DK1593690T3 - Fremstilling af ScFv-antistoffragmenter - Google Patents

Fremstilling af ScFv-antistoffragmenter

Info

Publication number
DK1593690T3
DK1593690T3 DK04010702T DK04010702T DK1593690T3 DK 1593690 T3 DK1593690 T3 DK 1593690T3 DK 04010702 T DK04010702 T DK 04010702T DK 04010702 T DK04010702 T DK 04010702T DK 1593690 T3 DK1593690 T3 DK 1593690T3
Authority
DK
Denmark
Prior art keywords
antibody fragments
preparation
scfv antibody
methods
invention further
Prior art date
Application number
DK04010702T
Other languages
English (en)
Inventor
Tobias Raum
Julia Henckel
Eva Krinner
Silke Mittelstrass
Andreas Wolf
Original Assignee
Micromet Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromet Ag filed Critical Micromet Ag
Application granted granted Critical
Publication of DK1593690T3 publication Critical patent/DK1593690T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK04010702T 2004-05-05 2004-05-05 Fremstilling af ScFv-antistoffragmenter DK1593690T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04010702A EP1593690B1 (en) 2004-05-05 2004-05-05 Preparation of ScFv antibody fragments

Publications (1)

Publication Number Publication Date
DK1593690T3 true DK1593690T3 (da) 2009-11-09

Family

ID=34924877

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04010702T DK1593690T3 (da) 2004-05-05 2004-05-05 Fremstilling af ScFv-antistoffragmenter

Country Status (8)

Country Link
US (2) US8247194B2 (da)
EP (2) EP1593690B1 (da)
AT (1) ATE435238T1 (da)
AU (1) AU2005238203B2 (da)
CA (1) CA2562604C (da)
DE (1) DE602004021773D1 (da)
DK (1) DK1593690T3 (da)
WO (1) WO2005105844A2 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE435238T1 (de) * 2004-05-05 2009-07-15 Micromet Ag Herstellung eines einkettigen fv antikörperfragments
MX2007012569A (es) * 2005-04-18 2007-12-06 Micromet Ag Neutralizadores de anticuerpos del factor estimulante de la colonia de macrofagos-granulocitos humanos.
ES2918209T3 (es) 2005-05-18 2022-07-14 Morphosys Ag Anticuerpos anti-GM-CSF y usos a partir de los mismos
JP4736037B2 (ja) * 2005-10-26 2011-07-27 株式会社イーベック ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分
AU2013201228B2 (en) * 2006-02-08 2016-01-21 Eisai, Inc. Antigenic gm-csf peptides and antibodies to gm-csf
KR101395515B1 (ko) 2006-02-08 2014-05-14 모르포테크, 인크. 항원성 ｇｍ-ｃｓｆ 펩티드 및 ｇｍ-ｃｓｆ에 대한 항체
AR064333A1 (es) 2006-12-14 2009-04-01 Schering Corp Anticuerpo anti-tslp de diseno
TW200918553A (en) * 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
US8679502B2 (en) 2007-11-13 2014-03-25 Evec Inc. Monoclonal antibodies that bind to HGM-CSF and medical compositions comprising same
US8840890B2 (en) * 2008-11-12 2014-09-23 University Of Maryland, Baltimore Rapid expression cloning of human monoclonal antibodies from memory B cells
EP3381471B1 (en) 2008-12-22 2024-03-20 The University of Melbourne Pain treatment
DK2376121T4 (da) 2008-12-22 2021-08-16 Univ Melbourne Slidgigtbehandling
EP3594356A1 (en) 2009-11-04 2020-01-15 Merck Sharp & Dohme Corp. Engineered anti-tslp antibody
WO2014004549A2 (en) 2012-06-27 2014-01-03 Amgen Inc. Anti-mesothelin binding proteins
US9833410B2 (en) 2012-10-31 2017-12-05 Takeda Gmbh Lyophilized formulation comprising GM-CSF neutralizing compound
AR093297A1 (es) 2012-10-31 2015-05-27 Amgen Res Munich Gmbh Formulacion liquida que comprende un compuesto neutralizante de gm-csf
RU2714919C2 (ru) 2013-08-30 2020-02-21 Такеда Гмбх Антитела, нейтрализующие gm-csf, для применения в лечении ревматоидного артрита или в качестве анальгетиков
MX2016017393A (es) 2014-07-01 2017-09-05 Pfizer Diacuerpos heterodimericos biespecificos y sus usos.
CA3064375A1 (en) * 2017-05-25 2018-11-29 Memorial Sloan Kettering Cancer Center Use of the il-15/il-15ra complex in the generation of antigen-specific t cells for adoptive immunotherapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265150B1 (en) * 1995-06-07 2001-07-24 Becton Dickinson & Company Phage antibodies
ATE435238T1 (de) * 2004-05-05 2009-07-15 Micromet Ag Herstellung eines einkettigen fv antikörperfragments

Also Published As

Publication number Publication date
ATE435238T1 (de) 2009-07-15
DE602004021773D1 (de) 2009-08-13
AU2005238203A1 (en) 2005-11-10
CA2562604C (en) 2014-02-18
US8247194B2 (en) 2012-08-21
WO2005105844A3 (en) 2006-01-26
AU2005238203B2 (en) 2010-09-02
US9279017B2 (en) 2016-03-08
EP1593690B1 (en) 2009-07-01
US20080193978A1 (en) 2008-08-14
US20130171165A1 (en) 2013-07-04
EP1742967A2 (en) 2007-01-17
WO2005105844A2 (en) 2005-11-10
CA2562604A1 (en) 2005-11-10
EP1593690A1 (en) 2005-11-09

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