ATE435238T1 - Herstellung eines einkettigen fv antikörperfragments - Google Patents

Herstellung eines einkettigen fv antikörperfragments

Info

Publication number
ATE435238T1
ATE435238T1 AT04010702T AT04010702T ATE435238T1 AT E435238 T1 ATE435238 T1 AT E435238T1 AT 04010702 T AT04010702 T AT 04010702T AT 04010702 T AT04010702 T AT 04010702T AT E435238 T1 ATE435238 T1 AT E435238T1
Authority
AT
Austria
Prior art keywords
preparation
antibody fragment
single chain
methods
antibody fragments
Prior art date
Application number
AT04010702T
Other languages
English (en)
Inventor
Tobias Raum
Julia Henckel
Eva Krinner
Silke Mittelstrass
Andreas Wolf
Original Assignee
Micromet Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromet Ag filed Critical Micromet Ag
Application granted granted Critical
Publication of ATE435238T1 publication Critical patent/ATE435238T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT04010702T 2004-05-05 2004-05-05 Herstellung eines einkettigen fv antikörperfragments ATE435238T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04010702A EP1593690B1 (de) 2004-05-05 2004-05-05 Herstellung eines einkettigen fv Antikörperfragments

Publications (1)

Publication Number Publication Date
ATE435238T1 true ATE435238T1 (de) 2009-07-15

Family

ID=34924877

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04010702T ATE435238T1 (de) 2004-05-05 2004-05-05 Herstellung eines einkettigen fv antikörperfragments

Country Status (8)

Country Link
US (2) US8247194B2 (de)
EP (2) EP1593690B1 (de)
AT (1) ATE435238T1 (de)
AU (1) AU2005238203B2 (de)
CA (1) CA2562604C (de)
DE (1) DE602004021773D1 (de)
DK (1) DK1593690T3 (de)
WO (1) WO2005105844A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE435238T1 (de) * 2004-05-05 2009-07-15 Micromet Ag Herstellung eines einkettigen fv antikörperfragments
BRPI0608281B8 (pt) * 2005-04-18 2021-05-25 Amgen Res Munich Gmbh anticorpo monoclonal humano ou seu fragmento, seu uso no tratamento de doenças inflamatórias, bem como composição farmacêutica que o compreende
RU2447085C2 (ru) 2005-05-18 2012-04-10 МорфоСис АГ Анти-gm-csf антитела и их применение
JP4736037B2 (ja) * 2005-10-26 2011-07-27 株式会社イーベック ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分
US7741450B2 (en) 2006-02-08 2010-06-22 Morphotek Inc. Antibodies to GM-CSF
AU2013201228B2 (en) * 2006-02-08 2016-01-21 Eisai, Inc. Antigenic gm-csf peptides and antibodies to gm-csf
JP5059119B2 (ja) 2006-12-14 2012-10-24 シェーリング コーポレイション 操作された抗ｔｓｌｐ抗体
TW200918553A (en) * 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
CN104072613A (zh) 2007-11-13 2014-10-01 Evec股份有限公司 与hGM-CSF结合的单克隆抗体及包含它的药物组合物
CN102272158B (zh) * 2008-11-12 2014-05-07 乔治·K·刘易斯 源自记忆b细胞的人单克隆抗体的快速表达克隆
CA2747206C (en) 2008-12-22 2018-04-24 The University Of Melbourne Pain treatment
CN102271705A (zh) 2008-12-22 2011-12-07 墨尔本大学 骨关节炎治疗
ES2784123T3 (es) 2009-11-04 2020-09-22 Merck Sharp & Dohme Anticuerpo anti TSLP genomodificado
WO2014004549A2 (en) 2012-06-27 2014-01-03 Amgen Inc. Anti-mesothelin binding proteins
AR093297A1 (es) 2012-10-31 2015-05-27 Amgen Res Munich Gmbh Formulacion liquida que comprende un compuesto neutralizante de gm-csf
WO2014068029A1 (en) 2012-10-31 2014-05-08 Takeda Gmbh Lyophilized formulation comprising gm-csf neutralizing compound
US10745475B2 (en) 2013-08-30 2020-08-18 Takeda Gmbh Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics
WO2016001810A1 (en) 2014-07-01 2016-01-07 Pfizer Inc. Bispecific heterodimeric diabodies and uses thereof
US12338458B2 (en) * 2017-05-25 2025-06-24 Memorial Sloan Kettering Cancer Center Use of the IL-15/IL-15Rα complex in the generation of antigen-specific T cells for adoptive immunotherapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265150B1 (en) * 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
ATE435238T1 (de) * 2004-05-05 2009-07-15 Micromet Ag Herstellung eines einkettigen fv antikörperfragments

Also Published As

Publication number Publication date
CA2562604A1 (en) 2005-11-10
AU2005238203B2 (en) 2010-09-02
DK1593690T3 (da) 2009-11-09
WO2005105844A3 (en) 2006-01-26
WO2005105844A2 (en) 2005-11-10
EP1593690B1 (de) 2009-07-01
US8247194B2 (en) 2012-08-21
US9279017B2 (en) 2016-03-08
EP1742967A2 (de) 2007-01-17
US20130171165A1 (en) 2013-07-04
DE602004021773D1 (de) 2009-08-13
US20080193978A1 (en) 2008-08-14
CA2562604C (en) 2014-02-18
AU2005238203A1 (en) 2005-11-10
EP1593690A1 (de) 2005-11-09

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