXPA05013549A (de) |
| PL (1) | PL1641803T6 (de) |
| SI (1) | SI1641803T1 (de) |
| WO (1) | WO2004111057A1 (de) |
| ZA (1) | ZA200600225B (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| JP2008505084A (ja) * | 2004-06-29 | 2008-02-21 | アムゲン インコーポレイティッド | フラノピリミジン |
| WO2006047397A1 (en) * | 2004-10-21 | 2006-05-04 | Dow Agrosciences Llc | Thieno-pyrimidine compounds having fungicidal activity |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| US7576080B2 (en) * | 2004-12-23 | 2009-08-18 | Memory Pharmaceuticals Corporation | Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors |
| US7915410B2 (en) | 2005-09-09 | 2011-03-29 | Bristol-Myers Squibb Company | Acyclic IKur inhibitors |
| GB0525164D0 (en) * | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| DE102007027800A1 (de) * | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte bicyclische Heteroaryl-Verbindungen und ihre Verwendung |
| US8883852B2 (en) | 2008-10-22 | 2014-11-11 | University of Pittburgh—Of the Commonwealth System of Higher Education | Radioprotective agents |
| EP2923734B1 (de) | 2009-03-13 | 2018-01-10 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Purineanaloga und ihre verwendung als immunosuppressiva |
| EP2473487B1 (de) | 2009-09-03 | 2016-10-26 | Bristol-Myers Squibb Company | Chinazoline als kaliumionenkanalhemmer |
| EP3533797B1 (de) * | 2010-02-17 | 2023-12-20 | Takeda Pharmaceutical Company Limited | Heterocyclische verbindung |
| GB201012889D0 (en) | 2010-08-02 | 2010-09-15 | Univ Leuven Kath | Antiviral activity of novel bicyclic heterocycles |
| GB201015411D0 (en) | 2010-09-15 | 2010-10-27 | Univ Leuven Kath | Anti-cancer activity of novel bicyclic heterocycles |
| WO2012044993A1 (en) * | 2010-09-30 | 2012-04-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compounds, pharmaceutical compositions, and methods of treating or preventing neurodegenerative diseases or disorders |
| GB201105659D0 (en) | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
| NO3175985T3 (de) | 2011-07-01 | 2018-04-28 | ||
| AR090037A1 (es) | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
| JP2014533258A (ja) * | 2011-11-15 | 2014-12-11 | ゼンション・リミテッドＸｅｎｔｉｏｎ Ｌｉｍｉｔｅｄ | カリウムチャネル阻害剤としてのチエノ［２，３−ｃ］ピラゾールの使用 |
| IN2014CN04558A (de) | 2011-11-23 | 2015-09-18 | Cancer Rec Tech Ltd | |
| JP2015504923A (ja) | 2012-01-27 | 2015-02-16 | ギリアード サイエンシーズ， インコーポレイテッド | 後期ナトリウムイオンチャネル遮断剤およびカリウムイオンチャネル遮断剤を使用する併用療法 |
| WO2014134419A1 (en) | 2013-03-01 | 2014-09-04 | Gilead Sciences, Inc. | Use of ikach blockers for the treatment of cardiac diseases |
| EP2964654A4 (de) * | 2013-03-07 | 2016-08-10 | Glaxosmithkline Llc | Thien[3,2-d]pyrimidin-6-carboxamide und analoga als sirtuin-modulatoren |
| FR3015483B1 (fr) * | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN106727587A (zh) * | 2016-11-28 | 2017-05-31 | 李娜 | 一种治疗心律失常的药物组合物 |
| KR102736865B1 (ko) * | 2017-06-21 | 2024-12-03 | 샤이 테라퓨틱스 엘엘씨 | 암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물 |
| JP7407461B2 (ja) | 2018-12-19 | 2024-01-04 | シャイ・セラピューティクス・エルエルシー | がん、炎症性疾患、ｒａｓ病、及び線維性疾患の処置のためのｒａｓスーパーファミリーと相互作用する化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD248593A1 (de) * | 1985-01-11 | 1987-08-12 | Univ Halle Wittenberg | Verfahren zur herstellung von 4-basischsubstituierten thieno/2,3-d/pyrimidin-6-ylcarbonsaeureestern |
| EP1240147A1 (de) * | 1999-12-21 | 2002-09-18 | Icagen, Inc. | Kaliumkanalblocker |
| US6566380B2 (en) | 2000-07-25 | 2003-05-20 | Icagen, Inc. | Potassium channel inhibitors |
| US6849634B2 (en) | 2000-12-21 | 2005-02-01 | Icagen | Potassium channel inhibitors |
-
2004
- 2004-06-10 CN CN2004800201950A patent/CN1823071B/zh not_active Expired - Fee Related
- 2004-06-10 AU AU2004247470A patent/AU2004247470B2/en not_active Ceased
- 2004-06-10 SI SI200431150T patent/SI1641803T1/sl unknown
- 2004-06-10 DK DK04736524T patent/DK1641803T3/da active
- 2004-06-10 CA CA2528848A patent/CA2528848C/en not_active Expired - Fee Related
- 2004-06-10 BR BRPI0411239-3A patent/BRPI0411239A/pt not_active Application Discontinuation
- 2004-06-10 KR KR1020057023928A patent/KR101186678B1/ko not_active Expired - Fee Related
- 2004-06-10 DE DE602004020070T patent/DE602004020070D1/de not_active Expired - Lifetime
- 2004-06-10 PL PL04736524T patent/PL1641803T6/pl unknown
- 2004-06-10 WO PCT/GB2004/002454 patent/WO2004111057A1/en not_active Ceased
- 2004-06-10 ES ES04736524T patent/ES2324536T7/es active Active
- 2004-06-10 EP EP04736524A patent/EP1641803B3/de not_active Expired - Lifetime
- 2004-06-10 AT AT04736524T patent/ATE425982T1/de active
- 2004-06-10 MX MXPA05013549A patent/MXPA05013549A/es active IP Right Grant
-
2006
- 2006-01-10 ZA ZA200600225A patent/ZA200600225B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1641803A1 (de) | 2006-04-05 |
| WO2004111057A1 (en) | 2004-12-23 |
| MXPA05013549A (es) | 2006-04-05 |
| SI1641803T1 (sl) | 2009-08-31 |
| CN1823071A (zh) | 2006-08-23 |
| EP1641803B3 (de) | 2010-12-08 |
| PL1641803T3 (pl) | 2009-08-31 |
| DK1641803T3 (da) | 2009-06-29 |
| ES2324536T7 (es) | 2012-03-16 |
| ES2324536T3 (es) | 2009-08-10 |
| KR20060057539A (ko) | 2006-05-26 |
| CN1823071B (zh) | 2012-12-19 |
| DE602004020070D1 (de) | 2010-10-07 |
| ZA200600225B (en) | 2007-04-25 |
| CA2528848A1 (en) | 2004-12-23 |
| EP1641803B1 (de) | 2009-03-18 |
| KR101186678B1 (ko) | 2012-09-27 |
| BRPI0411239A (pt) | 2006-07-18 |
| AU2004247470A1 (en) | 2004-12-23 |
| HK1093064A1 (en) | 2007-02-23 |
| AU2004247470B2 (en) | 2009-04-23 |
| PL1641803T6 (pl) | 2011-04-29 |
| CA2528848C (en) | 2012-09-04 |
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